公开(公告)号：US20050066963A1

公开(公告)日：2005-03-31

申请号：US10670924

申请日：2003-09-25

申请人： Russell Beavis ,  Larry Gray ,  David Howlett

发明人： Russell Beavis ,  Larry Gray ,  David Howlett

IPC分类号： A61M15/00 ,  A61M16/00 ,  B05B12/08 ,  G01F17/00 ,  G01F22/00 ,  G01F23/14 ,  G10K9/04 ,  A61M11/00

CPC分类号： A61M15/008 ,  A61M15/0003 ,  A61M15/002 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/0065 ,  A61M15/0066 ,  A61M15/0068 ,  A61M15/0085 ,  A61M15/009 ,  A61M2016/0021 ,  A61M2016/0039 ,  A61M2202/03 ,  A61M2205/3306 ,  A61M2205/3368 ,  A61M2205/3375 ,  A61M2205/3379 ,  A61M2205/50 ,  A61M2205/52 ,  B05B12/006 ,  B05B12/085 ,  G01F1/007 ,  G01F17/00 ,  G01F22/00 ,  G01F23/14 ,  G01H3/00 ,  G10K9/04

摘要： An apparatus comprises a variable acoustic source and a microphone, both acoustically coupled to a volume having a fluid region and an air region. The apparatus also can include a processor to determine a volume of the air region based on signals received from the microphone and the variable acoustic source. A fluid valve is coupled to the processor, and is configured to allow an amount of fluid to exit the fluid region associated with the volume of the air region. An atomizer, coupled to the fluid region, is configured to aerosolize at least a portion of the fluid.

摘要翻译： 一种装置包括声音耦合到具有流体区域和空气区域的体积的可变声源和麦克风。 该装置还可以包括处理器，用于基于从麦克风和可变声源接收的信号来确定空气区域的体积。 流体阀联接到处理器，并且被配置为允许一定量的流体离开与空气区域的体积相关联的流体区域。 耦合到流体区域的雾化器被配置为使至少一部分流体雾化。

公开(公告)号：US5896853A

公开(公告)日：1999-04-27

申请号：US847390

申请日：1997-04-24

申请人： David Howlett

发明人： David Howlett

IPC分类号： A61M15/00 ,  A61M16/10 ,  F16K11/00 ,  G05D11/02

CPC分类号： A61M15/009 ,  A61M15/002 ,  A61M15/0026 ,  A61M15/0086

摘要： The invention relates to an inhaler for products such as medicaments, and particularly to an inhaler for transferring to a patient, at a controlled air flow, a metered dose of a medicament contained in a pressurised dispensing container. The inhaler includes a housing adapted to receive a pressurised dispensing container, a mouthpiece, a duct connecting the container outlet with the mouthpiece, and an air inlet arrangement having at least one air inlet for allowing air into the inhaler when a user applies suction to the mouthpiece. The air inlet arrangement also has an air flow controller in which a piston member with a tapering external surface is movable due to a pressure change when suction is applied to the mouthpiece. The resulting piston movement effects a change in the flow of air through the air inlet. The air flow controller also includes a spring for urging the piston member to a rest position to allow maximum air flow to the air inlet. The piston member is movable axially against the action of the spring within the air inlet due to the pressure change, whereby a gap between the external surface of the piston member and the air inlet is increasingly reduced as the piston member moves further into the air inlet.

摘要翻译： 本发明涉及一种用于诸如药物的产品的吸入器，特别涉及一种用于以受控的空气流转移给患者的吸入器，其包含在加压分配容器中的计量剂量的药物。 吸入器包括适于接纳加压分配容器，接口管，将容器出口与接口连接的管道的壳体，以及具有至少一个空气入口的空气入口装置，用于当用户向吸入器施加吸入时，允许空气进入吸入器 喉舌。 空气入口装置还具有空气流量控制器，其中具有锥形外表面的活塞构件由于当向接口进行抽吸时由于压力变化而是可移动的。 所产生的活塞运动影响通过进气口的空气流动的变化。 空气流量控制器还包括用于将活塞构件推到静止位置以允许最大空气流入空气入口的弹簧。 活塞构件由于压力变化而抵抗空气入口内的弹簧的作用而轴向移动，由此当活塞构件进一步进入空气入口时，活塞构件的外表面与空气入口之间的间隙越来越小 。

