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1.发明授权Aberrant mitochondrial DNA, associated fusion transcripts and translation products and hybridization probes therefor 有权异常线粒体DNA，相关融合转录物和翻译产物及其杂交探针公开(公告)号：US08715960B2
公开(公告)日：2014-05-06
申请号：US13260497
申请日：2010-03-29
申请人： Ryan Parr , Gabriel Dakubo , Andrew Harbottle , Brian Reguly , Jennifer Creed , Kerry Robinson , Daniel Klein
发明人： Ryan Parr , Gabriel Dakubo , Andrew Harbottle , Brian Reguly , Jennifer Creed , Kerry Robinson , Daniel Klein
CPC分类号： C12Q1/6886 , C07K14/4748 , C12Q2600/158
摘要： The present invention provides novel mitochondrial fusion transcripts, the parent mutated mtDNA molecules, and the resulting translation products (proteins) for predicting, diagnosing and/or monitoring cancer. Hybridization probes complementary thereto for use in the methods of the invention are also provided.
摘要翻译： 本发明提供新的线粒体融合转录物，亲本突变的mtDNA分子，以及用于预测，诊断和/或监测癌症的所得翻译产物（蛋白质）。 还提供了用于本发明方法的互补的杂交探针。
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2.发明申请ABERRANT MITOCHONDRIAL DNA, ASSOCIATED FUSION TRANSCRIPTS AND TRANSLATION PRODUCTS AND HYBRIDIZATION PROBES THEREFORE 有权ABERRANT MITOCHONDRIAL DNA，相关融合转录物和翻译产物及其混合物探针公开(公告)号：US20130059299A1
公开(公告)日：2013-03-07
申请号：US13260497
申请日：2010-03-29
申请人： Ryan Parr , Andrew Harbottle , Brian Reguly , Jennifer Creed , Kerry Robinson , Daniel Klein
发明人： Ryan Parr , Gabriel Dakubo , Andrew Harbottle , Brian Reguly , Jennifer Creed , Kerry Robinson , Daniel Klein
CPC分类号： C12Q1/6886 , C07K14/4748 , C12Q2600/158
摘要： The present invention provides novel mitochondrial fusion transcripts, the parent mutated mtDNA molecules, and the resulting translation products (proteins) for predicting, diagnosing and/or monitoring cancer. Hybridization probes complementary thereto for use in the methods of the invention are also provided.
摘要翻译： 本发明提供新的线粒体融合转录物，亲本突变的mtDNA分子，以及用于预测，诊断和/或监测癌症的所得翻译产物（蛋白质）。 还提供了用于本发明方法的互补的杂交探针。
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3.发明申请Mitochondrial DNA Deletion Between About Residues 12317-16254 for Use in the Detection of Cancer 审中-公开关于残留物之间的线粒体DNA缺失12317-16254用于检测癌症公开(公告)号：US20100311057A1
公开(公告)日：2010-12-09
申请号：US12742032
申请日：2008-11-10
申请人： Ryan Parr , Jennifer Creed , Kerry Robinson , Andrea Maggrah , Katrina Maki , Gabriel Dakubo , Brian Reguly , Andrew Harbottle , Jude Alexander
发明人： Ryan Parr , Jennifer Creed , Kerry Robinson , Andrea Maggrah , Katrina Maki , Gabriel Dakubo , Brian Reguly , Andrew Harbottle , Jude Alexander
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to methods for predicting, diagnosing and monitoring cancer. The methods comprise obtaining biological samples, extracting mitochondrial DNA (mtDNA) from the samples, quantifying mitochondrial DNA mutation in the sample and comparing the level of mtDNA mutation with a reference value. The methods of the invention may also be effective in screening for new therapeutic agents and treatment regimes, and may also be useful for monitoring the response of a subject to a preventative or therapeutic treatment.
摘要翻译： 本发明涉及预测，诊断和监测癌症的方法。 方法包括获取生物样品，从样品中提取线粒体DNA（mtDNA），定量样品中的线粒体DNA突变，并将mtDNA突变水平与参考值进行比较。 本发明的方法还可以有效地筛选新的治疗剂和治疗方案，并且还可用于监测受试者对预防或治疗性治疗的反应。
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4.发明申请Methods for Assaying MC1R Variants and Mitochondrial Markers in Skin Samples 审中-公开在皮肤样品中测定MC1R变体和线粒体标记物的方法公开(公告)号：US20110045471A1
公开(公告)日：2011-02-24
申请号：US12682338
申请日：2008-09-14
申请人： Ryan Parr , Mark Birch-Machin , Andrew Harbottle , Robert Thayer , Jennifer Creed , Andrea Maggrah , Kerry Robinson , Gabriel Dakubo , Brian Reguly , Katrina Maki
发明人： Ryan Parr , Mark Birch-Machin , Andrew Harbottle , Robert Thayer , Jennifer Creed , Andrea Maggrah , Kerry Robinson , Gabriel Dakubo , Brian Reguly , Katrina Maki
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156
摘要： The present invention relates to methods for predicting, diagnosing and monitoring skin states and skin diseases. The methods combine the use of non-invasive skin collecting techniques with one or more assays for determining mitochondrial DNA (mtDNA) aberrations and Melanocortin 1 Receptor (MC1R) variants, thereby providing a comprehensive tool for identifying, predicting and/or monitoring photoageing, ultraviolet radiation (UVR) damage or skin disease. The methods of the invention may also be effective in screening for new therapeutic agents, skin care products and treatment regimes, and may also be useful for monitoring the response of a subject to a preventative or therapeutic treatment.
