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公开(公告)号：US07528160B2
公开(公告)日：2009-05-05
申请号：US10541502
申请日：2003-12-31
申请人： Scott Eugene Conner , James Allen Knobelsdorf , Nathan Bryan Mantlo , Daniel Ray Mayhugh , Xiaodong Wang , Guoxin Zhu , Jeffrey Michael Schkeryantz
发明人： Scott Eugene Conner , James Allen Knobelsdorf , Nathan Bryan Mantlo , Daniel Ray Mayhugh , Xiaodong Wang , Guoxin Zhu , Jeffrey Michael Schkeryantz
IPC分类号： A61K31/427 , C07D277/24
CPC分类号： C07D263/57 , C07D209/10 , C07D235/18 , C07D277/60 , C07D277/66 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D513/04
摘要： The present invention is directed to a method of treatment by modulating a peroxisome proliferator activated receptor by employing a compound of Structural Formula (I). The variables in I are defined herein. Also included are compounds, methods of making compounds, and pharmaceutical compositions. The compounds of the present invention are believed to be effective in treating and preventing Syndrome X, Type H diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, atherosclerosis, and other disorders related to Syndrome X and cardiovascular diseases.
摘要翻译： 本发明涉及通过使用结构式（I）的化合物调节过氧化物酶体增殖物激活受体的治疗方法。 I中的变量在此定义。 还包括化合物，制备化合物的方法和药物组合物。 认为本发明的化合物可有效治疗和预防X综合征，H型糖尿病，高血糖症，高脂血症，肥胖症，凝血病，高血压，动脉粥样硬化以及与X综合征和心血管疾病相关的其他疾病。
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公开(公告)号：US07153878B2
公开(公告)日：2006-12-26
申请号：US10505089
申请日：2003-02-13
申请人： Scott Eugene Conner , James Allen Knobelsdorf , Nathan Bryan Mantlo , Jeffrey Michael Schkeryantz , Quanrong Shen , Alan M Warshawsky , Guoxin Zhu
发明人： Scott Eugene Conner , James Allen Knobelsdorf , Nathan Bryan Mantlo , Jeffrey Michael Schkeryantz , Quanrong Shen , Alan M Warshawsky , Guoxin Zhu
IPC分类号： A61K31/426 , A61K31/429 , A61K31/421 , A61K31/5377 , A61K31/506 , A61K31/497 , A61K31/443 , A61K31/4439 , A61K31/4525
CPC分类号： C07D263/32 , C07D277/24 , C07D277/26 , C07D277/28 , C07D277/30 , C07D403/10 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/10 , C07D417/14
摘要： The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts thereof, Formula I. (Formula I); wherein: (a) R5 is selected from the group consisting of (C1–C6)alkyl, (C1–C6)alkenyl, aryl (C0–C4)alkyl, aryloxy(C0–C4)alkyl, arylthio(C0–C4)alkyl, and further wherein when R5 is alkyl, R5 can optionally combine with W to form a 6 membered cycloheteroalkyl ring that is fused with the oxazole or thiazole ring to which the R5 group is attached; (b) R9 is selected from the group consisting of C1–C5alkyl, C1–C5alkenyl, and arylC0–C3alkyl. (c) T1 is selected from the group consisting of C and N, (d) W is selected from the group consisting of CH2, C(O)N(R21), N(R21), N(R21)CH2, O, OCH2, S, and SO2; and (e) X is selected from the group consisting of C, CH2C, and CCH2
摘要翻译： 本发明涉及由以下结构式表示的化合物及其药学上可接受的盐，式I（式I）; 其中：（a）R 5选自（C 1 -C 6 -C 6）烷基，（C 1 -C 6 - C 烷基，芳基（C 0 -C 4 -C 4）烷基，芳氧基（C 1 -C 4）烷基， 烷基，芳硫基（C 0 -C 4 -C 4）烷基，并且其中当R 5为烷基时，R 5可任意地与W结合形成6元 与R5基团连接的恶唑或噻唑环稠合的环杂烷基环; （b）R 9选自C 1 -C 5烷基，C 1 -C 5烷基，C 1 -C 5 - 烯基和芳基C 0 -C 3烷基。 （c）T 1选自C和N，（d）W选自CH 2，C（O）N（ R 21），N（R 21），N（R 21）CH 2，O，OCH 2，S和SO 2; 和（e）X选自C，CH 2 C和CCH 2，
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公开(公告)号：US07754742B2
公开(公告)日：2010-07-13
申请号：US12502252
申请日：2009-07-14
IPC分类号： A61K31/4172 , A61K31/4439 , C07D233/64 , C07D401/12
CPC分类号： C07D233/92
摘要： The present invention provides certain imidazole carboxamide derivatives, pharmaceutical compositions thereof, methods of using the same and processes for preparing the same.