公开(公告)号：US06170482B2

公开(公告)日：2001-01-09

申请号：US09031667

申请日：1998-02-27

申请人： David Howlett

发明人： David Howlett

IPC分类号： A61M1100

CPC分类号： A61M15/0091 ,  A61M15/0095 ,  A61M15/0096 ,  A61M2206/16

摘要： This invention relates to an inhalation apparatus for dispensing substances for inhalation and, in particular, but not exclusively, for dispensing medicinal products in aerosol form from a pressurized dispensing container. The inhalation apparatus comprises an inhaler apparatus for dispensing a product comprising a housing having a portion adapted to receive a pressurized dispensing container of a product and a mouthpiece. The apparatus further comprises duct means communicating with the container, said duct means having an outlet defining the direction of flow of the product towards the mouthpiece section. Air inlet valve means are provided comprising at least one air inlet for allowing air into the housing and an airflow controller is biased to seal said air inlet. The airflow controller is manually movable to unseal the air inlet to allow air to flow into the housing when a user applies suction to the mouthpiece. Passage means are provided to direct the airflow to a location adjacent the outlet of the duct means and the positioning of the passage means relative to the duct means outlet and the mouthpiece is such that a component of the initial air flow direction opposes the product flow before being directed towards the mouthpiece.

摘要翻译： 本发明涉及一种用于分配用于吸入的物质的吸入装置，特别是但不限于，用于从加压分配容器分配气溶胶形式的药物。 吸入装置包括用于分配产品的吸入器装置，该吸入器装置包括具有适于容纳产品的加压分配容器和接口的部分的壳体。 该装置还包括与容器连通的管道装置，所述管道装置具有限定产品朝向接口部分的流动方向的出口。 空气入口阀装置设置有至少一个空气入口，用于允许空气进入壳体，并且气流控制器被偏置以密封所述空气入口。 当用户向吸嘴施加吸力时，气流控制器可手动地移动以开启空气入口以允许空气流入壳体。 提供通道装置以将气流引导到与管道装置的出口相邻的位置，并且通道装置相对于管道装置出口的定位和接口管使得初始空气流动方向的部件与产品流动相反 指向喉舌。

公开(公告)号：US5938085A

公开(公告)日：1999-08-17

申请号：US838530

申请日：1997-04-09

申请人： Gary Conroy ,  David Howlett

发明人： Gary Conroy ,  David Howlett

IPC分类号： B65D83/14 ,  B65D83/00

CPC分类号： B65D83/425 ,  B65D83/54

摘要： A metering valve for dispensing an accurately metered dose of a product includes a valve stem having at one end a piston extending within and slidable relative to a cup shaped valve body. A spring member urges the piston against a base of the valve body. Movement of the valve stem against the spring action causes the piston to move away from the base of the valve body to define a temporary metering chamber between the valve stem and valve body. A clearance between an outer surface of the piston and an inner surface of the valve body provides a path for the product to flow from the container to the metering chamber. A seal within the container is contacted by an end of the piston to prevent the flow of product along the path, and the product is dispensed from the temporary metering chamber through an outlet in the valve stem.

摘要翻译： 用于分配准确计量剂量的产品的计量阀包括阀杆，阀杆的一端具有在杯状阀体内延伸并可相对于杯形阀体滑动的活塞。 弹簧构件将活塞推向阀体的基部。 阀杆抵抗弹簧作用的运动导致活塞远离阀体的基部移动，以在阀杆和阀体之间限定临时计量室。 活塞的外表面和阀体的内表面之间的间隙提供了产品从容器流到计量室的路径。 容器内的密封件由活塞的端部接触以防止产品沿着路径流动，并且产品通过阀杆中的出口从临时计量室分配。

公开(公告)号：US5860416A

公开(公告)日：1999-01-19

申请号：US855760

申请日：1997-04-24

申请人： David Howlett

发明人： David Howlett

IPC分类号： A61M15/00 ,  B05B1/34 ,  A61M11/00

CPC分类号： A61M15/009 ,  B05B1/3436 ,  A61M2206/16

摘要： The invention relates to an inhaler for products such as medicaments, and particularly to an inhaler for transferring to a patient a metered dose of product contained in a pressurized dispensing container. The inhaler includes a housing adapted to receive a pressurized dispensing container, a mouthpiece, duct means for connecting an outlet of the container with the mouthpiece and air inlet means for allowing air into the inhaler for when a user applies suction to the mouthpiece. The housing also comprises a mechanical break-up component located in the duct means. The component breaks up the product as it passes along the duct means, before mixing with the air flow to effect atomization of the product. The duct means includes a chamber for receiving the mechanical break-up component, the chamber having an end wall providing a barrier between the chamber and the mouthpiece to prevent the mechanical break-up component from entering the mouthpiece.

