公开(公告)号：US10117904B2

公开(公告)日：2018-11-06

申请号：US15221380

申请日：2016-07-27

Applicant: Signum Biosciences, Inc.

Inventor： Jeffry B. Stock ,  Maxwell Stock

IPC: A61K38/05 ,  A61K31/198 ,  A61K31/341 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/5375 ,  A61K9/00 ,  A61K31/165

Abstract: Disclosed herein are methods of inactivating and/or decolonizing bacteria on a surface. The present invention also discloses methods for treatment of epithelial conditions caused or aggravated by bacteria, such as acne vulgaris, in a subject in need thereof. The present invention additionally discloses inventive compounds and compositions that exhibit anti-bacterial and/or anti-inflammatory effects.

公开(公告)号：US20170049841A1

公开(公告)日：2017-02-23

申请号：US15221380

申请日：2016-07-27

Applicant: Signum Biosciences, Inc.

Inventor： Jeffry B. Stock ,  Maxwell Stock

IPC: A61K38/05 ,  A61K31/198 ,  A61K31/381 ,  A61K31/5375 ,  A61K31/4045 ,  A61K9/00 ,  A61K31/341

CPC classification number: A61K38/05 ,  A61K9/0014 ,  A61K9/007 ,  A61K31/165 ,  A61K31/198 ,  A61K31/341 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/5375 ,  Y02A50/478 ,  Y02A50/481

Abstract: Disclosed herein are methods of inactivating and/or decolonizing bacteria on a surface. The present invention also discloses methods for treatment of epithelial conditions caused or aggravated by bacteria, such as acne vulgaris, in a subject in need thereof. The present invention additionally discloses inventive compounds and compositions that exhibit anti-bacterial and/or anti-inflammatory effects.

Abstract translation: 本文公开了在表面上灭活和/或非殖民细菌的方法。 本发明还公开了在有需要的受试者中治疗由细菌如寻常痤疮引起或加重的上皮状况的方法。 本发明还公开了具有抗细菌和/或抗炎作用的本发明化合物和组合物。

公开(公告)号：US20170266161A1

公开(公告)日：2017-09-21

申请号：US15346636

申请日：2016-11-08

Applicant: Signum Biosciences, Inc.

Inventor： SCOTT VAFAI ,  Michael Voronkov ,  Maxwell Stock ,  Jeffry B. Stock ,  Seung-Yub Lee ,  Zhu Li ,  Haoming Gu

IPC: A61K31/405

CPC classification number: A61K31/405

Abstract: The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2A and/or modulating the activity of PP2A.

公开(公告)号：US09744147B2

公开(公告)日：2017-08-29

申请号：US15151221

申请日：2016-05-10

Applicant: SIGNUM BIOSCIENCES, INC.

Inventor： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC: A61K31/197 ,  C07C323/59 ,  C07C335/08 ,  A61K9/00 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24 ,  C07C243/34 ,  C07C321/18 ,  C07D207/16 ,  C07D243/34

CPC classification number: A61K31/197 ,  A61K9/0014 ,  C07C243/34 ,  C07C321/18 ,  C07C323/59 ,  C07C335/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D243/34 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24

Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

公开(公告)号：US20170368011A1

公开(公告)日：2017-12-28

申请号：US15665922

申请日：2017-08-01

Applicant: SIGNUM BIOSCIENCES, INC.

Inventor： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC: A61K31/197 ,  C07D307/54 ,  A61K9/00 ,  C07D295/145 ,  C07D243/34 ,  C07D217/26 ,  C07D209/48 ,  C07D209/18 ,  C07D207/16 ,  C07C335/08 ,  C07C323/59 ,  C07C321/18 ,  C07C243/34 ,  C07D333/24 ,  C07C2601/14 ,  C07C2601/02

CPC classification number: A61K31/197 ,  A61K9/0014 ,  C07C243/34 ,  C07C321/18 ,  C07C323/59 ,  C07C335/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D243/34 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24

Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

公开(公告)号：US10583119B2

公开(公告)日：2020-03-10

申请号：US15346636

申请日：2016-11-08

Applicant: Signum Biosciences, Inc.

Inventor： Scott Vafai ,  Michael Voronkov ,  Maxwell Stock ,  Jeffry B. Stock ,  Seung-Yub Lee ,  Zhu Li ,  Haoming Gu

IPC: A61K31/405

Abstract: The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2A and/or modulating the activity of PP2A.

公开(公告)号：US10314802B2

公开(公告)日：2019-06-11

申请号：US15665922

申请日：2017-08-01

Applicant: Signum Biosciences, Inc.

Inventor： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC: A61K31/197 ,  A61K9/00 ,  C07C323/59 ,  C07C335/08 ,  C07C243/34 ,  C07C321/18 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24 ,  C07D207/16 ,  C07D243/34

Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

公开(公告)号：US20160361283A1

公开(公告)日：2016-12-15

申请号：US15151221

申请日：2016-05-10

Applicant: SIGNUM BIOSCIENCES, INC.

Inventor： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC: A61K31/197 ,  A61K9/00

CPC classification number: A61K31/197 ,  A61K9/0014 ,  C07C243/34 ,  C07C321/18 ,  C07C323/59 ,  C07C335/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D243/34 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24

Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

Abstract translation: 除此之外，本发明提供能够有效调节炎症反应的新型异戊二烯基化合物和包含这些异戊二烯基化合物的药物，化妆品，药​​妆和局部组合物。 本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。 本发明的促炎症化合物可用于治疗或预防与抑制炎性反应相关的疾病或病症。 因此，本发明还提供了用于治疗或预防与炎症相关的疾病或病症的方法以及可用于治疗或预防与抑制炎性反应相关的疾病或病症的方法。