公开(公告)号：US20050112182A1

公开(公告)日：2005-05-26

申请号：US10854336

申请日：2004-05-27

申请人： Saburo Minami ,  Eiko Renbutsu ,  Yoshihiko Omura ,  Fumiaki Nakatsubo ,  Yoshiharu Okamoto ,  Hiroyuki Saimoto ,  Yoshihro Shigemasa

发明人： Saburo Minami ,  Eiko Renbutsu ,  Yoshihiko Omura ,  Fumiaki Nakatsubo ,  Yoshiharu Okamoto ,  Hiroyuki Saimoto ,  Yoshihro Shigemasa

IPC分类号： A61K47/36 ,  A61F13/02 ,  A61L15/16 ,  A61L24/00 ,  A61L24/08 ,  A61L26/00 ,  A61L29/00 ,  A61P17/02 ,  A61P31/02 ,  C08B37/08 ,  C08F2/48 ,  C08J3/28 ,  C08J5/00 ,  C09J105/08

CPC分类号： A61L26/0061 ,  A61L24/001 ,  A61L24/08 ,  A61L26/0023 ,  C08L5/08

摘要： Provided is an N-alkyl chitosan derivative having an ultraviolet ray-curable functional group represented by formula (I) given below: where l+m+n=1, 0

摘要翻译： 本发明提供具有以下式（I）表示的可紫外线固化性官能团的N-烷基壳聚糖衍生物：其中l + m + n = 1,0

公开(公告)号：US20140363673A1

公开(公告)日：2014-12-11

申请号：US14344962

申请日：2012-06-27

申请人： Saburo Minami ,  Kazuo Azuma ,  Tomohiro Osaki ,  Shinsuke Ifuku ,  Hiroyuki Saimoto

发明人： Saburo Minami ,  Kazuo Azuma ,  Tomohiro Osaki ,  Shinsuke Ifuku ,  Hiroyuki Saimoto

IPC分类号： A61K31/722

CPC分类号： A61K31/722 ,  A61K9/0092 ,  A61K9/1652 ,  A61K47/36 ,  Y10T428/298

摘要： The present invention provides a therapeutic and/or prophylactic agent for inflammatory bowel disease and an NF-kB activation inhibitor, each of which comprises chitin nanofibers or chitosan nanofibers.

摘要翻译： 本发明提供了炎症性肠病的治疗和/或预防剂和NF-kB活化抑制剂，其各自包含几丁质纳米纤维或壳聚糖纳米纤维。

公开(公告)号：US20120065158A1

公开(公告)日：2012-03-15

申请号：US13258108

申请日：2010-03-19

申请人： Yoshiharu Okamoto ,  Saburo Minami ,  Takeshi Tsuka ,  Yasunari Miki

发明人： Yoshiharu Okamoto ,  Saburo Minami ,  Takeshi Tsuka ,  Yasunari Miki

IPC分类号： A61K31/737 ,  A61P35/00 ,  C07H5/10

CPC分类号： C08B37/0036 ,  A23L33/105

摘要： Disclosed is a medium-molecular weight fucoidan which can be used in treating and/or preventing proliferative diseases, in particular, cancer. Specifically disclosed are a medium-molecular weight fucoidan, a method for producing the same, a medicinal composition containing the same, and use of the medium-molecular weight fucoidan in producing a drug for treating and/or preventing preventing proliferative diseases, in particular, cancer. The aforesaid medium-molecular weight fucoidan has an average molecular weight of about 6,000 to about 2,000,000, preferably an average molecular weight of about 40,000 to about 330,000, more preferably an average molecular weight of about 40,000 to about 244,000, and still more preferably an average molecular weight of about 80,000 to about 200,000.

摘要翻译： 公开了可用于治疗和/或预防增殖性疾病，特别是癌症的中分子量岩藻依聚糖。 具体公开的是中分子量岩藻依聚糖，其制备方法，含有该中间分子量岩藻依聚糖的药物组合物，以及中分子量岩藻依聚糖在制备用于治疗和/或预防增殖性疾病的药物中的用途， 癌症。 上述中分子量岩藻依聚糖的平均分子量为约6000至约2,000,000，优选平均分子量为约40,000至约330,000，更优选平均分子量为约40,000至约244,000，还更优选为平均分子量 分子量约为80,000至约200,000。

公开(公告)号：US20120071439A1

公开(公告)日：2012-03-22

申请号：US13258270

申请日：2009-12-25

申请人： Saburo Minami ,  Yoshiharu Okamoto ,  Yasunari Miki

发明人： Saburo Minami ,  Yoshiharu Okamoto ,  Yasunari Miki

IPC分类号： A61K31/737 ,  A61P19/04 ,  C07H11/00

CPC分类号： A61K31/737 ,  A61K31/726 ,  C08B37/0036

摘要： Disclosed is a therapy which is for preventing or treating cartilage damage and diseases associated with cartilage damage, such as arthritides and osteoarthritis, and utilizes a more effective and more safe medicinal agent. Specifically disclosed are a cartilage production promoter, a glucosaminoglycan and/or proteoglycan production promoter, and a prophylactic or therapeutic agent for diseases associated with cartilage damage, each of which comprises fucoidan as an active ingredient.