摘要翻译： 本发明涉及一种用于诸如药物的产品的吸入器，特别涉及用于将包含在加压分配容器中的计量剂量的产品转移给患者的吸入器。 吸入器包括适于接纳加压分配容器的外壳，接口管，用于将容器的出口与接口管连接的管道装置和用于当使用者向吸嘴施加吸力时允许空气进入吸入器的空气入口装置。 壳体还包括位于管道装置中的机械分解部件。 在与空气流混合以产生产物雾化之前，该组分在沿着管道装置通过时分解产物。 管道装置包括用于接收机械分解部件的腔室，该腔室具有在腔室和吸嘴之间提供阻挡物的端壁，以防止机械分解部件进入口部件。

公开(公告)号：US07086571B2

公开(公告)日：2006-08-08

申请号：US10312198

申请日：2002-04-17

申请人： Richard John Warby ,  David Howlett

发明人： Richard John Warby ,  David Howlett

IPC分类号： B65D83/00

CPC分类号： B65D83/54

摘要： A valve for use with a pressurized dispensing container containing a liquid, the valve including a slidable valve stem, the valve stem including an inlet port for conveyance, in use, of liquid from the pressurized dispensing container into the valve stem, and a flange against which biases the valve stem into a non-dispensing position, wherein an external opening of the inlet port is located within the flange.

摘要翻译： 一种用于与包含液体的加压分配容器一起使用的阀，所述阀包括可滑动的阀杆，所述阀杆包括用于在使用中从加压分配容器输入到阀杆中的液体的入口端口， 其将阀杆偏压到非分配位置，其中入口端口的外部开口位于凸缘内。

公开(公告)号：US6062214A

公开(公告)日：2000-05-16

申请号：US959447

申请日：1997-10-28

申请人： David Howlett

发明人： David Howlett

IPC分类号： A61M15/00 ,  A61M16/12 ,  A61M11/00

CPC分类号： A61M15/009 ,  A61M16/127 ,  A61M2206/16

摘要： The invention relates to inhaler products, such as medicaments, and particularly to an inhaler for transferring to a patient a metered dose of medicament contained in a pressurized dispensing container. The inhaler includes a housing for receiving a pressurized dispensing container of medicament and a mouthpiece for insertion into the mouth or a user of the inhaler. An outlet in the housing communicates with the mouth piece via a duct ending in an outlet. At least one air inlet is provided for allowing air into the inhaler. The air inlet(s) being positioned downstream relative to the duct outlet. A restricted airflow passage is provided between the air inlet(s) and a location adjacent to the outlet of the duct. The inhaler also includes a vortex generating arrangement positioned in the restricted airflow passage, such that, in use, when a user inhales through the mouthpiece, a swirling airflow is created from the inlet(s) to the mouthpiece along the passage towards the duct outlet. The swirling airflow exits the restricted airflow passage to create a swirling airflow in the neck region of the duct outlet that swirls about a central axis of the duct outlet and the swirling airflow has a component directed in reverse to the airflow form the duct outlet of the mouthpiece for reducing the velocity of medicament dispensed from the pressurized dispensing container via the duct and duct outlet.

摘要翻译： 本发明涉及吸入器产品，例如药物，特别涉及一种用于向包含在加压分配容器中的计量剂量的药物转移给患者的吸入器。 吸入器包括用于接收药物的加压分配容器的壳体和用于插入入口或吸入器的使用者的接口管。 壳体中的出口通过终止于出口的管道与口部件连通。 提供至少一个空气入口以允许空气进入吸入器。 进气口相对于管道出口位于下游。 在空气入口和与管道出口相邻的位置之间设置有限制的气流通道。 吸入器还包括定位在限制气流通道中的涡流产生装置，使得在使用时，当使用者通过吸嘴吸入时，沿着通向管道出口的通道从入口到吸嘴产生旋转气流 。 旋流气流离开受限制的气流通道，以在管道出口的颈部区域中产生旋转的气流，其围绕管道出口的中心轴线旋转，并且旋流气流具有与气流形成相反的部件，从而形成管道出口的管道出口 吸嘴，用于通过管道和管道出口降低从加压分配容器分配的药物的速度。

