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公开(公告)号：US11802107B2
公开(公告)日：2023-10-31
申请号：US18075399
申请日：2022-12-05
Applicant: Signum Biosciences, Inc.
Inventor： Michael Voronkov , Eduardo Perez , Jason Healy , Jose Fernandez
IPC: C07C275/20 , A61P29/00 , A61K9/00 , C07C233/47 , C07D205/04 , C07D207/16 , C07D213/80 , C07D221/00 , C07D239/42 , C07D241/28 , C07C233/04
CPC classification number: C07C275/20 , A61K9/0014 , A61P29/00 , C07C233/04 , C07D205/04 , C07D207/16 , C07D213/80 , C07D221/00 , C07D239/42 , C07D241/28
Abstract: The present invention provides compounds useful in treating or preventing inflammation, acne, bacterial conditions and promoting the appearance of healthy skin and compositions including these compounds.
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公开(公告)号：US20230174467A1
公开(公告)日：2023-06-08
申请号：US18075399
申请日：2022-12-05
Applicant: Signum Biosciences, Inc.
Inventor： Michael Voronkov , Eduardo Perez , Jason Healy , Jose Fernandez
IPC: C07C275/20 , A61P29/00 , A61K9/00 , C07C233/47 , C07D205/04 , C07D207/16 , C07D213/80 , C07D221/00 , C07D239/42 , C07D241/28
CPC classification number: C07C275/20 , A61P29/00 , A61K9/0014 , C07C233/47 , C07D205/04 , C07D207/16 , C07D213/80 , C07D221/00 , C07D239/42 , C07D241/28
Abstract: The present invention provides compounds useful in treating or preventing inflammation, acne, bacterial conditions and promoting the appearance of healthy skin and compositions including these compounds.
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公开(公告)号：US20170266161A1
公开(公告)日：2017-09-21
申请号：US15346636
申请日：2016-11-08
Applicant: Signum Biosciences, Inc.
Inventor： SCOTT VAFAI , Michael Voronkov , Maxwell Stock , Jeffry B. Stock , Seung-Yub Lee , Zhu Li , Haoming Gu
IPC: A61K31/405
CPC classification number: A61K31/405
Abstract: The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2A and/or modulating the activity of PP2A.
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公开(公告)号：US09744147B2
公开(公告)日：2017-08-29
申请号：US15151221
申请日：2016-05-10
Applicant: SIGNUM BIOSCIENCES, INC.
Inventor： Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen , Jinglong Chen
IPC: A61K31/197 , C07C323/59 , C07C335/08 , A61K9/00 , C07D209/18 , C07D209/48 , C07D217/26 , C07D295/145 , C07D307/54 , C07D333/24 , C07C243/34 , C07C321/18 , C07D207/16 , C07D243/34
CPC classification number: A61K31/197 , A61K9/0014 , C07C243/34 , C07C321/18 , C07C323/59 , C07C335/08 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D209/18 , C07D209/48 , C07D217/26 , C07D243/34 , C07D295/145 , C07D307/54 , C07D333/24
Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.
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公开(公告)号：US20210261499A1
公开(公告)日：2021-08-26
申请号：US17199511
申请日：2021-03-12
Applicant: Signum Biosciences, Inc.
Inventor： Michael Voronkov , Edwardo Perez , Jason Healy , Jose Fernandez
IPC: C07C275/20 , A61P29/00 , A61K9/00 , C07C233/47 , C07D205/04 , C07D207/16 , C07D213/80 , C07D221/00 , C07D239/42 , C07D241/28
Abstract: The present invention provides compounds useful in treating or preventing inflammation, acne, bacterial conditions and promoting the appearance of healthy skin and compositions including these compounds.
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Patent Agency Ranking
公开(公告)号：US11518738B2
公开(公告)日：2022-12-06
申请号：US17199511
申请日：2021-03-12
Applicant: Signum Biosciences, Inc.
