公开(公告)号：US20170266161A1

公开(公告)日：2017-09-21

申请号：US15346636

申请日：2016-11-08

Applicant: Signum Biosciences, Inc.

Inventor： SCOTT VAFAI ,  Michael Voronkov ,  Maxwell Stock ,  Jeffry B. Stock ,  Seung-Yub Lee ,  Zhu Li ,  Haoming Gu

IPC: A61K31/405

CPC classification number: A61K31/405

Abstract: The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2A and/or modulating the activity of PP2A.

公开(公告)号：US09744147B2

公开(公告)日：2017-08-29

申请号：US15151221

申请日：2016-05-10

Applicant: SIGNUM BIOSCIENCES, INC.

Inventor： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC: A61K31/197 ,  C07C323/59 ,  C07C335/08 ,  A61K9/00 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24 ,  C07C243/34 ,  C07C321/18 ,  C07D207/16 ,  C07D243/34

CPC classification number: A61K31/197 ,  A61K9/0014 ,  C07C243/34 ,  C07C321/18 ,  C07C323/59 ,  C07C335/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D243/34 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24

Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

公开(公告)号：US20170368011A1

公开(公告)日：2017-12-28

申请号：US15665922

申请日：2017-08-01

Applicant: SIGNUM BIOSCIENCES, INC.

Inventor： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC: A61K31/197 ,  C07D307/54 ,  A61K9/00 ,  C07D295/145 ,  C07D243/34 ,  C07D217/26 ,  C07D209/48 ,  C07D209/18 ,  C07D207/16 ,  C07C335/08 ,  C07C323/59 ,  C07C321/18 ,  C07C243/34 ,  C07D333/24 ,  C07C2601/14 ,  C07C2601/02

CPC classification number: A61K31/197 ,  A61K9/0014 ,  C07C243/34 ,  C07C321/18 ,  C07C323/59 ,  C07C335/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D243/34 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24

Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

公开(公告)号：US10117904B2

公开(公告)日：2018-11-06

申请号：US15221380

申请日：2016-07-27

Applicant: Signum Biosciences, Inc.

Inventor： Jeffry B. Stock ,  Maxwell Stock

IPC: A61K38/05 ,  A61K31/198 ,  A61K31/341 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/5375 ,  A61K9/00 ,  A61K31/165

Abstract: Disclosed herein are methods of inactivating and/or decolonizing bacteria on a surface. The present invention also discloses methods for treatment of epithelial conditions caused or aggravated by bacteria, such as acne vulgaris, in a subject in need thereof. The present invention additionally discloses inventive compounds and compositions that exhibit anti-bacterial and/or anti-inflammatory effects.

公开(公告)号：US20170049841A1

公开(公告)日：2017-02-23

申请号：US15221380

申请日：2016-07-27

Applicant: Signum Biosciences, Inc.

Inventor： Jeffry B. Stock ,  Maxwell Stock

IPC: A61K38/05 ,  A61K31/198 ,  A61K31/381 ,  A61K31/5375 ,  A61K31/4045 ,  A61K9/00 ,  A61K31/341

CPC classification number: A61K38/05 ,  A61K9/0014 ,  A61K9/007 ,  A61K31/165 ,  A61K31/198 ,  A61K31/341 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/5375 ,  Y02A50/478 ,  Y02A50/481

Abstract: Disclosed herein are methods of inactivating and/or decolonizing bacteria on a surface. The present invention also discloses methods for treatment of epithelial conditions caused or aggravated by bacteria, such as acne vulgaris, in a subject in need thereof. The present invention additionally discloses inventive compounds and compositions that exhibit anti-bacterial and/or anti-inflammatory effects.

Abstract translation: 本文公开了在表面上灭活和/或非殖民细菌的方法。 本发明还公开了在有需要的受试者中治疗由细菌如寻常痤疮引起或加重的上皮状况的方法。 本发明还公开了具有抗细菌和/或抗炎作用的本发明化合物和组合物。

公开(公告)号：US10912812B2

公开(公告)日：2021-02-09

申请号：US16514337

申请日：2019-07-17

Applicant: Signum Biosciences, Inc.

