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17 条记录 (耗时 0.017 秒)

    Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors
    1.
    发明授权
    Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors 有权
    下呼吸道炎症性疾病与促炎细胞因子抑制剂的局部治疗

    公开(公告)号：US08940683B2

    公开(公告)日：2015-01-27

    申请号：US12377027

    申请日：2007-08-10

    申请人： Roy C. Levitt

    发明人： Roy C. Levitt

    IPC分类号： A61K9/12 ,  A61K38/20 ,  A61K9/00 ,  A61K31/70 ,  C07K14/715 ,  C12Q1/68

    CPC分类号： A61K9/0075 ,  A61K9/0078 ,  A61K9/008 ,  A61K31/70 ,  A61K38/20 ,  C07K14/7155

    摘要： The present invention is drawn to methods and compositions for treating inflammatory disorders of the lower airways, comprising administering an effective amount of an agent, which modulates the expression and/or activity of a proinflammatory cytokine or fragment thereof, preferably in a human. The proinflammatory cytokine contemplated by the invention includes IL-1, IL-6, IL-8 and TNF-alpha. The present invention describes a kit comprising a delivery device and a pharmaceutical composition for administration of the agent. The pharmaceutical composition includes at least one proinflammatory cytokine inhibitor, optionally one or more additional active ingredients, and at least one pharmaceutically active carrier. The delivery device further comprises a nebulizer, an inhaler, a powder dispenser, an intrapulmonary aerosolizer and a sub-miniature aerosolizer.

    摘要翻译： 本发明涉及用于治疗下呼吸道炎症性疾病的方法和组合物，包括给予有效量的调节促炎细胞因子或其片段（优选人）的表达和/或活性的药剂。 本发明考虑的促炎细胞因子包括IL-1，IL-6，IL-8和TNF-α。 本发明描述了一种试剂盒，其包含递送装置和用于给药试剂的药物组合物。 药物组合物包括至少一种促炎细胞因子抑制剂，任选的一种或多种另外的活性成分，和至少一种药物活性载体。 输送装置还包括雾化器，吸入器，粉末分配器，肺内雾化器和亚微型雾化器。

    Process and apparatus for localizing a source of charged particles using an electric field
    3.
    发明授权
    Process and apparatus for localizing a source of charged particles using an electric field 失效
    使用电场来定位带电粒子源的方法和装置

    公开(公告)号：US5384462A

    公开(公告)日：1995-01-24

    申请号：US987194

    申请日：1992-12-08

    申请人： Roy C. Levitt

    发明人： Roy C. Levitt

    IPC分类号： G01T1/185 ,  G01T1/29

    CPC分类号： G01T1/185

    摘要： Improved efficiency and spatial resolution are obtained without collimators or ionizable media by a locating system in which radioactive sources to be located are disposed within an electric field sufficient to force radio-emitted charged particles directly towards an oppositely charged electrode without appreciable scattering. In one aspect, the two oppositely charged electrodes are separated at a distance that avoids arcing. In other aspects, dielectric materials may be disposed between the electrodes, and the area between the electrodes can be evacuated.

    摘要翻译： 通过定位系统获得提高的效率和空间分辨率，其中要定位的放射源被放置在足以迫使放射性发射的带电粒子直接朝向相反电荷的电极而没有明显的散射的定位系统。 在一个方面，两个相对充电的电极在避免电弧的距离​​处分开。 在其它方面，介电材料可以设置在电极之间，并且可以抽出电极之间的区域。

    Localized Therapy of Lower Airways Inflammatory Disorders with Proinflammatory Cytokine Inhibitors
    4.
    发明申请
    Localized Therapy of Lower Airways Inflammatory Disorders with Proinflammatory Cytokine Inhibitors 有权
    下呼吸道炎症细胞因子抑制剂炎症性疾病的局部治疗

    公开(公告)号：US20100209357A1

    公开(公告)日：2010-08-19

    申请号：US12377027

    申请日：2007-08-10

    申请人： Roy C. Levitt

    发明人： Roy C. Levitt

    IPC分类号： A61K9/12 ,  A61K38/20 ,  A61K39/395 ,  A61K38/17 ,  A61K31/7088 ,  A61M15/00

    CPC分类号： A61K9/0075 ,  A61K9/0078 ,  A61K9/008 ,  A61K31/70 ,  A61K38/20 ,  C07K14/7155

    摘要： The present invention is drawn to methods and compositions for treating inflammatory disorders of the lower airways, comprising administering an effective amount of an agent, which modulates the expression and/or activity of a proinflammatory cytokine or fragment thereof, preferably in a human. The proinflammatory cytokine contemplated by the invention includes IL-1, IL-6, IL-8 and TNF-alpha. The present invention describes a kit comprising a delivery device and a pharmaceutical composition for administration of the agent. The pharmaceutical composition includes at least one proinflammatory cytokine inhibitor, optionally one or more additional active ingredients, and at least one pharmaceutically active carrier. The delivery device further comprises a nebulizer, an inhaler, a powder dispenser, an intrapulmonary aerosolizer and a sub-miniature aerosolizer.

    摘要翻译： 本发明涉及用于治疗下呼吸道炎症性疾病的方法和组合物，包括给予有效量的调节促炎细胞因子或其片段（优选人）的表达和/或活性的药剂。 本发明考虑的促炎细胞因子包括IL-1，IL-6，IL-8和TNF-α。 本发明描述了一种试剂盒，其包含递送装置和用于给药试剂的药物组合物。 药物组合物包括至少一种促炎细胞因子抑制剂，任选的一种或多种另外的活性成分，和至少一种药物活性载体。 输送装置还包括雾化器，吸入器，粉末分配器，肺内雾化器和亚微型雾化器。