公开(公告)号：US20070156233A1

公开(公告)日：2007-07-05

申请号：US11509469

申请日：2006-08-24

申请人： Samir Kapadia ,  Jay Yadav ,  E. Tuzcu

发明人： Samir Kapadia ,  Jay Yadav ,  E. Tuzcu

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61B2017/00243 ,  A61F2/2409 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0066 ,  A61F2230/0065 ,  A61F2230/0071 ,  A61F2230/0076

摘要： An apparatus for percutaneously replacing a diseased cardiac valve includes an expandable support member for positioning in an atrial chamber. The expandable support member includes at least one anchoring portion for anchoring in at least one opening that extends from the atrial chamber and a main body portion located adjacent the at least one anchoring portion. The main body portion has a cage-like structure and is adapted to conform to a size and shape of the atrial chamber. An expandable ring is selectively connected to the main body portion. The expandable ring is adapted to engage an annulus of the diseased cardiac valve. A prosthetic valve is attached to the expandable ring. The prosthetic valve is adapted to replace the diseased cardiac valve. A method for percutaneously replacing a diseased cardiac valve is also described.

摘要翻译： 用于经皮置换患病心脏瓣膜的装置包括用于定位在心房中的可扩张支撑构件。 可扩张支撑构件包括至少一个锚固部分，用于锚固在从心房延伸的至少一个开口中，以及主体部分，邻近于至少一个锚定部分。 主体部分具有笼状结构并且适于符合心房的尺寸和形状。 可膨胀环选择性地连接到主体部分。 可膨胀环适于接合患病心脏瓣膜的环。 假肢瓣附接到可扩张环。 人造瓣膜适于替换患病的心脏瓣膜。 还描述了用于经皮置换患病心脏瓣膜的方法。

公开(公告)号：US07901454B2

公开(公告)日：2011-03-08

申请号：US11638864

申请日：2006-12-14

申请人： Samir Kapadia ,  Jay Yadav

发明人： Samir Kapadia ,  Jay Yadav

IPC分类号： A61F2/24

CPC分类号： A61B17/0401 ,  A61B17/00234 ,  A61B2017/00575 ,  A61B2017/00588 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00606 ,  A61B2017/00615 ,  A61B2017/0417 ,  A61B2017/0443 ,  A61F2/246 ,  A61F2/2496

摘要： An apparatus for treating regurgitation of blood through a diseased heart valve having at least two leaflets includes an occluding member configured to be positioned within the diseased heart valve so that at least a portion of the occluding member is positioned adjacent to one of the at least two leaflets. The at least one portion of the occluding member contacts at least one surface of the at least one leaflet. The occluding member is dimensioned so that the at least one leaflet abuts the at least one surface of the occluding member. The apparatus further includes a suspending wire operatively attached to the occluding member and configured to facilitate positioning of the occluding member within the heart valve. The suspending wire includes an anchoring portion having a coiled shape. The anchoring portion is configured to secure the suspending wire to at least one of a blood vessel and a heart wall surrounding a heart chamber.

摘要翻译： 用于通过具有至少两个小叶的患病心脏瓣膜治疗血液反流的装置包括被配置为定位在患病心脏瓣膜内的阻塞构件，使得至少一部分阻塞构件邻近至少两个之一 传单。 阻塞构件的至少一部分接触至少一个传单的至少一个表面。 闭塞构件的尺寸设计成使得至少一个叶片邻接闭塞构件的至少一个表面。 该装置还包括可操作地附接到闭塞构件并构造成便于将闭塞构件定位在心脏瓣膜内的悬挂线。 悬挂线包括具有盘绕形状的锚固部分。 锚定部分被构造成将悬挂线固定到围绕心脏腔室的血管和心脏壁中的至少一个。

公开(公告)号：US07611534B2

公开(公告)日：2009-11-03

申请号：US11509469

申请日：2006-08-24

申请人： Samir Kapadia ,  Jay Yadav ,  E. Murat Tuzcu

发明人： Samir Kapadia ,  Jay Yadav ,  E. Murat Tuzcu

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61B2017/00243 ,  A61F2/2409 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0066 ,  A61F2230/0065 ,  A61F2230/0071 ,  A61F2230/0076

摘要： An apparatus for percutaneously replacing a diseased cardiac valve includes an expandable support member for positioning in an atrial chamber. The expandable support member includes at least one anchoring portion for anchoring in at least one opening that extends from the atrial chamber and a main body portion located adjacent the at least one anchoring portion. The main body portion has a cage-like structure and is adapted to conform to a size and shape of the atrial chamber. An expandable ring is selectively connected to the main body portion. The expandable ring is adapted to engage an annulus of the diseased cardiac valve. A prosthetic valve is attached to the expandable ring. The prosthetic valve is adapted to replace the diseased cardiac valve. A method for percutaneously replacing a diseased cardiac valve is also described.

