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42 条记录 (耗时 0.048 秒)

    Human monoclonal antibodies that bind CXCR4
    7.
    发明授权
    Human monoclonal antibodies that bind CXCR4 有权
    结合CXCR4的人单克隆抗体

    公开(公告)号：US08450464B2

    公开(公告)日：2013-05-28

    申请号：US12444130

    申请日：2007-10-01

    申请人： Michelle Kuhne ,  Peter Brams ,  Dawn M. Tanamachi ,  Alan J. Korman ,  Josephine M. Cardarelli

    发明人： Michelle Kuhne ,  Peter Brams ,  Dawn M. Tanamachi ,  Alan J. Korman ,  Josephine M. Cardarelli

    IPC分类号： C07K16/28 ,  C07K16/00 ,  A61K39/395

    CPC分类号： C07K16/2866 ,  A61K47/6803 ,  A61K47/6849 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76

    摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to CXCR4 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CXCR4, as well as methods for treating various cancers, inflammatory disorders and HIV infection using an anti-CXCR4 antibody of this disclosure.

    摘要翻译： 本公开提供以高亲和力特别是人单克隆抗体特异性结合CXCR4的分离的单克隆抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了用于检测CXCR4的方法，以及使用本公开的抗CXCR4抗体治疗各种癌症，炎性疾病和HIV感染的方法。

    Interferon Alpha Receptor I Antibodies And Their Use
    10.
    发明申请
    Interferon Alpha Receptor I Antibodies And Their Use 有权
    干扰素α受体I抗体及其用途

    公开(公告)号：US20100143369A1

    公开(公告)日：2010-06-10

    申请号：US12704948

    申请日：2010-02-12

    申请人： Josephine M. Cardarelli ,  Alison Witte ,  Mohan Srinivasan

    发明人： Josephine M. Cardarelli ,  Alison Witte ,  Mohan Srinivasan

    IPC分类号： A61K39/395 ,  A61P37/06

    CPC分类号： C07K16/2866 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92

    摘要： The present invention provides isolated human monoclonal antibodies that bind to IFNAR-1 and that are capable of inhibiting the biological activity of Type I interferons. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting Type I interferon-mediated disorders using the antibodies of the invention, including methods for treating autoimmune disorders, transplant rejection or Graft Versus Host Disease using the antibodies of the invention.

    摘要翻译： 本发明提供了与IFNAR-1结合并且能够抑制I型干扰素的生物活性的分离的人单克隆抗体。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体抑制I型干扰素介导的病症的方法，包括使用本发明的抗体治疗自身免疫疾病，移植排斥或移植物抗宿主病的方法。