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公开(公告)号：US20110123460A1
公开(公告)日：2011-05-26
申请号：US13054844
申请日：2009-07-02
申请人： Rudolf Wilhelm , Pröls Markus
发明人： Rudolf Wilhelm , Pröls Markus
CPC分类号： A61K31/58 , A61K9/0007 , A61K9/0095
摘要： The invention relates to an effervescent tablet for preparing a mouth rinsing solution, wherein the effervescent tablet exhibits a high release rate of budesonide. A high availability of the active ingredient during use as a mouth rinsing solution on the inflamed mucosa of the upper digestive tract is thereby achieved. The advantage of the formulation according to the invention lies in the bioavailability comparable to oral forms of administration, which allows the formulation to be used safely over an extended period of time.
摘要翻译： 本发明涉及一种用于制备口腔清洗溶液的泡腾片剂，其中泡腾片剂表现出布地奈德的高释放速率。 因此，在使用期间活性成分的高可用性作为上消化道的发炎粘膜上的口腔清洗溶液。 根据本发明的制剂的优点在于与口服给药形式相当的生物利用度，其允许制剂在延长的时间段内安全使用。
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公开(公告)号：US08580300B2
公开(公告)日：2013-11-12
申请号：US13054844
申请日：2009-07-02
申请人： Rudolf Wilhelm , Pröls Markus
发明人： Rudolf Wilhelm , Pröls Markus
CPC分类号： A61K31/58 , A61K9/0007 , A61K9/0095
摘要： The invention relates to an effervescent tablet for preparing a mouth rinsing solution, wherein the effervescent tablet exhibits a high release rate of budesonide. A high availability of the active ingredient during use as a mouth rinsing solution on the inflamed mucosa of the upper digestive tract is thereby achieved. The advantage of the formulation according to the invention lies in the bioavailability comparable to oral forms of administration, which allows the formulation to be used safely over an extended period of time.
摘要翻译： 本发明涉及一种用于制备口腔清洗溶液的泡腾片剂，其中泡腾片剂表现出布地奈德的高释放速率。 因此，在使用期间活性成分的高可用性作为上消化道的发炎粘膜上的口腔清洗溶液。 根据本发明的制剂的优点在于与口服给药形式相当的生物利用度，其允许制剂在延长的时间段内安全使用。
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3.发明授权Optimized synthesis of pure, non-polymorphic, crystalline bile acids with defined particle size 有权优化了具有规定粒径的纯非多晶型结晶胆汁酸的合成公开(公告)号：US09512167B2
公开(公告)日：2016-12-06
申请号：US13989012
申请日：2011-11-30
IPC分类号： A61K31/575 , C07J9/00 , C07J7/00
CPC分类号： C07J9/005 , C07B2200/13 , C07J7/008 , Y10T428/2982
摘要： The present invention relates to a pure polymorph of Nor-UDCA or Bis-nor-UDCA, or of a pharmaceutically acceptable salt thereof. The invention further provides a pharmaceutical composition comprising the polymorph of the invention, and a method for preparing the polymorph. The invention includes the pharmaceutical use of the polymorph or of the pharmaceutical composition of the invention.
摘要翻译： 本发明涉及Nor-UDCA或Bis-nor-UDCA或其药学上可接受的盐的纯多晶型物。 本发明还提供了包含本发明多晶型物的药物组合物和制备该多晶型物的方法。 本发明包括本发明的多晶型物或药物组合物的药物用途。
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4.发明申请Optimized Synthesis Of Pure, Non-Polymorphic, Crystalline Bile Acids With Defined Particle Size 有权具有定义粒径的纯非多晶型结晶胆汁酸的优化合成公开(公告)号：US20140050791A1
公开(公告)日：2014-02-20
申请号：US13989012
申请日：2011-11-30
IPC分类号： C07J7/00
CPC分类号： C07J9/005 , C07B2200/13 , C07J7/008 , Y10T428/2982
摘要： The present invention relates to a pure polymorph of Nor-UDCA or Bis-nor-UDCA, or of a pharmaceutically acceptable salt thereof. The inventions further provides a pharmaceutical composition comprising the polymorph of the invention, and a method for preparing the polymorph. The invention includes the pharmaceutical use of the polymorph or of the pharmaceutical composition of the invention.
摘要翻译： 本发明涉及Nor-UDCA或Bis-nor-UDCA或其药学上可接受的盐的纯多晶型物。 本发明还提供包含本发明多晶型物的药物组合物和制备该多晶型物的方法。 本发明包括本发明的多晶型物或药物组合物的药物用途。
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5.发明授权Method and system for speed-modified reproduction of video signals stored on video recording tape 失效视频记录磁带上存储的视频信号的速度修改再现方法和系统
公开(公告)号：US4210938A
公开(公告)日：1980-07-01
申请号：US908930
申请日：1978-05-24
申请人： Jurgen Heitmann , Rudolf Wilhelm
发明人： Jurgen Heitmann , Rudolf Wilhelm
摘要： A head wheel is rotated at a predetermined, essentially constant speed within a tape cylinder over which a tape is guided in a spiral path, on which video signal tracks are recorded in inclined track portions. The instantaneous position of the head wheel is determined, for example by a tacho generator applying signals to a counter, phase-synchronized by the outputs from the head wheel tacho generator. The instantaneous position of the tape is determined, for example from sensing the cross modulation of signals derived from the head as the head crosses from one track portion to another, or by sensing the phase jump of the pulse sequence of the horizontal synchronization signals; the two position signals are combined in a logic stage so that a line address can be derived of a signal transduced at any one instant by said head from an incremental area of the tape, the signal being associated with the line address for storage, for example in a memory for subsequent re-recording or reproduction at a time relation (slow motion or fast motion) differing from the original recording speed.