摘要翻译： 用于经皮置换患病心脏瓣膜的装置包括用于定位在心房中的可扩张支撑构件。 可扩张支撑构件包括至少一个锚固部分，用于锚固在从心房延伸的至少一个开口中，以及主体部分，邻近于至少一个锚定部分。 主体部分具有笼状结构并且适于符合心房的尺寸和形状。 可膨胀环选择性地连接到主体部分。 可膨胀环适于接合患病心脏瓣膜的环。 假肢瓣附接到可扩张环。 人造瓣膜适于替换患病的心脏瓣膜。 还描述了用于经皮置换患病心脏瓣膜的方法。

公开(公告)号：US20070185571A1

公开(公告)日：2007-08-09

申请号：US11700295

申请日：2007-01-31

申请人： Samir Kapadia ,  Jay Yadav

发明人： Samir Kapadia ,  Jay Yadav

IPC分类号： A61F2/24

CPC分类号： A61B17/00234 ,  A61B5/1076 ,  A61B17/0401 ,  A61B2017/00575 ,  A61B2017/0443 ,  A61F2/2412 ,  A61F2/246 ,  A61F2/2466 ,  A61F2/2475 ,  A61F2002/30545 ,  A61F2250/0003 ,  A61F2250/001

摘要： An apparatus for treating regurgitation of blood through a diseased valve having at least one leaflet includes a valve member having a support structure with a diameter and at least one valvular leaflet attached to the support structure. The valve member is dimensioned so that at least one leaflet of the diseased valve abuts at least one surface of the valve member to mitigate regurgitation of blood through the diseased valve. The apparatus further includes a suspending mechanism operatively coupled to the valve member. The suspending mechanism is configured so that the valve member is freely suspended within the diseased valve.

摘要翻译： 用于通过具有至少一个小叶的患病瓣治疗血液反流的装置包括具有直径的支撑结构的阀构件和附接到支撑结构的至少一个瓣状小叶。 阀构件的尺寸使得患病阀的至少一个叶片抵靠阀构件的至少一个表面以减轻通过病变阀的血液反流。 该装置还包括可操作地联接到阀构件的悬挂机构。 悬挂机构构造成使得阀构件自由地悬挂在患病阀内。

公开(公告)号：US20070198082A1

公开(公告)日：2007-08-23

申请号：US11638864

申请日：2006-12-14

申请人： Samir Kapadia ,  Jay Yadav

发明人： Samir Kapadia ,  Jay Yadav

IPC分类号： A61F2/24 ,  A61M29/02

CPC分类号： A61B17/0401 ,  A61B17/00234 ,  A61B2017/00575 ,  A61B2017/00588 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00606 ,  A61B2017/00615 ,  A61B2017/0417 ,  A61B2017/0443 ,  A61F2/246 ,  A61F2/2496

摘要： An apparatus for treating regurgitation of blood through a diseased heart valve having at least two leaflets includes an occluding member configured to be positioned within the diseased heart valve so that at least a portion of the occluding member is positioned adjacent to one of the at least two leaflets. The at least one portion of the occluding member contacts at least one surface of the at least one leaflet. The occluding member is dimensioned so that the at least one leaflet abuts the at least one surface of the occluding member. The apparatus further includes a suspending wire operatively attached to the occluding member and configured to facilitate positioning of the occluding member within the heart valve. The suspending wire includes an anchoring portion having a coiled shape. The anchoring portion is configured to secure the suspending wire to at least one of a blood vessel and a heart wall surrounding a heart chamber.

摘要翻译： 用于通过具有至少两个小叶的患病心脏瓣膜治疗血液反流的装置包括被配置为定位在患病心脏瓣膜内的阻塞构件，使得至少一部分阻塞构件邻近至少两个之一 传单。 阻塞构件的至少一部分接触至少一个传单的至少一个表面。 闭塞构件的尺寸设计成使得至少一个叶片邻接闭塞构件的至少一个表面。 该装置还包括可操作地附接到闭塞构件并构造成便于将闭塞构件定位在心脏瓣膜内的悬挂线。 悬挂线包括具有盘绕形状的锚固部分。 锚定部分被构造成将悬挂线固定到围绕心脏腔室的血管和心脏壁中的至少一个。

