公开(公告)号：US20220243021A1

公开(公告)日：2022-08-04

申请号：US17268884

申请日：2018-12-07

Applicant: SIO2 MEDICAL PRODUCTS, INC.

Inventor： Ahmad Taha ,  Brian Maurer ,  Matthew Wills

IPC: C08J7/12 ,  C12M1/24 ,  C12M1/00 ,  C12M1/12 ,  C12M3/04

Abstract: A polymeric substrate has a plasma treated contact surface which is roughened, hydrophilic and has a higher oxygen atomic content than the interior portion. The treated contact surface has an enhanced cell adhesion, cell growth and cell recovery rate. During the treatment, the contact surface is contacted with a process gas introduced through a gas inlet near the treated surface and radio frequency electrical power is introduced in the process gas, forming a treated contact surface that has improved cell recovery compared to an untreated contact surface. The process gas optionally can be nitrogen gas, oxygen gas, or a gas that contains nitrogen atoms, oxygen atoms, or a combination of nitrogen and oxygen atoms. The process optionally improves cell recovery of a chicken embryo cell culture from the treated contact surface.

公开(公告)号：US20200291342A1

公开(公告)日：2020-09-17

申请号：US16756525

申请日：2018-10-19

Applicant: SIO2 MEDICAL PRODUCTS, INC.

Inventor： Ahmad Taha ,  Brian Maurer ,  Matthew Wills

IPC: C12M3/04 ,  C08J7/12 ,  C12M1/00

Abstract: A polymeric substrate is contacted with a process gas and radio frequency electrical power is introduced in the process gas, forming a treated contact surface that has improved cell recovery compared to an untreated contact surface. The process gas optionally can be nitrogen gas, oxygen gas, or a gas that contains nitrogen atoms, oxygen atoms, or a combination of nitrogen and oxygen atoms. The process optionally improves cell recovery of a chicken embryo cell culture from the treated contact surface.

公开(公告)号：US20230340670A1

公开(公告)日：2023-10-26

申请号：US18020867

申请日：2021-08-12

Applicant: SiO2 Medical Products, Inc.

Inventor： Ahmad Taha ,  Matthew Wills ,  Robert Abrams

IPC: C23C16/40 ,  C23C16/02 ,  C23C16/54 ,  C23C16/505

CPC classification number: C23C16/505 ,  C23C16/0272 ,  C23C16/401 ,  C23C16/54

Abstract: Methods and systems for processing a plurality of vessels, for example to provide a gas barrier, are disclosed. The gas barrier may be deposited using pulsed plasma enhanced chemical vapor deposition concurrently in a plurality of vessels where each vessel is within an opening of an RF electrode.

公开(公告)号：USD977142S1

公开(公告)日：2023-01-31

申请号：US29712182

申请日：2019-11-06

Applicant: SIO2 MEDICAL PRODUCTS, INC.

Designer： Matthew Wills ,  Kenneth Wade Kelly ,  Benjamin Hunt

公开(公告)号：US20190015561A1

公开(公告)日：2019-01-17

申请号：US15753524

申请日：2016-08-18

Applicant: SIO2 MEDICAL PRODUCTS, INC.

Inventor： Matthew Wills ,  Ahmad Taha ,  Christopher Weikart

IPC: A61L29/08 ,  A61L31/06 ,  C08L83/04 ,  C23C16/40 ,  C23C16/515

Abstract: Processing an evacuated blood sample collection tube or other vessel by plasma enhanced chemical vapor deposition to apply a tie coating or layer (289), a barrier coating or layer (288), and optionally one or more additional coatings or layers. The tie coating or layer of SiOxCy is applied under partial vacuum and, while maintaining the partial vacuum unbroken in the lumen, the barrier coating or layer is applied. Then optionally, while maintaining the partial vacuum unbroken in the lumen, a pH protective coating or layer of SiOxCy can be applied. As a result of this processing, a coated vessel is produced having a lower gas permeation rate constant into the lumen than a corresponding vessel made by the same process except breaking the partial vacuum in the lumen between applying the tie coating or layer and applying the barrier coating or layer. Retention features are also described for keeping the vessels stoppered during exposure to reduced ambient pressure.

公开(公告)号：US20160015898A1

公开(公告)日：2016-01-21

申请号：US14771751

申请日：2014-02-28

Applicant: SIO2 MEDICAL PRODUCTS, INC.

Inventor： Joseph A. Jones ,  Christopher Weikart ,  Steven J. Martin ,  Matthew Wills

IPC: A61M5/31 ,  A61L31/10 ,  A61L31/14 ,  A61M5/315

CPC classification number: A61M5/31 ,  A61L31/026 ,  A61L31/048 ,  A61L31/088 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L2400/10 ,  A61L2420/02 ,  A61L2420/08 ,  A61M5/3129 ,  A61M5/31513 ,  A61M2005/3104 ,  A61M2005/3131 ,  A61M2205/0238 ,  C23C16/401 ,  C23C16/50

Abstract: A syringe comprising a wall having a generally cylindrical interior surface defining a lumen with a primer coating or layer between 1 and 1000 nm thick of SiOx Cy Hz, in which x is from about 0.5 to about 2.4, y is from about 0.6 to about 3, and z is from about 2 to about 9, on at least a portion of the interior surface, the primer coating or layer having an outside surface facing the interior surface of the barrel and an inside surface facing the lumen. A deposit of fluid lubricant on the inside surface of the primer coating or layer is further provided.

Abstract translation: 一种注射器，其包括壁，所述壁具有大致圆柱形的内表面，所述壁具有限定内腔的底部涂层或层之间的大致圆柱形内表面，所述底漆涂层或层之间具有1至1000nm厚的SiO x Cy Hz，其中x为约0.5至约2.4，y为约0.6至约3 ，并且在所述内表面的至少一部分上，z为约2至约9，底漆涂层或层具有面向筒的内表面的外表面和面向内腔的内表面。 还提供了底漆涂层或层的内表面上的流体润滑剂沉积物。

公开(公告)号：US11077233B2

公开(公告)日：2021-08-03

申请号：US15753524

申请日：2016-08-18

Applicant: SIO2 MEDICAL PRODUCTS, INC.

Inventor： Matthew Wills ,  Ahmad Taha ,  Christopher Weikart

IPC: A61L29/08 ,  C23C16/40 ,  C23C16/515 ,  A61L31/06 ,  C23C16/30 ,  C23C16/04 ,  A61L27/34 ,  C08L83/04

Abstract: Processing an evacuated blood sample collection tube or other vessel by plasma enhanced chemical vapor deposition to apply a tie coating or layer (289), a barrier coating or layer (288), and optionally one or more additional coatings or layers. The tie coating or layer of SiOxCy is applied under partial vacuum and, while maintaining the partial vacuum unbroken in the lumen, the barrier coating or layer is applied. Then optionally, while maintaining the partial vacuum unbroken in the lumen, a pH protective coating or layer of SiOxCy can be applied. As a result of this processing, a coated vessel is produced having a lower gas permeation rate constant into the lumen than a corresponding vessel made by the same process except breaking the partial vacuum in the lumen between applying the tie coating or layer and applying the barrier coating or layer. Retention features are also described for keeping the vessels stoppered during exposure to reduced ambient pressure.