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    AMINE-CONTAINING COMPOUND ANALYSIS METHODS
    7.
    发明申请
    AMINE-CONTAINING COMPOUND ANALYSIS METHODS 有权
    含胺化合物分析方法

    公开(公告)号：US20100093011A1

    公开(公告)日：2010-04-15

    申请号：US12555319

    申请日：2009-09-08

    申请人： Subodh B. NIMKAR ,  Subhasish Purkayastha ,  Darryl Pappin ,  Scott Daniels

    发明人： Subodh B. NIMKAR ,  Subhasish Purkayastha ,  Darryl Pappin ,  Scott Daniels

    IPC分类号： C12Q1/26 ,  G01N33/00 ,  G01N33/68

    CPC分类号： G01N33/6848 ,  Y10T436/142222 ,  Y10T436/173845 ,  Y10T436/24

    摘要： The present teachings provide methods for analyzing one or more amine-containing compounds in one or more samples using isobaric labels and parent-daughter ion transition monitoring (PDITM). In various embodiments, the methods comprise the steps of: (a) labeling one or more amine-containing compounds with different isobaric tags from a set of isobaric tags, each isobaric tag comprising a reporter ion portion; (b) combining at least a portion of each of the isobarically labeled amine-containing compounds to produce a combined sample; (c) subjecting at least a portion of the combined sample to PDITM; (d) measuring the ion signal of one or more of the transmitted reporter ions; and (e) determining the concentration of one or more of the isobarically labeled amine-containing compounds based at least on a comparison of the measured ion signal of the corresponding reporter ion to one or more measured ion signals of a standard compound.

    摘要翻译： 本教导提供了使用等压标记和亲 - 子离子跃迁监测（PDITM）在一个或多个样品中分析一种或多种含胺化合物的方法。 在各种实施方案中，所述方法包括以下步骤：（a）从一组等压标签组合标记具有不同等压标签的一种或多种含胺化合物，每个同量异位标签包含报告离子部分; （b）将每个等压标记的含胺化合物的至少一部分合并以产生组合的样品; （c）使组合样品的至少一部分经受PDITM; （d）测量一个或多个所传递的报道离子的离子信号; 至少基于相应报道离子的测量离子信号与标准化合物的一个或多个测量离子信号的比较来确定一种或多种等压标记的含胺化合物的浓度。

    Amine-containing compound analysis methods
    8.
    发明授权
    Amine-containing compound analysis methods 有权
    含胺化合物分析方法

    公开(公告)号：US08569071B2

    公开(公告)日：2013-10-29

    申请号：US12555319

    申请日：2009-09-08

    申请人： Subodh B. Nimkar ,  Subhasish Purkayastha ,  Darryl Pappin ,  Scott Daniels

    发明人： Subodh B. Nimkar ,  Subhasish Purkayastha ,  Darryl Pappin ,  Scott Daniels

    IPC分类号： G01N24/00

    CPC分类号： G01N33/6848 ,  Y10T436/142222 ,  Y10T436/173845 ,  Y10T436/24

    摘要： The present teachings provide methods for analyzing one or more amine-containing compounds in one or more samples using isobaric labels and parent-daughter ion transition monitoring (PDITM). In various embodiments, the methods comprise the steps of: (a) labeling one or more amine-containing compounds with different isobaric tags from a set of isobaric tags, each isobaric tag comprising a reporter ion portion; (b) combining at least a portion of each of the isobarically labeled amine-containing compounds to produce a combined sample; (c) subjecting at least a portion of the combined sample to PDITM; (d) measuring the ion signal of one or more of the transmitted reporter ions; and (e) determining the concentration of one or more of the isobarically labeled amine-containing compounds based at least on a comparison of the measured ion signal of the corresponding reporter ion to one or more measured ion signals of a standard compound.

    摘要翻译： 本教导提供了使用等压标记和亲 - 子离子跃迁监测（PDITM）在一个或多个样品中分析一种或多种含胺化合物的方法。 在各种实施方案中，所述方法包括以下步骤：（a）从一组等压标签组合标记具有不同等压标签的一种或多种含胺化合物，每个同量异位标签包含报告离子部分; （b）将每个等压标记的含胺化合物的至少一部分合并以产生组合的样品; （c）使组合样品的至少一部分经受PDITM; （d）测量一个或多个所传递的报道离子的离子信号; 至少基于相应报道离子的测量离子信号与标准化合物的一个或多个测量离子信号的比较来确定一种或多种等压标记的含胺化合物的浓度。

    Amine-containing compound analysis methods
    9.
    发明申请
    Amine-containing compound analysis methods 审中-公开

    公开(公告)号：US20060183238A1

    公开(公告)日：2006-08-17

    申请号：US11350147

    申请日：2006-02-08

    申请人： Subodh Nimkar ,  Subhasish Purkayastha ,  Darryl Pappin ,  Scott Daniels

    发明人： Subodh Nimkar ,  Subhasish Purkayastha ,  Darryl Pappin ,  Scott Daniels

    IPC分类号： G01N33/00

    CPC分类号： G01N33/6848 ,  Y10T436/142222 ,  Y10T436/173845 ,  Y10T436/24

    摘要： The present teachings provide methods for analyzing one or more amine-containing compounds in one or more samples using isobaric labels and parent-daughter ion transition monitoring (PDITM). In various embodiments, the methods comprise the steps of: (a) labeling one or more amine-containing compounds with different isobaric tags from a set of isobaric tags, each isobaric tag comprising a reporter ion portion; (b) combining at least a portion of each of the isobarically labeled amine-containing compounds to produce a combined sample; (c) subjecting at least a portion of the combined sample to PDITM; (d) measuring the ion signal of one or more of the transmitted reporter ions; and (e) determining the concentration of one or more of the isobarically labeled amine-containing compounds based at least on a comparison of the measured ion signal of the corresponding reporter ion to one or more measured ion signals of a standard compound.