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11 条记录 (耗时 0.031 秒)

    Direct Reversal Of The Suppressive Function Of CD4+Regulatory T Cells Via Toll-Like Receptor 8 Signaling
    2.
    发明申请
    Direct Reversal Of The Suppressive Function Of CD4+Regulatory T Cells Via Toll-Like Receptor 8 Signaling 审中-公开
    通过Toll样受体8信号直接逆转CD4 +调节性T细胞的抑制功能

    公开(公告)号：US20090209620A1

    公开(公告)日：2009-08-20

    申请号：US11816902

    申请日：2006-03-09

    申请人： Rong-Fu Wang ,  Guangyon Peng ,  Yicheng Wang

    发明人： Rong-Fu Wang ,  Guangyon Peng ,  Yicheng Wang

    IPC分类号： A61K31/7088 ,  C12N5/06 ,  C12Q1/02 ,  C40B30/06

    CPC分类号： C12N15/113 ,  C12N15/1138 ,  C12N15/117 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/17 ,  C12N2310/315

    摘要： CD4+ regulatory T (Treg) cells profoundly suppress host immune responses and thus protect against autoimmune disease while restricting desired immune responses such as antitumor immunity. Synthetic phosphorothioate-protected, guanosine-containing oligonucleotides can directly reverse the suppressive activity of Treg cells without involving dendritic cells. This effect appears to be transduced by signaling through Toll-like receptor (TLR) 8 and engagement of the MyD88 and IRAK4 molecules in Treg cells. Stimulation of Treg cells with natural ligands for human TLR8 recapitulated the effect of the synthetic guanosine-containing oligonucleotides .

    摘要翻译： CD4 +调节T（Treg）细胞深刻地抑制宿主免疫应答，从而防止自身免疫疾病，同时限制所需的免疫应答如抗肿瘤免疫。 合成的硫代磷酸酯保护的含鸟苷酸寡核苷酸可以直接逆转Treg细胞的抑制活性而不涉及树突状细胞。 该效应似乎通过Toll样受体（TLR）8的信号转导和MyD88和IRAK4分子在Treg细胞中的结合来转导。 人TLR8天然配体对Treg细胞的刺​​激重现了含有合成含鸟苷酸的寡核苷酸的作用。

    REVERSAL OF THE SUPPRESSIVE FUNCTION OF SPECIFIC T CELLS VIA TOLL-LIKE RECEPTOR 8 SIGNALING
    3.
    发明申请
    REVERSAL OF THE SUPPRESSIVE FUNCTION OF SPECIFIC T CELLS VIA TOLL-LIKE RECEPTOR 8 SIGNALING 审中-公开
    特异性T细胞通过类似受体8信号的抑制功能的反转

    公开(公告)号：US20080026986A1

    公开(公告)日：2008-01-31

    申请号：US11757235

    申请日：2007-06-01

    申请人： Rong-Fu Wang ,  Guangyong Peng ,  Yicheng Wang

    发明人： Rong-Fu Wang ,  Guangyong Peng ,  Yicheng Wang

    IPC分类号： A61K31/7042 ,  A61K38/02 ,  A61P35/00

    CPC分类号： A61K31/7042 ,  C12N15/115 ,  C12N15/117

    摘要： CD8+ regulatory T (Treg) cells and γδ Treg cells profoundly suppress host immune responses and thus protect against autoimmune disease while restricting desired immune responses such as antitumor immunity. Synthetic phosphorothioate-protected, guanosine-containing oligonucleotides can directly reverse the suppressive activity of Treg cells without involving dendritic cells. This effect appears to be transduced by signaling through Toll-like receptor (TLR) 8 and engagement of the MyD88 and IRAK4 molecules in Treg cells, in specific embodiments. Stimulation of Treg cells with natural ligands for human TLR8 recapitulated the effect of the synthetic guanosine-containing oligonucleotides.

    摘要翻译： CD8 + Treg细胞和Gammadelta Treg细胞深刻地抑制宿主免疫应答，从而防止自身免疫疾病，同时限制所需的免疫应答如抗肿瘤免疫。 合成的硫代磷酸酯保护的含鸟苷酸寡核苷酸可以直接逆转Treg细胞的抑制活性而不涉及树突状细胞。 在特定的实施方案中，这种作用似乎通过Toll样受体（TLR）8的信号转导和MyD88和IRAK4分子在Treg细胞中的接合而转导。 人TLR8天然配体对Treg细胞的刺​​激重现了含有合成含鸟苷酸的寡核苷酸的作用。

    Antibodies to the protein product encoded by ORF3 of the TRP-1 gene and compositions and kits thereof
    7.
    发明授权
    Antibodies to the protein product encoded by ORF3 of the TRP-1 gene and compositions and kits thereof 失效
    由TRP-1基因的ORF3编码的蛋白质产物的抗体及其组合物和试剂盒

    公开(公告)号：US07015312B1

    公开(公告)日：2006-03-21

    申请号：US09571313

    申请日：2000-05-16

    申请人： Rong-Fu Wang ,  Steven A. Rosenberg

    发明人： Rong-Fu Wang ,  Steven A. Rosenberg

    IPC分类号： C07K16/00

    CPC分类号： A61K39/0011 ,  A61K2039/5158

    摘要： The present invention discloses that the normal melanogenic gene, gp75 gene, encodes a gene product, a 24 amino acid peptide of ORF3, which is processed to an antigenic cancer peptide recognized by T lymphocytes. The cancer peptide of the invention derived from ORF3 is recognized by cancer antigen specific T lymphocytes as a tumor rejection antigen. The products of this gene are promising candidates for immunotherapeutic strategies for the treatment and diagnosis of patients with cancer.

    摘要翻译： 本发明公开了正常的黑素生成基因gp75基因，编码基因产物，ORF3的24个氨基酸的肽，被加工成由T淋巴细胞识别的抗原性癌肽。 衍生自ORF3的本发明的癌肽被癌抗原特异性T淋巴细胞识别为肿瘤排斥抗原。 该基因的产物是用于癌症患者的治疗和诊断的免疫治疗策略的有希望的候选者。