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公开(公告)号：US20050272064A1
公开(公告)日：2005-12-08
申请号：US11067323
申请日：2005-02-23
申请人： S. Davis , Richard Fox , Gjalt Huisman , Vesna Gavrilovic , Lisa Newman
发明人： S. Davis , Richard Fox , Gjalt Huisman , Vesna Gavrilovic , Lisa Newman
摘要： The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
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公开(公告)号：US20050153417A1
公开(公告)日：2005-07-14
申请号：US10917179
申请日：2004-08-11
申请人： S. Davis , Richard Fox , Gjalt Huisman , Vesna Gavrilovic , Lisa Newman
发明人： S. Davis , Richard Fox , Gjalt Huisman , Vesna Gavrilovic , Lisa Newman
摘要： The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
摘要翻译： 本发明涉及新型卤代醇脱卤素酶多肽和编码它们的多核苷酸。 这些多肽可用于制备4-取代-3-丁酸衍生物和连位氰基羟基取代的羧酸酯。 本发明还提供相关载体，宿主细胞和方法。
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公开(公告)号：US20060099700A1
公开(公告)日：2006-05-11
申请号：US11266747
申请日：2005-11-02
申请人： S. Davis , Richard Fox , Gjalt Huisman , Vesna Gavrilovic , Emily Mundorff , Lisa Newman
发明人： S. Davis , Richard Fox , Gjalt Huisman , Vesna Gavrilovic , Emily Mundorff , Lisa Newman
摘要： The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
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公开(公告)号：US20060195947A1
公开(公告)日：2006-08-31
申请号：US10916311
申请日：2004-08-11
申请人： S. Davis , Gjalt Huisman , Stephane Jenne , Anke Krebber , Lisa Newman
发明人： S. Davis , Gjalt Huisman , Stephane Jenne , Anke Krebber , Lisa Newman
CPC分类号： C12N9/0006
摘要： The present invention is directed to variant polypeptides having enhanced ketoreductase activity and/or thermostability for use in the stereospecific reduction of ketones. In addition, the present invention is directed to polynucleotides that encode the ketoreductase polypeptides, including codon optimized versions of the polynucleotides which provide for enhanced expression in host cells. In another aspect, the present invention is directed to nucleotide constructs, vectors and host cells that are transformed with polynucleotides of the present invention.
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5.发明申请Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives 有权用于生产4-取代的3-羟基丁酸衍生物的酶法公开(公告)号：US20070161094A1
公开(公告)日：2007-07-12
申请号：US11502745
申请日：2006-08-10
申请人： S. Davis , John Grate , David Gray , John Gruber , Gjalt Huisman , Steven Ma , Lisa Newman , Roger Sheldon , Li A. Wang
发明人： S. Davis , John Grate , David Gray , John Gruber , Gjalt Huisman , Steven Ma , Lisa Newman , Roger Sheldon , Li A. Wang
IPC分类号： C12P13/00
CPC分类号： C12P13/002 , C12N9/14 , C12P7/62 , C12P13/02
摘要： The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives The present invention also provides methods and compositions for preparing vicinal cyano, hydroxyl substituted carboxylic acid esters.
摘要翻译： 本发明提供了通过卤代醇脱卤酶催化的4-卤代-3-羟基丁酸衍生物的转化来制备4-取代的3-羟基丁酸衍生物的方法和组合物。 本发明还提供了通过酮还原酶催化转化4-卤代-3-酮丁酸衍生物来制备4-卤代-3-羟基丁酸衍生物的方法和组合物。本发明还提供了用于制备邻位氰基，羟基取代的羧酸的方法和组合物 酸酯。
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公开(公告)号：US20050095619A1
公开(公告)日：2005-05-05
申请号：US10915927
申请日：2004-08-11
申请人： S. Davis , Stephane Jenne , Anke Krebber , Lisa Newman
发明人： S. Davis , Stephane Jenne , Anke Krebber , Lisa Newman
CPC分类号： C12N9/0006
摘要： The present invention is directed to glucose dehydrogenase (GDH) polypeptides that have enhanced GDH activity and/or thermostability relative to the backbone wild-type glucose dehydrogenase polypeptide. In addition, the present invention is directed to a polynucleotide that encodes for the GDH polypeptides of the present invention, to nucleic acid sequences comprising the polynucleotides, to expression vectors comprising the polynucleotides operatively linked to a promoter, to host cells transformed to express the GDH polypeptides, and to a method for producing the GDH polypeptides of the present invention.
摘要翻译： 本发明涉及相对于骨架野生型葡萄糖脱氢酶多肽具有增强的GDH活性和/或热稳定性的葡萄糖脱氢酶（GDH）多肽。 此外，本发明涉及编码本发明的GDH多肽的多核苷酸，包含多核苷酸的核酸序列，包含与启动子有效连接的多核苷酸的表达载体，转化为表达GDH的宿主细胞 多肽，以及本发明的GDH多肽的制备方法。
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公开(公告)号：US08716553B2
公开(公告)日：2014-05-06
申请号：US12714856
申请日：2010-03-01
申请人： Shoba Sivasankar , Lisa Newman
发明人： Shoba Sivasankar , Lisa Newman
CPC分类号： C12N15/8273
摘要： The present invention provides compositions and methods for regulating expression of nucleotide sequences in a plant. Compositions comprise novel nucleic acid sequences encoding a transcriptional activator involved in modulating gene expression in response to abiotic stress such as cold or drought. Methods for expressing the nucleic acid sequence in a plant and improving cold and/or drought tolerance of plants are also provided.
摘要翻译： 本发明提供调节植物中核苷酸序列表达的组合物和方法。 组合物包含编码参与调节基因表达以响应非生物胁迫如冷或干旱的转录激活剂的新型核酸序列。 还提供了在植物中表达核酸序列并改善植物的耐冷和/或耐旱性的方法。
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公开(公告)号：US20070271628A1
公开(公告)日：2007-11-22
申请号：US11754389
申请日：2007-05-29
申请人： Keith Lowe , Rebecca Cahoon , Christopher Scelonge , Yumin Tao , William Gordon-Kamm , Wesley Bruce , Lisa Newman
发明人： Keith Lowe , Rebecca Cahoon , Christopher Scelonge , Yumin Tao , William Gordon-Kamm , Wesley Bruce , Lisa Newman
CPC分类号： C12N15/8241 , C07K14/415 , C12N15/62 , C12N15/8201 , C12N15/8207 , C12N15/8261 , Y02A40/146
摘要： This invention relates to isolated polynucleotides encoding WUS polypeptides. The invention further provides isolated WUS polypeptides. The invention also provides methods of using the polynucleotides to modulate the level of WUS, improve transformation efficiency, to stimulate plant cell growth, including stem cells, to stimulate organogenesis, to stimulate somatic embryogenesis, to induce apomixis, and to provide a positive selection for cells comprising the polynucleotide. The invention also relates to cells, plants and seeds comprising the polynucleotides of the invention or produced by the methods of the invention.
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