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公开(公告)号：US20150099804A1
公开(公告)日：2015-04-09
申请号：US14566237
申请日：2014-12-10
IPC分类号： A61K31/555 , A61K45/06
CPC分类号： A61K31/555 , A61K9/0019 , A61K9/0024 , A61K31/661 , A61K33/24 , A61K38/00 , A61K45/06 , A61L27/54 , A61L2300/102 , A61L2300/45 , A61L2430/02 , A61K2300/00
摘要： This invention provides a method of promoting bone healing by locally administering a vanadium-based insulin mimetic agent to a patient in need thereof. The invention also provides a new use of insulin-mimetic vanadium compounds for manufacture of medicaments for accelerating bone-healing processes. In addition, the invention also encompasses a bone injury treatment kit suitable for localized administration of insulin-mimetic vanadium compounds or compositions thereof to a patient in need of such treatment.
摘要翻译： 本发明提供了一种通过局部给予有需要的患者的钒基胰岛素模拟物来促进骨愈合的方法。 本发明还提供了胰岛素模拟钒化合物的新用途，用于制造用于加速骨愈合过程的药物。 此外，本发明还包括适用于局部给予需要这种治疗的患者的胰岛素模拟钒化合物或其组合物的骨损伤治疗试剂盒。
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2.发明公开公开(公告)号：US20240157000A1
公开(公告)日：2024-05-16
申请号：US18423580
申请日：2024-01-26
IPC分类号： A61L2/00 , A61L27/36 , A61L27/54 , A61L101/30
CPC分类号： A61L2/0088 , A61L27/3608 , A61L27/3612 , A61L27/54 , A61L2101/30 , A61L2300/404
摘要： Methods for producing allograft tissue by applying an antimicrobial solution to allograft tissue. The antimicrobial solution exhibits antimicrobial activity to make allograft resistant to microbial organisms, such as bacterium. Surface-modified tissue grafts prepared by these methods are also disclosed.
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公开(公告)号：US20160151416A1
公开(公告)日：2016-06-02
申请号：US15010332
申请日：2016-01-29
发明人： Sheldon S. Lin , David N. Paglia , James P. O'Connor , Joseph Benevenia , Aaron Wey , Sangeeta Subramanian , John Koerner , Paul Chirichella , Michael J. Vives
CPC分类号： A61K33/32 , A61B17/7061 , A61B17/866 , A61B2017/561 , A61B2017/564 , A61F2/4455 , A61F2002/4475 , A61F2210/0085 , A61K31/28 , A61K31/315 , A61K31/69 , A61K33/00 , A61K33/24 , A61K33/30 , A61K45/06 , A61L27/54 , A61L31/16 , A61L2300/414 , A61L2430/02 , A61L2430/38 , A61K2300/00
摘要： Methods of promoting bone healing or regeneration by locally administering insulin mimetic agents to patients in need thereof and new uses of insulin-mimetic compounds for accelerating bone-healing processes are disclosed. Bone injury treatment and void filler devices, products and kit suitable for local administration of insulin-mimetic, agents or compositions thereof to patients in need of such treatment are also disclosed.
摘要翻译： 公开了通过局部给予有需要的患者的胰岛素模拟物促进骨愈合或再生的方法以及用于加速骨愈合过程的胰岛素模拟化合物的新用途。 还公开了骨损伤治疗和适用于需要这种治疗的患者局部施用胰岛素模拟物，试剂或组合物的空隙填充装置，产品和试剂盒。
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4.发明申请BORON COMPOSITE SURFACE COATINGS AND THEIR APPLICATION ON IMPLANTABLE DEVICES TO ACCELERATE OSSEOUS HEALING 审中-公开BORON复合表面涂料及其在可植入装置上的应用，以加速OSSEOUS HEALING公开(公告)号：US20150314047A1
公开(公告)日：2015-11-05
申请号：US14267633
申请日：2014-05-01
CPC分类号： A61L31/088 , A61L27/306 , A61L27/54 , A61L31/16 , A61L2300/102 , A61L2300/412 , A61L2300/414 , A61L2300/416 , A61L2420/02 , A61L2420/04 , A61L2430/02 , C23C14/16 , C23C16/38
摘要： The present invention discloses boron composite surface coatings, application of these coatings onto implantable devices, and use of the implantable devices for accelerating osseous healing. The implantable devices have wide applications, including but not limited to treating bone fracture, bone trauma, arthrodesis, and other bone deficit conditions, as well as bone injuries incurred in military and sports activities.
摘要翻译： 本发明公开了硼复合表面涂层，这些涂层在可植入装置上的应用，以及使用可植入装置来加速骨愈合。 可植入装置具有广泛的应用，包括但不限于治疗骨折，骨创伤，关节固定术和其他骨缺损状况，以及在军事和体育活动中引起的骨损伤。
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公开(公告)号：US20220088271A1
公开(公告)日：2022-03-24
申请号：US17540856
申请日：2021-12-02
发明人： Sheldon S. Lin , Joseph Benevenia , Michael J. Vives , Pradeep Kumar , David Alland , James Patrick O'Connor
摘要： The present invention is a method for producing allograft tissue by applying an antimicrobial solution to allograft tissue. The antimicrobial solution exhibits antimicrobial activity to make allograft resistant to microbial organisms, such as a bacterium.
