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公开(公告)号：US20050272680A1
公开(公告)日：2005-12-08
申请号：US11066725
申请日：2005-02-24
申请人： Sanjay Bhanot , Kenneth Dobie , Xing-Xian Yu , Brett Monia
发明人： Sanjay Bhanot , Kenneth Dobie , Xing-Xian Yu , Brett Monia
IPC分类号： C07H21/02 , C12N15/113 , A61K48/00
CPC分类号： C12N15/1137 , C07H21/02 , C12N2310/11 , C12N2310/14
摘要： Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节二酰基甘油酰基转移酶2的表达。该组合物包含靶向编码二酰基甘油酰基转移酶的核酸的寡核苷酸2.使用这些化合物调节二酰基甘油酰基转移酶2表达并用于诊断和治疗疾病的方法 提供了与二酰基甘油酰基转移酶2的表达相关的病症。
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公开(公告)号：US20050043524A1
公开(公告)日：2005-02-24
申请号：US10643801
申请日：2003-08-18
申请人： Sanjay Bhanot , Kenneth Dobie , Xing-Xian Yu
发明人： Sanjay Bhanot , Kenneth Dobie , Xing-Xian Yu
IPC分类号： C07H21/02 , C12N15/113 , A61K48/00
CPC分类号： C12N15/1137 , C07H21/02 , C12N2310/11 , C12N2310/14
摘要： Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of disease associated with expression of diacylglycerol acyltransferase 2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节二酰基甘油酰基转移酶2的表达。该组合物包含靶向编码二酰基甘油酰基转移酶的核酸的寡核苷酸2.使用这些化合物调节二酰基甘油酰基转移酶2表达并用于诊断和治疗疾病相关的方法 提供二酰基甘油酰基转移酶2的表达。
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公开(公告)号：US20110177097A1
公开(公告)日：2011-07-21
申请号：US12993435
申请日：2009-05-22
申请人： Gerald Shulman , Sanjay Bhanot , Xing-Xian Yu , Brett P. Monia
发明人： Gerald Shulman , Sanjay Bhanot , Xing-Xian Yu , Brett P. Monia
IPC分类号： A61K39/395 , A61K31/7088 , A61K38/02 , A61K31/7125 , A61K31/712 , A61K31/7115 , A61P3/00 , A61P9/00 , A61P3/06 , A61P3/04 , A61P3/10 , A61P9/10 , A61P1/16 , A61P5/50
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Methods are provided for modulating CREB by administering a CREB-specific modulator. Also provided are methods for treating cardiovascular and metabolic disorders in a subject or delaying or preventing risk factors thereof through the modulation of CREB. The present invention is also directed to methods of decreasing lipid levels in a subject or for preventing or delaying the onset of a rise in lipid levels in a subject, comprising administering to said subject a CREB-specific inhibitor.
摘要翻译： 提供了通过施用CREB特异性调节剂调节CREB的方法。 还提供了通过调节CREB来治疗受试者的心血管和代谢紊乱或延缓或预防其危险因素的方法。 本发明还涉及降低受试者中的脂质水平或用于预防或延迟受试者中脂质水平升高的发生的方法，包括向所述受试者施用CREB特异性抑制剂。
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4.发明申请公开(公告)号：US20090054359A1
公开(公告)日：2009-02-26
申请号：US11834640
申请日：2007-08-06
申请人： Xing-Xian Yu , Sanjay Bhanot , Brett P. Monia
发明人： Xing-Xian Yu , Sanjay Bhanot , Brett P. Monia
IPC分类号： A61K31/7052 , A61P1/16
CPC分类号： C12N15/1137 , C12N2310/11 , C12Y203/0102
摘要： Disclosed herein are compounds, compositions and methods for modulating DGAT-1 activity. Preferably, the expression of DGAT-1 from a nucleic acid is inhibited. Methods are provided for treating, ameliorating or treating liver fibrosis, either directly or by treating an underlying etiological factor. Preferably, the treatment, amelioration or prevention comprises administering a DGAT-1 activity modulator.
摘要翻译： 本文公开了用于调节DGAT-1活性的化合物，组合物和方法。 优选地，来自核酸的DGAT-1的表达被抑制。 提供了直接治疗或改善肝纤维化或通过治疗潜在病因的方法。 优选地，治疗，改善或预防包括施用DGAT-1活性调节剂。
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5.发明申请公开(公告)号：US20120029050A1
公开(公告)日：2012-02-02
申请号：US13177457
申请日：2011-07-06
申请人： Xing-Xian Yu , Sanjay Bhanot , Brett P. Monia
发明人： Xing-Xian Yu , Sanjay Bhanot , Brett P. Monia
IPC分类号： A61K31/713 , A61P1/16
CPC分类号： C12N15/1137 , C12N2310/11 , C12Y203/0102
摘要： Disclosed herein are compounds, compositions and methods for modulating DGAT-1 activity. Preferably, the expression of DGAT-1 from a nucleic acid is inhibited. Methods are provided for treating, ameliorating or treating liver fibrosis, either directly or by treating an underlying etiological factor. Preferably, the treatment, amelioration or prevention comprises administering a DGAT-1 activity modulator.
