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公开(公告)号：US09952134B2
公开(公告)日：2018-04-24
申请号：US13294799
申请日：2011-11-11
CPC分类号： G01N15/1404 , G01N2015/0065 , G01N2458/15 , H01J49/004 , H01J49/04 , H01J49/0431
摘要： An analytical instrument for cellular analysis of cellular particles tagged with elemental tags, such as lanthanide-based elemental tags. The analytical instrument has a sample introduction system for generating a stream of particles from the sample. An inductively coupled plasma ionization system atomizes and ionizes particles in the stream as they are received. The instrument has an ion pretreatment system and a mass analyzer. The ion pretreatment system is adapted to transport ions generated by the ionization system to the mass analyzer. The ion pretreatment system can filter out low mass ions, such as using a high-pass mass filter or a bandpass mass filter, to allow the elemental tags to pass therethrough. The mass analyzer is adapted to measure the amount of at least one element in individual particles from the stream by performing mass analysis on the ions from the atomized particles. The instrument can be adapted to measure the amount of many different tags, for example at least five different tags, at the same time to facilitate multi-parametric analysis of cells and other particles.
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公开(公告)号：US20140070092A1
公开(公告)日：2014-03-13
申请号：US14016198
申请日：2013-09-02
CPC分类号： G01N15/1404 , G01N2015/0065 , G01N2458/15 , H01J49/004 , H01J49/04 , H01J49/0431
摘要： An elemental flow cytometer includes a device to vaporize, atomize, and ionize material and an introduction system for introducing packets of discrete entities into said device to vaporize, atomize and ionize materials to vaporize, atomize and ionize the entities in the packets. A spectrometer is adapted to individually analyze elemental composition of one or more of the vaporized, atomized and excited or ionized packets.
摘要翻译： 元素流式细胞仪包括用于蒸发，雾化和离子化材料的装置以及用于将离散实体的分组引入所述装置的引入系统，用于蒸发，雾化和离子化材料以使分组中的实体蒸发，雾化和离子化。 光谱仪适于单独分析一种或多种蒸发的，雾化的和激发的或电离的包的元素组成。
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3.发明授权Device and method preventing ion source gases from entering reaction/collision cells in mass spectrometry 有权在质谱中防止离子源气体进入反应/碰撞电池的装置和方法公开(公告)号：US06630665B2
公开(公告)日：2003-10-07
申请号：US09678395
申请日：2000-10-03
IPC分类号： H01J4900
CPC分类号： H01J49/067
摘要： A mass spectrometer has an ion source for producing sample ions. The ions pass through an ion interface, to a reaction/collision cell section. An ion-neutral decoupling device is provided between the ion interface and the reaction/collision cell section, to provide substantial separation between ions and neutral particles. The supersonic jet entering the spectrometer can have sufficient energy to cause the plasma gases, such as argon, to overcome the pressure differential between the reaction/collision cell and an upstream section of the spectrometer so as to penetrate into the reaction/collision cell; the decoupling device prevents this. The decoupling device can have offset apertures provided by plates or rods or other comparable arrangements, or can comprise a quadrupolar electrostatic deflector, an electrostatic sector deflector or a magnetic sector deflector.
摘要翻译： 质谱仪具有用于产生样品离子的离子源。 离子通过离子界面到反应/碰撞电池部分。 在离子界面和反应/碰撞电池部分之间提供离子 - 中性去耦装置，以提供离子和中性粒子之间的实质分离。 进入光谱仪的超音速喷射器可以具有足够的能量来引起诸如氩气的等离子体气体克服反应/碰撞池与光谱仪的上游部分之间的压力差，从而渗入反应/碰撞池中; 去耦设备防止这种情况。 去耦装置可以具有由板或杆或其他可比较的布置提供的偏移孔，或者可以包括四极静电偏转器，静电扇形偏转器或磁性扇形偏转器。
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4.发明授权公开(公告)号：US08525107B2
公开(公告)日：2013-09-03
申请号：US13351909
申请日：2012-01-17
IPC分类号： H01J49/00
CPC分类号： G01N15/1404 , G01N2015/0065 , G01N2458/15 , H01J49/004 , H01J49/04 , H01J49/0431
摘要： An analytical instrument has a sample introduction system for generating a stream of particles from a sample and an ionization system for receiving the particles. The ionization system is operable to atomize the particles received from the sample introduction system and ionize atoms from the atomized particles. The instrument has an ion pretreatment system and a magnetic sector mass analyzer comprising an array detector. The ion pretreatment system is adapted to transport ions generated by the ionization system to the mass analyzer. The mass analyzer is adapted to detect a transient signal of at least one element from individual particles from said stream by performing mass analysis on the ions from the atomized particles. The magnetic sector mass analyzer is adapted determine an amount of said at least one element from an individual particle using the transient signal detected during mass analysis of the ions from said individual particle.
