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公开(公告)号：US07939115B2
公开(公告)日：2011-05-10
申请号：US12059868
申请日：2008-03-31
申请人： Ruo G. Huang , Stephen R. Missler , Marc J. P. Lemay , Edward W. Kahler , Donald J. Pusateri , Haeri Roh-Schmidt , Shyam Ramakrishnan
发明人： Ruo G. Huang , Stephen R. Missler , Marc J. P. Lemay , Edward W. Kahler , Donald J. Pusateri , Haeri Roh-Schmidt , Shyam Ramakrishnan
IPC分类号： A61K36/752 , A61K36/53 , A61K36/00
CPC分类号： A61K36/53 , A23L19/01 , A23L33/105 , A23L33/15 , A23L33/16 , A23V2002/00 , A61K31/4188 , A61K31/7048 , A61K31/714 , A61K33/00 , A61K33/04 , A61K33/06 , A61K33/18 , A61K33/24 , A61K33/30 , A61K33/32 , A61K33/34 , A61K33/42 , A61K36/185 , A61K36/752 , A61K36/8965 , A61K45/06 , A61K2300/00 , A23V2250/21162 , A23V2250/70 , A23V2250/156 , A23V2250/213
摘要： A composition including a unique combination of fruits, vegetables, herbs, and optionally vitamins, minerals and specialty ingredients. The composition can include a fruit ingredient, a vegetable ingredient and an herbal ingredient, wherein the fruit ingredient is at least one of pomegranate and citrus bioflavonoids, wherein the vegetable ingredient, is at least one of asparagus, lutein, lycopene and watercress, and wherein the herbal ingredient is at least one of basil, oregano and rosemary. The composition can be administered to subjects to correct a dietary deficiency of phytochemicals and other nutrients, improve plasma concentrations of antioxidant nutrients, and increase the activity of genetic mechanisms for DNA repair and stability.
摘要翻译： 包括水果，蔬菜，草药和任选的维生素，矿物质和特种成分的独特组合的组合物。 所述组合物可以包括水果成分，植物成分和草药成分，其中所述水果成分是石榴和柑橘类生物类黄酮中的至少一种，其中所述植物成分是芦笋，叶黄素，番茄红素和水田芥中的至少一种，并且其中 草药成分至少是罗勒，牛至和迷迭香中的一种。 可以将组合物施用于受试者以校正植物化学物质和其他营养物的膳食缺乏症，改善抗氧化营养物质的血浆浓度，并增加DNA修复和稳定性的遗传机制的活性。
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公开(公告)号：US20050148014A1
公开(公告)日：2005-07-07
申请号：US11063894
申请日：2005-02-23
申请人： Shyam Ramakrishnan
发明人： Shyam Ramakrishnan
IPC分类号： G01N33/50 , A61K31/7088 , A61K31/711 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/04 , A61P3/00 , A61P3/04 , A61P3/10 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/02 , A61P13/08 , A61P19/10 , A61P25/00 , A61P25/04 , A61P25/18 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/02 , A61P35/00 , A61P37/08 , A61P43/00 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07H21/04
CPC分类号： C07K16/28 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/705 , C07K2319/02
摘要： Reagents which regulate human P2Y1-like G protein-coupled receptor can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, infections such as bacterial, fungal, protozoan, and viral infections, particularly those caused by HIV viruses, pain, cancers, anorexia, bulimia, asthma, CNS diseases such as Parkinson's disease, acute heart failure, hypotension, hypertension, urinary retention, osteoporosis, diabetes, angina pectoris, myocardial infarction, ulcers, asthma, inflammation, allergies, multiple sclerosis, benign prostatic hypertrophy, and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, several mental retardation, and dyskinesias, such as Huntington's disease and Tourett's syndrome.
