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公开(公告)号：US09192790B2
公开(公告)日：2015-11-24
申请号：US13086116
申请日：2011-04-13
CPC分类号： A61N7/022 , A61B8/0891 , A61B8/12 , A61B8/4488 , A61B18/0206 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2090/3784 , A61N2007/003 , A61N2007/0095
摘要： Acoustic energy is delivered to innervated vascular that contributes to renal sympathetic nerve activity, such as innervated tissue of the renal artery and abdominal aorta. Focused acoustic energy is delivered via an intravascular device of sufficient power to ablate innervated renal or aortal tissue. Focused acoustic energy may be delivered via an intravascular or extracorporeal device to image and locate target innervated renal or aortal tissue. Intravascular, extravascular, or transvascular focused ultrasound devices provide for high precision denervation of innervated vascular to terminate renal sympathetic nerve activity.
摘要翻译： 声能传递给有助于肾交感神经活动的神经支配的血管，如肾动脉和腹主动脉的神经支配组织。 聚焦的声能通过具有足够功率的血管内装置递送以消融支配的肾脏或主动脉组织。 聚焦的声能可以通过血管内或体外装置递送到图像并定位目标神经支配的肾或主动脉组织。 血管内，血管外或经血管聚焦的超声装置提供神经支配血管的高精度去神经支配以终止肾交感神经活动。
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公开(公告)号：US20110257641A1
公开(公告)日：2011-10-20
申请号：US13086121
申请日：2011-04-13
IPC分类号： A61B18/24
CPC分类号： A61B18/24 , A61B2018/00011 , A61B2018/1807 , A61B2018/208 , A61B2018/263 , A61B2090/3782 , A61N2007/003
摘要： Apparatuses and methods facilitate delivery of optical or photoacoustic energy to innervated vascular that contributes to renal sympathetic nerve activity. The optical energy delivered may be of sufficient power to scan or image innervated renal or aortal tissue. The optical energy delivered may be of sufficient power to ablate innervated renal or aortal tissue, such as by thermal laser ablation or photoacoustic laser ablation. A catheter for intravascular or extravascular deployment supports an optical fiber arrangement comprising a coupling for receiving light from a laser light source. An optics arrangement is supported by the catheter and coupled to the optical fiber arrangement. The optics arrangement includes one or more optical elements arranged to receive the laser light and direct optical energy to target innervated tissue or a water source from which a cavitation bubble may be created and launched for acoustically shocking the target innervated tissue.
摘要翻译： 装置和方法有助于将光学或光声能量传递给有助于肾交感神经活动的神经支配的血管。 输送的光能可能具有足够的功率来扫描或图像支配的肾脏或主动脉组织。 输送的光能可能具有足够的功率来消融支配的肾或主动脉组织，例如通过热激光烧蚀或光声激光烧蚀。 用于血管内或血管外展开的导管支持包括用于接收来自激光光源的光的耦合器的光纤装置。 光学装置由导管支撑并耦合到光纤装置。 光学装置包括一个或多个光学元件，其布置成接收激光并将光能引导到目标主导组织或水源，从该水源可以产生和发射空化气泡用于声学震动目标神经组织。
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公开(公告)号：US20110257523A1
公开(公告)日：2011-10-20
申请号：US13086116
申请日：2011-04-13
CPC分类号： A61N7/022 , A61B8/0891 , A61B8/12 , A61B8/4488 , A61B18/0206 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2090/3784 , A61N2007/003 , A61N2007/0095
摘要： Acoustic energy is delivered to innervated vascular that contributes to renal sympathetic nerve activity, such as innervated tissue of the renal artery and abdominal aorta. Focused acoustic energy is delivered via an intravascular device of sufficient power to ablate innervated renal or aortal tissue. Focused acoustic energy may be delivered via an intravascular or extracorporeal device to image and locate target innervated renal or aortal tissue. Intravascular, extravascular, or transvascular focused ultrasound devices provide for high precision denervation of innervated vascular to terminate renal sympathetic nerve activity.
