公开(公告)号：US20120065158A1

公开(公告)日：2012-03-15

申请号：US13258108

申请日：2010-03-19

申请人： Yoshiharu Okamoto ,  Saburo Minami ,  Takeshi Tsuka ,  Yasunari Miki

发明人： Yoshiharu Okamoto ,  Saburo Minami ,  Takeshi Tsuka ,  Yasunari Miki

IPC分类号： A61K31/737 ,  A61P35/00 ,  C07H5/10

CPC分类号： C08B37/0036 ,  A23L33/105

摘要： Disclosed is a medium-molecular weight fucoidan which can be used in treating and/or preventing proliferative diseases, in particular, cancer. Specifically disclosed are a medium-molecular weight fucoidan, a method for producing the same, a medicinal composition containing the same, and use of the medium-molecular weight fucoidan in producing a drug for treating and/or preventing preventing proliferative diseases, in particular, cancer. The aforesaid medium-molecular weight fucoidan has an average molecular weight of about 6,000 to about 2,000,000, preferably an average molecular weight of about 40,000 to about 330,000, more preferably an average molecular weight of about 40,000 to about 244,000, and still more preferably an average molecular weight of about 80,000 to about 200,000.

摘要翻译： 公开了可用于治疗和/或预防增殖性疾病，特别是癌症的中分子量岩藻依聚糖。 具体公开的是中分子量岩藻依聚糖，其制备方法，含有该中间分子量岩藻依聚糖的药物组合物，以及中分子量岩藻依聚糖在制备用于治疗和/或预防增殖性疾病的药物中的用途， 癌症。 上述中分子量岩藻依聚糖的平均分子量为约6000至约2,000,000，优选平均分子量为约40,000至约330,000，更优选平均分子量为约40,000至约244,000，还更优选为平均分子量 分子量约为80,000至约200,000。

公开(公告)号：US20060228320A1

公开(公告)日：2006-10-12

申请号：US11448089

申请日：2006-06-07

申请人： Saburo Minami ,  Yoshiharu Okamoto

发明人： Saburo Minami ,  Yoshiharu Okamoto

IPC分类号： A61K31/722 ,  A61K31/7008 ,  A61K8/73

CPC分类号： A61K31/7008 ,  A61K31/722

摘要： The present invention has an object of revealing an epidermis regeneration effect of various chitin derivatives and providing an agent for therapy or treatment for wound which can be clinically used effectively. According to the present invention, it has been evidenced that N-acetyl-D-glucosamine has an effect of promoting proliferation of an epidermis keratinized cell. Accordingly, the present invention provides a proliferation promoting agent for epidermis keratinized cell comprising N-acetyl-D-glucosamine. According to another aspect of the present invention, there is provided a regeneration promoting agent or protecting agent for epithelium, skin or dermis comprising the proliferation promoting agent. Further, a therapeutic agent for wound is provided.

摘要翻译： 本发明的目的是揭示各种几丁质衍生物的表皮再生作用，并提供可有效临床使用的伤口治疗或治疗剂。 根据本发明，证明N-乙酰基-D-葡糖胺具有促进表皮角化细胞增殖的作用。 因此，本发明提供了包含N-乙酰基-D-葡糖胺的表皮角化细胞增殖促进剂。 根据本发明的另一方面，提供了包含增殖促进剂的用于上皮，皮肤或真皮的再生促进剂或保护剂。 此外，提供了一种用于伤口的治疗剂。

公开(公告)号：US20120071439A1

公开(公告)日：2012-03-22

申请号：US13258270

申请日：2009-12-25

申请人： Saburo Minami ,  Yoshiharu Okamoto ,  Yasunari Miki

发明人： Saburo Minami ,  Yoshiharu Okamoto ,  Yasunari Miki

IPC分类号： A61K31/737 ,  A61P19/04 ,  C07H11/00

CPC分类号： A61K31/737 ,  A61K31/726 ,  C08B37/0036

摘要： Disclosed is a therapy which is for preventing or treating cartilage damage and diseases associated with cartilage damage, such as arthritides and osteoarthritis, and utilizes a more effective and more safe medicinal agent. Specifically disclosed are a cartilage production promoter, a glucosaminoglycan and/or proteoglycan production promoter, and a prophylactic or therapeutic agent for diseases associated with cartilage damage, each of which comprises fucoidan as an active ingredient.

