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    UNSATURATED FATTY AMINO ACID DERIVATIVES AND USE THEREOF IN DERMAL COSMETOLOGY
    1.
    发明申请
    UNSATURATED FATTY AMINO ACID DERIVATIVES AND USE THEREOF IN DERMAL COSMETOLOGY 审中-公开
    不饱和脂肪氨基酸衍生物及其在真菌学中的应用

    公开(公告)号：US20100240754A1

    公开(公告)日：2010-09-23

    申请号：US12523231

    申请日：2008-01-16

    申请人： Roger Tarroux ,  Marie Charveron ,  Sylvie Daunes-Marion ,  Natacha Frison ,  Benôit Folleas ,  Jean-Louis Brayer

    发明人： Roger Tarroux ,  Marie Charveron ,  Sylvie Daunes-Marion ,  Natacha Frison ,  Benôit Folleas ,  Jean-Louis Brayer

    IPC分类号： C07C229/30 ,  C07C227/00 ,  A61K31/197 ,  A61K8/44 ,  A61Q19/08 ,  A61P17/00

    CPC分类号： C07C229/30 ,  C07C227/00 ,  C07C237/16

    摘要： The present invention relates to drugs consisting of unsaturated fatty amino-acid derivatives of the general formula (I), and to their pharmaceutically acceptable acid addition salts, in which: X is oxygen or NH, Rn are independently hydrogen or a (C1-C6)alkyl optionally substituted by halogen; R1 is hydrogen, fluorine, chlorine or bromine, or a CF3 or CHF2 or a (C1-C6)alkyl, (C1-C6)alkenyl or (C1-C6)alkynyl, optionally substituted by one or more halogen atoms; R is hydrogen or a (C1-C6)alkyl or (C3-C6)cycloalkyl optionally substituted by one or more halogen atoms; Ra and Rb are independently hydrogen (C1-C6)alkyl or (C1-C6)acyl, and Ra and Rb a hydrocarbonated cycle containing 4 to 6 carbon atoms; and n is an integer between 2 and 14.

    摘要翻译： 本发明涉及由通式（I）的不饱和脂肪氨基酸衍生物及其药学上可接受的酸加成盐组成的药物，其中：X为氧或NH，R n独立地为氢或（C 1 -C 6 ）烷基任选被卤素取代; R 1是任选被一个或多个卤素原子取代的氢，氟，氯或溴，或CF 3或CHF 2或（C 1 -C 6）烷基，（C 1 -C 6）烯基或（C 1 -C 6） R是氢或任选被一个或多个卤素原子取代的（C 1 -C 6）烷基或（C 3 -C 6）环烷基; Ra和Rb独立地是氢（C1-C6）烷基或（C1-C6）酰基，Ra和Rb是含有4-6个碳原子的烃基; n为2〜14的整数。

    Unsaturated fatty hydroxy acid derivatives and the dermocosmetologic use thereof
    2.
    发明授权
    Unsaturated fatty hydroxy acid derivatives and the dermocosmetologic use thereof 有权
    不饱和脂肪酸羟基酸衍生物及其皮肤用途

    公开(公告)号：US08158811B2

    公开(公告)日：2012-04-17

    申请号：US12083688

    申请日：2006-10-20

    申请人： Marie Charveron ,  Roger Tarroux ,  Pascal Bordat

    发明人： Marie Charveron ,  Roger Tarroux ,  Pascal Bordat

    IPC分类号： C07C59/00

    CPC分类号： C07C59/56 ,  C07C59/42

    摘要： The invention relates to unsaturated fatty hydroxy acid derivatives of formula (I), wherein Rn is independent from each other H or linear or branched alkyl group which contain from 1 to 6 carbon atoms and which are possibly substituted by a halogen atom, in particular a fluorine atom, RI is H, F, Cl, Br or CF3, R is H or linear or branched alkyl group which contain from 1 to 6 carbon atoms and which are possibly substituted by a halogen atom, in particular a fluorine atom and 3=n=14. Said derivatives is suitable for producing an anti-radical, anti-inflammatory and antipruritic dermocosmetologic composition and/or for treating keratinisation and pigmentation troubles and/or for improving healing.

