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    STABLE COMPOSITIONS COMPRISING CHROMOGENIC COMPOUNDS AND METHODS OF USE
    4.
    发明申请
    STABLE COMPOSITIONS COMPRISING CHROMOGENIC COMPOUNDS AND METHODS OF USE 审中-公开
    包含色素化合物的稳定组合物和使用方法

    公开(公告)号：US20120077211A1

    公开(公告)日：2012-03-29

    申请号：US13139873

    申请日：2009-12-15

    申请人： Lawrence Greenfield ,  Shawn Starkenburg ,  Matthew Shallice ,  Julie Nyhus ,  Louis Leong

    发明人： Lawrence Greenfield ,  Shawn Starkenburg ,  Matthew Shallice ,  Julie Nyhus ,  Louis Leong

    IPC分类号： G01N33/53 ,  C12Q1/28 ,  C09K3/00 ,  C07C211/54

    CPC分类号： G01N33/532 ,  C01B15/037

    摘要： Compositions, assays, methods, and kits are disclosed for use in applications that utilize oxidation of a chromogenic electron donor such as diaminobenzidine (DAB) to generate a signal. Applications include, but are not limited to, immunohistochemistry, chromogenic in situ hybridization, Western blots, Northern blots, Southern blots, ELISA assays, and microarray detection. The compositions, assays, methods, and kits disclosed herein make use of a novel, stabilized formulation of DAB and a novel, stabilized formulation of hydrogen peroxide.

    摘要翻译： 公开了组合物，测定法，方法和试剂盒，用于利用显色电子给体如二氨基联苯胺（DAB）氧化产生信号的应用中。 应用包括但不限于免疫组化，显色原位杂交，Western印迹，Northern印迹，Southern印迹，ELISA测定和微阵列检测。 本文公开的组合物，测定方法和试剂盒使用DAB的新型稳定制剂和新型稳定的过氧化氢制剂。

    Multiplex protease profiling
    7.
    发明申请
    Multiplex protease profiling 审中-公开
    多重蛋白酶分析

    公开(公告)号：US20050176076A1

    公开(公告)日：2005-08-11

    申请号：US11025608

    申请日：2004-12-28

    申请人： Hongye Sun ,  Lawrence Greenfield ,  Douglas Bost

    发明人： Hongye Sun ,  Lawrence Greenfield ,  Douglas Bost

    IPC分类号： C12Q1/37 ,  G01N33/53 ,  G01N33/537 ,  G01N33/543 ,  G01N33/574

    CPC分类号： C12Q1/37

    摘要： In certain embodiments, provided are methods and compositions useful for the detection and quantitation of catalytically active enzymes, particularly catalytically active proteases. The compositions comprise one or more multifunctional tags, wherein each different multifunctional tag comprises a different mobility modifier, a partitioner, a reporter, and a peptide substrate that is specifically or substantially specifically hydrolyzed by a target protease or target protease family. Hydrolysis of each different multifunctional tag by a target protease provides a different labeled hydrolytic product comprising a reporter and a mobility modifier but not a partitioner, where the mobility modifier confers a distinctive mobility on the labeled hydrolytic product in a mobility-dependent analysis technique.

    摘要翻译： 在某些实施方案中，提供了可用于检测和定量催化活性酶，特别是催化活性蛋白酶的方法和组合物。 组合物包含一个或多个多功能标签，其中每个不同的多功能标签包含由靶蛋白酶或靶蛋白酶家族特异性或基本上特异性水解的不同的迁移率调节剂，分隔器，报道分子和肽底物。 通过靶蛋白酶水解每种不同的多功能标签物提供了不同的标记的水解产物，其包含报道分子和迁移率调节剂，而不是分配器，其中迁移率调节剂在迁移依赖性分析技术中赋予标记的水解产物上独特的迁移率。

    Processing ambiguous search requests in a geographic information system
    8.
    发明授权
    Processing ambiguous search requests in a geographic information system 有权

    公开(公告)号：US10198521B2

    公开(公告)日：2019-02-05

    申请号：US11426760

    申请日：2006-06-27

    申请人： Lawrence Greenfield ,  Daniel Egnor ,  Francois Bailly ,  John Hanke

    发明人： Lawrence Greenfield ,  Daniel Egnor ,  Francois Bailly ,  John Hanke

    IPC分类号： G06F17/30 ,  G06F3/0481 ,  G06T17/05 ,  G06N7/00 ,  G06Q40/00

    摘要： Interactive geographic information systems (GIS) and techniques are disclosed that provide users with a greater degree of flexibility, utility, and information. A markup language is provided that facilitates communication between servers and clients of the interactive GIS, which enables a number of GIS features, such as network links (time-based and/or view-dependent dynamic data layers), ground overlays, screen overlays, placemarks, 3D models, and stylized GIS elements, such as geometry, icons, description balloons, polygons, and labels in the viewer by which the user sees the target area. Also, “virtual tours” of user-defined paths in the context of distributed geospatial visualization is enabled. Streaming and interactive visualization of filled polygon data are also enabled thereby allowing buildings and other such features to be provided in 3D. Also, techniques for enabling ambiguous search requests in a GIS are provided.