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    Human inflammatory breast carcinoma xenograft capable of lymphovascular invasion and methods for its use
    1.
    发明授权
    Human inflammatory breast carcinoma xenograft capable of lymphovascular invasion and methods for its use 失效
    人类炎性乳腺癌异种移植能够进行淋巴血管侵袭及其使用的方法

    公开(公告)号：US06998513B1

    公开(公告)日：2006-02-14

    申请号：US09856104

    申请日：2000-09-15

    申请人： Sanford H. Barsky ,  Mary L. Alpaugh ,  James S. Tomlinson

    发明人： Sanford H. Barsky ,  Mary L. Alpaugh ,  James S. Tomlinson

    IPC分类号： A01K67/00 ,  A01K67/033 ,  A61K49/00 ,  C12N5/00 ,  C12N5/08

    CPC分类号： A01K67/0271 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K49/0008 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/30 ,  C12N5/0693 ,  C12N2503/00

    摘要： The present invention provides human transplantable inflammatory breast carcinoma xenografts. Such xenografts exhibit a number of unique characteristics which allows their use in experimental models of inflammatory carcinoma in order to dissect out the molecular basis of this phenotype. This experimental model of inflammatory carcinoma can be used to identify molecular targets for therapeutic intervention and to assess the efficacy of a broad spectrum of diagnostic and therapeutic agents. Specific animal models of inflammatory breast cancer are described as well as methods for evaluating diagnostic and therapeutic agents for treating inflammatory breast cancer. Methods for identifying molecules whose expression is modulated in inflammatory breast cancer are provided. In addition, methods for diagnosing and inhibiting the growth of inflammatory breast cancer metastases in vivo are provided.

    摘要翻译： 本发明提供人类可移植的炎性乳腺癌异种移植物。 这种异种移植物表现出许多独特的特征，允许它们在炎性癌的实验模型中使用，以便剖析该表型的分子基础。 这种炎性癌的实验模型可用于鉴定治疗性干预的分子靶点，并评估广谱诊断和治疗药物的功效。 描述了炎性乳腺癌的具体动物模型以及用于评估用于治疗炎性乳腺癌的诊断和治疗剂的方法。 提供了用于鉴定表达在炎性乳腺癌中调节的分子的方法。 另外，提供了用于诊断和抑制体内炎性乳腺癌转移生长的方法。

    Methods and kits for identifying ductal orifices in a nipple
    2.
    发明授权
    Methods and kits for identifying ductal orifices in a nipple 有权
    用于识别乳头中导管孔的方法和试剂盒

    公开(公告)号：US06455027B1

    公开(公告)日：2002-09-24

    申请号：US09153564

    申请日：1998-09-15

    申请人： Sanford H. Barsky ,  Susan M. Love ,  Mary L. Alpaugh

    发明人： Sanford H. Barsky ,  Susan M. Love ,  Mary L. Alpaugh

    IPC分类号： A61B500

    CPC分类号： A61K49/0058 ,  A61K49/0013 ,  A61K49/0043 ,  A61K49/006

    摘要： Methods, kits, and apparatus for locating, labelling, and accessing breast ducts are described. An orifice to one or more ductal networks is marked to enhance visibility. In a first embodiment, the orifice is labelled using a specific binding substance, typically an antibody, specific for a tissue marker present on the orifice. Exemplary tissue markers include those present on the ductal epithelium, such as cytokeratins, including cytokeratin 8 and cytokeratin 18; cadhedrins, such as E cadhedrin; and epithelial membrane antigens. In a second embodiment, a dye is injected into the base of the nipple and preferentially accumulates at at least some of the orifices. Other marking techniques are also described. Marking of the ductal orifices permits reliable identification and access to each of the multiple ductal networks which may be present in an individual breast.

    摘要翻译： 描述了用于定位，标记和访问乳房导管的方法，套件和装置。 标记到一个或多个导管网络的孔口以增强可视性。 在第一个实施方案中，使用特定的结合物质（通常是针对存在于孔口上的组织标记物的抗体）标记孔。 示例性组织标志物包括存在于导管上皮上的那些，例如细胞角蛋白，包括细胞角蛋白8和细胞角蛋白18; 院士，如E小学生; 和上皮膜抗原。 在第二实施方案中，将染料注入到乳头的基部中，并且优选地在至少一些孔口处积聚。 还描述了其他标记技术。 导管孔的标记允许可靠地识别和进入可能存在于单独乳房中的多个导管网络中的每一个。

    Compositions and methods for intraductal gene therapy
    3.
    发明授权
    Compositions and methods for intraductal gene therapy 有权
    导管内基因治疗的组成和方法