摘要翻译： 磁头轮以预定的基本上恒定的速度旋转，在磁带筒中，磁带在螺旋路径中被引导，在该磁道气缸中，视频信号轨道被记录在倾斜轨迹部分中。 头轮的瞬时位置例如由转子发生器通过来自头轮转速发生器的输出相位同步的计数器施加信号来确定。 确定磁带的瞬时位置，例如，当磁头从一个轨道部分到另一磁道部分交叉时，或者通过感测水平同步信号的脉冲序列的相位跳跃来感测从磁头导出的信号的交叉调制; 两个位置信号被组合在一个逻辑级中，使得可以从线的增量区域中的所有头在任何一瞬间转换的信号导出行地址，该信号与用于存储的行地址相关联，例如 在与原始记录速度不同的时间关系（慢动作或快速运动）中用于随后重新记录或再现的存储器中。
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公开(公告)号：US4089026A
公开(公告)日：1978-05-09
申请号：US785764
申请日：1977-04-07
申请人： Rudolf Wilhelm , Jurgen Heitmann
发明人： Rudolf Wilhelm , Jurgen Heitmann
CPC分类号： H04N17/045
摘要： The invention provides an apparatus for producing video frequency color value signals which correspond to a desired arrangement of vertical or horizontal color bars on a television screen. In the case of vertical color bars the apparatus derives during each line period an identical series of pulses having a multiple of the line frequency. Each series of pulses is applied to a binary counter which provides as output a sequence of sets of binary signals. This sequence of sets of binary signals is translated by a pre-programmed store into a further sequence of sets of binary signals, these latter sets of signals being applied to a digital-to-analogue converter adapted to derive therefrom corresponding sets of color value signals. Each set of color value signals defines a differently colored line segment. The effect of this operation over a plurality of successive line periods is to build up a number of vertical color bars each composed of vertically adjacent line segments of the same color derived from identical sets of color value signals occurring in successive line periods.In the case of horizontal color bars the apparatus operates in a similar manner except that the series of pulses initially produced is at a fraction of the line frequency and is derived once for each field period rather than once for each line period.
摘要翻译： 本发明提供一种用于产生视频频率颜色值信号的装置，其对应于电视屏幕上垂直或水平色条的期望布置。 在垂直色条的情况下，装置在每个行周期中导出具有线频率的倍数的相同序列的脉冲。 每个脉冲串被施加到二进制计数器，该二进制计数器作为输出提供一组二进制信号。 二进制信号组的这一序列由预先编程的存储转换为二进制信号组的另一序列，这些后一组信号被施加到数模转换器，该数模转换器适于从其中导出对应的颜色值信号组 。 每组颜色值信号定义不同颜色的线段。 这种操作对多个连续的行周期的影响是建立多个垂直色条，每个垂直色条由相邻颜色的垂直相邻的线段组成，该线段由相继的行周期中出现的相同色彩值信号组合得到。
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公开(公告)号：US20110008390A1
公开(公告)日：2011-01-13
申请号：US12594074
申请日：2008-03-31
CPC分类号： A01N1/02 , A01N1/0205 , A01N1/0215 , A61K35/62
摘要： The present application describes a novel, advantageous purification method which guarantees the embryonation capability and the viability of a worm egg suspension. The T. suis worm eggs are first treated in a non-embryonated condition in a sulfuric acid solution at about=ph 2. Bacteria and viruses are thereby killed successfully. The germination number of yeasts and fungi is reduced. In a second step, the pH-value is increased and an orally tolerated preservative is added. Yeasts and fungi are thereby killed successfully. The suspension medium used in the second purification step can then be used as a culture medium for additional production (embryonation) and storage.
摘要翻译： 本申请描述了一种新颖的有利的纯化方法，其保证蠕虫卵悬液的胚胎能力和活力。 首先在大约= ph 2的硫酸溶液中以非含胚胎状态处理猪蛔虫卵。因此细菌和病毒被成功杀死。 酵母和真菌的发芽数量减少。 在第二步中，增加pH值并加入口服耐受性防腐剂。 因此，酵母和真菌被成功杀死。 然后可以将用于第二纯化步骤的悬浮介质用作用于额外生产（胚胎化）和储存的培养基。
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8.发明授权Channel plate assembly with parallel plates, process and fixture for manufacturing the same, and plate apparatus provided with the same 失效具有平行板的通道板组件，用于制造其的工艺和夹具以及具有该平板的板装置
公开(公告)号：US5249735A
公开(公告)日：1993-10-05
申请号：US926842
申请日：1992-08-06
申请人： Ulrich Sander , Helmut Zeh , Rudolf Wilhelm
发明人： Ulrich Sander , Helmut Zeh , Rudolf Wilhelm
CPC分类号： B01D61/50 , B01D61/36 , B01D63/081 , B01D63/084 , F28D9/0062
摘要： In a process of manufacturing a channel plate assembly including a plurality of partial plates confining passages for a first medium which continuously define on all sides in direction of flow and interconnected by a plurality of spacers spaced apart in the direction of flow, the spacers are fixed in a fixture and joined to a first plate, and then the spacers are joined to another plate in a fixture on a side which faces away from the first plate.
