公开(公告)号：US20170266161A1

公开(公告)日：2017-09-21

申请号：US15346636

申请日：2016-11-08

申请人： Signum Biosciences, Inc.

发明人： SCOTT VAFAI ,  Michael Voronkov ,  Maxwell Stock ,  Jeffry B. Stock ,  Seung-Yub Lee ,  Zhu Li ,  Haoming Gu

IPC分类号： A61K31/405

CPC分类号： A61K31/405

摘要： The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2A and/or modulating the activity of PP2A.

公开(公告)号：US09744147B2

公开(公告)日：2017-08-29

申请号：US15151221

申请日：2016-05-10

申请人： SIGNUM BIOSCIENCES, INC.

发明人： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC分类号： A61K31/197 ,  C07C323/59 ,  C07C335/08 ,  A61K9/00 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24 ,  C07C243/34 ,  C07C321/18 ,  C07D207/16 ,  C07D243/34

CPC分类号： A61K31/197 ,  A61K9/0014 ,  C07C243/34 ,  C07C321/18 ,  C07C323/59 ,  C07C335/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D243/34 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24

摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

公开(公告)号：US20170368011A1

公开(公告)日：2017-12-28

申请号：US15665922

申请日：2017-08-01

申请人： SIGNUM BIOSCIENCES, INC.

发明人： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC分类号： A61K31/197 ,  C07D307/54 ,  A61K9/00 ,  C07D295/145 ,  C07D243/34 ,  C07D217/26 ,  C07D209/48 ,  C07D209/18 ,  C07D207/16 ,  C07C335/08 ,  C07C323/59 ,  C07C321/18 ,  C07C243/34 ,  C07D333/24 ,  C07C2601/14 ,  C07C2601/02

CPC分类号： A61K31/197 ,  A61K9/0014 ,  C07C243/34 ,  C07C321/18 ,  C07C323/59 ,  C07C335/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D243/34 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24

摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

公开(公告)号：US10583119B2

公开(公告)日：2020-03-10

申请号：US15346636

申请日：2016-11-08

申请人： Signum Biosciences, Inc.

发明人： Scott Vafai ,  Michael Voronkov ,  Maxwell Stock ,  Jeffry B. Stock ,  Seung-Yub Lee ,  Zhu Li ,  Haoming Gu

IPC分类号： A61K31/405

摘要： The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2A and/or modulating the activity of PP2A.

公开(公告)号：US10314802B2

公开(公告)日：2019-06-11

申请号：US15665922

申请日：2017-08-01

申请人： Signum Biosciences, Inc.

发明人： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC分类号： A61K31/197 ,  A61K9/00 ,  C07C323/59 ,  C07C335/08 ,  C07C243/34 ,  C07C321/18 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24 ,  C07D207/16 ,  C07D243/34

摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

公开(公告)号：US20160361283A1

公开(公告)日：2016-12-15

申请号：US15151221

申请日：2016-05-10

申请人： SIGNUM BIOSCIENCES, INC.

发明人： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC分类号： A61K31/197 ,  A61K9/00

CPC分类号： A61K31/197 ,  A61K9/0014 ,  C07C243/34 ,  C07C321/18 ,  C07C323/59 ,  C07C335/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D243/34 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24

摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

摘要翻译： 除此之外，本发明提供能够有效调节炎症反应的新型异戊二烯基化合物和包含这些异戊二烯基化合物的药物，化妆品，药​​妆和局部组合物。 本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。 本发明的促炎症化合物可用于治疗或预防与抑制炎性反应相关的疾病或病症。 因此，本发明还提供了用于治疗或预防与炎症相关的疾病或病症的方法以及可用于治疗或预防与抑制炎性反应相关的疾病或病症的方法。