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6.发明授权公开(公告)号：US11224678B2
公开(公告)日：2022-01-18
申请号：US15425617
申请日：2017-02-06
发明人： Joseph Benevenia , Sheldon S. Lin , Michael Vives
IPC分类号： A61L27/36 , A61L2/00 , A61L27/54 , A61L101/30
摘要： The present invention is a method for producing allograft tissue by applying an antimicrobial solution to allograft tissue. The antimicrobial solution exhibits antimicrobial activity to make allograft resistant to microbial organisms, such as bacterium.
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7.发明申请公开(公告)号：US20180318344A1
公开(公告)日：2018-11-08
申请号：US15943369
申请日：2018-04-02
发明人： Sheldon S. Lin , David N. Paglia , James P. O'Connor , Aaron Wey , Joseph Benevenia , Virak Tan
摘要： A method for repairing an injury of cartilage in a patient by local administration of a zinc or manganese agent or use of an implantable device for delivery of an a zinc or manganese agent. Implantable devices containing a zinc or manganese agent and methods of making these implantable devices are also disclosed.
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公开(公告)号：US20150010499A1
公开(公告)日：2015-01-08
申请号：US14469549
申请日：2014-08-26
发明人： Sheldon S. Lin , David N. Paglia , James P. O'Connor , Joseph Benevenia , Aaron Wey , Sangeeta Subramanian , John D. Koerner
CPC分类号： A61K33/32 , A61B17/7061 , A61B17/866 , A61B2017/561 , A61B2017/564 , A61F2/4455 , A61F2002/4475 , A61F2210/0085 , A61K31/28 , A61K31/315 , A61K31/69 , A61K33/00 , A61K33/24 , A61K33/30 , A61K45/06 , A61L27/54 , A61L31/16 , A61L2300/414 , A61L2430/02 , A61L2430/38 , A61K2300/00
摘要： Methods of promoting bone healing or regeneration by locally administering insulin mimetic agents to patients in need thereof and new uses of insulin-mimetic compounds for accelerating bone-healing processes are disclosed. Bone injury treatment and void filler devices, products and kit suitable for local administration of insulin-mimetic agents or compositions thereof to patients in need of such treatment are also disclosed.
摘要翻译： 公开了通过局部给予有需要的患者的胰岛素模拟物促进骨愈合或再生的方法以及用于加速骨愈合过程的胰岛素模拟化合物的新用途。 还公开了骨损伤治疗和适合于局部给予需要这种治疗的患者的胰岛素模拟剂或其组合物的空隙填充装置，产品和试剂盒。
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公开(公告)号：US20210251215A1
公开(公告)日：2021-08-19
申请号：US17307493
申请日：2021-05-04
摘要： This disclosure provides systems and methods for storing and preserving an implantable device. The system comprises a first sealable container; a second sealable container housed within the first sealable container; and a storage solution comprising a zinc compound contained in the second sealable container. The storage solution exhibits antimicrobial activity of inhibiting or controlling growth of microbial organisms and is capable of maintaining the implantable device in a hydrated state.
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10.发明申请INSULIN-MIMETIC LOCAL THERAPEUTIC ADJUNCTS FOR ENHANCING SPINAL FUSION 审中-公开用于增强脊髓融合的INSULIN-MIMETIC局部治疗方法公开(公告)号：US20170035803A1
公开(公告)日：2017-02-09
申请号：US15297900
申请日：2016-10-19
CPC分类号： A61K33/24 , A61B17/7061 , A61B17/866 , A61B2017/561 , A61B2017/564 , A61F2/4455 , A61F2002/30677 , A61F2210/0085 , A61F2310/00179 , A61F2310/00293 , A61K31/28 , A61K31/315 , A61K31/69 , A61K33/00 , A61K33/30 , A61K33/32 , A61K45/06 , A61L27/047 , A61L27/10 , A61L27/54 , A61L2300/414 , A61L2430/02 , A61L2430/38 , A61K2300/00
摘要： Bone tissue materials comprising insulin-mimetic agents, such as suitable zinc, vanadium, tungsten, molybdenum, niobium, selenium, and manganese compounds, for facilitating spinal fusion of vertebrae M spinal fusion surgical procedures, and methods thereof. Additionally provided is a bone tissue kit for facilitating fusion of vertebrae in a spinal fusion surgical procedure including a composition formulated for facile application in a spinal fusion procedure comprising an insulin-mimetic agent and a pharmaceutically acceptable carrier. Yet further provided is an implantable device for enhancing spinal fusion including a prosthetic implant configured to stabilize and promote the fusion of two adjacent vertebrae, wherein the bone tissue contacting surfaces of the prosthetic implant are coated with a composition comprising an insulin-mimetic agent.
摘要翻译： 骨组织材料包括胰岛素模拟剂，例如合适的锌，钒，钨，钼，铌，硒和锰化合物，用于促进椎骨M脊柱融合外科手术的脊柱融合，及其方法。 另外提供了一种骨组织试剂盒，其用于促进椎骨融合外科手术中椎骨的融合，所述手术包括在包含胰岛素模拟剂和药学上可接受的载体的脊柱融合术中容易地应用的组合物。 还提供了一种用于增强脊柱融合的可植入装置，其包括被配置为稳定和促进两个相邻椎骨的融合的假体植入物，其中所述假体植入物的骨组织接触表面涂覆有包含胰岛素模拟剂的组合物。
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