公开(公告)号：US08019404B2

公开(公告)日：2011-09-13

申请号：US11867774

申请日：2007-10-05

申请人： Samir Kapadia

发明人： Samir Kapadia

IPC分类号： A61M25/00

CPC分类号： A61B17/3478 ,  A61B34/20 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00252 ,  A61B2017/00278 ,  A61B2017/22038 ,  A61B2017/22077 ,  A61B2017/22095 ,  A61B2017/3484 ,  A61B2018/00392 ,  A61B2090/3929 ,  A61B2090/3958 ,  A61N1/06

摘要： An apparatus for targeting a desired target site on a body tissue that separates a first body cavity from a second body cavity of a patient includes a catheter having a longitudinally extending catheter lumen and adapted to provide access to the first body cavity. A framing member has a collapsed condition in which the framing member is adapted for insertion into the first body cavity through the catheter lumen and an expanded condition in which the framing member is adapted for placement within the first body cavity. The framing member has a framing member body. At least one target point is carried by the framing member and is adapted for placement adjacent the desired target site. At least one target wire is attached to at least one target point. At least a portion of the target wire extends through the catheter lumen. The target wire is substantially spaced apart from the framing member body. A method of using the apparatus is also described.

摘要翻译： 用于对准将第一体腔与患者的第二体腔分离的身体组织上的期望目标部位的装置包括具有纵向延伸的导管内腔并适于提供对第一体腔的通路的导管。 框架构件具有折叠状态，其中框架构件适于通过导管腔插入第一体腔中，并且扩张状态，其中框架构件适于放置在第一体腔内。 框架构件具有框架构件体。 至少一个目标点由框架构件承载，并适于放置在所需目标位置附近。 至少一个目标线连接到至少一个目标点。 目标线的至少一部分延伸穿过导管内腔。 目标线与框架构件主体基本间隔开。 还描述了使用该装置的方法。

公开(公告)号：US08597225B2

公开(公告)日：2013-12-03

申请号：US13190512

申请日：2011-07-26

申请人： Samir Kapadia

发明人： Samir Kapadia

IPC分类号： A61M5/00 ,  A61M25/00

CPC分类号： A61F2/06 ,  A61B17/0057 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61B2017/00623 ,  A61B2017/00867 ,  A61F2/2412 ,  A61F2002/068

摘要： A method is provided for increasing blood flow in or about a cardiac structure to prevent thrombosis. One step of the method includes providing an implantable sprayer having an elongated tubular body with proximal and distal end portions. The distal end portion includes at least one opening and an anchoring mechanism. The distal end portion of the implantable sprayer is inserted into a cardiac chamber that includes the cardiac structure. The anchoring mechanism is then deployed so that the distal end portion of the implantable sprayer is secured in or about the cardiac structure. Next, the proximal end portion is anastomosed with an artery so that blood flows through the elongated tubular body of the implantable sprayer and is sprayed out of the at least one opening to continuously circulate blood in or about the cardiac structure.

摘要翻译： 提供了一种用于在心脏结构内或周围增加血流以防止血栓形成的方法。 该方法的一个步骤包括提供具有带有近端部分和远端部分的细长管状体的可植入喷雾器。 远端部分包括至少一个开口和锚定机构。 可植入喷雾器的远端部分插入包括心脏结构的心室中。 然后将锚定机构展开，使得可植入喷雾器的远端部分固定在心脏结构内或周围。 接下来，近端部分与动脉吻合，使得血液流过可植入喷雾器的细长管状体，并从该至少一个开口喷出以在心脏结构内或周围持续循环血液。

公开(公告)号：US20130190798A1

公开(公告)日：2013-07-25

申请号：US13559900

申请日：2012-07-27

申请人： Samir Kapadia

发明人： Samir Kapadia

IPC分类号： A61M29/02

CPC分类号： A61F2/246 ,  A61F2/2466 ,  A61F2250/0004 ,  A61F2250/001 ,  A61M29/02

摘要： An apparatus for treating regurgitation of blood through a diseased heart valve having at least two leaflets includes a lollipop-shaped body member having a proximal end portion, a distal end portion, and an intermediate portion extending between the end portions. The intermediate portion includes an expandable occluding member having an adjustable diameter so that, during at least a portion of the cardiac cycle, at least one of the heart leaflet coapts with a portion of the occluding member to mitigate or prevent regurgitation of blood through the diseased heart valve. The proximal end portion is physically connected to the occluding member and includes a connecting mechanism for operably mating with an adjustment member for adjusting the position and diameter of the occluding member within the diseased heart valve. The distal end portion includes an anchoring member for securing the apparatus in a heart chamber containing the diseased heart valve.

