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15 条记录 (耗时 0.031 秒)

    Preparation of 6-oxa-1-azatricyclo(6.2.2.0.sup.2,7)dodecane-5-ones
    1.
    发明授权
    Preparation of 6-oxa-1-azatricyclo(6.2.2.0.sup.2,7)dodecane-5-ones 失效
    6-氧杂-1-氮杂三环（6.2.2.02,7）十二烷-5-酮的制备

    公开(公告)号：US4309544A

    公开(公告)日：1982-01-05

    申请号：US58968

    申请日：1979-07-20

    申请人： Sasson Cohen ,  Abraham Fisher

    发明人： Sasson Cohen ,  Abraham Fisher

    IPC分类号： C07D453/02 ,  C07D487/02

    CPC分类号： C07D453/02

    摘要： The invention relates to the production of compounds of the general formula: ##STR1## wherein X is selected from the group consisting of oxygen, CH.sub.2 and CH radicals, and when X designates oxygen, R designates alkyl, isoalkyl, aralkyl, and substituted aralkyl groups and when X designates CH.sub.2 then R designates alkyl, phenyl or substituted phenyl group, and A-B is a single bond, and when X designates CH.sub.2, R designates alkyl, phenyl or substituted phenyl groups and A-B is a double bond; and physiologically acceptable salts of these, and pharmaceutical composition containing the same as active ingredient.

    摘要翻译： 本发明涉及以下通式的化合物的制备：其中X选自氧，CH 2和CH自由基，当X表示氧时，R表示烷基，异烷基，芳烷基和取代的芳烷基 当X表示CH2时，R表示烷基，苯基或取代的苯基，AB表示单键，当X表示CH2时，R表示烷基，苯基或取代的苯基，AB表示双键; 和这些的生理上可接受的盐，以及含有与活性成分相同的药物组合物。

    1,8-Ethano-5-oxo-octa- and -decahydroquinolines and mydriatic compositions thereof
    2.
    发明授权
    1,8-Ethano-5-oxo-octa- and -decahydroquinolines and mydriatic compositions thereof 失效
    1,8-乙酸-5-氧代 - 八 - 和 - 十氢喹啉和散瞳组合物

    公开(公告)号：US4183938A

    公开(公告)日：1980-01-15

    申请号：US852402

    申请日：1977-11-17

    申请人： Sasson Cohen ,  Abraham Fisher

    发明人： Sasson Cohen ,  Abraham Fisher

    IPC分类号： C07D453/02 ,  A61K31/47 ,  C07D215/20

    CPC分类号： C07D453/02

    摘要： Compounds of the general formula: ##STR1## wherein X is selected from the group consisting of oxygen, CH.sub.2 and CH radicals, and when X designates oxygen, R designates alkyl, isoalkyl, aralkyl, and substituted aralkyl groups and when X designates CH.sub.2 then R designates alkyl, phenyl or substituted phenyl group, and A-B is a single bond, and when X designates CH.sub.2 R designates alkyl, phenyl or substituted phenyl groups and A-B is a double bond; and physiologically acceptable salts of these, and mydriatic pharmaceutical compositions containing the same as active ingredient.

    摘要翻译： 通式为：其中X选自氧，CH 2和CH自由基的化合物，当X表示氧时，R表示烷基，异烷基，芳烷基和取代的芳烷基，当X表示CH2时，则R 表示烷基，苯基或取代的苯基，AB是单键，当X表示CH2 + L时，R表示烷基，苯基或取代的苯基，AB表示双键; 和这些的生理上可接受的盐，以及含有与活性成分相同的散瞳药物组合物。

    Novel heterocyclic compounds and pharmaceutical composition containing them
    3.
    发明授权
    Novel heterocyclic compounds and pharmaceutical composition containing them 失效
    新型杂环化合物和含有它们的药物组合物

