公开(公告)号：US20230181493A1

公开(公告)日：2023-06-15

申请号：US17995749

申请日：2021-04-09

Applicant: SENDA BIOSCIENCES, INC.

Inventor： Devin Forest Reed DOUD ,  Afrand KAMALI ,  Victoria CATANZANO ,  Yohannes TEFFERA ,  Spencer Cory PECK ,  William McELROY ,  Timothy F. BRIGGS ,  Steven John TAYLOR

IPC: A61K31/137 ,  G01N33/68 ,  A61P25/16

CPC classification number: A61K31/137 ,  G01N33/6896 ,  A61P25/16 ,  G01N2800/52

Abstract: The present disclosure relates to the treatment of Parkinson's disease. The present disclosure provides, in some embodiments, methods of treating Parkinson's disease in a patient in need thereof. In some embodiments, the methods disclosed herein comprise administering a levodopa therapy based on a patient's biomarker profile. In some embodiments, the levodopa therapy comprises or lacks a tyrosine decarboxylase inhibitor. Therapeutic uses and compositions are also disclosed.

公开(公告)号：US20230234917A1

公开(公告)日：2023-07-27

申请号：US18001238

申请日：2021-06-09

Applicant: SENDA BIOSCIENCES, INC.

Inventor： Spencer Cory PECK ,  Jenny LIU ,  Timothy F. BRIGGS ,  John Robert PROUDFOOT ,  William MCELROY ,  Robert Walter MYERS ,  Steven John TAYLOR

IPC: C07C237/10 ,  A61P35/00 ,  C07K5/062 ,  C07D305/08 ,  C07C275/14 ,  C07C271/20 ,  C07F9/40 ,  C07F9/42 ,  C07C317/08 ,  C07F5/02 ,  C07C237/22 ,  C07D263/32 ,  C07D233/64 ,  C07D257/04 ,  C07D249/08 ,  C07D271/06 ,  C07D271/10 ,  C07D249/04 ,  C07C255/29 ,  C07D213/40 ,  C07D333/20 ,  C07D235/16

CPC classification number: C07C237/10 ,  A61P35/00 ,  C07K5/06026 ,  C07D305/08 ,  C07C275/14 ,  C07C271/20 ,  C07F9/4006 ,  C07F9/425 ,  C07C317/08 ,  C07F5/027 ,  C07C237/22 ,  C07D263/32 ,  C07D233/64 ,  C07D257/04 ,  C07D249/08 ,  C07D271/06 ,  C07D271/10 ,  C07D249/04 ,  C07C255/29 ,  C07D213/40 ,  C07D333/20 ,  C07D235/16 ,  C07C2601/14

Abstract: The present disclosure relates to compounds of formulas (A) and (I), pharmaceutically acceptable salts thereof, and solvates of any of the foregoing, pharmaceutical compositions comprising the same, methods of preparing the same, intermediate compounds useful for preparing the same, and methods for treating or prophylaxis of diseases, in particular cancer, such as colorectal cancer, using the same.