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1.发明授权公开(公告)号：US07838715B2
公开(公告)日：2010-11-23
申请号：US12357108
申请日：2009-01-21
IPC分类号： A62D3/30
CPC分类号： A61K9/0002
摘要： A drug deactivation system according to some embodiments includes at least one degradable capsule exposed to at least one drug-retaining region of a drug delivery device and an agent. The agent is configured to render a drug ineffective upon degradation of the at least one capsule. The at least one drug-retaining region is configured to retain one of the drug and the agent and the at least one capsule is configured to retain the other of the drug and the agent.
摘要翻译： 根据一些实施方案的药物失活系统包括暴露于药物递送装置和药剂的至少一个药物保持区域的至少一个可降解胶囊。 该药剂配置成使药物对至少一个胶囊的降解无效。 所述至少一个药物保持区被配置为保留药物和药剂中的一种，并且所述至少一个胶囊被配置为保留药物和药剂中的另一个。
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2.发明申请公开(公告)号：US20100185037A1
公开(公告)日：2010-07-22
申请号：US12357224
申请日：2009-01-21
IPC分类号： A62D3/11
CPC分类号： A61N7/00 , A61F7/00 , Y10S588/90
摘要： A drug deactivation system according to some embodiments includes at least one drug-retaining region of a drug delivery device and at least one energy source coupled to the at least one drug-retaining region. The at least one drug-retaining region may be configured to retain a drug. The at least one energy source may be configured to transmit energy to the drug. The drug is capable of being rendered ineffective in the presence of the transmitted energy.
摘要翻译： 根据一些实施方案的药物失活系统包括药物递送装置的至少一个药物保持区域和与至少一个药物保持区域耦合的至少一个能量源。 至少一个药物保持区域可以被配置为保留药物。 所述至少一个能量源可以被配置为向所述药物传输能量。 药物能够在传播能量的存在下变得无效。
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公开(公告)号：US08642830B2
公开(公告)日：2014-02-04
申请号：US13541607
申请日：2012-07-03
IPC分类号： A62D3/10
CPC分类号： A61N7/00 , A61F7/00 , Y10S588/90
摘要： A drug deactivation system according to some embodiments includes at least one drug-retaining region of a drug delivery device and at least one energy source coupled to the at least one drug-retaining region. The at least one drug-retaining region may be configured to retain a drug. The at least one energy source may be configured to transmit energy to the drug. The drug is capable of being rendered ineffective in the presence of the transmitted energy.
摘要翻译： 根据一些实施方案的药物失活系统包括药物递送装置的至少一个药物保持区域和与至少一个药物保持区域耦合的至少一个能量源。 至少一个药物保持区域可以被配置为保留药物。 所述至少一个能量源可以被配置为向所述药物传输能量。 药物能够在传播能量的存在下变得无效。
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公开(公告)号：US20120277514A1
公开(公告)日：2012-11-01
申请号：US13541607
申请日：2012-07-03
CPC分类号： A61N7/00 , A61F7/00 , Y10S588/90
摘要： A drug deactivation system according to some embodiments includes at least one drug-retaining region of a drug delivery device and at least one energy source coupled to the at least one drug-retaining region. The at least one drug-retaining region may be configured to retain a drug. The at least one energy source may be configured to transmit energy to the drug. The drug is capable of being rendered ineffective in the presence of the transmitted energy.
摘要翻译： 根据一些实施方案的药物失活系统包括药物递送装置的至少一个药物保持区域和与至少一个药物保持区域耦合的至少一个能量源。 至少一个药物保持区域可以被配置为保留药物。 所述至少一个能量源可以被配置为向所述药物传输能量。 药物能够在传播能量的存在下变得无效。
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公开(公告)号：US08236238B2
公开(公告)日：2012-08-07
申请号：US12357224
申请日：2009-01-21
IPC分类号： A61L2/00
CPC分类号： A61N7/00 , A61F7/00 , Y10S588/90
摘要： A drug deactivation system according to some embodiments includes at least one drug-retaining region of a drug delivery device and at least one energy source coupled to the at least one drug-retaining region. The at least one drug-retaining region may be configured to retain a drug. The at least one energy source may be configured to transmit energy to the drug. The drug is capable of being rendered ineffective in the presence of the transmitted energy.
摘要翻译： 根据一些实施方案的药物失活系统包括药物递送装置的至少一个药物保持区域和与至少一个药物保持区域耦合的至少一个能量源。 至少一个药物保持区域可以被配置为保留药物。 所述至少一个能量源可以被配置为向所述药物传输能量。 药物能够在传播能量的存在下变得无效。
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6.发明申请公开(公告)号：US20100185038A1
公开(公告)日：2010-07-22
申请号：US12357108
申请日：2009-01-21
IPC分类号： A62D3/30
CPC分类号： A61K9/0002
摘要： A drug deactivation system according to some embodiments includes at least one degradable capsule exposed to at least one drug-retaining region of a drug delivery device and an agent. The agent is configured to render a drug ineffective upon degradation of the at least one capsule. The at least one drug-retaining region is configured to retain one of the drug and the agent and the at least one capsule is configured to retain the other of the drug and the agent.