    公开(公告)号：US4226996A

    公开(公告)日：1980-10-07

    申请号：US953514

    申请日：1978-10-23

    申请人： Sasson Cohen ,  Abraham Fisher

    发明人： Sasson Cohen ,  Abraham Fisher

    IPC分类号： C07D453/02 ,  C07D491/04 ,  C07D491/08

    CPC分类号： C07D453/02

    摘要： The invention relates to the production of compounds of the general formula: ##STR1## wherein X is selected from the group consisting of oxygen, CH.sub.2 and CH radicals, and when X designates oxygen, R designates alkyl, isoalkyl, aralkyl, and substituted aralkyl groups and when X designates CH.sub.2 then R designates alkyl, phenyl or substituted phenyl group, and A-B is a single bond, and when X designates CH.sub.2, R designates alkyl, phenyl or substituted phenyl groups and A-B is a double bond; and physiologically acceptable salts of these, and pharmaceutical compositions containing the same as active ingredient.

    摘要翻译： 本发明涉及以下通式的化合物的制备：其中X选自氧，CH 2和CH自由基，当X表示氧时，R表示烷基，异烷基，芳烷基和取代的芳烷基 当X表示CH2时，R表示烷基，苯基或取代的苯基，AB表示单键，当X表示CH2时，R表示烷基，苯基或取代的苯基，AB表示双键; 和这些的生理上可接受的盐，以及含有与活性成分相同的药物组合物。

    Spiro (1,3-dioxolane-4,3') quinuclidine compounds
    4.
    发明授权
    Spiro (1,3-dioxolane-4,3') quinuclidine compounds 失效
    螺（1,3-二氧戊环-4,3（40）奎宁环化合物

    公开(公告)号：US4104397A

    公开(公告)日：1978-08-01

    申请号：US656056

    申请日：1976-02-06

    申请人： Sasson Cohen ,  Abraham Fisher

    发明人： Sasson Cohen ,  Abraham Fisher

    IPC分类号： A61K31/435 ,  A61P25/02 ,  A61P27/02 ,  A61P27/06 ,  C07D491/20 ,  A61K31/445 ,  C07D455/02

    CPC分类号： C07D491/20

    摘要： Novel spiro (1,3-dioxolane-4,3') quinuclidine compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2, which may be identical or different, each designates a member of the group hydrogen, alkyl or aryl; a process for the production of these and pharmaceutical compositions of matter containing such compound as active ingredient.

    摘要翻译： 式（IMAGE）的新型螺（1,3-二氧戊环-4,3'）奎宁环化合物，其中R 1和R 2可以相同或不同，各自表示氢，烷基或芳基; 用于生产这些和含有这种化合物作为活性成分的物质的药物组合物的方法。

    6-Oxa-1-aza tricyclo dodecan-5-ones as psychomotor stimulators
    5.
    发明授权
    6-Oxa-1-aza tricyclo dodecan-5-ones as psychomotor stimulators 失效
    6-Oxa-1-氮杂三环十二烷-5-酮作为精神运动刺激物

    公开(公告)号：US4083985A

    公开(公告)日：1978-04-11

    申请号：US655650

    申请日：1976-02-06

    申请人： Sasson Cohen ,  Abraham Fisher

    发明人： Sasson Cohen ,  Abraham Fisher

    IPC分类号： C07D453/00 ,  A61K31/435 ,  A61P1/12 ,  A61P3/04 ,  A61P25/00 ,  A61P25/26 ,  A61P25/30 ,  A61P27/02 ,  A61P43/00 ,  B01J23/00 ,  C07B61/00 ,  C07D453/02 ,  C07D491/04 ,  C07D491/18 ,  A61K31/535

    CPC分类号： C07D453/02

    摘要： Compounds of the general formula ##STR1## wherein X is selected from the group consisting of oxygen CH.sub.2 and CH radicals, and when X designates oxygen, R designates alkyl, isoalkyl, aralkyl, and substituted aryl groups and when X designates ##STR2## then R designates alkyl, phenyl or substituted phenyl group, and A--B is a single bond and when X designates >CH, and A--B is a double bond, R designates alkyl, phenyl or substituted phenyl groups and physiologically acceptable salts of these, and pharmaceutical compositions containing same as active ingredient.