摘要翻译： 本发明涉及用于预测，诊断和监测皮肤状态和皮肤疾病的方法。 这些方法将非侵入性皮肤收集技术与一种或多种用于确定线粒体DNA（mtDNA）畸变和黑皮质素1受体（MC1R）变体的测定结合使用，从而提供用于鉴定，预测和/或监测光老化，紫外线 辐射（UVR）损伤或皮肤病。 本发明的方法还可以有效地筛选新的治疗剂，护肤产品和治疗方案，并且还可用于监测受试者对预防或治疗性治疗的反应。
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5.发明申请公开(公告)号：US20140024025A1
公开(公告)日：2014-01-23
申请号：US13582049
申请日：2011-03-01
申请人： Andrew Harbottle , Ryan L. Parr , Jennifer Creed , Brian Reguly , Kerry Robinson
发明人： Andrew Harbottle , Gabriel Dakubo , Ryan L. Parr , Jennifer Creed , Brian Reguly , Kerry Robinson
CPC分类号： C12Q1/6883 , C07K14/80 , C07K2319/00 , C12N9/0036 , C12N9/0053 , C12N9/12 , C12N9/14 , C12N15/62 , C12Q2600/148 , C12Q2600/156 , C12Y106/99003 , C12Y109/03001 , C12Y207/10001 , C12Y306/01003
摘要： The present invention provides novel mitochondrial fusion transcripts and related deletion molecules that are associated with UV exposure. Methods for in vivo and in vitro detection of mtDNA molecules and associated fusion transcripts is also provided, as is their use in the screening and testing of skin care products.
摘要翻译： 本发明提供了与UV暴露相关的新型线粒体融合转录物和相关缺失分子。 还提供了用于体外和体外检测mtDNA分子和相关融合转录物的方法，以及它们在护肤产品的筛选和测试中的用途。
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6.发明申请Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers 有权线粒体突变和重排作为检测阳光暴露，前列腺癌和其他癌症的诊断工具公开(公告)号：US20090192047A1
公开(公告)日：2009-07-30
申请号：US11975390
申请日：2007-10-18
申请人： Ryan Parr , Robert Thayer , Gabriel Dakubo , Jennifer Maki , Kerry Robinson , Andrea Maggrah , Brian Reguly , Andrew Harbottle , Mark Birch-Machin
发明人： Ryan Parr , Robert Thayer , Gabriel Dakubo , Jennifer Maki , Kerry Robinson , Andrea Maggrah , Brian Reguly , Andrew Harbottle , Mark Birch-Machin
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/156
摘要： Mitochondrial DNA deletions useful for the detection of cancers and sun exposure are provided. In particular, methods and kits for detecting mitochondrial DNA deletions for the early detection, diagnosis and progression of prostate cancer, sun exposure and non-melonoma skin cancer are provided.
摘要翻译： 提供了可用于检测癌症和阳光暴露的线粒体DNA缺失。 特别地，提供了用于检测用于前列腺癌的早期检测，诊断和进展的线粒体DNA缺失的方法和试剂盒，阳光暴露和非合成皮肤癌。
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7.发明申请3.4kb MITOCHONDRIAL DNA DELETION FOR USE IN THE DETECTION OF CANCER 审中-公开3.4kb用于检测癌症的MITOCHONDRIAL DNA DNA删除公开(公告)号：US20130022979A1
公开(公告)日：2013-01-24
申请号：US12748120
申请日：2010-03-26
申请人： Ryan Parr , Robert Thayer , Gabriel Dakubo , Jennifer Creed , Kerry Robinson , Andrea Maggrah , Brian Reguly
发明人： Ryan Parr , Robert Thayer , Gabriel Dakubo , Jennifer Creed , Kerry Robinson , Andrea Maggrah , Brian Reguly
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/156 , G01N33/57415 , G01N33/57434
摘要： The present invention broadly claims a method for detecting cancer in an individual. The method comprises detecting a deletion in the nucleic acid sequence between residues 10743 and 12125 in mitochondrial DNA. The method comprises obtaining a biological sample from the individual; extracting the mitochondrial DNA (mtDNA) from the sample; quantifying the amount of mtDNA in the sample having a deletion in the nucleic acid sequence between residues 10743 and 14125 of the mtDNA genome; and comparing the amount of mtDNA in the sample having the deletion to at least one known reference sample.