摘要翻译： 公开了用于预防或治疗软骨损伤和与软骨损伤相关的疾病如关节炎和骨关节炎的治疗，并且利用更有效和更安全的药剂。 具体公开的是软骨生产促进剂，葡糖胺聚糖和/或蛋白聚糖生产促进剂，以及与软骨损伤相关的疾病的预防或治疗剂，其中每一种都包含岩藻依聚糖作为活性成分。

公开(公告)号：US20100069824A1

公开(公告)日：2010-03-18

申请号：US12461758

申请日：2009-08-24

申请人： Yoshiharu Okamoto ,  Saburo Minami ,  Yoshimitsu Abiko ,  Satoshi Otsuka ,  Nobuhiko Ogawa ,  Masaru Matsui

发明人： Yoshiharu Okamoto ,  Saburo Minami ,  Yoshimitsu Abiko ,  Satoshi Otsuka ,  Nobuhiko Ogawa ,  Masaru Matsui

IPC分类号： A61M37/00

CPC分类号： A61N5/062 ,  A61K31/404 ,  A61K41/0052 ,  A61N2005/0644 ,  A61N2005/0659

摘要： A photodynamic hyperthermic chemotherapy of cancer comprising topically injecting a photosensitive dye agent, specifically indocyanine green, in the form of an acidic liquid formulation to a tumor or cancer tissue, or a surgically removed site thereof of a patient, and irradiating the tissue or site with light having such an output wavelength that the photosensitive dye agent absorbs the light and generates heat; and an apparatus and a system for photodynamic hyperthermic chemotherapy of cancer comprising a light source and a probe having a light introducing portion capable of topically irradiating a tumor or cancer tissue or a surgically removed site thereof of a patient with light derived from the light source by a continuous wave or a pulse wave at an output wavelength of 600 to 1600 nm and an output of 5000 mW or more.

摘要翻译： 癌症的光动力学高热化学疗法包括将酸性液体制剂形式的光敏染料，特别是吲哚菁绿局部注射到患者的肿瘤或癌组织或其外科手术移除的部位，并将组织或部位用 具有光敏染料剂吸收光并产生热量的输出波长的光; 以及用于癌症的光动力学高热化疗的装置和系统，包括光源和探针，所述探针具有能够通过光源衍生的光局部照射患者的肿瘤或癌组织或手术切除部位的光引入部分， 输出波长为600〜1600nm的连续波或脉波，输出为5000mW以上。

公开(公告)号：US20060228320A1

公开(公告)日：2006-10-12

申请号：US11448089

申请日：2006-06-07

申请人： Saburo Minami ,  Yoshiharu Okamoto

发明人： Saburo Minami ,  Yoshiharu Okamoto

IPC分类号： A61K31/722 ,  A61K31/7008 ,  A61K8/73

CPC分类号： A61K31/7008 ,  A61K31/722

摘要： The present invention has an object of revealing an epidermis regeneration effect of various chitin derivatives and providing an agent for therapy or treatment for wound which can be clinically used effectively. According to the present invention, it has been evidenced that N-acetyl-D-glucosamine has an effect of promoting proliferation of an epidermis keratinized cell. Accordingly, the present invention provides a proliferation promoting agent for epidermis keratinized cell comprising N-acetyl-D-glucosamine. According to another aspect of the present invention, there is provided a regeneration promoting agent or protecting agent for epithelium, skin or dermis comprising the proliferation promoting agent. Further, a therapeutic agent for wound is provided.

摘要翻译： 本发明的目的是揭示各种几丁质衍生物的表皮再生作用，并提供可有效临床使用的伤口治疗或治疗剂。 根据本发明，证明N-乙酰基-D-葡糖胺具有促进表皮角化细胞增殖的作用。 因此，本发明提供了包含N-乙酰基-D-葡糖胺的表皮角化细胞增殖促进剂。 根据本发明的另一方面，提供了包含增殖促进剂的用于上皮，皮肤或真皮的再生促进剂或保护剂。 此外，提供了一种用于伤口的治疗剂。

公开(公告)号：US4703636A

公开(公告)日：1987-11-03

申请号：US751010

申请日：1985-07-02

申请人： Saburo Minami

发明人： Saburo Minami

IPC分类号： F16B41/00 ,  E05B47/00

CPC分类号： F16B41/005 ,  Y10T70/5571 ,  Y10T70/5854 ,  Y10T70/5863 ,  Y10T70/7057

摘要： A center locking device of intermediary plate type for a disc wheel of motor vehicle. The device has a cap nut screwed onto a threaded section of a flange fixed to the axle of the disc wheel. The disc wheel is clamped between the cap nut and the flange. A locking device is provided to lock the cap nut to the threaded section of the flange for preventing the disc wheel from becoming loose and/or theft of the disc wheel.

