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    Phenyl derivatives and methods of use
    1.
    发明申请
    Phenyl derivatives and methods of use 失效
    苯基衍生物和使用方法

    公开(公告)号：US20060074086A1

    公开(公告)日：2006-04-06

    申请号：US11242318

    申请日：2005-10-03

    Applicant: Roland Dolle ,  Karin Worm ,  Q. Jean Zhou

    Inventor： Roland Dolle ,  Karin Worm ,  Q. Jean Zhou

    IPC: A61K31/537 ,  C07D265/30

    CPC classification number: C07D213/82 ,  C07C275/24 ,  C07C275/32 ,  C07C311/04 ,  C07C311/08 ,  C07D207/28 ,  C07D207/34 ,  C07D213/89 ,  C07D231/14 ,  C07D241/24 ,  C07D261/18 ,  C07D285/06 ,  C07D295/096 ,  C07D295/185 ,  C07D307/24 ,  C07D307/68 ,  C07D333/38

    Abstract: Novel phenyl compounds, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the compounds are agonists and/or ligands of cannabinoid receptors and may be useful, inter alia, for treating and/or preventing pain, gastrointestinal disorders, genitourinary disorders, inflammation, glaucoma, auto-immune diseases, ischemic conditions, immune-related disorders, and neurodegenerative diseases, for providing cardioprotection against ischemic and reperfusion effects, for inducing apoptosis in malignant cells, and as an appetite stimulant.

    Abstract translation: 公开了新的苯基化合物，含有这些化合物的药物组合物及其药物用途的方法。 在某些实施方案中，化合物是大麻素受体的激动剂和/或配体，并且可用于治疗和/或预防疼痛，胃肠道疾病，泌尿生殖器疾病，炎症，青光眼，自身免疫疾病，缺血性疾病，免疫 相关疾病和神经变性疾病，用于提供针对缺血和再灌注作用的心脏保护，用于诱导恶性细胞中的细胞凋亡以及作为食欲刺激剂。

    Sulfamoyl Benzamides and Methods of Their Use
    2.
    发明申请
    Sulfamoyl Benzamides and Methods of Their Use 失效
    磺酰胺苯甲酰胺及其使用方法

    公开(公告)号：US20080058302A1

    公开(公告)日：2008-03-06

    申请号：US11558332

    申请日：2006-11-09

    Applicant: Roland Dolle ,  Karin Worm

    Inventor： Roland Dolle ,  Karin Worm

    IPC: A61K31/195 ,  A61K31/34 ,  A61K31/397 ,  A61K31/40 ,  A61K31/445 ,  A61K31/535 ,  A61P25/00 ,  C07C307/02 ,  C07D265/30

    CPC classification number: C07D295/26 ,  C07C311/38 ,  C07C311/40 ,  C07C311/42 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/42 ,  C07C2603/74 ,  C07D207/12 ,  C07D209/44 ,  C07D211/42 ,  C07D211/44

    Abstract: Novel sulfamoyl benzamide compounds, pharmaceutical compositions containing the sulfamoyl benzamide compounds, and methods of their pharmaceutical use are disclosed. In certain embodiments, the sulfamoyl benzamide compounds are agonists and/or ligands of cannabinoid receptors and may be useful, inter alia, for treating and/or preventing pain, gastrointestinal disorders, inflammation, auto-immune diseases, ischemic conditions, immune-related disorders, hypertension, neurological disorders, and neurodegenerative diseases, for providing cardioprotection against ischemic and reperfusion effects, for inducing apoptosis in malignant cells, for inhibiting mechanical hyperalgesia associated with nerve injury, and as an appetite stimulant.

    Abstract translation: 公开了新型氨磺酰苯甲酰胺化合物，含有氨磺酰苯甲酰胺化合物的药物组合物及其药物用途的方法。 在某些实施方案中，氨磺酰苯甲酰胺化合物是大麻素受体的激动剂和/或配体，尤其可用于治疗和/或预防疼痛，胃肠道疾病，炎症，自身免疫疾病，缺血性病症，免疫相关疾病 ，高血压，神经系统疾病和神经变性疾病，用于提供针对缺血和再灌注作用的心脏保护，用于诱导恶性细胞凋亡，用于抑制与神经损伤相关的机械痛觉过敏以及作为食欲刺激剂。

    Sulfamoyl benzamide derivatives and methods of their use
    3.
    发明申请
    Sulfamoyl benzamide derivatives and methods of their use 失效
    氨磺酰苯甲酰胺衍生物及其使用方法

    公开(公告)号：US20060079557A1

    公开(公告)日：2006-04-13

    申请号：US11251160

    申请日：2005-10-13

    Applicant: Roland Dolle ,  Karin Worm ,  Q. Zhou

    Inventor： Roland Dolle ,  Karin Worm ,  Q. Zhou

    IPC: C07D211/06 ,  A61K31/445

    CPC classification number: C07D205/04 ,  C07C311/16 ,  C07C311/21 ,  C07C2602/42 ,  C07C2603/74 ,  C07D207/48 ,  C07D209/44 ,  C07D211/46 ,  C07D211/60 ,  C07D211/96 ,  C07D213/40 ,  C07D215/58 ,  C07D295/26

    Abstract: Novel sulfamoyl benzamide compounds, pharmaceutical compositions containing the sulfamoyl benzamide compounds, and methods of their pharmaceutical use are disclosed. In certain embodiments, the sulfamoyl benzamide compounds are agonists and/or modulating ligands of cannabinoid receptors and may be useful, inter alia, for treating and/or preventing pain, gastrointestinal disorders, inflammation, auto-immune diseases, ischemic conditions, immune-related disorders, hypertension, neurological disorders, and neurodegenerative diseases, for providing cardioprotection against ischemic and reperfusion effects, for inducing apoptosis in malignant cells, for inhibiting mechanical hyperalgesia associated with nerve injury, and as an appetite stimulant.

