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    TABLET-FORMED PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION AND METHOD FOR PRODUCING SAME
    4.
    发明申请
    TABLET-FORMED PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION AND METHOD FOR PRODUCING SAME 审中-公开
    用于口服给药的片剂形成的药物组合物及其生产方法

    公开(公告)号：US20130344147A1

    公开(公告)日：2013-12-26

    申请号：US14002989

    申请日：2012-03-05

    申请人： Ayumi Kainose ,  Yohei Koya ,  Yoshiki Machi ,  Saichi Ono ,  Tadahiko Chiba

    发明人： Ayumi Kainose ,  Yohei Koya ,  Yoshiki Machi ,  Saichi Ono ,  Tadahiko Chiba

    IPC分类号： A61K9/20 ,  A61K33/44

    CPC分类号： A61K9/20 ,  A61K9/205 ,  A61K9/2095 ,  A61K33/44

    摘要： The object of the present invention is to provide an adsorbent for oral administration, which can: obviate sandy texture of granules-formed adsorbent for oral administration, reduce the volume administered compared to encapsulated adsorbent for oral administration, and be easy to take.The object of the present invention is solved by a tablet-formed pharmaceutical composition consisting of 65% or more by weight of particulate substance as an active ingredient and one or more additives, characterized in that: (a) the particulate substance does not exhibit water solubility and swelling property in water, has a distortion rate of 2% or less when subjected to a pressure of 2 MPa, and has a fracture strength of 5 MPa or more, (b) the tablet-formed pharmaceutical composition comprises one or more particle-formulating additives wherein the amount of the particle-formulating additives is 1% or more by weight in total with respect to the weight of the tablet-formed pharmaceutical composition, and a thin layer of the particle-formulating additive can be formed when 0.5 mL of solution or dispersion liquid of the particle-formulating additive of 1% by weight is dropped on a plane surface of fluorine resin and heat-dried.

    摘要翻译： 本发明的目的是提供一种用于口服给药的吸附剂，其可以：消除用于口服给药的颗粒形成的吸附剂的沙质质，与口服给药的封装吸附剂相比，减少施用的体积，并且容易服用。 本发明的目的是通过由作为活性成分的颗粒物质的65重量％或更多的添加剂和一种或多种添加剂组成的片剂形式的药物组合物来解决，其特征在于：（a）颗粒物质不显示水 在水中的溶解性和溶胀性在经受2MPa的压力时具有2％以下的变形率，断裂强度为5MPa以上，（b）片剂形成的药物组合物包含一种或多种颗粒 制剂添加剂，相对于片剂形成的药物组合物的重量，配制粉剂的总量为1重量％以上，配方添加剂的薄层可以在0.5mL 的配方添加剂的1重量％的溶液或分散液滴在氟树脂的平面上并进行加热干燥。

    SINGLE-DOSE PACKAGE
    5.
    发明申请
    SINGLE-DOSE PACKAGE 有权
    单剂包装

    公开(公告)号：US20130075299A1

    公开(公告)日：2013-03-28

    申请号：US13701381

    申请日：2011-06-03

    申请人： Saichi Ono

    发明人： Saichi Ono

    IPC分类号： B65D83/06 ,  B65B1/00

    CPC分类号： B65D83/06 ,  A61J1/10 ,  B32B15/085 ,  B32B27/32 ,  B32B27/36 ,  B32B2439/00 ,  B65B1/00 ,  Y10T428/1334 ,  Y10T428/1352

    摘要： The object of the present invention is to provide an single-dose package containing an internal adsorbent wherein the internal adsorbent is not trapped in the heat-sealed region thereof. In addition, the object of the present invention is to provide a single-dose package containing internal adsorbent wherein adhesion of the internal adsorbent around the vacuumed open region thereof is slight, whereby the internal adsorbent does not spill out on opening the package. The object of the present invention can be solved by a single-dose package characterized in that the internal adsorbent is tight-packed using a packaging material having a mean specific surface resistivity of from 4.4×109Ω or more to 1.0×1016Ω or less at its internal surface, under warming and/or reduced pressure.

    摘要翻译： 本发明的目的是提供一种含有内部吸附剂的单剂量包装，其中内部吸附剂不被捕获在其热密封区域中。 此外，本发明的目的是提供一种含有内部吸附剂的单剂量包装，其中内部吸附剂围绕其真空开口区域的粘附是轻微的，由此内部吸附剂在打开包装时不会溢出。 本发明的目的可以通过单剂量包装来解决，其特征在于使用平均比表面电阻率为4.4×10 9Ω·cm的包装材料将内部吸附剂紧密包装。 或更多为1.0×1016＆OHgr; 或更低的温度和/或减压下的内表面。

    Housing body for deglutition of solid molding for oral ingestion, container for the housing body, and deglutition method
    7.
    发明申请
    Housing body for deglutition of solid molding for oral ingestion, container for the housing body, and deglutition method 审中-公开
    用于口腔摄入的固体成型用于脱脂的壳体，用于壳体的容器和脱脂方法

    公开(公告)号：US20060293641A1

    公开(公告)日：2006-12-28

    申请号：US10556592

    申请日：2004-05-14

    申请人： Fuyuhiko Nishijima ,  Saichi Ono ,  Tadahiko Chiba ,  Yukio Iwase ,  Yoshiaki Osaka ,  Koichi Niimura

    发明人： Fuyuhiko Nishijima ,  Saichi Ono ,  Tadahiko Chiba ,  Yukio Iwase ,  Yoshiaki Osaka ,  Koichi Niimura