摘要翻译： 根据一些实施方案的药物失活系统包括暴露于药物递送装置和药剂的至少一个药物保持区域的至少一个可降解胶囊。 该药剂配置成使药物对至少一个胶囊的降解无效。 所述至少一个药物保持区被配置为保留药物和药剂中的一种，并且所述至少一个胶囊被配置为保留药物和药剂中的另一个。
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公开(公告)号：US07727768B2
公开(公告)日：2010-06-01
申请号：US11149632
申请日：2005-06-10
IPC分类号： G01N33/00
CPC分类号： B82Y15/00 , G01N25/4846 , G01N25/4866 , Y10S977/957 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： A method for detecting chemical reactions uses a nanocalorimeter having a substrate including thermal isolation capability residing on the substrate, thermal equilibration regions residing within the thermal isolation capability, and thermal measurement capability residing within each of the thermal equilibration regions. The thermal measurement device is connected to detection electronics. The method includes depositing drops of potentially reactive chemical solutions within the thermal equilibration region. These potentially reactive solution drops are merged through the use of drop merging electrodes residing within the thermal isolation region. The thermal change occurring within the merged solution drops is then measured with the detection electronics.
摘要翻译： 用于检测化学反应的方法使用具有包含驻留在基底上的热隔离能力的基底，驻留在热隔离能力内的热平衡区域和驻留在每个热平衡区域内的热测量能力的纳米光度计。 热测量设备连接到检测电子设备。 该方法包括在热平衡区域内沉积潜在的反应性化学溶液的液滴。 这些潜在的反应性溶液滴通过使用位于热隔离区域内的滴合并电极而合并。 然后用检测电子元件测量在合并溶液中发生的热变化。
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公开(公告)号：US07914735B2
公开(公告)日：2011-03-29
申请号：US11037666
申请日：2005-01-18
申请人： Francisco E. Torres , Michael Chabinyc , Scott Elrod , Eric Peeters , Gregory B. Anderson , Alan G. Bell , Richard H. Bruce
发明人： Francisco E. Torres , Michael Chabinyc , Scott Elrod , Eric Peeters , Gregory B. Anderson , Alan G. Bell , Richard H. Bruce
IPC分类号： G01N33/00
CPC分类号： G01N25/482 , G01K17/006
摘要： A detection system includes a detection device and an anti-evaporation device. The detection device comprises a region configured to merge at least two small drops and to detect a potential transient signal generated by the merger of the drops. The an anti-evaporation is configured to enclose the region and limit evaporation from the region. A method for detecting a signal includes the following steps: depositing drops of potentially reactive chemical solutions on a detection device within a drop-merging region; placing an anti-evaporation device over the drop-merging region to form a seal around the drop-merging region; merging the drops of potentially reactive chemical solutions; and measuring a signal occurring within the merged solution drops.
摘要翻译： 检测系统包括检测装置和防蒸发装置。 检测装置包括被配置为合并至少两个小液滴并且检测由液滴的合并产生的潜在瞬态信号的区域。 防蒸发被配置为包围该区域并限制该区域的蒸发。 一种用于检测信号的方法包括以下步骤：在滴合并区域内的检测装置上沉积潜在的反应性化学溶液滴; 将防蒸发装置放置在熔融合并区域上以形成围绕滴合并区域的密封; 合并潜在的活性化学溶液滴; 并且测量在合并溶液中发生的信号下降。
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公开(公告)号：US07141210B2
公开(公告)日：2006-11-28
申请号：US10114611
申请日：2002-04-01
IPC分类号： G01N31/00
CPC分类号： B82Y15/00 , G01N25/4846 , G01N25/4866 , Y10S977/957 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： A nanocalorimeter array for detecting chemical reactions includes at least one thermal isolation region residing on a substrate. Each thermal isolation region includes at least one thermal equilibration region, within which resides a thermal measurement device connected to detection electronics.
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10.发明授权公开(公告)号：US07416897B2
公开(公告)日：2008-08-26
申请号：US10719961
申请日：2003-11-21
CPC分类号： G01N25/4866 , B01J2219/00599 , B01J2219/00702 , C40B50/08 , Y10T436/11 , Y10T436/25 , Y10T436/25125 , Y10T436/2575
摘要： A method is disclosed for high-throughput screening assay sample preparation and testing for the identification of binding between drug targets and library compounds, for use with a calorimetric device measuring the enthalpy of reaction for the binding. The method includes mixing a library compound with a specified solvent and mixing a target compound solution with a second specified solvent on a calorimetric device. The library compound/solvent is merged with the target compound/solvent solution and the library compound/solvent solution is also merged with a third solvent solution on the calorimetric device. The heats of reaction are detected for both merged solutions and are compared.
摘要翻译： 公开了用于高通量筛选测定样品制备和用于鉴定药物靶标和文库化合物之间的结合的测试的方法，用于测量结合反应焓的量热器件。 该方法包括将文库化合物与指定溶剂混合，并将目标化合物溶液与第二指定溶剂混合在量热装置上。 文库化合物/溶剂与目标化合物/溶剂溶液合并，文库化合物/溶剂溶液也与量热装置上的第三溶剂溶液合并。 对于两个合并的溶液检测反应热，并进行比较。
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