公开(公告)号：US06657717B2

公开(公告)日：2003-12-02

申请号：US10085983

申请日：2002-02-28

Applicant: Theodore E. Cadell ,  Paul Drennan ,  James Samsoondar ,  Romuald Pawluczyk ,  Ashwani Kaushal ,  Bronislaw Bednarz ,  John Kuta

Inventor： Theodore E. Cadell ,  Paul Drennan ,  James Samsoondar ,  Romuald Pawluczyk ,  Ashwani Kaushal ,  Bronislaw Bednarz ,  John Kuta

IPC: G01J410

CPC classification number: B82Y15/00 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B2560/0233 ,  G01N21/4785 ,  Y10S977/904 ,  Y10S977/926 ,  Y10S977/954 ,  Y10S977/958

Abstract: The present invention provides an artificial member (80, 210) which mimics the absorbance spectrum of a body part and includes the spectral components of blood analytes. The artificial member comprises a light scattering and reflecting material, and has a chamber portion comprising one or more chambers (90, 100, 220). The artificial member is configured to be reproducibly received in a measuring receptor which receptor is operatively connected to a non-invasive monitoring device.

公开(公告)号：US06765669B1

公开(公告)日：2004-07-20

申请号：US10021307

申请日：2001-10-22

Applicant: Romuald Pawluczyk

Inventor： Romuald Pawluczyk

IPC: G01J328

CPC classification number: G01J3/10 ,  G01J3/2803 ,  G01J2003/102 ,  G01J2003/1282

Abstract: The present invention provides an apparatus and method for enhancing the system response of a photodetector array based spectrometer. For a spectrometer with a given system response curve, secondary light sources are provided to improve the system response in the spectral ranges where the dynamic range is less than at the peak of the curve. In one embodiment, multiple light sources can be combined by means of multiple branches of fibre optic bundles. The secondary light sources may be used in combination with suitable shaping filters and/or masks to further flatten the system response.

Abstract translation: 本发明提供了一种用于增强基于光电检测器阵列的光谱仪的系统响应的装置和方法。 对于具有给定系统响应曲线的光谱仪，提供二次光源以改善动态范围小于曲线峰值的光谱范围内的系统响应。 在一个实施例中，可以通过光纤束的多个分支来组合多个光源。 二次光源可以与合适的整形滤波器和/或掩模组合使用，以进一步平坦化系统响应。

公开(公告)号：US06615151B1

公开(公告)日：2003-09-02

申请号：US09939707

申请日：2001-08-28

Applicant: Thomas Scecina ,  Theodore E. Cadell ,  Romuald Pawluczyk

Inventor： Thomas Scecina ,  Theodore E. Cadell ,  Romuald Pawluczyk

IPC: G01N1506

CPC classification number: G01N21/274 ,  G01N21/359

Abstract: The present invention relates to a method of building instrument variation tolerance into calibration algorithms for spectroscopic devices for chemical composition analysis with spectroscopic methods. The method of the present invention is particularly suitable for blood glucose, cholesterol and other chemical components prediction based on near-infrared spectrophotometry measurements. A method includes developing a calibration algorithm on a first instrument; applying the calibration algorithm to a second instrument; calibrating the second instrument and adjusting the calibration algorithm to account for differences between the first instrument and the second instrument; and repeating the step of applying (above) in respect of (n) further instruments to provide a calibration algorithm which may then be used on other instruments. Methods are also provided that develop calibration algorithms by adding instrument variations, based on mathematical manipulation, of the spectral data collected on calibration instruments.

Abstract translation: 本发明涉及一种利用光谱方法对用于化学成分分析的光谱装置的校准算法建立仪器变异公差的方法。 本发明的方法特别适用于基于近红外分光光度法测量的血糖，胆固醇和其他化学成分预测。 一种方法包括在第一仪器上开发校准算法; 将校准算法应用于第二仪器; 校准第二台仪器并调整校准算法以解决第一台仪器与第二台仪器之间的差异; 并重复对（n）个其他仪器应用（上述）的步骤，以提供可以在其他仪器上使用的校准算法。 还提供了通过在校准仪器上收集的光谱数据的基础上添加基于数学操作的仪器变化来开发校准算法的方法。

公开(公告)号：US06582964B1

公开(公告)日：2003-06-24

申请号：US09958933

申请日：2002-01-23

Applicant: James Samsoondar ,  Romuald Pawluczyk ,  Petersen Borge ,  Theordore E. Cadell ,  Bernard Zinman ,  Bronislaw Bednarz