Inventor： Michael Voronkov , Edwardo Perez , Jason Healy , Jose Fernandez
IPC: C07C275/20 , A61P29/00 , A61K9/00 , C07C233/47 , C07D205/04 , C07D207/16 , C07D213/80 , C07D221/00 , C07D239/42 , C07D241/28
Abstract: The present invention provides compounds useful in treating or preventing inflammation, acne, bacterial conditions and promoting the appearance of healthy skin and compositions including these compounds.
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公开(公告)号：US10975023B2
公开(公告)日：2021-04-13
申请号：US16469255
申请日：2018-01-12
Applicant: Signum Biosciences, Inc.
Inventor： Michael Voronkov , Edwardo Perez , Jason Healy , Jose Fernandez
IPC: C07C275/20 , C07D207/16 , C07C233/47 , C07D221/00 , C07D213/80 , C07D205/04 , C07D239/42 , C07D241/28 , A61P29/00 , A61K9/00
Abstract: The present invention provides compounds useful in treating or preventing inflammation acne, bacterial conditions and promoting the appearance of healthy skin and compositions including these compounds.
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公开(公告)号：US20170368011A1
公开(公告)日：2017-12-28
申请号：US15665922
申请日：2017-08-01
Applicant: SIGNUM BIOSCIENCES, INC.
Inventor： Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen , Jinglong Chen
IPC: A61K31/197 , C07D307/54 , A61K9/00 , C07D295/145 , C07D243/34 , C07D217/26 , C07D209/48 , C07D209/18 , C07D207/16 , C07C335/08 , C07C323/59 , C07C321/18 , C07C243/34 , C07D333/24 , C07C2601/14 , C07C2601/02
CPC classification number: A61K31/197 , A61K9/0014 , C07C243/34 , C07C321/18 , C07C323/59 , C07C335/08 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D209/18 , C07D209/48 , C07D217/26 , C07D243/34 , C07D295/145 , C07D307/54 , C07D333/24
Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.
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公开(公告)号：US10912812B2
公开(公告)日：2021-02-09
申请号：US16514337
申请日：2019-07-17
Applicant: Signum Biosciences, Inc.
Inventor： Kristen Huber , Michael Voronkov , Jose Fernandez , Karl Rouzard , Eduardo Perez , Maxwell Stock , Jeffry Stock
IPC: A61K8/97 , A61K36/9066 , A61K36/77 , A61K36/87 , A61K36/33 , A61K36/73 , A61K45/06 , A61K9/00 , A61K36/14 , A61K36/185 , A61K36/23 , A61K36/235 , A61K36/28 , A61K36/31 , A61K36/45 , A61K36/52 , A61K36/54 , A61K36/575 , A61K36/71 , A61K36/736 , A61K36/79 , A61Q19/08
Abstract: Method of preparing a botanical extract that includes contacting a raw botanical with a solvent having a dielectric constant ranging from about 2.3 to about 25 and allowing the mixture to reside for a sufficient time to obtain a crude extract; filtering out remaining raw botanical and evaporating the solvent from the crude extract under reduced pressure to obtain a dried crude extract; washing the dried crude extract with a polar solvent having a dielectric constant of no less than 30, heating the resulting mixture, and allowing to cool to ambient; collecting a filtrate from the above cooled mixture; washing the collected filtrate with a non-polar solvent having a dielectric constant of no more than 2.0; and filtering and drying the mixture to obtain the botanical extract.
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公开(公告)号：US10583119B2
公开(公告)日：2020-03-10
申请号：US15346636
申请日：2016-11-08
Applicant: Signum Biosciences, Inc.
Inventor： Scott Vafai , Michael Voronkov , Maxwell Stock , Jeffry B. Stock , Seung-Yub Lee , Zhu Li , Haoming Gu
IPC: A61K31/405
Abstract: The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2A and/or modulating the activity of PP2A.
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