摘要翻译： 本发明提供某些咪唑羧酰胺衍生物，其药物组合物，其使用方法及其制备方法。
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公开(公告)号：US20100016373A1
公开(公告)日：2010-01-21
申请号：US12502252
申请日：2009-07-14
IPC分类号： A61K31/4439 , C07D233/64 , C07D401/12 , A61K31/4164
CPC分类号： C07D233/92
摘要： The present invention provides certain imidazole carboxamide derivatives, pharmaceutical compositions thereof, methods of using the same and processes for preparing the same.
摘要翻译： 本发明提供某些咪唑羧酰胺衍生物，其药物组合物，其使用方法及其制备方法。
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公开(公告)号：US07858646B2
公开(公告)日：2010-12-28
申请号：US11718446
申请日：2005-11-15
申请人： Thomas Daniel Aicher , Dana Rae Benesh , Maria-Jesus Blanco-Pillado , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsäter , Jeffrey Michael Schkeryantz , Tony Pisal Tang
发明人： Thomas Daniel Aicher , Dana Rae Benesh , Maria-Jesus Blanco-Pillado , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsäter , Jeffrey Michael Schkeryantz , Tony Pisal Tang
IPC分类号： C07D401/04 , C07D213/79 , A61K31/41 , A61K31/4439
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： The present invention provides compounds of formula (I); pharmaceutical compositions thereof, and methods of using the same, processes or preparing the same, and intermediates thereof.
摘要翻译： 本发明提供式（I）化合物; 其药物组合物及其使用方法，方法或制备方法及其中间体。
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公开(公告)号：US07803938B2
公开(公告)日：2010-09-28
申请号：US12549571
申请日：2009-08-28
申请人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Micheal Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang
发明人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Micheal Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang
IPC分类号： C07D239/32 , C07D271/113 , C07D291/04
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： This application relates to a substituted hydroxyphenyl ketone compound of formula I, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof and its use in treating migraine. This application also relates to processes for preparing a compound of formula I, and intermediate compounds useful therein.
摘要翻译： 本申请涉及式I的取代羟基苯基酮化合物或其药学上可接受的盐，其药物组合物及其在治疗偏头痛中的用途。 本申请还涉及制备式I化合物的方法和其中有用的中间体化合物。
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公开(公告)号：US07816523B2
公开(公告)日：2010-10-19
申请号：US12549552
申请日：2009-08-28
申请人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang
发明人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang
IPC分类号： C07D239/32 , C07D213/02
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： This application relates to a substituted hydroxyphenyl ketone compound of formula I, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof and its use in treating migraine. This application also relates to processes for preparing a compound of formula I, and intermediate compounds useful therein.
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公开(公告)号：US07678794B2
公开(公告)日：2010-03-16
申请号：US11718742
申请日：2005-11-15
申请人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang
发明人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang
IPC分类号： A61K31/50 , C07D209/54
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： The present invention provides a compound of formula (I): pharmaceutical compositions thereof, and methods of using the same, processes for preparing the same, and intermediates thereof.
摘要翻译： 本发明提供式（I）化合物：其药物组合物及其使用方法，其制备方法及其中间体。
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公开(公告)号：US20080139505A1
公开(公告)日：2008-06-12
申请号：US11718753
申请日：2005-11-15
申请人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang , Nicholas Andrew Magnus
发明人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang , Nicholas Andrew Magnus
IPC分类号： A61K31/19 , C07D309/00 , A61K31/695 , A61K31/35 , C07C255/00 , A61K31/24 , C07D401/00 , C07D211/78 , C07D239/02 , C07D333/24 , A61K31/381 , A61K31/425 , C07D277/00 , A61K31/505 , C07D271/06 , A61K31/44 , C07C229/00 , A61K31/275 , A61K31/41 , C07D257/04 , C07C63/04
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： The present invention provides compounds of formula (I): pharmaceutical compositions thereof, and methods of using the same, processes or preparing the same, and intermediates thereof.
摘要翻译： 本发明提供式（I）化合物：其药物组合物及其使用方法，方法或制备方法及其中间体。
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公开(公告)号：US07598423B2
公开(公告)日：2009-10-06
申请号：US11718753
申请日：2005-11-15
申请人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang , Nicholas Andrew Magnus
发明人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang , Nicholas Andrew Magnus
IPC分类号： C07D239/26 , C07D239/28 , C07D241/10 , C07D401/10 , C07D213/02 , C07D291/04 , C07D271/06 , C07D277/20 , C07D417/10 , C07D333/06 , C07D319/06 , C07C49/76
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： This application relates to a substituted hydroxyphenyl ketone compound of formula I, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof and its use in treating migraine. This application also relates to processes for preparing a compound of formula I, and intermediate compounds useful therein.
摘要翻译： 本申请涉及式I的取代羟基苯基酮化合物或其药学上可接受的盐，其药物组合物及其在治疗偏头痛中的用途。 本申请还涉及制备式I化合物的方法和其中有用的中间体化合物。
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