摘要翻译： 公开了用于预防或治疗软骨损伤和与软骨损伤相关的疾病如关节炎和骨关节炎的治疗，并且利用更有效和更安全的药剂。 具体公开的是软骨生产促进剂，葡糖胺聚糖和/或蛋白聚糖生产促进剂，以及与软骨损伤相关的疾病的预防或治疗剂，其中每一种都包含岩藻依聚糖作为活性成分。

公开(公告)号：US20100069824A1

公开(公告)日：2010-03-18

申请号：US12461758

申请日：2009-08-24

申请人： Yoshiharu Okamoto ,  Saburo Minami ,  Yoshimitsu Abiko ,  Satoshi Otsuka ,  Nobuhiko Ogawa ,  Masaru Matsui

发明人： Yoshiharu Okamoto ,  Saburo Minami ,  Yoshimitsu Abiko ,  Satoshi Otsuka ,  Nobuhiko Ogawa ,  Masaru Matsui

IPC分类号： A61M37/00

CPC分类号： A61N5/062 ,  A61K31/404 ,  A61K41/0052 ,  A61N2005/0644 ,  A61N2005/0659

摘要： A photodynamic hyperthermic chemotherapy of cancer comprising topically injecting a photosensitive dye agent, specifically indocyanine green, in the form of an acidic liquid formulation to a tumor or cancer tissue, or a surgically removed site thereof of a patient, and irradiating the tissue or site with light having such an output wavelength that the photosensitive dye agent absorbs the light and generates heat; and an apparatus and a system for photodynamic hyperthermic chemotherapy of cancer comprising a light source and a probe having a light introducing portion capable of topically irradiating a tumor or cancer tissue or a surgically removed site thereof of a patient with light derived from the light source by a continuous wave or a pulse wave at an output wavelength of 600 to 1600 nm and an output of 5000 mW or more.

摘要翻译： 癌症的光动力学高热化学疗法包括将酸性液体制剂形式的光敏染料，特别是吲哚菁绿局部注射到患者的肿瘤或癌组织或其外科手术移除的部位，并将组织或部位用 具有光敏染料剂吸收光并产生热量的输出波长的光; 以及用于癌症的光动力学高热化疗的装置和系统，包括光源和探针，所述探针具有能够通过光源衍生的光局部照射患者的肿瘤或癌组织或手术切除部位的光引入部分， 输出波长为600〜1600nm的连续波或脉波，输出为5000mW以上。

公开(公告)号：US20050112182A1

公开(公告)日：2005-05-26

申请号：US10854336

申请日：2004-05-27

申请人： Saburo Minami ,  Eiko Renbutsu ,  Yoshihiko Omura ,  Fumiaki Nakatsubo ,  Yoshiharu Okamoto ,  Hiroyuki Saimoto ,  Yoshihro Shigemasa

发明人： Saburo Minami ,  Eiko Renbutsu ,  Yoshihiko Omura ,  Fumiaki Nakatsubo ,  Yoshiharu Okamoto ,  Hiroyuki Saimoto ,  Yoshihro Shigemasa

IPC分类号： A61K47/36 ,  A61F13/02 ,  A61L15/16 ,  A61L24/00 ,  A61L24/08 ,  A61L26/00 ,  A61L29/00 ,  A61P17/02 ,  A61P31/02 ,  C08B37/08 ,  C08F2/48 ,  C08J3/28 ,  C08J5/00 ,  C09J105/08