摘要翻译： 本发明广泛地要求用于检测个体癌症的方法。 该方法包括检测线粒体DNA中残基10743和12125之间的核酸序列中的缺失。 该方法包括从个体获得生物样品; 从样品中提取线粒体DNA（mtDNA）; 定量在mtDNA基因组的残基10743和14125之间的核酸序列中具有缺失的样品中的mtDNA的量; 并将具有缺失的样品中的mtDNA的量与至少一个已知参考样品进行比较。
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8.发明申请ABERRANT MITOCHONDRIAL DNA, ASSOCIATED FUSION TRANSCRIPTS AND HYBRIDIZATION PROBES THEREFOR 审中-公开ABERRANT MITOCHONDRIAL DNA，相关融合转录物及其杂交探针公开(公告)号：US20110172113A1
公开(公告)日：2011-07-14
申请号：US12935181
申请日：2009-03-27
申请人： Ryan Parr , Brian Reguly , Gabriel Dakubo , Jennifer Creed , Kerry Robinson
发明人： Ryan Parr , Brian Reguly , Gabriel Dakubo , Jennifer Creed , Kerry Robinson
CPC分类号： C12Q1/6886 , C07K14/4748 , C12Q2600/158
摘要： The present invention provides novel mitochondrial fusion transcripts and the parent mutated mtDNA molecules that are useful for predicting, diagnosing and/or monitoring cancer. Hybridization probes complementary thereto for use in the methods of the invention are also provided.
摘要翻译： 本发明提供了可用于预测，诊断和/或监测癌症的新型线粒体融合转录物和亲本突变的mtDNA分子。 还提供了用于本发明方法的互补的杂交探针。
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9.发明申请MITOCHONDRIAL MUTATIONS AND REARRANGEMENTS AS A DIAGNOSTIC TOOL FOR THE DETECTION OF SUN EXPOSURE, PROSTATE CANCER AND OTHER CANCERS 审中-公开作为用于检测阳光暴露，前列腺癌和其他癌症的诊断工具的麻醉药物突变和重新定位公开(公告)号：US20120058483A1
公开(公告)日：2012-03-08
申请号：US13221618
申请日：2011-08-30
申请人： Ryan Parr , Robert Thayer , Gabriel Dakubo , Jennifer Maki , Kerry Robinson , Andrea Maggrah , Brian Reguly , Andrew Harbottle , Mark Birch-Machin
发明人： Ryan Parr , Robert Thayer , Gabriel Dakubo , Jennifer Maki , Kerry Robinson , Andrea Maggrah , Brian Reguly , Andrew Harbottle , Mark Birch-Machin
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/156
摘要： Mitochondrial DNA deletions useful for the detection of cancers and sun exposure are provided. In particular, methods and kits for detecting mitochondrial DNA deletions for the early detection, diagnosis and progression of prostate cancer, sun exposure and non-melonoma skin cancer are provided.
摘要翻译： 提供了可用于检测癌症和阳光暴露的线粒体DNA缺失。 特别地，提供了用于检测用于前列腺癌的早期检测，诊断和进展的线粒体DNA缺失的方法和试剂盒，阳光暴露和非合成皮肤癌。
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10.发明授权Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers 有权线粒体突变和重排作为检测阳光暴露，前列腺癌和其他癌症的诊断工具公开(公告)号：US08008008B2
公开(公告)日：2011-08-30
申请号：US11975390
申请日：2007-10-18
申请人： Ryan Parr , Robert Thayer , Gabriel Dakubo , Jennifer Maki , Kerry Robinson , Andrea Maggrah , Brian Reguly , Andrew Harbottle , Mark Birch-Machin
发明人： Ryan Parr , Robert Thayer , Gabriel Dakubo , Jennifer Maki , Kerry Robinson , Andrea Maggrah , Brian Reguly , Andrew Harbottle , Mark Birch-Machin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/156
摘要： Mitochondrial DNA deletions useful for the detection of cancers and sun exposure are provided. In particular, methods and kits for detecting mitochondrial DNA deletions for the early detection, diagnosis and progression of prostate cancer, sun exposure and non-melanoma skin cancer are provided.
摘要翻译： 提供了可用于检测癌症和阳光暴露的线粒体DNA缺失。 特别地，提供了用于检测线粒体DNA缺失以用于前列腺癌的早期检测，诊断和进展，阳光暴露和非黑素瘤皮肤癌的方法和试剂盒。
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