Inventor： James Samsoondar ,  Romuald Pawluczyk ,  Petersen Borge ,  Theordore E. Cadell ,  Bernard Zinman ,  Bronislaw Bednarz

IPC: G01N3372

CPC classification number: B01L3/508 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150343 ,  A61B5/150351 ,  B01L2300/043 ,  B01L2300/0809 ,  G01N21/03 ,  G01N21/314 ,  G01N33/721 ,  G01N33/726

Abstract: Described is a method and apparatus for determining a diabetic patient's compliance with their insulin dosing regime. The method and apparatus involves taking a blood sample from a patient by a routine finger prick and placing it in a special sample tab which is placed in a spectrophotometer sample housing. The spectrophotometer measures Hb and HbA1c concentrations and allows for calculating a ratio of HbA1c to Hb which is indicative of the degree of patient compliance.

Abstract translation: 描述了一种用于确定糖尿病患者对其胰岛素给药方案的依从性的方法和装置。 该方法和装置包括通过常规手指刺从患者取血样并将其放置在放置在分光光度计样品壳体中的特殊样品片中。 分光光度计测量Hb和HbA1c浓度，并允许计算HbA1c与Hb的比值，表示患者依从程度。

公开(公告)号：US07636158B1

公开(公告)日：2009-12-22

申请号：US11234252

申请日：2005-09-26

Applicant: Romuald Pawluczyk ,  Olga Pawluczyk

Inventor： Romuald Pawluczyk ,  Olga Pawluczyk

IPC: G01J3/02 ,  G01J3/28

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/024 ,  G01J3/0291 ,  G01J3/0297 ,  G01J3/28 ,  G01J3/2823 ,  G02B21/002

Abstract: An optical coupling relay system has an imaging optical system having an object plane, an exit pupil and an image plane. An image analyzer has an image plane and an entrance pupil, and a detector is located in a detector plane and contains photosensitive material. An optical coupling relay couples the optical system to the image analyzer, for projecting the image produced by the imaging optical system into the image plane of the image analyzer and simultaneously for projecting the exit pupil of the imaging optical system into the entry pupil of the image analyzer.

Abstract translation: 光耦合继电器系统具有成像光学系统，其具有物平面，出射光瞳和图像平面。 图像分析仪具有图像平面和入射光瞳，并且检测器位于检测器平面中并且包含感光材料。 光耦合继电器将光学系统耦合到图像分析器，用于将由成像光学系统产生的图像投射到图像分析仪的图像平面中，同时用于将成像光学系统的出射光瞳投影到图像的入射光瞳中 分析仪

公开(公告)号：US07613488B1

公开(公告)日：2009-11-03

申请号：US10745234

申请日：2003-12-22

Applicant: George N. Maracas ,  Romuald Pawluczyk ,  Duncan MacIntyre ,  Bronislaw Bednarz ,  Darin L. Farrelly ,  Chris Sterne ,  Ash Kaushal ,  Mang Li ,  Kenneth Anthony Morand

Inventor： George N. Maracas ,  Romuald Pawluczyk ,  Duncan MacIntyre ,  Bronislaw Bednarz ,  Darin L. Farrelly ,  Chris Sterne ,  Ash Kaushal ,  Mang Li ,  Kenneth Anthony Morand

IPC: A61B5/1455

CPC classification number: A61B5/14546 ,  A61B5/0053 ,  A61B5/0055 ,  A61B5/14532 ,  A61B2560/0252

Abstract: The present invention provides a method for measuring a blood analyte concentration of a body part comprising removing a portion or all of the blood from the body part to produce a modified body part, and recording a first absorbance value of the modified body part. This is followed by filling the body part with blood to produce a filled body part, and recording a second absorbance value of the filled body part. A difference spectrum is obtained by subtracting the first absorbance values from the second absorbance values, and a calibration algorithm for the blood analyte is applied to the difference spectrum, thereby measuring the concentration of the blood analyte. Also provided is an apparatus for determining the concentration of a blood analyte of a body part. The apparatus comprising a chamber of a size and shape to receive the body part, where the chamber comprises an element for withdrawing and reintroducing blood from the body part, when the body part is inserted within the chamber. The chamber also comprising one or more than one port for introducing electromagnetic radiation into the chamber and onto that body part, and collecting remaining electromagnetic radiation following interaction with the body part.