    公开(公告)号：US06514695B1

    公开(公告)日：2003-02-04

    申请号：US09488464

    申请日：2000-01-20

    申请人： Sanford H. Barsky ,  Mary L. Alpaugh

    发明人： Sanford H. Barsky ,  Mary L. Alpaugh

    IPC分类号： C12Q168

    CPC分类号： C12N15/86 ,  A61K38/57 ,  A61K48/00 ,  C12N2710/10343 ,  C12N2750/14143 ,  C12N2810/6018

    摘要： The present invention provides methods for the selective transduction of a cell in a ductal system in a mammary gland by contacting, via ductal cannulation, the cell with a vector that selectively targets the cell. In this context, the invention provides prophylactic and therapeutic methods of treating the ductal epithelium of the breast, for disease, in particular cancer. The present invention further provides diagnostic methods of determining the presence of disease in the ductal epithelium of the breast, in particular cancer.

    摘要翻译： 本发明提供了通过导管插管将细胞与选择性靶向细胞的载体接触来选择性转导乳腺导管系统中的细胞的方法。 在本文中，本发明提供了治疗乳腺导管上皮，特别是癌症的预防和治疗方法。 本发明还提供了确定乳腺导管上皮，特别是癌症中疾病存在的诊断方法。

    Method of growing cells in a mammal
    4.
    发明授权
    Method of growing cells in a mammal 失效
    哺乳动物生长细胞的方法

    公开(公告)号：US5508188A

    公开(公告)日：1996-04-16

    申请号：US184720

    申请日：1994-01-21

    申请人： Sanford H. Barsky ,  Mark Sternlicht

    发明人： Sanford H. Barsky ,  Mark Sternlicht

    IPC分类号： C12N5/09 ,  C12N5/16 ,  G01N33/50 ,  C12N5/00 ,  C12N5/02

    CPC分类号： G01N33/5011 ,  C12N5/0693 ,  C12N5/16 ,  C12N2502/098 ,  C12N2502/30 ,  C12N2503/02

    摘要： Human basement membrane matrix is provided, produced by a novel tumorigenic cell line, where the basement membrane can be used for the growth of a variety of cells, in culture and in vivo. Other cell lines are provided, which may serve to evaluate in vivo the response of tumorigenic cells to various agents, including basement membrane. The basement membrane finds use in allowing the growth of cells in culture and in vivo, particularly cells which are otherwise refractory to xenografting.

    摘要翻译： 提供人类基底膜基质，由新型致瘤细胞系产生，其中基底膜可用于培养和体内各种细胞的生长。 提供其他细胞系，其可用于体内评估致瘤细胞对各种试剂（包括基底膜）的反应。 基底膜可用于允许细胞在培养和体内的生长，特别是否则对异种移植不耐受的细胞。

    Method for automated processing of digital images of tissue micro-arrays (TMA)
    5.
    发明授权
    Method for automated processing of digital images of tissue micro-arrays (TMA) 有权
    用于组织微阵列（TMA）的数字图像的自动处理的方法

    公开(公告)号：US08428887B2

    公开(公告)日：2013-04-23

    申请号：US13292290

    申请日：2011-11-09

    申请人： Abhijeet S. Gholap ,  Gauri A. Gholap ,  Prithviraj Jadhav ,  Sanford H. Barsky ,  Chiruvolu V. K. Rao ,  Madhura Vipra

    发明人： Abhijeet S. Gholap ,  Gauri A. Gholap ,  Prithviraj Jadhav ,  Sanford H. Barsky ,  Chiruvolu V. K. Rao ,  Madhura Vipra

    IPC分类号： G01N33/48

    CPC分类号： G06K9/00127

    摘要： A method and system for automated quantitation of tissue micro-array image (TMA) digital analysis. The method and system automatically analyze a digital image of a TMA with plural TMA cores created using a needle to biopsy or other techniques to create standard histologic sections and placing the resulting needle cores into TMA. The automated analysis allows a medical conclusion such as a medical diagnosis or medical prognosis (e.g., for a human cancer) to be automatically determined. The method and system provides reliable automatic TMA core gridding and automated TMA core boundary detection including detection of overlapping or touching TMA cores on a grid.

    摘要翻译： 一种用于自动定量组织微阵列图像（TMA）数字分析的方法和系统。 该方法和系统自动分析TMA的数字图像，其具有使用针进行活检或其他技术创建的多个TMA芯，以创建标准组织切片并将所得到的针芯置于TMA中。 自动分析允许自动确定例如医学诊断或医学预后（例如，对于人类癌症）的医学结论。 该方法和系统提供可靠的自动TMA核心网格化和自动TMA核心边界检测，包括检测网格上的重叠或触摸TMA核心。

    METHOD FOR AUTOMATED PROCESSING OF DIGITAL IMAGES OF TISSUE MICRO-ARRAYS (TMA)
    6.
    发明申请
    METHOD FOR AUTOMATED PROCESSING OF DIGITAL IMAGES OF TISSUE MICRO-ARRAYS (TMA) 有权
    组织微阵列数字图像自动处理方法（TMA）

