公开(公告)号：US20170231955A1

公开(公告)日：2017-08-17

申请号：US15518755

申请日：2015-10-15

申请人： Signum Biosciences, Inc.

发明人： Jeffry STOCK ,  Maxwell STOCK ,  Michael VORONKOV ,  Jose FERNANDEZ ,  Kristen HUBER

IPC分类号： A61K31/405

CPC分类号： A61K31/405 ,  C07D209/16 ,  A61K2300/00

摘要： EHT extract including a mixture of late eluting tryptamides and early eluting tryptamides in a weight ratio of at least about 7:1 late eluting tryptamides:early eluting tryptamides, wherein the EHT extract includes at least 30% eicosanoyl-5-hydroxytryptamide, based on the total weight of the tryptamides in the EHT extract.

公开(公告)号：US20170266161A1

公开(公告)日：2017-09-21

申请号：US15346636

申请日：2016-11-08

申请人： Signum Biosciences, Inc.

发明人： SCOTT VAFAI ,  Michael Voronkov ,  Maxwell Stock ,  Jeffry B. Stock ,  Seung-Yub Lee ,  Zhu Li ,  Haoming Gu

IPC分类号： A61K31/405

CPC分类号： A61K31/405

摘要： The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2A and/or modulating the activity of PP2A.

公开(公告)号：US09744147B2

公开(公告)日：2017-08-29

申请号：US15151221

申请日：2016-05-10

申请人： SIGNUM BIOSCIENCES, INC.

发明人： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC分类号： A61K31/197 ,  C07C323/59 ,  C07C335/08 ,  A61K9/00 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24 ,  C07C243/34 ,  C07C321/18 ,  C07D207/16 ,  C07D243/34

CPC分类号： A61K31/197 ,  A61K9/0014 ,  C07C243/34 ,  C07C321/18 ,  C07C323/59 ,  C07C335/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D243/34 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24

摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

公开(公告)号：US11518738B2

公开(公告)日：2022-12-06

申请号：US17199511

申请日：2021-03-12

申请人： Signum Biosciences, Inc.

发明人： Michael Voronkov ,  Edwardo Perez ,  Jason Healy ,  Jose Fernandez

IPC分类号： C07C275/20 ,  A61P29/00 ,  A61K9/00 ,  C07C233/47 ,  C07D205/04 ,  C07D207/16 ,  C07D213/80 ,  C07D221/00 ,  C07D239/42 ,  C07D241/28

摘要： The present invention provides compounds useful in treating or preventing inflammation, acne, bacterial conditions and promoting the appearance of healthy skin and compositions including these compounds.

公开(公告)号：US10975023B2

公开(公告)日：2021-04-13

申请号：US16469255

申请日：2018-01-12

申请人： Signum Biosciences, Inc.

发明人： Michael Voronkov ,  Edwardo Perez ,  Jason Healy ,  Jose Fernandez

IPC分类号： C07C275/20 ,  C07D207/16 ,  C07C233/47 ,  C07D221/00 ,  C07D213/80 ,  C07D205/04 ,  C07D239/42 ,  C07D241/28 ,  A61P29/00 ,  A61K9/00

摘要： The present invention provides compounds useful in treating or preventing inflammation acne, bacterial conditions and promoting the appearance of healthy skin and compositions including these compounds.

公开(公告)号：US20200179319A1

公开(公告)日：2020-06-11

申请号：US16324045

申请日：2017-08-04

申请人： Signum Biosciences, Inc.

发明人： Thomas John Willi ,  John Frederick Lang ,  Laura Jean Weston

IPC分类号： A61K31/197 ,  A61K9/00

摘要： Disclosed herein are pharmaceutical compositions, comprising a therapeutically effective amount of 4-((1-carboxy-2-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)ethyl)amino)-4-oxobutanoic acid, or a pharmaceutically acceptable salt thereof, and at least one protective agent, and uses thereof.

公开(公告)号：US20190167619A1

公开(公告)日：2019-06-06

申请号：US16323970

申请日：2017-08-08

申请人： SIGNUM BIOSCIENCES, INC.

发明人： Michael VORONKOV ,  Gareth WINCKLE

IPC分类号： A61K31/197 ,  A61K47/10 ,  A61K47/02 ,  A61K47/14

摘要： A pharmaceutical composition comprising (a) at least one protective agent selected from the group consisting of butylated hydroxyanisole, butylated hydroxytoluene, sodium metabisulfite, tert-butylhydroquinone, methylparaben, propylparaben, benzyl alcohol, poly(acrylic acid), hydroxyethyl cellulose, emulsifying wax, PEG-21 stearyl ether, PEG-2 stearyl ether, white petrolatum, myristyl lactate, diisopropyl adipate, cetyl alcohol, cyclomethicone, oleyl alcohol, cholesterol, and polyoxyethylene(4)lauryl ether; and (b) a therapeutically effective amount of an IPC Active Agent or a pharmaceutically acceptable salt or ester thereof.

公开(公告)号：US20170368011A1

公开(公告)日：2017-12-28

申请号：US15665922

申请日：2017-08-01

申请人： SIGNUM BIOSCIENCES, INC.

发明人： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC分类号： A61K31/197 ,  C07D307/54 ,  A61K9/00 ,  C07D295/145 ,  C07D243/34 ,  C07D217/26 ,  C07D209/48 ,  C07D209/18 ,  C07D207/16 ,  C07C335/08 ,  C07C323/59 ,  C07C321/18 ,  C07C243/34 ,  C07D333/24 ,  C07C2601/14 ,  C07C2601/02

CPC分类号： A61K31/197 ,  A61K9/0014 ,  C07C243/34 ,  C07C321/18 ,  C07C323/59 ,  C07C335/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D243/34 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24

摘要： Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

公开(公告)号：US20210261499A1

公开(公告)日：2021-08-26

申请号：US17199511

申请日：2021-03-12

申请人： Signum Biosciences, Inc.

发明人： Michael Voronkov ,  Edwardo Perez ,  Jason Healy ,  Jose Fernandez

IPC分类号： C07C275/20 ,  A61P29/00 ,  A61K9/00 ,  C07C233/47 ,  C07D205/04 ,  C07D207/16 ,  C07D213/80 ,  C07D221/00 ,  C07D239/42 ,  C07D241/28

摘要： The present invention provides compounds useful in treating or preventing inflammation, acne, bacterial conditions and promoting the appearance of healthy skin and compositions including these compounds.

公开(公告)号：US10117904B2

公开(公告)日：2018-11-06

申请号：US15221380

申请日：2016-07-27

申请人： Signum Biosciences, Inc.

发明人： Jeffry B. Stock ,  Maxwell Stock

IPC分类号： A61K38/05 ,  A61K31/198 ,  A61K31/341 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/5375 ,  A61K9/00 ,  A61K31/165

摘要： Disclosed herein are methods of inactivating and/or decolonizing bacteria on a surface. The present invention also discloses methods for treatment of epithelial conditions caused or aggravated by bacteria, such as acne vulgaris, in a subject in need thereof. The present invention additionally discloses inventive compounds and compositions that exhibit anti-bacterial and/or anti-inflammatory effects.