摘要翻译： 分析仪器具有用于从样品产生颗粒流的样品引入系统和用于接收颗粒的电离系统。 电离系统可操作以使从样品引入系统接收的颗粒雾化并从原子化的颗粒离子化原子。 仪器具有离子预处理系统和包括阵列检测器的磁性部门质量分析仪。 离子预处理系统适于将由电离系统产生的离子输送到质量分析器。 质量分析器适于通过对来自雾化颗粒的离子进行质量分析来从所述流中检测来自各个颗粒的至少一种元素的瞬态信号。 使用在来自所述单个颗粒的离子的质量分析期间检测到的瞬态信号，适于使用磁性质量分析器确定来自单个颗粒的所述至少一种元素的量。
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5.发明申请公开(公告)号：US20120126114A1
公开(公告)日：2012-05-24
申请号：US13351909
申请日：2012-01-17
CPC分类号： G01N15/1404 , G01N2015/0065 , G01N2458/15 , H01J49/004 , H01J49/04 , H01J49/0431
摘要： An analytical instrument has a sample introduction system for generating a stream of particles from a sample and an ionization system for receiving the particles. The ionization system is operable to atomize the particles received from the sample introduction system and ionize atoms from the atomized particles. The instrument has an ion pretreatment system and a magnetic sector mass analyzer comprising an array detector. The ion pretreatment system is adapted to transport ions generated by the ionization system to the mass analyzer. The mass analyzer is adapted to detect a transient signal of at least one element from individual particles from said stream by performing mass analysis on the ions from the atomized particles. The magnetic sector mass analyzer is adapted determine an amount of said at least one element from an individual particle using the transient signal detected during mass analysis of the ions from said individual particle.
摘要翻译： 分析仪器具有用于从样品产生颗粒流的样品引入系统和用于接收颗粒的电离系统。 电离系统可操作以使从样品引入系统接收的颗粒雾化并从原子化的颗粒离子化原子。 仪器具有离子预处理系统和包括阵列检测器的磁性部门质量分析仪。 离子预处理系统适于将由电离系统产生的离子输送到质量分析器。 质量分析器适于通过对来自雾化颗粒的离子进行质量分析来从所述流中检测来自各个颗粒的至少一种元素的瞬态信号。 使用在来自所述单个颗粒的离子的质量分析期间检测到的瞬态信号，适于使用磁性质量分析器确定来自单个颗粒的所述至少一种元素的量。
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公开(公告)号：US20120056086A1
公开(公告)日：2012-03-08
申请号：US13294799
申请日：2011-11-11
CPC分类号： G01N15/1404 , G01N2015/0065 , G01N2458/15 , H01J49/004 , H01J49/04 , H01J49/0431
摘要： An analytical instrument has a sample introduction system for generating a stream of particles from a sample. An ionization system atomizes and ionizes particles in the stream as they are received. The instrument has an ion pretreatment system and a mass analyzer. The ion pretreatment system is adapted to transport ions generated by the ionization system to the mass analyzer. The mass analyzer is adapted measure the amount of at least one element in individual particles from the stream by performing mass analysis on the ions from the atomized particles. The instrument can be adapted to measure the amount of many different tags, for example at least five different tags, at the same time to facilitate multi-parametric analysis of cells and other particles.
摘要翻译： 分析仪器具有用于从样品产生颗粒流的样品引入系统。 离子化系统在接收物流时雾化和电离粒子。 仪器具有离子预处理系统和质量分析仪。 离子预处理系统适于将由电离系统产生的离子输送到质量分析器。 通过对来自雾化颗粒的离子进行质量分析，质量分析器适于测量来自流的单个颗粒中的至少一种元素的量。 该仪器可以适应于同时测量许多不同标签的量，例如至少五个不同的标签，以促进细胞和其他颗粒的多参数分析。
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7.发明申请CELL INJECTOR FOR FLOW CYTOMETER HAVING MASS SPECTROMETER DETECTOR AND METHOD FOR USING SAME 审中-公开具有大量光谱仪检测器的流式细胞仪的细胞注射器及其使用方法公开(公告)号：US20110024615A1
公开(公告)日：2011-02-03
申请号：US12521272
申请日：2007-12-28
CPC分类号： H05H1/30 , G01N15/10 , G01N15/1459 , H01J49/0431 , H01J49/105
摘要： A flow cytometer instrument and method for use thereof is described. The cell injector can receive particles from a sample slurry of particles associated with a biological material, and the cell injector can select particles from the sample slurry for injection into a mass spectrometer detector for the analysis of the individual particle. The spectrometer can have a plasma torch having a center tube being connected to the cell injector to receive the particles, a radio frequency power source and a load coil coupled to the plasma torch to generate and maintain a plasma in the plasma torch for ionizing the received particles, and a mass detector disposed downstream of the plasma torch for receiving ionized particles from the plasma torch and operative for detecting the particles in the sample slurry.