摘要翻译： 调节人P2Y1样G蛋白偶联受体的试剂可以在预防，改善或纠正功能障碍或疾病中发挥作用，包括但不限于细菌，真菌，原生动物和病毒感染等感染，特别是由 艾滋病病毒，疼痛，癌症，厌食症，贪食症，哮喘，CNS疾病如帕金森病，急性心力衰竭，低血压，高血压，尿潴留，骨质疏松症，糖尿病，心绞痛，心肌梗死，溃疡，哮喘，炎症，过敏，多发 硬化症，良性前列腺肥大，以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁，del妄，痴呆，几种智力迟钝和运动障碍，如亨廷顿病和图雷特综合征。
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3.发明申请Molecular Targets and Dietary Modulators of Exercise-Induced Muscle Damage 审中-公开运动诱发肌肉损伤的分子靶点和膳食调节剂公开(公告)号：US20110097427A1
公开(公告)日：2011-04-28
申请号：US12912508
申请日：2010-10-26
申请人： Shyam Ramakrishnan , Aida Briseno , Mary A. Murray , Kerry Grann
发明人： Shyam Ramakrishnan , Aida Briseno , Mary A. Murray , Kerry Grann
IPC分类号： A61K36/738 , A61K36/87 , A61P21/00
CPC分类号： A61K31/122 , A61K36/33 , A61K36/41 , A61K36/738 , A61K36/87 , A61K2300/00
摘要： Dietary supplement compositions include an adaptogenic agent, an anti-inflammation agent, and an anti-oxidant. Methods for using dietary supplement compositions include (i) inhibiting, decreasing, and/or preventing delayed onset of muscle soreness (DOMS); (ii) inhibiting, decreasing, and/or preventing exercise-induced muscle damage; and/or (iii) modulating the expression of genes that are correlated with exercise-induced muscle damage.
摘要翻译： 膳食补充剂组合物包括适应剂，抗炎剂和抗氧化剂。 使用膳食补充剂组合物的方法包括（i）抑制，减少和/或预防肌肉酸痛延迟发作（DOMS）; （ii）抑制，减少和/或预防运动引起的肌肉损伤; 和/或（iii）调节与运动诱发的肌肉损伤相关的基因的表达。
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公开(公告)号：US06184342B2
公开(公告)日：2001-02-06
申请号：US08330594
申请日：1994-10-28
IPC分类号： A61K3800
CPC分类号： C07K14/705 , A61K38/00
摘要： These compositions are new synthetic peptides and antibodies which are potent chemotactic agents for human neutrophils, and methods for their use. The specificity of these peptides is amino acid sequence specific for binding to a heretofore unidentified receptor on the surface of neutrophils. Neutrophil response to this peptide is specific, since monocytes and fibroblasts do not show any expression of this receptor. Antibodies against these peptides block the chemotactic response. Such antibodies are useful to modulate neutrophil recruitment to a wound site for enhancing or inhibiting inflammation and early effects of wound healing.
摘要翻译： 这些组合物是用于人嗜中性粒细胞的有效趋化剂的新的合成肽和抗体及其使用的方法。 这些肽的特异性是与嗜中性粒细胞表面上迄今未鉴定的受体结合特异性的氨基酸序列。 对这种肽的嗜中性粒细胞反应是特异性的，因为单核细胞和成纤维细胞不显示该受体的任何表达。 针对这些肽的抗体阻断趋化反应。 这样的抗体可用于调节嗜中性粒细胞募集到伤口部位以增强或抑制炎症和伤口愈合的早期作用。
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公开(公告)号：US07192732B2
公开(公告)日：2007-03-20
申请号：US11357125
申请日：2006-02-21
申请人： Shyam Ramakrishnan
发明人： Shyam Ramakrishnan
CPC分类号： C12N9/6475 , A61K38/00 , C07K2319/00 , C12Y304/22036
摘要： Screening methods to identify candidate therapeutic agents using a newly identified human caspases-1-like protease.