摘要翻译： 在制造通道板组件的过程中，该通道板组件包括用于第一介质的多个局部板限制通道，该第一介质在流动方向上的所有侧面上连续地限定并且通过在流动方向上间隔开的多个间隔件而互相连接， 在固定装置中并连接到第一板上，然后将间隔件接合到固定装置中的另一个板上，该固定装置面向远离第一板的一侧。
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9.发明授权Channel plate assembly with parallel plates, process and fixture for manufacturing the same, and plate apparatus provided with the same 失效具有平行板的通道板组件，用于制造其的工艺和装置以及与其同时提供的板装置
公开(公告)号：US5161611A
公开(公告)日：1992-11-10
申请号：US599310
申请日：1990-10-17
申请人： Ulrich Sander , Helmut Zeh , Rudolf Wilhelm
发明人： Ulrich Sander , Helmut Zeh , Rudolf Wilhelm
CPC分类号： F28D9/0062 , B01D61/36 , B01D61/50 , B01D63/081 , B01D63/084
摘要： A channel plate assembly comprises parallel plates, which are joined to each other and define passages for a first flowing fluid. Each of said passages is continuously defined on all sides in the direction of flow. Parallel plates are interconnected by spacers, which are spaced apart in the direction of flow and have a width that is smaller than the width of each passage which is continuously defined in the direction of flow. A process of manufacturing the channel plate assembly, two fixtures for use in carrying out the process and the use of the channel plate assembly for supplying and/or discharging a first flowing fluid in a plate apparatus are provided.
摘要翻译： 通道板组件包括平行板，它们彼此连接并限定用于第一流动流体的通道。 每个所述通道在流动方向的所有侧面上连续地限定。 平行板通过间隔件互相连接，间隔件沿流动方向间隔开，并且具有小于在流动方向上连续限定的每个通道的宽度的宽度。 提供了制造通道板组件的过程，用于执行该过程的两个固定装置和用于在板装置中供应和/或排出第一流动流体的通道板组件的使用。
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10.发明授权Method and apparatus for the variable speed reproduction of a video signal stored on magnetic tape 失效用于存储在磁带上的视频信号的可变速度再现的方法和装置
公开(公告)号：US4293879A
公开(公告)日：1981-10-06
申请号：US75978
申请日：1979-09-17
申请人： Jurgen Heitmann , Hans-Peter Maly , Rudolf Wilhelm
发明人： Jurgen Heitmann , Hans-Peter Maly , Rudolf Wilhelm
CPC分类号： H04N5/937 , H04N5/9201
摘要： This invention concerns a method of reproducing, at a selectable magnetic tape speed different from that used during the recording, a video signal stored in a plurality of separate tracks inclined to the center line of the magnetic tape by means of a head wheel carrying peripherally arranged magnetic heads, wherein the addresses of reproduced lines of picture information are derived solely from the composite signal reproduced from the magnetic tape, wherein useful lines are read into respective locations of a picture store in accordance with these line addresses, and wherein the stored lines are read out from the store in a predetermined sequence.In the embodiment described the line addresses are derived by a counter to the counting input of which are delivered pulses which correspond to that of the horizontal synchronizing pulses taken from the magnetic tape, to the resetting input of which are delivered pulses which correspond to the vertical synchronizing pulses taken from the magnetic tape, and to a third input of which are delivered pulses the frequency of which corresponds to the frequency of cross modulation disturbances and each of which causes a change in the registered count by an amount which is determined by the registered count itself and whether the tape reproduction speed is greater or less than the recording speed.
摘要翻译： 本发明涉及一种在与记录期间不同的可选择的磁带速度下再现存储在多个独立磁道中的视频信号，该视频信号通过一个外围布置的磁头轮与磁带的中心线倾斜， 磁头，其中图像信息的再现行的地址仅从从磁带再现的复合信号中导出，其中根据这些行地址将有用行读入图片存储器的相应位置，并且其中存储的行是 以预定的顺序从商店读出。 在所描述的实施例中，线路地址是通过计数输入的计数器导出的，这些计数输入是对应于从磁带获取的水平同步脉冲的递送脉冲，其复位输入是对应于垂直 从磁带获取的同步脉冲和其第三输入的输出脉冲的频率对应于交叉调制干扰的频率，并且每个脉冲引起注册计数的改变量，其由登记的 计数自身以及磁带重放速度是否大于或小于记录速度。
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