    Abstract translation: 公开了新型氨磺酰苯甲酰胺化合物，含有氨磺酰苯甲酰胺化合物的药物组合物及其药物用途的方法。 在某些实施方案中，氨磺酰苯甲酰胺化合物是大麻素受体的激动剂和/或调节配体，并且尤其可用于治疗和/或预防疼痛，胃肠道疾病，炎症，自身免疫疾病，缺血性病症，免疫相关 疾病，高血压，神经系统疾病和神经变性疾病，用于提供针对缺血和再灌注作用的心脏保护，用于诱导恶性细胞凋亡，用于抑制与神经损伤相关的机械痛觉过敏以及作为食欲刺激剂。

    Sulfamoyl benzamides and methods of their use
    6.
    发明授权
    Sulfamoyl benzamides and methods of their use 失效
    氨磺酰苯甲酰胺及其使用方法

    公开(公告)号：US07544676B2

    公开(公告)日：2009-06-09

    申请号：US11558332

    申请日：2006-11-09

    Applicant: Roland E. Dolle ,  Karin Worm

    Inventor： Roland E. Dolle ,  Karin Worm

    IPC: A61K31/195 ,  A61K31/34 ,  A61K31/397 ,  A61K31/40 ,  A61K31/445 ,  A61K31/535 ,  A61P25/00 ,  C07C307/02 ,  C07D265/30

    CPC classification number: C07D295/26 ,  C07C311/38 ,  C07C311/40 ,  C07C311/42 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/42 ,  C07C2603/74 ,  C07D207/12 ,  C07D209/44 ,  C07D211/42 ,  C07D211/44

    Abstract: Novel sulfamoyl benzamide compounds, pharmaceutical compositions containing the sulfamoyl benzamide compounds, and methods of their pharmaceutical use are disclosed. In certain embodiments, the sulfamoyl benzamide compounds are agonists and/or ligands of cannabinoid receptors and may be useful, inter alia, for treating and/or preventing pain, gastrointestinal disorders, inflammation, auto-immune diseases, ischemic conditions, immune-related disorders, hypertension, neurological disorders, and neurodegenerative diseases, for providing cardioprotection against ischemic and reperfusion effects, for inducing apoptosis in malignant cells, for inhibiting mechanical hyperalgesia associated with nerve injury, and as an appetite stimulant.

    Abstract translation: 公开了新型氨磺酰苯甲酰胺化合物，含有氨磺酰苯甲酰胺化合物的药物组合物及其药物用途的方法。 在某些实施方案中，氨磺酰苯甲酰胺化合物是大麻素受体的激动剂和/或配体，尤其可用于治疗和/或预防疼痛，胃肠道疾病，炎症，自身免疫疾病，缺血性病症，免疫相关疾病 ，高血压，神经系统疾病和神经变性疾病，用于提供针对缺血和再灌注作用的心脏保护，用于诱导恶性细胞凋亡，用于抑制与神经损伤相关的机械痛觉过敏以及作为食欲刺激剂。

    Sulfamoyl benzamide derivatives and methods of their use
    7.
    发明授权
    Sulfamoyl benzamide derivatives and methods of their use 失效
    氨磺酰苯甲酰胺衍生物及其使用方法

    公开(公告)号：US07297796B2

    公开(公告)日：2007-11-20

    申请号：US11251160

    申请日：2005-10-13

    Applicant: Roland E. Dolle ,  Karin Worm ,  Q. Jean Zhou

    Inventor： Roland E. Dolle ,  Karin Worm ,  Q. Jean Zhou

    IPC: C07D211/06

    CPC classification number: C07D205/04 ,  C07C311/16 ,  C07C311/21 ,  C07C2602/42 ,  C07C2603/74 ,  C07D207/48 ,  C07D209/44 ,  C07D211/46 ,  C07D211/60 ,  C07D211/96 ,  C07D213/40 ,  C07D215/58 ,  C07D295/26

    Abstract: Novel sulfamoyl benzamide compounds, pharmaceutical compositions containing the sulfamoyl benzamide compounds, and methods of their pharmaceutical use are disclosed. In certain embodiments, the sulfamoyl benzamide compounds are agonists and/or modulating ligands of cannabinoid receptors and may be useful, inter alia, for treating and/or preventing pain, gastrointestinal disorders, inflammation, auto-immune diseases, ischemic conditions, immune-related disorders, hypertension, neurological disorders, and neurodegenerative diseases, for providing cardioprotection against ischemic and reperfusion effects, for inducing apoptosis in malignant cells, for inhibiting mechanical hyperalgesia associated with nerve injury, and as an appetite stimulant.

    Abstract translation: 公开了新型氨磺酰苯甲酰胺化合物，含有氨磺酰苯甲酰胺化合物的药物组合物及其药物用途的方法。 在某些实施方案中，氨磺酰苯甲酰胺化合物是大麻素受体的激动剂和/或调节配体，并且尤其可用于治疗和/或预防疼痛，胃肠道疾病，炎症，自身免疫疾病，缺血性病症，免疫相关 疾病，高血压，神经系统疾病和神经变性疾病，用于提供针对缺血和再灌注作用的心脏保护，用于诱导恶性细胞凋亡，用于抑制与神经损伤相关的机械痛觉过敏以及作为食欲刺激剂。

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