公开(公告)号：US20120055467A1

公开(公告)日：2012-03-08

申请号：US13226017

申请日：2011-09-06

申请人： Gaetano Brambilla ,  David Andrew Lewis ,  Robert Johnson ,  David Howlett

发明人： Gaetano Brambilla ,  David Andrew Lewis ,  Robert Johnson ,  David Howlett

IPC分类号： A61M11/00 ,  A61M16/14

CPC分类号： A61M15/009 ,  A61J1/2037 ,  A61J1/2089 ,  A61M15/0003 ,  B65D83/54 ,  B65D83/682

摘要： A metered-dose inhaler includes at least one vessel and an actuator for receiving the at least one vessel. The at least one vessel includes a first reservoir containing a first formulation and a second reservoir containing a second formulation. The metered-dose inhaler is actuable when the at least one vessel is received by the actuator. The metered-dose inhaler is configured to simultaneously deliver a first metered dose of the first formulation and a second metered dose of the second formulation upon actuation.

摘要翻译： 计量吸入器包括至少一个容器和用于容纳至少一个容器的致动器。 所述至少一个容器包括含有第一制剂的第一储存器和含有第二制剂的第二储存器。 当至少一个容器被致动器接收时，计量吸入器是致动的。 计量吸入器构造成在致动时同时递送第一制剂的第一计量剂量和第二制剂的第二计量剂量。

公开(公告)号：US20060053156A1

公开(公告)日：2006-03-09

申请号：US11219975

申请日：2005-09-06

申请人： Howard Kaushansky ,  Ted Kremer ,  David Howlett

发明人： Howard Kaushansky ,  Ted Kremer ,  David Howlett

IPC分类号： G06F17/30

CPC分类号： G06F16/338 ,  G06F16/358

摘要： Systems and methods for analysis and generating reports presenting analysis involving capturing unstructured data from online information services. Speaker attributes and semantic attributes associated with items of the captured data are determined. The captured data, speaker attributes, and semantic attributes are analyzed to generate processed information based on the captured data. A report is generated to present the processed information.

摘要翻译： 用于分析和生成报告的系统和方法，介绍从在线信息服务捕获非结构化数据的分析。 确定与拍摄数据的项目相关联的扬声器属性和语义属性。 分析捕获的数据，说话者属性和语义属性，以便基于捕获的数据生成处理的信息。 生成一个报告来呈现已处理的信息。

公开(公告)号：US06354290B1

公开(公告)日：2002-03-12

申请号：US09458047

申请日：1999-12-10

申请人： David Howlett

发明人： David Howlett

IPC分类号： A61M1160

CPC分类号： A61M15/0091 ,  A61M15/0026 ,  A61M15/0068 ,  A61M15/009

摘要： The present invention relates to an inhalation apparatus for dispensing substances for inhalation and, in particular, but not exclusively, for dispensing medicinal products in aerosol form from a pressurised dispensing container. An inhalation apparatus (1) is provided for dispensing a product comprising housing (20) adapted to receive a pressurised dispensing container (10) and a mouthpiece (22). The apparatus also comprises a duct for conveying, in use, product from the container to the mouthpiece, a sliding seal member (44, 45) movable under action of triggering means (60) between a first position in which the duct is closed and a second position in which the duct is open, wherein a spring means (50) is provided to bias the sliding seal member towards the second position. At least one air inlet (25) is provided for allowing air into the housing and a flow sensor (70) is activatable, by means of an airflow created when a user applies suction to the mouthpiece to activate said triggering means such that said sealing member is moved by said spring means into its second position to allow product to be dispensed into the airflow.

摘要翻译： 本发明涉及用于分配用于吸入的物质的吸入装置，特别是但不限于，用于从加压分配容器分配气溶胶形式的药物。 提供吸入装置（1），用于分配包括适于接纳加压分配容器（10）和接口（22）的壳体（20）的产品。 该设备还包括用于在使用中从容器输送到容器的产品的管道，滑动密封构件（44,45），其可在触发装置（60）的作用下在导管闭合的第一位置和 其中管道打开的第二位置，其中提供弹簧装置（50）以朝向第二位置偏压滑动密封构件。 至少一个空气入口（25）用于允许空气进入壳体，并且流量传感器（70）可通过当用户向吸嘴施加吸力而产生的气流激活时激活所述触发装置，使得所述密封构件 被所述弹簧装置移动到其第二位置以允许将产品分配到气流中。