    摘要翻译： 本发明涉及式（I）的不饱和脂肪酸羟基酸衍生物，其中R n彼此独立地为H或含有1至6个碳原子且可被卤素原子取代的直链或支链烷基，特别是 氟原子，R 1为H，F，Cl，Br或CF 3，R为H或含有1至6个碳原子并且可被卤素原子特别是氟原子取代的直链或支链烷基，且3 = n = 14。 所述衍生物适于产生抗自由基，抗炎和止痒皮肤组织学组合物和/或用于治疗角质化和色素沉着问题和/或改善愈合。

    Novel Unsaturated Fatty Hydroxy Acid Derivatives and the Dermocosmetologic Use Thereof
    3.
    发明申请
    Novel Unsaturated Fatty Hydroxy Acid Derivatives and the Dermocosmetologic Use Thereof 有权
    新型不饱和脂肪酸羟基衍生物及其皮肤用途

    公开(公告)号：US20090238784A1

    公开(公告)日：2009-09-24

    申请号：US12083688

    申请日：2006-10-20

    申请人： Marie Charveron ,  Roger Tarroux ,  Pascal Bordat

    发明人： Marie Charveron ,  Roger Tarroux ,  Pascal Bordat

    IPC分类号： A61K8/365 ,  C07C59/115 ,  A61Q19/02

    CPC分类号： C07C59/56 ,  C07C59/42

    摘要： The invention relates to unsaturated fatty hydroxy acid derivatives of formula (I), wherein Rn is independent from each other H or linear or branched alkyl group which contain from 1 to 6 carbon atoms and which are possibly substituted by a halogen atom, in particular a fluorine atom, R1 is H, F, Cl, Br or CF3, R is H or linear or branched alkyl group which contain from 1 to 6 carbon atoms and which are possibly substituted by a halogen atom, in particular a fluorine atom and 3=n=14. Said derivatives is suitable for producing an anti-radical, anti-inflammatory and antipruritic dermocosmetologic composition and/or for treating keratinisation and pigmentation troubles and/or for improving healing.

    摘要翻译： 本发明涉及式（I）的不饱和脂肪酸羟基酸衍生物，其中R n彼此独立地为H或含有1至6个碳原子且可被卤素原子取代的直链或支链烷基，特别是 氟原子，R 1是H，F，Cl，Br或CF 3，R是H或含有1至6个碳原子并且可以被卤素原子特别是氟原子取代的直链或支链烷基，3 = n = 14。 所述衍生物适于产生抗自由基，抗炎和止痒皮肤组织学组合物和/或用于治疗角质化和色素沉着问题和/或改善愈合。

    1-Aryl 2-aminomethyl cyclopropane carboxylates (Z)
    6.
    发明授权
    1-Aryl 2-aminomethyl cyclopropane carboxylates (Z) 失效
    2-芳基2-氨基甲基环丙烷羧酸酯（Z）

    公开(公告)号：US4567288A

    公开(公告)日：1986-01-28

    申请号：US656443

    申请日：1984-10-01

    申请人： Henri Cousse ,  Gilbert Mouzin ,  Bernard Bonnaud ,  Marie Charveron ,  Francois Fauran

    发明人： Henri Cousse ,  Gilbert Mouzin ,  Bernard Bonnaud ,  Marie Charveron ,  Francois Fauran

    IPC分类号： A61K31/445 ,  A61K31/451 ,  A61P25/04 ,  C07C67/00 ,  C07C229/46 ,  C07C301/00 ,  C07C303/40 ,  C07C311/39 ,  C07D211/14 ,  C07D295/155 ,  C07D307/14 ,  C07C79/46 ,  C07C101/02 ,  C07C101/30

    CPC分类号： C07D295/155 ,  C07D211/14 ,  C07D307/14

    摘要： The present invention concerns new derivatives of 1-aryl 2-aminomethyl cyclopropane carboxylates (Z), their preparation and their use as useful drugs for the treatment of various pains.The new derivatives of the present invention have the general formula I ##STR1## in which: R represents a hydrogen or halogen atom, a C.sub.1 to C.sub.4 lower alkyl group, a C.sub.1 to C.sub.4 lower alkoxy group, or a nitro, amino, sulfamoyl or hydroxy group;n represents the values 1, 2 or 3;(R).sub.n may together with the benzene ring also form the naphthyl group;R.sub.1 represents a linear or branched C.sub.1 to C.sub.5 alkyl or alkenyl group or an aryl or benzyl group;R.sub.2 and R.sub.3 represent a hydrogen atom, a linear or branched C.sub.1 to C.sub.5 alkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl or dialkylaminoalkyl group or an aryl, arylalkyl or cycloalkyl group;R.sub.2 and R.sub.3 possibly also forming a heterocycle of 5 or 6 members with the adjacent nitrogen atom,provided however that when R.sub.1 represents the ethyl radical and R represents a hydrogen atom, R.sub.2 and R.sub.3 cannot simultaneously represent a methyl radical.

