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公开(公告)号：US20120283272A1
公开(公告)日：2012-11-08
申请号：US13552755
申请日：2012-07-19
申请人： Shoujun Chen , Junyi Zhang , Jun Jiang , Gary Bohnert , Nha Vo , Qinglin Che , Zhiqiang Xia , Lijun Sun
发明人： Shoujun Chen , Junyi Zhang , Jun Jiang , Gary Bohnert , Nha Vo , Qinglin Che , Zhiqiang Xia , Lijun Sun
IPC分类号： A61K31/444 , C07D417/04 , A61K31/497 , A61K31/4436 , C07D409/06 , C07D409/14 , C07D417/14 , A61K31/4439
CPC分类号： C07D417/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The invention relates to certain compounds, or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
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公开(公告)号：US20130165451A9
公开(公告)日：2013-06-27
申请号：US13552755
申请日：2012-07-19
申请人： Shoujun Chen , Junyi Zhang , Jun Jiang , Gary Bohnert , Nha Vo , Qinglin Che , Zhiqiang Xia , Lijun Sun
发明人： Shoujun Chen , Junyi Zhang , Jun Jiang , Gary Bohnert , Nha Vo , Qinglin Che , Zhiqiang Xia , Lijun Sun
IPC分类号： A61K31/444 , C07D417/04 , A61K31/497 , A61K31/4436 , C07D409/06 , C07D409/14 , C07D417/14 , A61K31/4439
CPC分类号： C07D417/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The invention relates to certain compounds, or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
摘要翻译： 本发明涉及可用作免疫抑制剂并用于治疗和预防炎性病症，过敏性疾病和免疫疾病的某些化合物或其药学上可接受的盐，溶剂化物，包合物或前药。
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3.发明授权Compounds inclunding substituted pyridines for inflammation and immune-related uses 失效包含取代吡啶类化合物用于炎症和免疫相关用途的化合物公开(公告)号：US08314130B2
公开(公告)日：2012-11-20
申请号：US12572103
申请日：2009-10-01
申请人： Shoujun Chen , Junyi Zhang , Jun Jiang , Gary Bohnert , Nha Vo , Qinglin Che , Zhiqiang Xia , Lijun Sun
发明人： Shoujun Chen , Junyi Zhang , Jun Jiang , Gary Bohnert , Nha Vo , Qinglin Che , Zhiqiang Xia , Lijun Sun
IPC分类号： A61K31/44
CPC分类号： C07D417/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The invention relates to certain compounds including substituted pyridines, or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
摘要翻译： 本发明涉及可用作免疫抑制剂并用于治疗和预防炎性病症，过敏性疾病和免疫疾病的某些化合物，包括取代的吡啶或其药学上可接受的盐，溶剂合物，包合物或前药。
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公开(公告)号：US20100130510A1
公开(公告)日：2010-05-27
申请号：US12572103
申请日：2009-10-01
申请人： SHOUJUN CHEN , Junyi Zhang , Jun Jiang , Gary Bohnert , Nha Vo , Qinglin Che , Zhiqiang Xia , Lijun Sun
发明人： SHOUJUN CHEN , Junyi Zhang , Jun Jiang , Gary Bohnert , Nha Vo , Qinglin Che , Zhiqiang Xia , Lijun Sun
IPC分类号： A61K31/497 , A61K31/444 , A61K31/4439 , C07D409/14 , C07D401/14 , C07D417/04 , A61P25/28 , A61P19/02 , A61P3/10 , A61P17/00 , A61P37/00 , A61P11/06 , A61P19/08 , A61P25/16
CPC分类号： C07D417/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The invention relates to certain compounds, or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
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5.发明申请公开(公告)号：US20070275960A1
公开(公告)日：2007-11-29
申请号：US11698982
申请日：2007-01-25
申请人： Jun Jiang , Junyi Zhang , Nha Vo , Shoujun Chen
发明人： Jun Jiang , Junyi Zhang , Nha Vo , Shoujun Chen
IPC分类号： A61K31/535 , A61K31/34 , A61K31/38 , A61K31/41 , A61K31/54 , C07D239/00 , C07D277/20 , C07D333/00 , C07D413/00 , C12N5/08 , C07D417/00 , C07D409/00 , C07D307/02 , C07D271/10 , A61P37/00 , A61K31/42 , A61K31/425 , A61K31/505
CPC分类号： C07D333/38 , C07D277/28 , C07D277/56 , C07D307/68 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein R1, X1, X2, Y, Z, L, and n are defined herein. The compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
摘要翻译： 本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物或前药，其中R 1，X 1，X， > 2 ，Y，Z，L和n在本文中定义。 这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症，过敏性疾病和免疫疾病。
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公开(公告)号：US20100249195A1
公开(公告)日：2010-09-30
申请号：US12749317
申请日：2010-03-29
申请人： Jun Jiang , Zhi-Qiang Xia , Junyi Zhang , Gary Bohnert , Shoujun Chen , Yu Xie
发明人： Jun Jiang , Zhi-Qiang Xia , Junyi Zhang , Gary Bohnert , Shoujun Chen , Yu Xie
IPC分类号： A61K31/4439 , A61K31/4418 , A61P29/00 , A61P37/00 , C12N5/071 , C12N5/0781 , C12N5/0783