摘要翻译： 用于通过具有至少两个小叶的患病心脏瓣膜治疗血液反流的装置包括具有近端部分，远端部分和在端部之间延伸的中间部分的棒棒糖状体部件。 中间部分包括具有可调节直径的可膨胀闭塞构件，使得在心脏周期的至少一部分期间，至少一个心脏小叶与一部分闭塞构件相结合以减轻或防止血液通过病变的反流 心脏瓣膜。 近端部分物理地连接到阻塞构件，并且包括用于与调节构件可操作地配合的连接机构，用于调节患病心脏瓣膜内的阻塞构件的位置和直径。 远端部分包括用于将装置固定在容纳患病心脏瓣膜的心室中的锚定构件。

公开(公告)号：US20120022427A1

公开(公告)日：2012-01-26

申请号：US13190512

申请日：2011-07-26

申请人： Samir Kapadia

发明人： Samir Kapadia

IPC分类号： A61M1/36 ,  A61M11/00

CPC分类号： A61F2/06 ,  A61B17/0057 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61B2017/00623 ,  A61B2017/00867 ,  A61F2/2412 ,  A61F2002/068

摘要： A method is provided for increasing blood flow in or about a cardiac structure to prevent thrombosis. One step of the method includes providing an implantable sprayer having an elongated tubular body with proximal and distal end portions. The distal end portion includes at least one opening and an anchoring mechanism. The distal end portion of the implantable sprayer is inserted into a cardiac chamber that includes the cardiac structure. The anchoring mechanism is then deployed so that the distal end portion of the implantable sprayer is secured in or about the cardiac structure. Next, the proximal end portion is anastomosed with an artery so that blood flows through the elongated tubular body of the implantable sprayer and is sprayed out of the at least one opening to continuously circulate blood in or about the cardiac structure.

摘要翻译： 提供了一种用于在心脏结构内或周围增加血流以防止血栓形成的方法。 该方法的一个步骤包括提供具有带有近端部分和远端部分的细长管状体的可植入喷雾器。 远端部分包括至少一个开口和锚定机构。 可植入喷雾器的远端部分插入包括心脏结构的心室中。 然后将锚定机构展开，使得可植入喷雾器的远端部分固定在心脏结构内或周围。 接下来，近端部分与动脉吻合，使得血液流过可植入喷雾器的细长管状体，并从该至少一个开口喷出以在心脏结构内或周围持续循环血液。

公开(公告)号：US08694077B2

公开(公告)日：2014-04-08

申请号：US13206639

申请日：2011-08-10

申请人： Samir Kapadia

发明人： Samir Kapadia

IPC分类号： A61M25/00

CPC分类号： A61B17/3478 ,  A61B34/20 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00252 ,  A61B2017/00278 ,  A61B2017/00292 ,  A61B2017/22038 ,  A61B2017/22077 ,  A61B2017/22095 ,  A61B2017/3405 ,  A61B2017/3411 ,  A61B2017/3484 ,  A61B2018/00392 ,  A61B2090/3925 ,  A61B2090/3929 ,  A61B2090/3958 ,  A61N1/06

摘要： An apparatus for targeting a desired target site on a body tissue that separates a first body cavity from a second body cavity of a patient includes a catheter having a longitudinally extending catheter lumen and adapted to provide access to the first body cavity. A framing member has a collapsed condition in which the framing member is adapted for insertion into the first body cavity through the catheter lumen and an expanded condition in which the framing member is adapted for placement within the first body cavity. The framing member has a framing member body. At least one target point is carried by the framing member and is adapted for placement adjacent the desired target site. At least one target pathway is attached to at least one target point. At least a portion of the target pathway extends through the catheter lumen. The target pathway is substantially spaced apart from the framing member body. A method of using the apparatus is also described.

摘要翻译： 用于对准将第一体腔与患者的第二体腔分离的身体组织上的期望目标部位的装置包括具有纵向延伸的导管内腔并适于提供对第一体腔的通路的导管。 框架构件具有折叠状态，其中框架构件适于通过导管腔插入第一体腔中，并且扩张状态，其中框架构件适于放置在第一体腔内。 框架构件具有框架构件体。 至少一个目标点由框架构件承载，并适于放置在所需目标位置附近。 至少一个目标通路连接至至少一个目标点。 目标通路的至少一部分延伸穿过导管内腔。 目标路径与框架构件主体基本间隔开。 还描述了使用该装置的方法。