Abstract translation: 本发明提供一种用于测量身体部位的血液分析物浓度的方法，包括从身体部位除去一部分或全部血液以产生修饰体部，并记录修饰体部的第一吸光度值。 随后用血液填充身体部分以产生填充体部分，并记录填充体部分的第二吸光度值。 通过从第二吸光度值减去第一吸光度值获得差分光谱，并且将血液分析物的校准算法应用于差分光谱，从而测量血液分析物的浓度。 还提供了一种用于确定身体部位的血液分析物的浓度的装置。 所述装置包括容纳身体部分的尺寸和形状的腔室，其中当所述身体部分插入所述腔室内时，所述腔室包括用于从所述身体部分抽出并再次引入血液的元件。 所述腔室还包括一个或多于一个端口，用于将电磁辐射引入所述腔室并且到达所述身体部分，并且在与身体部位相互作用之后收集剩余的电磁辐射。

公开(公告)号：US06975891B2

公开(公告)日：2005-12-13

申请号：US10032145

申请日：2001-12-21

Applicant: Romuald Pawluczyk

Inventor： Romuald Pawluczyk

IPC: A61B5/00 ,  G01N21/65 ,  G01J3/44

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/6826 ,  A61B5/6838 ,  G01N21/65 ,  G01N2021/651 ,  G01N2201/06126 ,  G01N2201/065

Abstract: The present invention provides an apparatus for measurement of Raman scattered radiation comprising. The apparatus comprises at least one source of electromagnetic radiation for producing an electromagnetic radiation beam characterized by a narrow spectral width, an integrating cavity having an interior and an exterior, wherein a sample is placed in said interior. The integrating cavity further having at least one port for insertion of the sample in the interior and for transmission of the electromagnetic radiation into and out from the interior, the at least one port extending from the exterior to said interior of said integrating cavity. The integrating cavity also comprises a first optical element for transmitting the electromagnetic radiation into the interior of the integrating cavity through the at least one port, and a second optical element for collecting Raman scattered electromagnetic radiation from the sample through the at least one port. The apparatus also comprises a spectrum analyzer for determining spectral composition of the Raman scattered electromagnetic radiation, a detector for measuring the Raman scattered electromagnetic radiation; and a system for determining concentration of at least one chemical compound from the measured Raman scattered electromagnetic radiation. The apparatus may also comprise a radiation expanding element. A method for measuring the concentration of one or more chemical compounds in a sample using Raman scattering is also provided.

Abstract translation: 本发明提供了一种用于测量拉曼散射辐射的装置，包括： 该装置包括至少一个电磁辐射源，用于产生特征在于窄光谱宽度的电磁辐射束，具有内部和外部的积分腔，其中将样品放置在所述内部中。 积分腔还具有用于将样品插入内部的至少一个端口和用于将电磁辐射传入和移出内部的至少一个端口，所述至少一个端口从外部延伸到所述积分腔的内部。 积分腔还包括用于通过至少一个端口将电磁辐射传输到积分腔的内部的第一光学元件和用于从样品通过至少一个端口收集拉曼散射的电磁辐射的第二光学元件。 该装置还包括用于确定拉曼散射电磁辐射的光谱组成的光谱分析仪，用于测量拉曼散射电磁辐射的检测器; 以及用于根据所测量的拉曼散射电磁辐射确定至少一种化合物浓度的系统。 该装置还可以包括辐射扩张元件。 还提供了使用拉曼散射测量样品中一种或多种化合物的浓度的方法。

公开(公告)号：US20070167248A1

公开(公告)日：2007-07-19

申请号：US11620115

申请日：2007-01-05

Applicant: Jack P. Fler ,  Romuald Pawluczyk

Inventor： Jack P. Fler ,  Romuald Pawluczyk

IPC: A63B69/36

CPC classification number: G02B23/105 ,  A63B53/0487 ,  A63B60/52 ,  A63B69/3614 ,  A63B69/3685 ,  A63B2053/0441

Abstract: The golf putter has at least one and preferably three beams, preferably laser, projecting from the front face of the putter, spread vertically. In one embodiment, a single laser is centrally mounted, to project a beam over the top of a ball positioned at the desired impact point on the face of the putter. In another embodiment, two lasers are mounted to project parallel beams on either side of a ball positioned at the desired impact point on the face of the putter. In a preferred embodiment, there are three lasers, namely one projecting a beam over the top of the ball, and two projecting parallel beams on either side of the ball. Preferably there are two switches in the grip of the putter, with the light source(s) being powered only when both switches are pressed.