摘要翻译： 声能传递给有助于肾交感神经活动的神经支配的血管，如肾动脉和腹主动脉的神经支配组织。 聚焦的声能通过具有足够功率的血管内装置递送以消融支配的肾脏或主动脉组织。 聚焦的声能可以通过血管内或体外装置递送到图像并定位目标神经支配的肾或主动脉组织。 血管内，血管外或经血管聚焦的超声装置提供神经支配血管的高精度去神经支配以终止肾交感神经活动。
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公开(公告)号：US20110319778A1
公开(公告)日：2011-12-29
申请号：US13168531
申请日：2011-06-24
IPC分类号： A61B5/0245 , A61N1/365
CPC分类号： A61N1/36514 , A61B5/02133 , A61B5/026 , A61N1/08 , A61N1/36142 , A61N1/36578
摘要： Systems and methods to monitor cardiac function using information indicative of lead motion are described. In an example, a system including an implantable medical device can include a receiver circuit configured to be electrically coupled to conductor comprising a portion of an implantable lead and be configured to obtain information indicative of a movement of the implantable lead due at least in part to a motion of a heart. The system can include a sensing circuit configured to obtain information indicative of cardiac electrical activity. The system can include a processor circuit configured to construct a template representative of a contraction of the heart, where the template can be constructed using the information indicative of the movement of the implantable lead due at least in part to the motion of the heart during the contraction, and using the information indicative of the cardiac electrical activity sensed during the contraction.
摘要翻译： 描述使用指示引导运动的信息来监测心脏功能的系统和方法。 在一个示例中，包括可植入医疗装置的系统可以包括被配置为电耦合到导体的接收器电路，该导体包括可植入引线的一部分，并且被配置为获得指示可植入引线的移动的信息， 一个心脏的动作。 该系统可以包括被配置为获得指示心脏电活动的信息的感测电路。 该系统可以包括配置成构造代表心脏收缩的模板的处理器电路，其中可以使用指示可植入导线的运动的信息来构建模板，至少部分地由于心脏的运动 并且使用指示在收缩期间感测到的心脏电活动的信息。
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5.发明授权Cardiac mechanical vibration monitor using information indicative of lead motion 有权心脏机械振动监测器使用指示引导运动的信息公开(公告)号：US08532770B2
公开(公告)日：2013-09-10
申请号：US13168547
申请日：2011-06-24
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61B5/02133 , A61B5/026 , A61N1/08 , A61N1/36142 , A61N1/36578
摘要： Systems and methods to monitor cardiac mechanical vibrations using information indicative of lead motion are described. In an example, a system including an implantable medical device can include an excitation circuit configured to provide a non-tissue stimulating, non-therapeutic electrical excitation signal to a portion of an implantable lead. A receiver circuit can be configured to obtain information indicative of a mechanical vibration of the implantable lead due at least in part to one or more of an impact of at least a portion of the heart to the implantable lead, or friction contact between the implantable lead and cardiac tissue. The system can include a processor circuit configured to determine one or more of a lead mechanical status, or information indicative of valvular activity using the information indicative of the mechanical vibration of the implantable lead.
摘要翻译： 描述使用指示引导运动的信息来监测心脏机械振动的系统和方法。 在一个示例中，包括可植入医疗装置的系统可以包括被配置为向可植入引线的一部分提供非组织刺激的非治疗电激励信号的激励电路。 接收器电路可以被配置为获得指示可植入引线的机械振动的信息，其至少部分地由至少一部分心脏到可植入引线的冲击或可植入引线之间的摩擦接触 和心脏组织。 该系统可以包括处理器电路，其被配置为使用指示可植入引线的机械振动的信息来确定引导机械状态或指示瓣膜活动的信息中的一个或多个。
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公开(公告)号：US08649853B2
公开(公告)日：2014-02-11
申请号：US13168531
申请日：2011-06-24
CPC分类号： A61N1/36514 , A61B5/02133 , A61B5/026 , A61N1/08 , A61N1/36142 , A61N1/36578
摘要： Systems and methods to monitor cardiac function using information indicative of lead motion are described. In an example, a system including an implantable medical device can include a receiver circuit configured to be electrically coupled to conductor comprising a portion of an implantable lead and be configured to obtain information indicative of a movement of the implantable lead due at least in part to a motion of a heart. The system can include a sensing circuit configured to obtain information indicative of cardiac electrical activity. The system can include a processor circuit configured to construct a template representative of a contraction of the heart, where the template can be constructed using the information indicative of the movement of the implantable lead due at least in part to the motion of the heart during the contraction, and using the information indicative of the cardiac electrical activity sensed during the contraction.