摘要翻译： 使用新鉴定的人类半胱天冬酶-1样蛋白酶鉴定候选治疗剂的筛选方法。
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公开(公告)号：US20050019331A1
公开(公告)日：2005-01-27
申请号：US10718930
申请日：2003-11-20
申请人： Darrell Carney , Shyam Ramakrishnan
发明人： Darrell Carney , Shyam Ramakrishnan
IPC分类号： A61K38/00 , C07K14/705 , C12P21/08 , A61K39/395 , A61K38/17 , C07K16/30
CPC分类号： C07K14/705 , A61K38/00
摘要： These compositions are new synthetic peptides and antibodies which are potent chemotactic agents for human neutrophils, and methods for their use. The specificity of these peptides is amino acid sequence specific for binding to a heretofore unidentified receptor on the surface of neutrophils. Neutrophil response to this peptide is specific, since monocytes and fibroblasts do not show any expression of this receptor. Antibodies against these peptides block the chemotactic response. Such antibodies are useful to modulate neutrophil recruitment to a wound site for enhancing or inhibiting inflammation and early effects of wound healing.
摘要翻译： 这些组合物是用于人嗜中性粒细胞的有效趋化剂的新的合成肽和抗体及其使用的方法。 这些肽的特异性是与嗜中性粒细胞表面上迄今未鉴定的受体结合特异性的氨基酸序列。 对这种肽的嗜中性粒细胞反应是特异性的，因为单核细胞和成纤维细胞不显示该受体的任何表达。 针对这些肽的抗体阻断趋化反应。 这样的抗体可用于调节嗜中性粒细胞募集到伤口部位以增强或抑制炎症和伤口愈合的早期作用。
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公开(公告)号：US20060121554A1
公开(公告)日：2006-06-08
申请号：US11332138
申请日：2006-01-17
申请人： Shyam Ramakrishnan
发明人： Shyam Ramakrishnan
IPC分类号： C12Q1/02
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00
摘要： Screening assays for compounds useful to treat pain.
摘要翻译： 用于治疗疼痛的化合物的筛选试验。
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公开(公告)号：US20060110769A1
公开(公告)日：2006-05-25
申请号：US11316907
申请日：2005-12-27
申请人： Shyam Ramakrishnan , Ingo Flamme , Felix Oehme
发明人： Shyam Ramakrishnan , Ingo Flamme , Felix Oehme
CPC分类号： C12N9/0071 , A61K38/00 , A61K48/00 , C12Q1/26 , G01N2500/20
摘要： Reagents that regulate human prolyl 4-hydroxylase and reagents which bind to human prolyl 4-hydroxylase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to cardiovascular disorders, cancer, inflammatory diseases, fibrotic disorders, anemia, and CNS disorders, such as stroke.
摘要翻译： 调节人脯氨酰4-羟化酶的试剂和与人脯氨酰4-羟化酶基因产物结合的试剂可以在预防，改善或矫正功能障碍或疾病中发挥作用，包括但不限于心血管疾病，癌症，炎性疾病，纤维化疾病 ，贫血和中枢神经系统疾病，如中风。
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公开(公告)号：US20050214908A1
公开(公告)日：2005-09-29
申请号：US11117441
申请日：2005-04-29
申请人： Shyam Ramakrishnan
发明人： Shyam Ramakrishnan
CPC分类号： C12N9/1022 , A61K48/00 , C07K2319/00
摘要： Reagents which regulate human transketolase-like enzyme and reagents which bind to human transketolase-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including but not limited to, cancer, anemia, and end-stage renal disease, including sensory periphery neuropathy associated with uremia.
摘要翻译： 调节人类转酮醇酶样酶的试剂和与人类转酮酶样酶基因产物结合的试剂可以在预防，改善或矫正功能障碍或疾病中发挥作用，包括但不限于癌症，贫血和终末期肾病 ，包括与尿毒症相关的感觉性周围神经病变。
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公开(公告)号：US20060141552A1
公开(公告)日：2006-06-29
申请号：US11357125
申请日：2006-02-21
申请人： Shyam Ramakrishnan
发明人： Shyam Ramakrishnan
IPC分类号： C12Q1/37
CPC分类号： C12N9/6475 , A61K38/00 , C07K2319/00 , C12Y304/22036
摘要： Screening methods to identify candidate therapeutic agents using a newly identified human caspases-1-like protease.
摘要翻译： 使用新鉴定的人类半胱天冬酶-1样蛋白酶鉴定候选治疗剂的筛选方法。
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