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15 条记录 (耗时 0.045 秒)

    Pharmaceutical compositions comprising S-(−)-N-propargyl-1-aminoindan
    5.
    发明授权
    Pharmaceutical compositions comprising S-(−)-N-propargyl-1-aminoindan 有权
    包含S - （ - ） - N-炔丙基-1-氨基茚满的药物组合物

    公开(公告)号：US06277886B1

    公开(公告)日：2001-08-21

    申请号：US09228153

    申请日：1999-01-11

    申请人： Ruth Levy ,  Moussa B. H. Youdim ,  John P. M. Finberg ,  Sasson Cohen ,  Jeff Sterling

    发明人： Ruth Levy ,  Moussa B. H. Youdim ,  John P. M. Finberg ,  Sasson Cohen ,  Jeff Sterling

    IPC分类号： A61K31135

    CPC分类号： C07C211/42 ,  A61K31/135 ,  C07C2602/08 ,  Y10S514/878 ,  Y10S514/879 ,  Y10S514/903

    摘要： Pharmaceutical compositions for the treatment of a neurological disorder of neurotrauma or for improving memory in a patient comprising a therapeutically effective amount of S-(−)-N-proparygl-1-aminoindan or a pharmaceutically acceptable salt thereof as active ingredient, and a pharmaceutically active carrier. The pharmaceutical compositions are adapted, in particular for treating a neurological hypoxia or anoxia, neurodegenerative diseases. Parkinson's Disease, Alzheimer's Disease, neurotoxic injury, head trauma injury, spinal trauma injury or any other form of nerve damage.

    摘要翻译： 用于治疗神经损伤神经障碍或改善患者记忆力的药物组合物，其包含治疗有效量的S-（ - ） - N-丙酰基-1-氨基茚满或其药学上可接受的盐作为活性成分，和药学上可接受的盐 主动载体。 药物组合物特别适用于治疗神经缺氧或缺氧，神经变性疾病。 帕金森病，阿尔茨海默氏病，神经毒性损伤，头部创伤损伤，脊髓损伤或任何其他形式的神经损伤。

    Antiarrhythmic quinuclidine carboxylic acid xylidide and method of producing the same and similar compounds
    7.
    发明授权
    Antiarrhythmic quinuclidine carboxylic acid xylidide and method of producing the same and similar compounds 失效
    抗坏血酸喹喔啉羧酸酰亚胺及其制备方法及类似化合物

    公开(公告)号：US4146628A

    公开(公告)日：1979-03-27

    申请号：US821748

    申请日：1977-08-04

    申请人： Edna Oppenheimer ,  Eliezer Kaplinsky ,  Sasson Cohen

    发明人： Edna Oppenheimer ,  Eliezer Kaplinsky ,  Sasson Cohen

    IPC分类号： A61K31/445

    CPC分类号： A61K31/445 ,  Y10S514/821

    摘要： The invention relates to the compound 2-6-xylidide of quinuclidine-3-carboxylic acid and its pharmaceutically acceptable salts, such as the hydrochloride, which have been found to be effective antiarrhythmic agents. The invention further relates to the production of this antiarrhythmic compound which method is applicable also to the production of related compounds which, however, do not have antiarrhythmic action, e.g. the quinuclidine-2-carboxylic acid xylidides. The compounds are produced according to this method by reacting the quinuclidine carboxylic acid in anhydrous chloroform and oxalyl chloride with the dimethylaniline. The desired compound is produced in high yield with a high degree of purity.

    Preparation of 6-oxa-1-azatricyclo(6.2.2.0.sup.2,7)dodecane-5-ones
    10.
    发明授权
    Preparation of 6-oxa-1-azatricyclo(6.2.2.0.sup.2,7)dodecane-5-ones 失效
    6-氧杂-1-氮杂三环（6.2.2.02,7）十二烷-5-酮的制备

    公开(公告)号：US4309544A

    公开(公告)日：1982-01-05

    申请号：US58968

    申请日：1979-07-20

    申请人： Sasson Cohen ,  Abraham Fisher

    发明人： Sasson Cohen ,  Abraham Fisher

    IPC分类号： C07D453/02 ,  C07D487/02

    CPC分类号： C07D453/02

    摘要： The invention relates to the production of compounds of the general formula: ##STR1## wherein X is selected from the group consisting of oxygen, CH.sub.2 and CH radicals, and when X designates oxygen, R designates alkyl, isoalkyl, aralkyl, and substituted aralkyl groups and when X designates CH.sub.2 then R designates alkyl, phenyl or substituted phenyl group, and A-B is a single bond, and when X designates CH.sub.2, R designates alkyl, phenyl or substituted phenyl groups and A-B is a double bond; and physiologically acceptable salts of these, and pharmaceutical composition containing the same as active ingredient.

    摘要翻译： 本发明涉及以下通式的化合物的制备：其中X选自氧，CH 2和CH自由基，当X表示氧时，R表示烷基，异烷基，芳烷基和取代的芳烷基 当X表示CH2时，R表示烷基，苯基或取代的苯基，AB表示单键，当X表示CH2时，R表示烷基，苯基或取代的苯基，AB表示双键; 和这些的生理上可接受的盐，以及含有与活性成分相同的药物组合物。