CPC分类号： C07D417/14 , C07D211/70 , C07D211/72 , C07D213/72 , C07D213/75 , C07D213/81 , C07D401/12 , C07D405/10 , C07D409/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/12
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein Y, L, X1, X2, Z, R3, R4, and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
摘要翻译： 本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂合物，包合物或前药，其中Y，L，X1，X2，Z，R3，R4和n如本文所定义。 这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症，过敏性疾病和免疫疾病。
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公开(公告)号：US20070254926A1
公开(公告)日：2007-11-01
申请号：US11701170
申请日：2007-01-31
申请人： Jun Jiang , Zhi-Qiang Xia , Junyi Zhang , Gary Bohnert , Shoujun Chen , Yu Xie
发明人： Jun Jiang , Zhi-Qiang Xia , Junyi Zhang , Gary Bohnert , Shoujun Chen , Yu Xie
IPC分类号： A61K31/44 , C07D211/70 , C07D211/72 , C07D213/72
CPC分类号： C07D417/14 , C07D211/70 , C07D211/72 , C07D213/72 , C07D213/75 , C07D213/81 , C07D401/12 , C07D405/10 , C07D409/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/12
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein Y, L, X1, X2, Z, R3, R4, and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
摘要翻译： 本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂合物，包合物或前药，其中Y，L，X 1，X 2， ，Z，R 3，R 4和n如本文所定义。 这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症，过敏性疾病和免疫疾病。
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公开(公告)号：US08592486B2
公开(公告)日：2013-11-26
申请号：US13470772
申请日：2012-05-14
申请人： Lijun Sun , Shoujun Chen , Zhi-Qiang Xia , Jun Jiang , Yu Xie , Junyi Zhang
发明人： Lijun Sun , Shoujun Chen , Zhi-Qiang Xia , Jun Jiang , Yu Xie , Junyi Zhang
IPC分类号： A61K31/415 , A61K31/433 , A61K31/455 , A61K31/537 , A61K31/165
CPC分类号： A61K31/426 , A61K31/24 , A61K31/41 , A61K31/421 , A61K31/433 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K45/06 , C07C233/81 , C07D207/335 , C07D213/40 , C07D213/64 , C07D213/81 , C07D231/12 , C07D249/10 , C07D249/12 , C07D257/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D277/22 , C07D277/28 , C07D285/12 , C07D295/135 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The invention relates to compounds of structural formulas (I), (VII) and (XI): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein X1, X2, X3, Y, Z, L, R1, R2, R3, R18 and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
摘要翻译： 本发明涉及结构式（I），（VII）和（XI）的化合物或其药学上可接受的盐，溶剂合物，包合物或前药，其中X1，X2，X3，Y，Z，L，R1，R2 ，R 3，R 18和n如本文所定义。 这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症，过敏性疾病和免疫疾病。
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9.发明申请SUBSTITUTED BENZOIMIDAZOLYL-PYRAZINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES 失效用于炎症和免疫相关用途的替代苯甲酰甲霜灵 - 吡嗪化合物公开(公告)号：US20100273751A1
公开(公告)日：2010-10-28
申请号：US12678790
申请日：2008-09-19
申请人： Shoujun Chen , Jun Jiang , Junyi Zhang , Lijun Sun
发明人： Shoujun Chen , Jun Jiang , Junyi Zhang , Lijun Sun
IPC分类号： A61K31/56 , C07D403/04 , A61K31/497 , A61P3/10 , A61P37/00 , A61P19/02 , A61P11/06 , A61P25/28 , A61P25/16 , A61P9/10 , A61P35/00 , A61P1/16 , A61P27/16 , A61P27/02
CPC分类号： C07D403/04 , C07D413/14
摘要： This invention relates to certain biologically active chemical compounds, namely benzoimidazolyl-pyrazine derivatives or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
摘要翻译： 本发明涉及某些生物活性化合物，即苯并咪唑基 - 吡嗪衍生物或其药学上可接受的盐，溶剂合物，包合物或前药。 这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症，过敏性疾病和免疫疾病。
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公开(公告)号：US20100130522A1
公开(公告)日：2010-05-27
申请号：US12572088
申请日：2009-10-01
申请人： JUN JIANG , Junyi Zhang , Shoujun Chen , Lijun Sun
发明人： JUN JIANG , Junyi Zhang , Shoujun Chen , Lijun Sun
IPC分类号： A61K31/4402 , C07D213/60 , C07D401/10 , A61K31/506 , A61P37/08
CPC分类号： C07D401/10 , C07D213/30 , C07D213/40 , C07D213/64 , C07D213/643 , C07D213/75 , C07D213/81 , C07D233/61 , C07D263/32 , C07D277/28 , C07D277/34 , C07D401/12 , C07D417/04 , C07D417/10 , C07D417/14
摘要： The invention relates to certain compounds according to Formula (I): or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders and immune disorders.
摘要翻译： 本发明涉及可用作免疫抑制剂并用于治疗和预防炎性病症，过敏性疾病和免疫疾病的根据式（I）的某些化合物或其药学上可接受的盐，溶剂化物，包合物或前药。
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