摘要翻译： 描述使用指示引导运动的信息来监测心脏功能的系统和方法。 在一个示例中，包括可植入医疗装置的系统可以包括被配置为电耦合到导体的接收器电路，该导体包括可植入引线的一部分，并且被配置为获得指示可植入引线的移动的信息， 一个心脏的动作。 该系统可以包括被配置为获得指示心脏电活动的信息的感测电路。 该系统可以包括配置成构造代表心脏收缩的模板的处理器电路，其中可以使用指示可植入导线的运动的信息构造模板，至少部分地由于心脏的运动 并且使用指示在收缩期间感测到的心脏电活动的信息。
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7.发明申请CARDIAC CONTRACTION DETECTION USING INFORMATION INDICATIVE OF LEAD MOTION 有权使用指示铅运动的信息进行CARDIAC承包检测公开(公告)号：US20110319776A1
公开(公告)日：2011-12-29
申请号：US13168507
申请日：2011-06-24
IPC分类号： A61B5/0245 , A61B5/042 , A61N1/365
CPC分类号： A61N1/36514 , A61B5/02133 , A61B5/026 , A61N1/08 , A61N1/36142 , A61N1/36578
摘要： Systems and methods for cardiac contraction detection using information indicative of lead motion are described. In an example, an implantable medical device can include a receiver circuit configured to be electrically coupled to conductor comprising a portion of an implantable lead and be configured to obtain information indicative of a movement of the implantable lead due at least in part to a motion of a heart. The device can include a processor circuit configured to determine whether a cardiac mechanical contraction occurred during a specified interval included in the obtained information indicative of the movement of the implantable lead. The processor circuit can be configured to determine information about the cardiac mechanical contraction using the obtained information indicative of the movement of the implantable lead.
摘要翻译： 描述使用指示引导运动的信息进行心脏收缩检测的系统和方法。 在一个示例中，可植入医疗设备可以包括被配置为电耦合到导体的接收器电路，该导体包括可植入引线的一部分，并被配置为获得指示可植入引线的运动的信息，至少部分地由 一个心脏。 该装置可以包括处理器电路，该处理器电路被配置为确定在所获得的指示可植入引线的运动的信息中包括的指定间隔期间是否发生心脏机械收缩。 处理器电路可以被配置为使用获得的指示可植入引线的移动的信息来确定关于心脏机械收缩的信息。
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公开(公告)号：US08478392B2
公开(公告)日：2013-07-02
申请号：US13168481
申请日：2011-06-24
IPC分类号： A61B5/04
CPC分类号： A61N1/36514 , A61B5/02133 , A61B5/026 , A61N1/08 , A61N1/36142 , A61N1/36578
摘要： Systems and methods for rhythm discrimination using the motion of an implantable lead are described. In an example, an implantable medical device can include a receiver circuit configured to be electrically coupled to an implantable lead and be configured to obtain information indicative of a movement of the implantable lead due at least in part to a motion of a heart. The device can include an arrhythmia detection circuit configured to determine an arrhythmia status using the information indicative of the movement of the implantable lead and an arrhythmia classification circuit configured to determine one or more of a location or a type of an arrhythmia, using the information indicative of the movement of the implantable lead, when the arrhythmia status indicates that an arrhythmia is occurring or has occurred.