CPC分类号： A61L26/0061 ,  A61L24/001 ,  A61L24/08 ,  A61L26/0023 ,  C08L5/08

摘要： Provided is an N-alkyl chitosan derivative having an ultraviolet ray-curable functional group represented by formula (I) given below: where l+m+n=1, 0

摘要翻译： 本发明提供具有以下式（I）表示的可紫外线固化性官能团的N-烷基壳聚糖衍生物：其中l + m + n = 1,0

公开(公告)号：US4801219A

公开(公告)日：1989-01-31

申请号：US65438

申请日：1987-06-23

申请人： Masayuki Yazawa ,  Mitsuo Fukukawa ,  Kazumitsu Asai ,  Yoshiharu Okamoto

发明人： Masayuki Yazawa ,  Mitsuo Fukukawa ,  Kazumitsu Asai ,  Yoshiharu Okamoto

IPC分类号： E01C19/26 ,  E01C19/23 ,  E02D3/039

CPC分类号： E01C19/236 ,  E02D3/039

摘要： A compactor having the roller shafts mounted for changing the inclination of the roller through a linkage system. The compactor is connected to an anchor vehicle by a tension member which deters lateral shifting and has a sensor indicating the inclination angle. The sensor is connected to a control which varies the tension.

摘要翻译： 具有安装辊轴的压实机，用于通过连杆系统改变辊的倾斜度。 压实机通过张紧构件连接到锚固车辆，该张紧构件阻止横向移位，并具有指示倾斜角度的传感器。 传感器连接到可以改变张力的控制器。

公开(公告)号：US4587127A

公开(公告)日：1986-05-06

申请号：US534278

申请日：1983-09-21

申请人： Takeshi Akao ,  Shuichi Nagata ,  Katsumichi Osaki ,  Yoshiharu Okamoto

发明人： Takeshi Akao ,  Shuichi Nagata ,  Katsumichi Osaki ,  Yoshiharu Okamoto

IPC分类号： A23L27/50 ,  A23L1/20

CPC分类号： A23L27/50

摘要： A process for producing a liquid seasoning, which comprises allowing a hydrolyzate of soy sauce raw materials, in liquid state at a pH of 4.0 to 9.0, to contact with immobilized cells of soy sauce lactic acid bacteria for 30 minutes or more to obtain a lactic fermentation mixture, and subjecting the mixture to the fermentation by a soy sauce yeast.

摘要翻译： 一种液体调味品的制造方法，其特征在于，使液态pH为4.0〜9.0的酱油原料的水解物与酱油乳酸菌的固定化细胞接触30分钟以上，得到乳酸 发酵混合物，并通过酱油酵母对混合物进行发酵。

公开(公告)号：US4852278A

公开(公告)日：1989-08-01

申请号：US65528

申请日：1987-06-23

申请人： Seiichiro Takizawa ,  Mitsuo Fukukawa ,  Masayuki Yazawa ,  Kazumitsu Asai ,  Yoshiharu Okamoto

发明人： Seiichiro Takizawa ,  Mitsuo Fukukawa ,  Masayuki Yazawa ,  Kazumitsu Asai ,  Yoshiharu Okamoto

IPC分类号： E02F5/00 ,  E02F9/20

CPC分类号： E02F9/2025 ,  E02F5/00

摘要： Apparatus is disclosed for grading and measuring surfaces such as roadbeds which have curved and inclined profiles which may have different shapes in successive transverse sections of the roadbed. A blade and screw cutter are supported by a frame which extends over the surface being worked, and these tools are movable along this frame. The tools are movable toward and away from the surface being shaped in response to a control means which has memorized the appropriate positions, or by reference to a deformable rule which may also be reshaped in response to computer-memorized data. According to a disclsoed method, the rule is reshaped for different sections of the surface.An apparatus for checking and measuring a surface which has a curved profile includes a plurality of piston-cylinder units which are mounted on a main frame. A flexible rule is connected by the piston cylinder units to the main frame, and controls are provided for setting the extended positions of the piston-cylinder units to control the shape of the flexible rule.

