公开(公告)号：US09744147B2

公开(公告)日：2017-08-29

申请号：US15151221

申请日：2016-05-10

申请人： SIGNUM BIOSCIENCES, INC.

发明人： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC分类号： A61K31/197 ,  C07C323/59 ,  C07C335/08 ,  A61K9/00 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24 ,  C07C243/34 ,  C07C321/18 ,  C07D207/16 ,  C07D243/34

CPC分类号： A61K31/197 ,  A61K9/0014 ,  C07C243/34 ,  C07C321/18 ,  C07C323/59 ,  C07C335/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D243/34 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24

摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

公开(公告)号：US20170368011A1

公开(公告)日：2017-12-28

申请号：US15665922

申请日：2017-08-01

申请人： SIGNUM BIOSCIENCES, INC.

发明人： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC分类号： A61K31/197 ,  C07D307/54 ,  A61K9/00 ,  C07D295/145 ,  C07D243/34 ,  C07D217/26 ,  C07D209/48 ,  C07D209/18 ,  C07D207/16 ,  C07C335/08 ,  C07C323/59 ,  C07C321/18 ,  C07C243/34 ,  C07D333/24 ,  C07C2601/14 ,  C07C2601/02

CPC分类号： A61K31/197 ,  A61K9/0014 ,  C07C243/34 ,  C07C321/18 ,  C07C323/59 ,  C07C335/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D243/34 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24

摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

公开(公告)号：US10912812B2

公开(公告)日：2021-02-09

申请号：US16514337

申请日：2019-07-17

申请人： Signum Biosciences, Inc.

发明人： Kristen Huber ,  Michael Voronkov ,  Jose Fernandez ,  Karl Rouzard ,  Eduardo Perez ,  Maxwell Stock ,  Jeffry Stock

IPC分类号： A61K8/97 ,  A61K36/9066 ,  A61K36/77 ,  A61K36/87 ,  A61K36/33 ,  A61K36/73 ,  A61K45/06 ,  A61K9/00 ,  A61K36/14 ,  A61K36/185 ,  A61K36/23 ,  A61K36/235 ,  A61K36/28 ,  A61K36/31 ,  A61K36/45 ,  A61K36/52 ,  A61K36/54 ,  A61K36/575 ,  A61K36/71 ,  A61K36/736 ,  A61K36/79 ,  A61Q19/08

摘要： Method of preparing a botanical extract that includes contacting a raw botanical with a solvent having a dielectric constant ranging from about 2.3 to about 25 and allowing the mixture to reside for a sufficient time to obtain a crude extract; filtering out remaining raw botanical and evaporating the solvent from the crude extract under reduced pressure to obtain a dried crude extract; washing the dried crude extract with a polar solvent having a dielectric constant of no less than 30, heating the resulting mixture, and allowing to cool to ambient; collecting a filtrate from the above cooled mixture; washing the collected filtrate with a non-polar solvent having a dielectric constant of no more than 2.0; and filtering and drying the mixture to obtain the botanical extract.

公开(公告)号：US20190336561A1

公开(公告)日：2019-11-07

申请号：US16514337

申请日：2019-07-17

申请人： Signum Biosciences, Inc.

发明人： Kristen Huber ,  Michael Voronkov ,  Jose Fernandez ,  Karl Rouzard ,  Eduardo Perez ,  Maxwell Stock ,  Jeffry Stock

IPC分类号： A61K36/9066 ,  A61K36/73 ,  A61K36/33 ,  A61K45/06 ,  A61K36/31 ,  A61K36/28 ,  A61K36/235 ,  A61K36/23 ,  A61K36/185 ,  A61K36/14 ,  A61K9/00 ,  A61K8/97 ,  A61K36/87 ,  A61K36/77 ,  A61K36/45 ,  A61K36/52 ,  A61K36/54 ,  A61K36/575 ,  A61K36/71 ,  A61K36/736 ,  A61K36/79 ,  A61Q19/08

摘要： Compositions containing natural and botanical extracts for use in inhibiting one, two, or three of (a)-(c): (a) demethylation of PP2A by PME-1 methylesterase; (b) formation of free radicals and reactive oxygen species; and/or (c) inflammation. These compositions include an extract of one or more botanicals selected from the group consisting of: juniper berry fruit, schisandra fruit, strawberry fruit, avocado seeds, black raspberry seeds, blueberry seeds, celery seeds, cranberry seeds, fennel seeds, grape seeds, guarana seeds, red raspberry seeds, maca root, goldenseal root, turmeric root, magnolia bark, pygeum bark, red raspberry leaf, almond, cocoa powder, Echinacea angustifolia, prickly pear cactus and walnut.

公开(公告)号：US10314802B2

公开(公告)日：2019-06-11

申请号：US15665922

申请日：2017-08-01

申请人： Signum Biosciences, Inc.

发明人： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC分类号： A61K31/197 ,  A61K9/00 ,  C07C323/59 ,  C07C335/08 ,  C07C243/34 ,  C07C321/18 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24 ,  C07D207/16 ,  C07D243/34

摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

公开(公告)号：US20160361283A1

公开(公告)日：2016-12-15

申请号：US15151221

申请日：2016-05-10

申请人： SIGNUM BIOSCIENCES, INC.

发明人： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC分类号： A61K31/197 ,  A61K9/00

CPC分类号： A61K31/197 ,  A61K9/0014 ,  C07C243/34 ,  C07C321/18 ,  C07C323/59 ,  C07C335/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D243/34 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24

摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

摘要翻译： 除此之外，本发明提供能够有效调节炎症反应的新型异戊二烯基化合物和包含这些异戊二烯基化合物的药物，化妆品，药​​妆和局部组合物。 本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。 本发明的促炎症化合物可用于治疗或预防与抑制炎性反应相关的疾病或病症。 因此，本发明还提供了用于治疗或预防与炎症相关的疾病或病症的方法以及可用于治疗或预防与抑制炎性反应相关的疾病或病症的方法。