公开(公告)号：US20240360522A1

公开(公告)日：2024-10-31

申请号：US18287776

申请日：2022-04-21

申请人： Rutgers, The State University of New Jersey

发明人： Bassel Ghaddar ,  Subhajyoti De

IPC分类号： C12Q1/689 ,  C12Q1/6886 ,  C12Q1/6895

CPC分类号： C12Q1/689 ,  C12Q1/6886 ,  C12Q1/6895 ,  C12Q2600/118 ,  C12Q2600/158

摘要： Disclosed herein are systems and methods for identifying biomarkers. Biomarker identification can be achieved while increasing efficiency and decreasing data and computation complexity but maintaining accuracy. Such biomarker identification can be achieved via analysis of differential gene expression, such as determined using single cell RNA-sequencing data sets.

公开(公告)号：US20240355410A1

公开(公告)日：2024-10-24

申请号：US18645966

申请日：2024-04-25

申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ,  THE TRUSTEES OF PRINCETON UNIVERSITY

发明人： Adam J. Gormley ,  Matthew Tamasi ,  Shashank Kosuri ,  Michael Anthony Webb ,  Carlos Hernan Borca ,  Roshan Anit Patel

IPC分类号： G16B15/20 ,  G06F30/27 ,  G16B15/30 ,  G16B40/20

CPC分类号： G16B15/20 ,  G06F30/27 ,  G16B15/30 ,  G16B40/20

摘要： Disclosed are systems and methods that provide a framework for machine-assisted discovery of Chondroitinase ABC (ChABC) complexes towards sustained neural regeneration. In some embodiments, the framework may leverage a determination of a diverse set of tailor-made random copolymers that complex and stabilize ChABC at physiological temperature. The copolymer designs, which are based on chain length and/or composition of the copolymers, may be identified using an active machine learning paradigm, which involves, but is not limited to, copolymer synthesis, testing for ChABC thermostability upon copolymer complexation, Gaussian Process Regression modeling and Bayesian optimization. Copolymers are synthesized by automated PET-RAFT, and thermostability of ChABC may be assessed by retained enzyme activity (REA) after a predefined interval of hours at 37° C.

公开(公告)号：US20240333522A1

公开(公告)日：2024-10-03

申请号：US18737353

申请日：2024-06-07

申请人： Rutgers, the State University of New Jersey

发明人： Naftaly H. Minsky ,  Chen Cong ,  David M. Zimmerman

IPC分类号： H04L9/32 ,  H04L9/00 ,  H04L9/06

CPC分类号： H04L9/3247 ,  H04L9/0643 ,  H04L9/3236 ,  H04L9/50 ,  H04L2209/56

摘要： Systems and methods for enforcing contract/protocol/law execution have a wide range of applicability. Embodiments have very low latency between a transaction and its validation and have strong scalability. An embodiment is a system for enforcing execution of a protocol among a plurality of parties. The example system includes (i) a controller provider configured to manage a plurality of automated controllers, (ii) a ledger, and (iii) an inspector. The controllers correspond to the plurality of parties. Each controller is configured to enforce execution of the protocol using a computer program integrated with the controller. The controller provider intercepts messages sent or received by the controllers and stores them in the ledger, representing history of events or operations between the parties, and the treatment of those events or operations by the controllers. The inspector accesses the ledger and evaluates whether representations of events or operations stored therein comply with the protocol.

公开(公告)号：US12103966B2

公开(公告)日：2024-10-01

申请号：US17837888

申请日：2022-06-10

申请人： Rutgers, The State University of New Jersey

发明人： Renata Pasqualini ,  Wadih Arap ,  Fernanda Iamassaki Staquicini ,  Fortunato Ferrara ,  Sara D'Angelo ,  Andrew R. M. Bradbury

IPC分类号： C07K16/18 ,  A61K39/395 ,  A61K47/68 ,  A61P35/00 ,  C07K16/30 ,  G01N33/574 ,  A61K38/07 ,  A61K39/00 ,  A61K49/00 ,  C07K14/47 ,  C07K16/00 ,  C07K16/28 ,  C12N15/10 ,  C12N15/64 ,  C12Q1/6869 ,  G01N33/50

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K39/39558 ,  A61K47/6803 ,  A61K47/68031 ,  A61K47/68033 ,  A61P35/00 ,  C07K16/30 ,  C07K16/3023 ,  G01N33/574 ,  A61K38/07 ,  A61K2039/505 ,  A61K47/6817 ,  A61K47/6843 ,  A61K47/6849 ,  A61K47/6891 ,  A61K49/0008 ,  C07K14/47 ,  C07K16/005 ,  C07K16/28 ,  C07K16/2866 ,  C07K2317/21 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/77 ,  C12N15/1037 ,  C12N15/64 ,  C12N2810/00 ,  C12Q1/6869 ,  G01N33/5011 ,  G01N33/57423

摘要： Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.

公开(公告)号：US12098026B2

公开(公告)日：2024-09-24

申请号：US15733768

申请日：2019-04-17

申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

发明人： Guohong Li ,  Eva Y. Andrei ,  Angela Coe

IPC分类号： B65G1/00 ,  B65G1/04 ,  B66C1/24 ,  F16M13/02 ,  B66D1/26

CPC分类号： B65G1/0464 ,  B65G1/045 ,  B66C1/24 ,  F16M13/02 ,  B66D1/26

摘要： A system for transferring objects into a device inside a controlled environment includes a winch, tool and carousel. The winch includes a drum, and wire arrangement configured to be reversibly wound onto the drum by a first drive. The tool is suspended below a distal end of the wire arrangement and configured to suspend an object. Both the tool and the object are sized to fit inside a device located below the winch. The carousel is connected to a second drive configured to rotate the carousel around a vertical axis, and includes a storage space centered at a first horizontal angle and a pass-through opening at a different second horizontal angle. The pass-through opening being large enough to pass the tool and the object as the wire arrangement is unwound from the drum thereby lowering the tool and object inside the device.