摘要翻译： 公开了用于分级和测量诸如路基的表面的装置，其具有弯曲和倾斜的轮廓，其可以在路基的连续横截面中具有不同的形状。 刀片和螺丝刀由框架支撑，该框架在被加工的表面上延伸，并且这些工具可沿该框架移动。 这些工具可以响应于已经存储了适当位置的控制装置，或者参考可变形规则，朝向和远离被成形的表面移动，该可变形规则也可以响应于计算机存储的数据重新形成。 根据方法，对于表面的不同部分重新整理规则。 用于检查和测量具有弯曲轮廓的表面的装置包括安装在主框架上的多个活塞 - 气缸单元。 弹性规则通过活塞缸单元连接到主框架，并且提供控制以设置活塞 - 缸体单元的延伸位置以控制柔性规则的形状。

公开(公告)号：US4710975A

公开(公告)日：1987-12-01

申请号：US365345

申请日：1982-04-05

申请人： Yoshiharu Okamoto ,  Izumi Horikawa ,  Shozo Komaki

发明人： Yoshiharu Okamoto ,  Izumi Horikawa ,  Shozo Komaki

IPC分类号： H04B7/08

CPC分类号： H04B7/084

摘要： A space diversity reception system which minimizes the inband amplitude and/or phase dispersion by controlling the phase shifter is described. According to the present invention, the interference waves in the two antenna outputs are combined in anti-phase condition. The phase shifter control direction is decided by the sign of the two parameters. One of them is difference between two antenna levels at the center frequency of the pass-band, and the other is the difference of the combined signal levels at the extreme edges of the pass-band. The control means comprises four detectors for detecting said levels, two subtractors for providing said level differences between them, and the control circuit for deciding the phase shifter control direction.

摘要翻译： 描述了通过控制移相器来最小化带内幅度和/或相位色散的空间分集接收系统。 根据本发明，两个天线输出中的干扰波被组合成反相状态。 移相器控制方向由两个参数的符号决定。 其中之一是在通带的中心频率处的两个天线电平之间的差异，另一个是通带极端边缘处的组合信号电平的差异。 控制装置包括用于检测所述电平的四个检测器，用于提供它们之间的所述电平差的两个减法器和用于确定移相器控制方向的控制电路。

公开(公告)号：US4326294A

公开(公告)日：1982-04-20

申请号：US113591

申请日：1980-01-21

申请人： Yoshiharu Okamoto ,  Izumi Horikawa ,  Shozo Komaki

发明人： Yoshiharu Okamoto ,  Izumi Horikawa ,  Shozo Komaki

IPC分类号： H04B7/08

CPC分类号： H04B7/084

摘要： A space diversity reception system which minimizes the inband amplitude and/or phase dispersion by controlling the phase shifter is described. According to the present invention, the interference waves in the two antenna outputs are combined in anti-phase condition. The phase shifter control direction is decided by the sign of the two parameters. One of them is difference between two antenna levels at the center frequency of the pass-band, and the other is the difference of the combined signal levels at the extreme edges of the pass-band. The control means comprises four detectors for detecting said levels, two subtractors for providing said level difference between them, and the control circuit for deciding the phase shifter control direction.

摘要翻译： 描述了通过控制移相器来最小化带内幅度和/或相位色散的空间分集接收系统。 根据本发明，两个天线输出中的干扰波被组合成反相状态。 移相器控制方向由两个参数的符号决定。 其中之一是在通带的中心频率处的两个天线电平之间的差异，另一个是通带极端边缘处的组合信号电平的差异。 控制装置包括用于检测所述电平的四个检测器，用于提供它们之间的所述电平差的两个减法器和用于确定移相器控制方向的控制电路。