公开(公告)号：US20240125794A1

公开(公告)日：2024-04-18

申请号：US18278094

申请日：2022-02-02

Applicant: SHIMADZU CORPORATION

Inventor： Ritsuko YODA

IPC: G01N33/68 ,  G01N30/02 ,  G01N33/58

CPC classification number: G01N33/6848 ,  G01N30/02 ,  G01N33/58 ,  G01N2030/025 ,  G01N2030/027 ,  G01N2333/4709 ,  G01N2560/00

Abstract: A quality control standard for peptide (including protein) measurement, and a quality control for peptide (including proteins) measurement are provided. A QC standard sample for measurement of a target peptide, the QC standard sample comprising: a blood sample comprising a peptide, and a peptide labeled with a stable isotope that is spiked into said blood sample. The target peptide to be measured includes, for example, at least one selected from the group consisting of Aβ1-42 (SEQ ID NO.: 9), Aβ1-38 (SEQ ID NO.: 11), Aβ1-40 (SEQ ID NO.: 7), and APP669-711 (SEQ ID NO.: 10). The peptide labeled with a stable isotope that is spiked into the blood sample includes, for example, at least one selected from the group consisting of SIL-Aβ1-42, SIL-Aβ1-38, SIL-Aβ1-40, and SIL-APP669-711.

公开(公告)号：US20230132727A1

公开(公告)日：2023-05-04

申请号：US17918648

申请日：2020-11-26

Applicant: SHIMADZU CORPORATION

Inventor： Akihito KORENAGA ,  Ritsuko YODA ,  Tatsuki OKUBO ,  Tomonori OSHIKAWA ,  Yuko KOBAYASHI ,  Yoshiki TAINAKA ,  Kohei SUZUKI

IPC: H01J49/16 ,  H01J49/00 ,  H01J49/04

Abstract: One mode of the present invention provides a laser power adjustment method for ionization in a laser desorption/ionization mass spectrometer, the laser power adjustment method including: a measurement step (S1) in which intensity information on ions derived from a specific component in a specimen are acquired while changing laser power in n stages (n is 3 or more) for the identical specimen; and a processing step (S2, S6, and S7) in which a slope of a straight line connecting two adjacent plot points on a laser power axis is calculated in a two-axis graph in which a relationship between n ionic intensities obtained by the measurement step or a signal value, which is an SN ratio obtained from the ionic intensities, and laser power is plotted; an index value reflecting a ratio between a forward slope value, which is a slope of a straight line on a front side of the plot point, and a backward slope value, which is a slope of a straight line on a rear side, is obtained for each plot point; and appropriate laser power is selected using the index value.

公开(公告)号：US20210125815A1

公开(公告)日：2021-04-29

申请号：US17078344

申请日：2020-10-23

Applicant: SHIMADZU CORPORATION

Inventor： Tatsuki OKUBO ,  Chisato MIYAKE ,  Yuko OHASHI ,  Tomonori OSHIKAWA ,  Ritsuko YODA

IPC: H01J49/00 ,  H01J49/16 ,  G06T11/00

Abstract: A mass spectrometry device includes: an image generation unit that generates an image indicating a mass spectrometry sample arranged on each sample mounting portion in which each position of a plurality of sample mounting portions in a sample plate for laser desorption/ionization corresponds to each position of the plurality of sample mounting portions in an image, wherein: in the image, a display element indicating a direction is displayed at a position corresponding to the sample mounting portion.

公开(公告)号：US20220187332A1

公开(公告)日：2022-06-16

申请号：US17518003

申请日：2021-11-03

Applicant: SHIMADZU CORPORATION

Inventor： Naoki KANEKO ,  Ritsuko YODA ,  Akihito KORENAGA

IPC: G01N35/10 ,  H01J49/16

Abstract: In a sample pretreatment device, a container storage section (2) holds multiple containers, including a first well plate having wells in an N×M matrix form and a second well plate having N elongated wells whose length corresponds to M wells in one row of the first well plate or M elongated wells whose length corresponds to N wells in one column of the first well plate. A dispensing section (3) includes: a platform (30) on winch containers can be placed; a pipette unit (311, 312) including an M-channel tip corresponding to M wells in one row of the first well plate or an N-channel tip corresponding to N wells in one column of the first well plate; and a pump unit (313) for suctioning/ejecting a liquid from/into a container on the platform through the pipette unit. A transfer section (4) transfers containers between the container storage section and the platform. A controller (5) controls operations of the dispensing section and the transfer section.

公开(公告)号：US20210156871A1

公开(公告)日：2021-05-27

申请号：US16693783

申请日：2019-11-25

Applicant: SHIMADZU CORPORATION

Inventor： Ritsuko YODA

IPC: G01N33/68 ,  C07K1/32

Abstract: In the analysis method according to the present invention, a predetermined peptide is separated by immunoprecipitation using an antibody which specifically binds to either an N-terminus or a C-terminus of the predetermined peptide. The separated predetermined peptide is digested with a protease to prepare peptide fragments, and among the peptide fragments, a peptide fragment at a terminus opposite to a terminus binding to the antibody is mass-spectrometrically detected.