    摘要翻译： 通式为其中X选自氧CH 2和CH基团的通式为其中的化合物，当X表示氧时，R表示烷基，异烷基，芳烷基和取代的芳基，当X表示时， R表示烷基，苯基或取代的苯基，AB是单键，当X表示> CH时，AB表示双键，R表示烷基，苯基或取代的苯基及其生理学上可接受的盐， 与活性成分相同。

    Antiarrhythmic quinuclidine carboxylic acid xylidide and method of producing the same and similar compounds
    6.
    发明授权
    Antiarrhythmic quinuclidine carboxylic acid xylidide and method of producing the same and similar compounds 失效
    抗坏血酸喹喔啉羧酸酰亚胺及其制备方法及类似化合物

    公开(公告)号：US4146628A

    公开(公告)日：1979-03-27

    申请号：US821748

    申请日：1977-08-04

    申请人： Edna Oppenheimer ,  Eliezer Kaplinsky ,  Sasson Cohen

    发明人： Edna Oppenheimer ,  Eliezer Kaplinsky ,  Sasson Cohen

    IPC分类号： A61K31/445

    CPC分类号： A61K31/445 ,  Y10S514/821

    摘要： The invention relates to the compound 2-6-xylidide of quinuclidine-3-carboxylic acid and its pharmaceutically acceptable salts, such as the hydrochloride, which have been found to be effective antiarrhythmic agents. The invention further relates to the production of this antiarrhythmic compound which method is applicable also to the production of related compounds which, however, do not have antiarrhythmic action, e.g. the quinuclidine-2-carboxylic acid xylidides. The compounds are produced according to this method by reacting the quinuclidine carboxylic acid in anhydrous chloroform and oxalyl chloride with the dimethylaniline. The desired compound is produced in high yield with a high degree of purity.

    Pharmaceutical compositions comprising S-(−)-N-propargyl-1-aminoindan
    9.
    发明授权
    Pharmaceutical compositions comprising S-(−)-N-propargyl-1-aminoindan 有权
    包含S - （ - ） - N-炔丙基-1-氨基茚满的药物组合物

    公开(公告)号：US06277886B1

    公开(公告)日：2001-08-21

    申请号：US09228153

    申请日：1999-01-11

    申请人： Ruth Levy ,  Moussa B. H. Youdim ,  John P. M. Finberg ,  Sasson Cohen ,  Jeff Sterling

    发明人： Ruth Levy ,  Moussa B. H. Youdim ,  John P. M. Finberg ,  Sasson Cohen ,  Jeff Sterling

    IPC分类号： A61K31135

    CPC分类号： C07C211/42 ,  A61K31/135 ,  C07C2602/08 ,  Y10S514/878 ,  Y10S514/879 ,  Y10S514/903

    摘要： Pharmaceutical compositions for the treatment of a neurological disorder of neurotrauma or for improving memory in a patient comprising a therapeutically effective amount of S-(−)-N-proparygl-1-aminoindan or a pharmaceutically acceptable salt thereof as active ingredient, and a pharmaceutically active carrier. The pharmaceutical compositions are adapted, in particular for treating a neurological hypoxia or anoxia, neurodegenerative diseases. Parkinson's Disease, Alzheimer's Disease, neurotoxic injury, head trauma injury, spinal trauma injury or any other form of nerve damage.

    摘要翻译： 用于治疗神经损伤神经障碍或改善患者记忆力的药物组合物，其包含治疗有效量的S-（ - ） - N-丙酰基-1-氨基茚满或其药学上可接受的盐作为活性成分，和药学上可接受的盐 主动载体。 药物组合物特别适用于治疗神经缺氧或缺氧，神经变性疾病。 帕金森病，阿尔茨海默氏病，神经毒性损伤，头部创伤损伤，脊髓损伤或任何其他形式的神经损伤。