公开(公告)号：US12092596B2

公开(公告)日：2024-09-17

申请号：US17250026

申请日：2019-05-31

申请人： Colgate-Palmolive Company ,  Rutgers, the State University of New Jersey

发明人： Michael Fitzgerald ,  Shamim Ansari ,  Zhongtian Lin ,  Jianye Sui ,  Mehdi Javanmard ,  Donghui Wu

IPC分类号： G01N27/02 ,  G01N33/543 ,  G01N33/68

CPC分类号： G01N27/02 ,  G01N33/5438 ,  G01N33/6803 ,  G01N27/028

摘要： Described herein are methods, systems and devices for rapidly detecting biomarkers in a biological sample.

公开(公告)号：US12082914B2

公开(公告)日：2024-09-10

申请号：US17745425

申请日：2022-05-16

申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

发明人： Andrew J. Gow ,  Gillian M. Cannon

IPC分类号： A61B5/0205 ,  A61B5/00 ,  A61B5/02 ,  A61B5/021 ,  A61B5/022 ,  A61B5/024 ,  A61B5/026 ,  G16H50/30

CPC分类号： A61B5/0205 ,  A61B5/02007 ,  A61B5/026 ,  A61B5/4035 ,  A61B5/486 ,  A61B5/4884 ,  G16H50/30 ,  A61B5/02108 ,  A61B5/02233 ,  A61B5/024 ,  A61B5/02416

摘要： A cardiovascular health assessment score, representing a working tissue flow and indicating the dependence on central and peripheral control mechanisms, is generated by an evaluation system and used to support a variety of individualized medicine and health applications. One or more of the individualized medicine and health applications may be implemented as part of the evaluation system and incorporate the cardiovascular health assessment.

公开(公告)号：US12065700B2

公开(公告)日：2024-08-20

申请号：US16486611

申请日：2018-02-17

申请人： CORNELL UNIVERSITY ,  RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

发明人： Christopher E. Mason ,  Jeffrey Rosenfeld ,  Delia Tomoiaga

IPC分类号： C12Q1/68 ,  C12Q1/6827 ,  C12Q1/6883 ,  G16B20/20 ,  G16B30/20 ,  G16H50/30

CPC分类号： C12Q1/6883 ,  C12Q1/6827 ,  G16B20/20 ,  G16B30/20 ,  G16H50/30 ,  C12Q2600/156 ,  C12Q2600/158

摘要： The present disclosure is directed to methods for typing and characterizing sperm. The technology employs a sequencing-based method for detecting and measuring RNA transcripts from single sperm cells and the analysis of the sequencing data for the prediction of male parent contribution to autism.

公开(公告)号：US12037529B2

公开(公告)日：2024-07-16

申请号：US17137813

申请日：2020-12-30

申请人： Rutgers, the State University of New Jersey

发明人： Ki-Bum Lee ,  Hudifah Rabie ,  Nicholas Pasquale ,  Yixiao Zhang

IPC分类号： C09K11/08 ,  A61K31/203 ,  A61K49/00 ,  B82Y5/00 ,  B82Y40/00 ,  C09K11/02 ,  C12N5/074 ,  C12N15/115

CPC分类号： C09K11/0833 ,  A61K31/203 ,  A61K49/0013 ,  C09K11/02 ,  C12N5/0696 ,  C12N15/115 ,  B82Y5/00 ,  B82Y40/00 ,  C12N2310/16 ,  C12N2500/05 ,  C12N2506/03 ,  C12N2529/10

摘要： Disclosed herein are embodiments of a composition comprising at least three layers. Layers one and two each either comprises a sensitizer or an emitter, typically a metal ion or a dye, and the third layer may or may not comprise a sensitizer or emitter. Upon exposure to light, such as infrared light, the composition produces visible and/or UV light. The composition may further comprise a capping moiety, a therapeutic agent, an uptake enhancer, a detection moiety that binds to a desired target, a quenching moiety, or a combination thereof. The composition may be a particle, such as a nanoparticle, or it may be a planar composition. Also disclosed are embodiments of a method for using the composition, including, but not limited to, a method for delivering a therapeutic agent, or a method for detecting a target, such as a biological target.

公开(公告)号：US20240188927A1

公开(公告)日：2024-06-13

申请号：US18586675

申请日：2024-02-26

申请人： Rutgers, The State University of New Jersey

发明人： Martin L. Yarmush ,  Alvin Chen ,  Max Balter ,  Joshua Leipheimer

IPC分类号： A61B8/08 ,  A61B8/00 ,  A61B8/06 ,  A61B8/12 ,  A61B34/20

CPC分类号： A61B8/0841 ,  A61B8/06 ,  A61B8/12 ,  A61B8/4218 ,  A61B8/466 ,  A61B2034/2065 ,  A61B2562/0219

摘要： A device and method for directing a cannula toward a target location under a patient's skin. The device is handheld and the device operations may be automated. The device includes an imaging probe for imaging the target location, a positioning unit for manipulating a cannula towards the target location, and a processor. The processor receives imaging data from the imaging probe, cannula pose data from at least one cannula position sensor, and device pose data from at least one device position sensor. The target location is identified from the imaging data, and a trajectory for manipulating the cannula towards the target location is determined based on the imaging data, the cannula pose data, and the device pose data. The processor may determine that the trajectory becomes misaligned with the target position, and may update to a corrected trajectory based on the imaging data, cannula pose data, and device pose data.