    摘要翻译： 本发明涉及1-芳基2-氨基甲基环丙烷羧酸酯（Z）的新衍生物，其制备及其作为治疗各种疼痛的有用药物的用途。 本发明的新衍生物具有通式I（I），其中：R表示氢或卤素原子，C1至C4低级烷基，C1至C4低级烷氧基或硝基，氨基 ，氨磺酰基或羟基; n表示值1,2或3; （R）n可以与苯环一起形成萘基; R1表示直链或支链C1至C5烷基或烯基或芳基或苄基; R2和R3表示氢原子，直链或支链C1至C5烷基，烯基，炔基，羟基烷基，烷氧基烷基，羧基烷基或二烷基氨基烷基或芳基，芳烷基或环烷基; R2和R3也可能与相邻的氮原子形成5或6个成员的杂环，但是当R1表示乙基且R表示氢原子时，R2和R3不能同时代表甲基。

    1-Aryl 2-aminomethyl cyclopropane carboxylates (Z) as drugs in the treatment of pain
    7.
    发明授权
    1-Aryl 2-aminomethyl cyclopropane carboxylates (Z) as drugs in the treatment of pain 失效
    1-芳基2-氨基甲基环丙烷羧酸盐（Z）作为药物治疗疼痛

    公开(公告)号：US4507318A

    公开(公告)日：1985-03-26

    申请号：US390811

    申请日：1982-06-22

    申请人： Henri Cousse ,  Gilbert Mouzin ,  Bernard Bonnaud ,  Marie Charveron ,  Francois Fauran

    发明人： Henri Cousse ,  Gilbert Mouzin ,  Bernard Bonnaud ,  Marie Charveron ,  Francois Fauran

    IPC分类号： A61K31/445 ,  A61K31/451 ,  A61P25/04 ,  C07C67/00 ,  C07C229/46 ,  C07C301/00 ,  C07C303/40 ,  C07C311/39 ,  C07D211/14 ,  C07D295/155 ,  C07D307/14 ,  A61K31/34 ,  A61K31/215 ,  A61K31/395 ,  C07C93/24

    CPC分类号： C07D295/155 ,  C07D211/14 ,  C07D307/14

    摘要： The present invention concerns new derivatives of 1-aryl 2-aminomethyl cyclopropane carboxylates (Z), their preparation and their use as useful drugs for the treatment of various pains.The new derivatives of the present invention have the general formula I ##STR1## in which: R represents a hydrogen or halogen atom, a C.sub.1 to C.sub.4 lower alkyl group, a C.sub.1 to C.sub.4 lower alkoxy group, or a nitro, amino, sulfamoyl or hydroxy group;n represents the values 1, 2 or 3;(R).sub.n may together with the benzene ring also form the naphthyl group;R.sub.1 represents a linear or branched C.sub.1 to C.sub.5 alkyl or alkenyl group or an aryl or benzyl group;R.sub.2 and R.sub.3 represent a hydrogen atom, a linear or branched C.sub.1 to C.sub.5 alkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl or dialkylaminoalkyl group or an aryl, arylalkyl or cycloalkyl group;R.sub.2 and R.sub.3 possibly also forming a heterocycle of 5 or 6 members with the adjacent nitrogen atom,provided however that when R.sub.1 represents the ethyl radical and R represents a hydrogen atom, R.sub.2 and R.sub.3 cannot simultaneously represent a methyl radical.

    摘要翻译： 本发明涉及1-芳基2-氨基甲基环丙烷羧酸酯（Z）的新衍生物，其制备及其作为治疗各种疼痛的有用药物的用途。 本发明的新衍生物具有通式I（I），其中：R表示氢或卤素原子，C1至C4低级烷基，C1至C4低级烷氧基或硝基，氨基 ，氨磺酰基或羟基; n表示值1,2或3; （R）n可以与苯环一起形成萘基; R1表示直链或支链C1至C5烷基或烯基或芳基或苄基; R2和R3表示氢原子，直链或支链C1至C5烷基，烯基，炔基，羟基烷基，烷氧基烷基，羧基烷基或二烷基氨基烷基或芳基，芳烷基或环烷基; R2和R3也可能与相邻的氮原子形成5或6个成员的杂环，但是当R1表示乙基且R表示氢原子时，R2和R3不能同时代表甲基。