Inventor： Kristen Huber ,  Michael Voronkov ,  Jose Fernandez ,  Karl Rouzard ,  Eduardo Perez ,  Maxwell Stock ,  Jeffry Stock

IPC: A61K8/97 ,  A61K36/9066 ,  A61K36/77 ,  A61K36/87 ,  A61K36/33 ,  A61K36/73 ,  A61K45/06 ,  A61K9/00 ,  A61K36/14 ,  A61K36/185 ,  A61K36/23 ,  A61K36/235 ,  A61K36/28 ,  A61K36/31 ,  A61K36/45 ,  A61K36/52 ,  A61K36/54 ,  A61K36/575 ,  A61K36/71 ,  A61K36/736 ,  A61K36/79 ,  A61Q19/08

Abstract: Method of preparing a botanical extract that includes contacting a raw botanical with a solvent having a dielectric constant ranging from about 2.3 to about 25 and allowing the mixture to reside for a sufficient time to obtain a crude extract; filtering out remaining raw botanical and evaporating the solvent from the crude extract under reduced pressure to obtain a dried crude extract; washing the dried crude extract with a polar solvent having a dielectric constant of no less than 30, heating the resulting mixture, and allowing to cool to ambient; collecting a filtrate from the above cooled mixture; washing the collected filtrate with a non-polar solvent having a dielectric constant of no more than 2.0; and filtering and drying the mixture to obtain the botanical extract.

公开(公告)号：US10583119B2

公开(公告)日：2020-03-10

申请号：US15346636

申请日：2016-11-08

Applicant: Signum Biosciences, Inc.

Inventor： Scott Vafai ,  Michael Voronkov ,  Maxwell Stock ,  Jeffry B. Stock ,  Seung-Yub Lee ,  Zhu Li ,  Haoming Gu

IPC: A61K31/405

Abstract: The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2A and/or modulating the activity of PP2A.

公开(公告)号：US20190336561A1

公开(公告)日：2019-11-07

申请号：US16514337

申请日：2019-07-17

Applicant: Signum Biosciences, Inc.

Inventor： Kristen Huber ,  Michael Voronkov ,  Jose Fernandez ,  Karl Rouzard ,  Eduardo Perez ,  Maxwell Stock ,  Jeffry Stock

IPC: A61K36/9066 ,  A61K36/73 ,  A61K36/33 ,  A61K45/06 ,  A61K36/31 ,  A61K36/28 ,  A61K36/235 ,  A61K36/23 ,  A61K36/185 ,  A61K36/14 ,  A61K9/00 ,  A61K8/97 ,  A61K36/87 ,  A61K36/77 ,  A61K36/45 ,  A61K36/52 ,  A61K36/54 ,  A61K36/575 ,  A61K36/71 ,  A61K36/736 ,  A61K36/79 ,  A61Q19/08

Abstract: Compositions containing natural and botanical extracts for use in inhibiting one, two, or three of (a)-(c): (a) demethylation of PP2A by PME-1 methylesterase; (b) formation of free radicals and reactive oxygen species; and/or (c) inflammation. These compositions include an extract of one or more botanicals selected from the group consisting of: juniper berry fruit, schisandra fruit, strawberry fruit, avocado seeds, black raspberry seeds, blueberry seeds, celery seeds, cranberry seeds, fennel seeds, grape seeds, guarana seeds, red raspberry seeds, maca root, goldenseal root, turmeric root, magnolia bark, pygeum bark, red raspberry leaf, almond, cocoa powder, Echinacea angustifolia, prickly pear cactus and walnut.

公开(公告)号：US10314817B2

公开(公告)日：2019-06-11

申请号：US15518755

申请日：2015-10-15

Applicant: Signum Biosciences, Inc.

Inventor： Jeffry Stock ,  Maxwell Stock ,  Michael Voronkov ,  Jose Fernandez ,  Kristen Huber

IPC: A61K31/405 ,  C07D209/16

Abstract: EHT extract including a mixture of late eluting tryptamides and early eluting tryptamides in a weight ratio of at least about 7:1 late eluting tryptamides:early eluting tryptamides, wherein the EHT extract includes at least 30% eicosanoyl-5-hydroxytryptamide, based on the total weight of the tryptamides in the EHT extract.

公开(公告)号：US10314802B2

公开(公告)日：2019-06-11

申请号：US15665922

申请日：2017-08-01

Applicant: Signum Biosciences, Inc.

Inventor： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

IPC: A61K31/197 ,  A61K9/00 ,  C07C323/59 ,  C07C335/08 ,  C07C243/34 ,  C07C321/18 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24 ,  C07D207/16 ,  C07D243/34

Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.