摘要翻译： 描述使用可植入引线的运动进行节律辨别的系统和方法。 在一个示例中，可植入医疗设备可以包括被配置为电耦合到可植入引线的接收器电路，并且被配置为获得至少部分地基于心脏的运动而指示可植入引线的运动的信息。 该装置可以包括心律失常检测电路，其被配置为使用指示可植入引线的移动的信息来确定心律失常状态，以及心律失常分类电路，其被配置为使用所述信息指示来确定心律不齐的位置或类型中的一个或多个 当心律失常状态表示发生心律失常或发生心律失常时，可植入性铅的运动。
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9.发明申请CARDIAC MECHANICAL VIBRATION MONITOR USING INFORMATION INDICATIVE OF LEAD MOTION 有权使用信号指示铅运动的心脏机械振动监测器公开(公告)号：US20110319782A1
公开(公告)日：2011-12-29
申请号：US13168547
申请日：2011-06-24
CPC分类号： A61N1/36514 , A61B5/02133 , A61B5/026 , A61N1/08 , A61N1/36142 , A61N1/36578
摘要： Systems and methods to monitor cardiac mechanical vibrations using information indicative of lead motion are described. In an example, a system including an implantable medical device can include an excitation circuit configured to provide a non-tissue stimulating, non-therapeutic electrical excitation signal to a portion of an implantable lead. A receiver circuit can be configured to obtain information indicative of a mechanical vibration of the implantable lead due at least in part to one or more of an impact of at least a portion of the heart to the implantable lead, or friction contact between the implantable lead and cardiac tissue. The system can include a processor circuit configured to determine one or more of a lead mechanical status, or information indicative of valvular activity using the information indicative of the mechanical vibration of the implantable lead.
摘要翻译： 描述使用指示引导运动的信息来监测心脏机械振动的系统和方法。 在一个示例中，包括可植入医疗装置的系统可以包括被配置为向可植入引线的一部分提供非组织刺激的非治疗电激励信号的激励电路。 接收器电路可以被配置为获得指示可植入引线的机械振动的信息，其至少部分地由至少一部分心脏到可植入引线的冲击或可植入引线之间的摩擦接触 和心脏组织。 该系统可以包括处理器电路，其被配置为使用指示可植入引线的机械振动的信息来确定引导机械状态或指示瓣膜活动的信息中的一个或多个。
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公开(公告)号：US20110319779A1
公开(公告)日：2011-12-29
申请号：US13168481
申请日：2011-06-24
IPC分类号： A61B5/0452 , A61B5/02 , A61N1/365
CPC分类号： A61N1/36514 , A61B5/02133 , A61B5/026 , A61N1/08 , A61N1/36142 , A61N1/36578
摘要： Systems and methods for rhythm discrimination using the motion of an implantable lead are described. In an example, an implantable medical device can include a receiver circuit configured to be electrically coupled to an implantable lead and be configured to obtain information indicative of a movement of the implantable lead due at least in part to a motion of a heart. The device can include an arrhythmia detection circuit configured to determine an arrhythmia status using the information indicative of the movement of the implantable lead and an arrhythmia classification circuit configured to determine one or more of a location or a type of an arrhythmia, using the information indicative of the movement of the implantable lead, when the arrhythmia status indicates that an arrhythmia is occurring or has occurred.
摘要翻译： 描述使用可植入引线的运动进行节律辨别的系统和方法。 在一个示例中，可植入医疗设备可以包括被配置为电耦合到可植入引线的接收器电路，并且被配置为获得至少部分地基于心脏的运动而指示可植入引线的运动的信息。 该装置可以包括心律失常检测电路，其被配置为使用指示可植入引线的移动的信息来确定心律失常状态，以及心律失常分类电路，其被配置为使用所述信息指示来确定心律不齐的位置或类型中的一个或多个 当心律失常状态表示发生心律失常或发生心律失常时，可植入性铅的运动。
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