摘要翻译： 本文公开了用于调节DGAT-1活性的化合物，组合物和方法。 优选地，来自核酸的DGAT-1的表达被抑制。 提供了直接治疗或改善肝纤维化或通过治疗潜在病因的方法。 优选地，治疗，改善或预防包括施用DGAT-1活性调节剂。
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公开(公告)号：US08101585B2
公开(公告)日：2012-01-24
申请号：US11834672
申请日：2007-08-06
申请人： Xing-Xian Yu , Sanjay Bhanot
发明人： Xing-Xian Yu , Sanjay Bhanot
CPC分类号： A61K31/07 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： The invention provides compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a gene encoding a Jun N-terminal kinase 1 (JNK1 protein.
摘要翻译： 本发明提供了用于治疗和诊断适于通过调节编码JunN-末端激酶1（JNK1蛋白）的基因的表达进行治疗的疾病或病症的组合物和方法。
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公开(公告)号：US20080255030A1
公开(公告)日：2008-10-16
申请号：US11834672
申请日：2007-08-06
申请人： Xing-Xian Yu , Sanjay Bhanot
发明人： Xing-Xian Yu , Sanjay Bhanot
IPC分类号： A61K38/28 , A61K31/155 , A61K31/426 , A61K31/17 , A61K31/4436 , A61K31/70 , A61K31/445 , A61K31/40 , A61K31/35 , A61K31/403 , A61K31/505 , A61K31/397 , A61K31/551 , A61K31/519 , A61K31/7052 , A61P3/10 , A61P3/00 , A61P9/00
CPC分类号： A61K31/07 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： The invention provides compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a gene encoding a Jun N-terminal kinase 1 (JNK1 protein.
摘要翻译： 本发明提供了用于治疗和诊断适于通过调节编码JunN-末端激酶1（JNK1蛋白）的基因的表达进行治疗的疾病或病症的组合物和方法。
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8.发明授权公开(公告)号：US08486904B2
公开(公告)日：2013-07-16
申请号：US12681360
申请日：2008-10-01
申请人： Sanjay Bhanot , Xing-Xian Yu , Susan M. Freier , Ravi Jain
发明人： Sanjay Bhanot , Xing-Xian Yu , Susan M. Freier , Ravi Jain
CPC分类号： C12N15/1138 , A61K31/7105 , A61K45/06 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of fibroblast growth factor receptor 4 (FGFR4). The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding fibroblast growth factor receptor 4. Methods of using these compounds for modulation of fibroblast growth factor receptor 4 expression and for treatment of diseases associated with expression of fibroblast growth factor receptor 4 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节成纤维细胞生长因子受体4（FGFR4）的表达。 组合物包含靶向编码成纤维细胞生长因子受体4的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节成纤维细胞生长因子受体4表达和治疗与成纤维细胞生长因子受体4表达相关的疾病的方法是 提供。
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公开(公告)号：US20130123331A1
公开(公告)日：2013-05-16
申请号：US13566674
申请日：2012-08-03
申请人： Sanjay Bhanot , Kenneth W. Dobie , Xing-Xian Yu , Brett P. Monia
发明人： Sanjay Bhanot , Kenneth W. Dobie , Xing-Xian Yu , Brett P. Monia
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , C07H21/02 , C12N2310/11 , C12N2310/14
摘要： Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节二酰基甘油酰基转移酶2的表达。该组合物包含靶向编码二酰基甘油酰基转移酶的核酸的寡核苷酸2.使用这些化合物调节二酰基甘油酰基转移酶2表达并用于诊断和治疗疾病的方法 提供了与二酰基甘油酰基转移酶2的表达相关的病症。
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10.发明授权公开(公告)号：US08003620B2
公开(公告)日：2011-08-23
申请号：US11834640
申请日：2007-08-06
申请人： Xing-Xian Yu , Sanjay Bhanot , Brett P. Monia
发明人： Xing-Xian Yu , Sanjay Bhanot , Brett P. Monia
CPC分类号： C12N15/1137 , C12N2310/11 , C12Y203/0102
摘要： Disclosed herein are compounds, compositions and methods for modulating DGAT-1 activity. Preferably, the expression of DGAT-1 from a nucleic acid is inhibited. Methods are provided for treating, ameliorating or treating liver fibrosis, either directly or by treating an underlying etiological factor. Preferably, the treatment, amelioration or prevention comprises administering a DGAT-1 activity modulator.
摘要翻译： 本文公开了用于调节DGAT-1活性的化合物，组合物和方法。 优选地，来自核酸的DGAT-1的表达被抑制。 提供了直接治疗或改善肝纤维化或通过治疗潜在病因的方法。 优选地，治疗，改善或预防包括施用DGAT-1活性调节剂。
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