    公开(公告)号：US20120093387A1

    公开(公告)日：2012-04-19

    申请号：US13292290

    申请日：2011-11-09

    申请人： Abhijeet S. Gholap ,  Gauri A. Gholap ,  Prithviraj Jadhav ,  Sanford H. Barsky ,  C. V. K. Rao ,  Madhura Vipra

    发明人： Abhijeet S. Gholap ,  Gauri A. Gholap ,  Prithviraj Jadhav ,  Sanford H. Barsky ,  C. V. K. Rao ,  Madhura Vipra

    IPC分类号： G06K9/00

    CPC分类号： G06K9/00127

    摘要： A method and system for automated quantitation of tissue micro-array image (TMA) digital analysis. The method and system automatically analyze a digital image of a TMA with plural TMA cores created using a needle to biopsy or other techniques to create standard histologic sections and placing the resulting needle cores into TMA. The automated analysis allows a medical conclusion such as a medical diagnosis or medical prognosis (e.g., for a human cancer) to be automatically determined. The method and system provides reliable automatic TMA core gridding and automated TMA core boundary detection including detection of overlapping or touching TMA cores on a grid.

    摘要翻译： 一种用于自动定量组织微阵列图像（TMA）数字分析的方法和系统。 该方法和系统自动分析TMA的数字图像，其具有使用针进行活检或其他技术创建的多个TMA芯，以创建标准组织切片并将所得到的针芯置于TMA中。 自动分析允许自动确定例如医学诊断或医学预后（例如，对于人类癌症）的医学结论。 该方法和系统提供可靠的自动TMA核心网格化和自动TMA核心边界检测，包括检测网格上的重叠或触摸TMA核心。

    Methods and kits for identifying ductal orifices
    8.
    发明授权
    Methods and kits for identifying ductal orifices 失效
    识别导管孔的方法和试剂盒

    公开(公告)号：US06168779A

    公开(公告)日：2001-01-02

    申请号：US08931786

    申请日：1997-09-16

    申请人： Sanford H. Barsky ,  Susan M. Love

    发明人： Sanford H. Barsky ,  Susan M. Love

    IPC分类号： A61K4900

    CPC分类号： A61K49/0058 ,  A61K49/0013 ,  A61K49/0043 ,  A61K49/006

    摘要： Methods, kits, and apparatus for locating, labelling, and accessing breast ducts are described. An orifice to one or more ductal networks is labelled using a specific binding substance, typically an antibody, specific for a tissue marker present on the orifice. Exemplary tissue markers include those present on the ductal epithelium, such as cytokeratins, including cytokeratin 8 and cytokeratin 18; E cadhedrin; and epithelial membrane antigen. Labelling of the ductal orifices permits reliable identification and access to each of the multiple ductal networks which may be present in an individual breast.

    摘要翻译： 描述了用于定位，标记和访问乳房导管的方法，套件和装置。 使用针对存在于孔口上的组织标记特异性的特异性结合物质（通常为抗体）来标记对一个或多个导管网络的孔。 示例性组织标志物包括存在于导管上皮上的那些，例如细胞角蛋白，包括细胞角蛋白8和细胞角蛋白18; 脑脊液 和上皮膜抗原。 导管孔的标记允许对可能存在于单个乳房中的多个导管网络中的每一个进行可靠的识别和访问。

    Methods for performing medical procedures within a breast duct
    9.
    发明授权
    Methods for performing medical procedures within a breast duct 有权
    在乳房管内执行医疗手术的方法

    公开(公告)号：US06890311B2

    公开(公告)日：2005-05-10

    申请号：US10099439

    申请日：2002-03-15

    申请人： Susan M. Love ,  Sanford H. Barsky

    发明人： Susan M. Love ,  Sanford H. Barsky

    IPC分类号： A61B10/00 ,  A61K49/00 ,  A61B5/00

    CPC分类号： A61B10/0045 ,  A61B10/0041 ,  A61K49/0013 ,  A61K49/0043 ,  A61K49/0058 ,  A61K49/006

    摘要： Methods for performing medical procedures within the duct of a breast are described. An exemplary embodiment of the invention includes the steps of introducing a guiding member into a breast duct; introducing and positioning a member having an internal lumen in the breast duct; introducing a wash fluid into the breast duct through the internal lumen; removing washings from the breast duct through the internal lumen; and collecting the washings for cytological analysis.

    摘要翻译： 描述了在乳房导管内执行医疗手术的方法。 本发明的示例性实施例包括以下步骤：将引导构件引入到胸罩中; 引导和定位在乳房管道中具有内腔的构件; 通过内腔将洗液引入乳房管道; 通过内腔清除乳房管道的洗涤液; 并收集洗涤液进行细胞学分析。