摘要翻译： 描述了流式细胞仪器及其使用方法。 细胞注射器可以接收来自与生物材料相关联的颗粒的样品浆料的颗粒，并且细胞注射器可以从样品浆料中选择颗粒以注射到质谱仪检测器中用于分析单个颗粒。 光谱仪可以具有等离子体焰炬，其中心管连接到电池注入器以接收粒子，射频电源和耦合到等离子体焰炬的负载线圈，以在等离子体焰炬中产生和维持等离子体，用于电离所接收的 颗粒和设置在等离子体焰炬下游的质量检测器，用于接收来自等离子体焰炬的电离颗粒，并用于检测样品浆料中的颗粒。
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8.发明授权公开(公告)号：US06713757B2
公开(公告)日：2004-03-30
申请号：US09796609
申请日：2001-03-02
IPC分类号： H01J4942
CPC分类号： H01J49/421
摘要： A method and apparatus for operating a mass spectrometer system, having a processing section, provides for the application of both an axial field and periodic application of a flush pulse to the processing section. This gives a reproducible output ion signal from the processing section that is very responsive to changes in operating conditions in the processing section. The mass spectrometer system can comprise: a collision/reaction cell having an input and an output; and a set of elongated rods extending between said input and output, said elongated rods spatially arranged. Separate auxiliary electrodes can be provided to generate the axial field. The invention has particular applicability to ICP-MS, where strong ion currents can result in a collision cell taking some time to reach equilibrium when the operating condition is changed.
摘要翻译： 用于操作具有处理部分的质谱仪系统的方法和装置提供轴向场和周期性地施加冲洗脉冲到处理部分的应用。 这提供了来自处理部分的可再现的输出离子信号，其对处理部分中的操作条件的变化非常敏感。 质谱仪系统可以包括：具有输入和输出的碰撞/反应池; 以及在所述输入和输出之间延伸的一组细长杆，所述细长杆在空间上布置。 可以提供单独的辅助电极以产生轴向场。 本发明特别适用于ICP-MS，其中强离子电流可导致碰撞池在运行条件改变时花费一些时间达到平衡。
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公开(公告)号：US08912486B2
公开(公告)日：2014-12-16
申请号：US14016198
申请日：2013-09-02
摘要： An elemental flow cytometer includes a device to vaporize, atomize, and ionize material and an introduction system for introducing packets of discrete entities into said device to vaporize, atomize and ionize materials to vaporize, atomize and ionize the entities in the packets. A spectrometer is adapted to individually analyze elemental composition of one or more of the vaporized, atomized and excited or ionized packets.
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10.发明授权公开(公告)号：US07479630B2
公开(公告)日：2009-01-20
申请号：US11089023
申请日：2005-03-25
IPC分类号： B01D59/44
CPC分类号： G01N15/1404 , G01N2015/0065 , G01N2458/15 , H01J49/004 , H01J49/04 , H01J49/0431
摘要： An apparatus (100) for sequentially analyzing particles such as single cells or single beads, by spectrometry. The apparatus, an elemental flow cytometer, includes means (102) for sequential particle introduction, means (104) to vaporize, atomize and excite or ionize the particles, or an elemental tag associated with an analyte on the particles, and means (106) to analyze the elemental composition of the vaporized, atomized and excited or ionized particles, or an elemental tag associated with the particles. Methods for sequentially analyzing particles such as singe cells or single beads by spectrometry are also described.
摘要翻译： 一种用于通过光谱法顺序分析诸如单细胞或单珠的颗粒的装置（100）。 装置，元件流式细胞仪，包括用于顺序颗粒引入的装置（102），用于蒸发，雾化和激发或电离颗粒的装置（104）或与颗粒上的分析物相关联的元素标签，以及装置（106） 分析蒸发的，雾化的和激发的或离子化的颗粒或与颗粒相关的元素标签的元素组成。 还描述了通过光谱法顺序分析诸如单细胞或单个珠粒子的方法。
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