公开(公告)号：US20220183945A1

公开(公告)日：2022-06-16

申请号：US17438362

申请日：2020-03-10

Applicant: STC. UNM

Inventor： Dominique Renee Perez ,  Larry A. Sklar ,  Alexandre Chigaev ,  Alison F. Franks

IPC: A61K8/49 ,  A61Q19/00 ,  A61Q15/00

Abstract: The present invention is directed to previously identified inhibitors of cAMP efflux (ICE) and their use in treating/masking body odor, inhibiting, reducing and/or eliminating hyperhidrosis (excessive sweating), tanning skin or protecting skin before and/or after exposure to the sun as well as for treating certain skin conditions, in one embodiment, the invention provides a method for inhibiting body odor, a condition that is characterized by an unpleasant odor from the products of the microbial sweat degradation. By inhibiting the efflux of the precursor compounds that are degraded, novel compounds are capable of preventing unwanted odors. Deodorant compositions that employ this new approach for the control of bodily odor are provided, ICE compounds can also be used as components, of cosmetic formulations including tanning and after-sun formulations, formulations for skin conditions as described herein and other cosmetic formulation.

公开(公告)号：US09310364B1

公开(公告)日：2016-04-12

申请号：US14174564

申请日：2014-02-06

Applicant: STC. UNM ,  TORREY PINES INSTITUTE FOR MOLECULAR STUDIES

Inventor： Bruce S. Edwards ,  Larry A. Sklar ,  Clemencia Pinilla ,  Richard A. Houghten ,  Jon R. Appel ,  Marc A. Giulianotti ,  Jose Medina-Franco

IPC: A61K38/00 ,  A61K31/17 ,  C07D241/08 ,  C40B30/02 ,  G01N33/566 ,  C07D403/14 ,  A61K31/496 ,  A61K45/06 ,  C07C275/28 ,  C07K1/04

CPC classification number: G01N33/6845 ,  A61K31/17 ,  A61K31/496 ,  A61K38/00 ,  A61K45/06 ,  B01J2219/00585 ,  C07C275/28 ,  C07D241/08 ,  C07D403/14 ,  C07K1/047 ,  C40B30/02 ,  G01N33/74 ,  G01N2333/726 ,  A61K2300/00

Abstract: The present invention provides novel methods and assays for high-throughput screening of combinatorial libraries to identify FPR1 and/or FPR2 ligands (e.g., agonists and/or antagonists), preferably FPR1 agonists and/or FPR2 antagonists, by positional scanning deconvolution.The invention also provides novel FPR1 and FPR2 ligands (e.g, agonists and antagonists), related pharmaceutical compositions and methods of treating FPR1 and FPR2-related disorders.

Abstract translation: 本发明提供了用于通过位置扫描反卷积来组合文库以鉴定FPR1和/或FPR2配体（例如激动剂和/或拮抗剂），优选FPR1激动剂和/或FPR2拮抗剂的高通量筛选的新方法和测定法。 本发明还提供新的FPR1和FPR2配体（例如激动剂和拮抗剂），相关的药物组合物和治疗FPR1和FPR2相关疾病的方法。