    IPC分类号： A61M31/00

    CPC分类号： A61J7/0038 ,  A47G21/183

    摘要： A housing body (10) for deglutition of a shaped solid (5) for oral ingestion which is stored therein, comprising a generally tubular water-resistant envelope (1); an opening-side end part (A) at one end of the envelope, having an unsealable structure part (2), and capable of forming an opening part (22) by removing the unsealable structure part; a shielding-side end part (B) at the other end of the envelope, having a means for preventing the shaped solid for oral ingestion from release, the means allowing liquid to pass therethrough but not allowing the shaped solid for oral ingestion to pass therethrough; and a storage chamber (6) storing the shaped solid for oral ingestion between the opening-side end part and the shielding-side end part is disclosed. A method for swallowing a shaped solid for oral ingestion, wherein an unsealable structure part installed at an opening-side end part of the housing body is removed; the shielding-side end part of the housing body is immersed into liquid in a vessel while the shaped solid for oral ingestion is stored in the storage chamber in the tubular envelope; and an opening part formed at the opening-side end part is held between the lips so that the shaped solid for oral ingestion is sucked in together with the liquid in the vessel is also disclosed.

    摘要翻译： 一种用于口腔成形固体（5）脱水的壳体（10），其用于口腔摄取，其存储在其中，包括大致管状的防水外壳（1）; 在封套的一端处的开口侧端部（A），具有可开封结构部分（2），并且能够通过移除开封结构部分形成开口部分（22）; 在封套的另一端处的屏蔽侧端部（B）具有用于防止成形固体口服摄取的装置，允许液体通过但不允许用于口服摄取的成形固体通过的装置 ; 公开了一种在开口侧端部和屏蔽侧端部之间存储用于口腔摄取的成形固体的储存室（6）。 一种吞咽用于口服摄取的成形固体的方法，其中移除安装在所述壳体的开口侧端部的开封结构部分; 将壳体的屏蔽侧端部浸入容器中的液体中，同时将用于口腔摄取的成形固体储存在管状外壳中的储存室中; 并且形成在开口侧端部处的开口部分保持在唇缘之间，使得用于口服摄取的成形固体与容器中的液体一起被吸入。

    Single dose package
    8.
    发明授权
    Single dose package 有权
    单剂量包装

    公开(公告)号：US09387974B2

    公开(公告)日：2016-07-12

    申请号：US13701381

    申请日：2011-06-03

    申请人： Saichi Ono

    发明人： Saichi Ono

    IPC分类号： B29D22/00 ,  B29D23/00 ,  B32B1/08 ,  B65D83/06 ,  B32B15/085 ,  B32B27/32 ,  B32B27/36 ,  B65B1/00 ,  A61J1/10

    CPC分类号： B65D83/06 ,  A61J1/10 ,  B32B15/085 ,  B32B27/32 ,  B32B27/36 ,  B32B2439/00 ,  B65B1/00 ,  Y10T428/1334 ,  Y10T428/1352

    摘要： The object of the present invention is to provide an single-dose package containing an internal adsorbent wherein the internal adsorbent is not trapped in the heat-sealed region thereof. In addition, the object of the present invention is to provide a single-dose package containing internal adsorbent wherein adhesion of the internal adsorbent around the vacuumed open region thereof is slight, whereby the internal adsorbent does not spill out on opening the package. The object of the present invention can be solved by a single-dose package characterized in that the internal adsorbent is tight-packed using a packaging material having a mean specific surface resistivity of from 4.4×109Ω or more to 1.0×1016Ω or less at its internal surface, under warming and/or reduced pressure.

    摘要翻译： 本发明的目的是提供一种含有内部吸附剂的单剂量包装，其中内部吸附剂不被捕获在其热密封区域中。 此外，本发明的目的是提供一种含有内部吸附剂的单剂量包装，其中内部吸附剂围绕其真空开口区域的粘附是轻微的，由此内部吸附剂在打开包装时不会溢出。 本发明的目的可以通过单剂量包装来解决，其特征在于使用平均比表面电阻率为4.4×10 9Ω·cm的包装材料将内部吸附剂紧密包装。 或更多为1.0×1016＆OHgr; 或更低的温度和/或减压下的内表面。

    Controlled release oral preparations of esculetin and its derivatives
    10.
    发明授权
    Controlled release oral preparations of esculetin and its derivatives 失效
    七叶亭及其衍生物的控释口服制剂

    公开(公告)号：US06750249B1

    公开(公告)日：2004-06-15

    申请号：US09806636

    申请日：2001-05-23

    申请人： Iwao Yamaguchi ,  Saichi Ono ,  Tadahiko Chiba

    发明人： Iwao Yamaguchi ,  Saichi Ono ,  Tadahiko Chiba

    IPC分类号： A61K3135

    CPC分类号： A61K9/5042 ,  A61K9/2054 ,  A61K9/2866 ,  A61K9/4866 ,  A61K31/37

    摘要： The present invention relates to an oral preparation of esculetin with controlled release. The oral preparation of esculetin with controlled release of the present invention comprises a gel-forming polymer base, preferably hydroxypropylmethylcellulose. The preparation may be coated with an enteric polymer base such as hydroxypropylmethylcellulose acetate succinate to thereby enhance solubility in the intestines. When orally administered, the preparation can continuously release esculetin. Thus, the administration frequency and dose can be reduced and a therapeutic effect on arthropathy can be established.

    摘要翻译： 本发明涉及具有控制释放的七叶亭的口服制剂。 具有本发明的控制释放的七叶亭的口服制剂包含凝胶形成聚合物基质，优选羟丙基甲基纤维素。 该制剂可以用肠溶性聚合物基质如乙酸琥珀酸羟丙基甲基纤维素包衣，从而增强肠内的溶解度。口服给药时，可以连续释放七叶亭。 因此，可以降低给药频率和剂量，并且可以建立对关节病的治疗效果。