摘要翻译： 一种用于机动车辆盘轮的中间板式中心锁定装置。 该装置具有螺母连接到固定到盘轮的轴的凸缘的螺纹部分上的螺母。 盘轮夹在盖螺母和法兰之间。 提供锁定装置以将盖帽螺母锁定到法兰的螺纹部分，以防止盘轮松动和/或盗取盘轮。

公开(公告)号：US07316460B2

公开(公告)日：2008-01-08

申请号：US10509063

申请日：2003-03-25

申请人： Hozumi Takeo ,  Kenichi Kubota ,  Saburo Minami ,  Takuji Minami

发明人： Hozumi Takeo ,  Kenichi Kubota ,  Saburo Minami ,  Takuji Minami

IPC分类号： A47B67/00 ,  A47B1/00

CPC分类号： A47B67/005 ,  A47G1/04

摘要： A makeup mirror unit includes a pair of sub mirrors and a pair of rack portions. In order to take goods from the rack portions, the sub mirrors are rotated inwardly around shafts of first hinges. In order to match the sub mirrors together, the sub mirrors are rotated toward the front side together with the frames around shafts of second hinges which are attached opposite with respect to the first hinges. When the left and right sub mirrors are opened, and the side ends of the sub mirrors are adjacent with respect to each other in a state where the left and right sub mirrors are positioned in the front center portion of the makeup mirror unit, by connecting the magnet and the magnet receiver to each other, the sub mirrors can easily be connected in the center to be in the same plane.

摘要翻译： 化妆镜单元包括一对子反射镜和一对齿条部分。 为了从货架部分收取物品，副镜向内围绕第一铰链的轴线旋转。 为了将副反射镜配合在一起，子反射镜与第二铰链的轴相邻的框架一起朝着前侧旋转，第二铰链相对于第一铰链相对地安装。 当左右子反射镜打开时，并且副镜的侧端在左右副镜位于化妆镜单元的前中央部的状态下相互相邻，通过连接 磁体和磁铁接收器彼此之间，副镜可以容易地连接在中心位于同一平面上。

公开(公告)号：US20050223487A1

公开(公告)日：2005-10-13

申请号：US10509063

申请日：2003-03-25

申请人： Hozumi Takeo ,  Kenichi Kubota ,  Saburo Minami ,  Takuji Minami

发明人： Hozumi Takeo ,  Kenichi Kubota ,  Saburo Minami ,  Takuji Minami

IPC分类号： A47B67/00 ,  A47G1/04 ,  E03C1/00

CPC分类号： A47B67/005 ,  A47G1/04

摘要： The present invention provides a makeup mirror which is easy to use. In order to take goods from the rack portion 7, the sub mirror 10 is rotated inwardly around the shaft 30a of the hinge 30. In order to use as a matched mirror, the sub mirror 10 is rotated toward the front side together with the frame 9 around the shaft 31a of the hinge 31 which is attached to the opposite end to the hinge 30. When the left and right sub mirrors 10, 10 are opened, and the side ends of the sub mirrors 10 are adjacent with respect to each other in a state where the left and right sub mirrors 10, 10 are positioned in the front center portion of the makeup mirror unit, by connecting the magnet 51 and the magnet receiver 52 to each other, the sub mirrors can easily be connected in the center to be in the same plane, and the user-friendliness can be improved.

摘要翻译： 本发明提供一种易于使用的化妆镜。 为了从货架部分7取货，副镜10绕铰链30的轴30a向内旋转。 为了用作匹配的反射镜，副镜10与框架9一起围绕连接到铰链30的相对端的铰链31的轴31a的方向向前侧旋转。 当左右副镜10,10打开时，并且副镜10的侧端在左右副镜10,10位于前后中央部的状态下相对于彼此相邻 化妆镜单元通过将磁体51和磁体接收器52彼此连接，副反射镜可以容易地在中心连接在同一平面上，并且可以改善用户友好性。

公开(公告)号：US4709564A

公开(公告)日：1987-12-01

申请号：US798682

申请日：1985-11-15

申请人： Saburo Minami

发明人： Saburo Minami

IPC分类号： E05B37/16 ,  E05B37/18

CPC分类号： E05B37/163 ,  Y10T70/424 ,  Y10T70/7226 ,  Y10T70/7311

摘要： A digital system lock can be unlocked by only pushing several push-buttons in the specified order. This digital system lock is unlocked by the cooperation of mechanical elements, without utilizing a microcomputer device, and does not require a key. If the push-buttons are pushed in an order which does not correspond to the specific order, mechanical elements also prevent the lock from being opened until a return button is pushed and the push-buttons are pushed in the specified order.

摘要翻译： 数字系统锁可以通过按指定的顺序推动几个按钮来解锁。 该数字系统锁通过机械元件的协作来解锁，而不需要使用微计算机装置，并且不需要钥匙。 如果按下按钮不符合特定顺序的按钮，机械元件也可以防止锁定被打开，直到按下返回按钮并按指定的顺序按下按钮。