Abstract translation: 高尔夫推杆具有从推杆的前表面突出的至少一个并且优选三个梁，优选地是激光，垂直地展开。 在一个实施例中，单个激光器被中心地安装，以将光束投射在位于推杆的表面上的期望的冲击点处的球的顶部上。 在另一个实施例中，两个激光器被安装成在位于推杆的表面上的期望的冲击点处的球的任一侧上投影平行光束。 在一个优选实施例中，存在三个激光器，即在球的顶部上投射光束的一个和在球的任一侧上的两个突出的平行光束。 优选地，在推杆的把手中有两个开关，只有当两个开关被按压时，光源才被供电。

公开(公告)号：US06912049B2

公开(公告)日：2005-06-28

申请号：US10321510

申请日：2002-12-18

Applicant: Romuald Pawluczyk ,  Theodore Cadell ,  Bronislaw Bednarz ,  Ashwani Kaushal

Inventor： Romuald Pawluczyk ,  Theodore Cadell ,  Bronislaw Bednarz ,  Ashwani Kaushal

IPC: G02B5/02 ,  G02B7/00 ,  G01J1/10

CPC classification number: G02B5/0294 ,  G02B5/0278 ,  G02B7/008

Abstract: The present invention provides a thermally stable reference member comprising, at least one radiation attenuating element and at least one radiation scattering element. The radiation attenuating element comprising at least one aperture for transmission of radiation therethrough. The attenuating and scattering elements placed in series so that radiation transmitted through the reference member passes through each of the attenuating and scattering elements. The attenuating and scattering elements of the reference member may further comprise a thermally stable mount to hold the elements in a selected position relative to each other, and in relation to an instrument, or the elements may be bonded together. The radiation attenuating element may be comprised of a material selected from the group consisting of INVAR, tungsten, brass, and a material substantially non-transparent for incident radiation, and the radiation scattering element may be comprised of a radiation scattering material selected from the group consisting of opalescent glass, SPECTRALON, PTFE, ZERODUR, fused silica, quartz, sapphire, diamond, and a transparent material with essentially low thermal expansion.

Abstract translation: 本发明提供了一种热稳定的参考构件，其包括至少一个辐射衰减元件和至少一个辐射散射元件。 所述辐射衰减元件包括用于透射辐射的至少一个孔。 衰减和散射元件串联放置，使得透射通过参考构件的辐射通过每个衰减和散射元件。 参考构件的衰减和散射元件还可以包括热稳定的安装件，以将元件保持在相对于彼此的选定位置，并且相对于仪器，或者元件可以结合在一起。 辐射衰减元件可以由选自I NVAR ，钨，黄铜以及对于入射辐射基本不透明的材料组成的组成，并且辐射散射元件可以由 选自乳光玻璃，S PECTRALON ，PTFE，Z ERODUR ，熔融石英，石英，蓝宝石，金刚石和透明材料的辐射散射材料，基本上 低热膨胀。

公开(公告)号：US06788849B1

公开(公告)日：2004-09-07

申请号：US10130078

申请日：2002-09-23

Applicant: Romuald Pawluczyk

Inventor： Romuald Pawluczyk

IPC: G02B634

CPC classification number: G02B6/2931 ,  G01J3/1838 ,  G02B6/29311

Abstract: A volume diffraction grating having a substrate and an optically active layer has a structure formed in the optically active layer. The structure is operational to diffract optical signals in two selected spectral bands. The grating may be formed in a high dispersion embodiment suitable for separating individual signals from composite signals of both spectral bands. Alternatively, the grating may be formed in a low dispersion version which can separate the composite signals from each other. In another embodiment, a second structure is formed in the optically active layer. Each of the structures is configured to be operational in one of the spectral bands, allowing signals in each band to be diffracted independently of one another. In another embodiment, the structure(s) may have a curved profile allowing the diffracted beams to be shaped or focused without the need for external lenses.

Abstract translation: 具有基板和光学活性层的体积衍射光栅具有在光学活性层中形成的结构。 该结构可操作以在两个选定的光谱带中衍射光信号。 光栅可以形成在适于从两个光谱带的复合信号分离各个信号的高色散实施例中。 或者，光栅可以以可以将复合信号彼此分离的低分散版本形成。 在另一个实施例中，在光学活性层中形成第二结构。 每个结构被配置为在一个频谱带中操作，允许每个频带中的信号彼此独立地被衍射。 在另一个实施例中，该结构可以具有允许衍射光束成形或聚焦而不需要外部透镜的弯曲轮廓。