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25 条记录 (耗时 0.049 秒)

    Peroxisome proliferator activated receptor modulators
    5.
    发明授权
    Peroxisome proliferator activated receptor modulators 失效
    过氧化物酶体增殖物激活受体调节剂

    公开(公告)号：US07259175B2

    公开(公告)日：2007-08-21

    申请号：US10505103

    申请日：2003-02-13

    申请人： Scott Eugene Conner ,  Nathan Bryan Mantlo ,  Guoxin Zhu

    发明人： Scott Eugene Conner ,  Nathan Bryan Mantlo ,  Guoxin Zhu

    IPC分类号： A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/4439 ,  C07D417/10 ,  C07D413/10

    CPC分类号： C07D413/04 ,  C07D263/32 ,  C07D277/24 ,  C07D277/26 ,  C07D413/10 ,  C07D417/04 ,  C07D417/10

    摘要： The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts thereof, Formula I: wherein: (a) R5 is selected from the group consisting of (C1-C6) alkyl, (C1-C6) alkenyl, substituted aryl(C0-C4)alkyl, substituted aryloxy(C0-C4)alkyl, substituted arylthio(C0-C4)alkyl, unsubstituted aryl(C0-C4)alkyl, unsubstituted aryloxy(C0-C4)alkyl, and unsubstituted arylthio(C0-C4)alkyl; (b) T1 is C or N; (c) Q is selected from the group consisting of O, a single bond, O(CH2)q and C; (d) q is 1 or 2; (e) W is selected from the group consisting of O, S, (CH2)rN(R20)(CH2)k, NHSO2, C(O)N(R20)(CH2)r, (CH2)rN(R20)C(O), and SO2; (f) X is CmH2m; (g) m is 0, 1 or 2; (h) A is an functional group selected from the group consisting of carboxyl, C1-C3 alkylnitrile, carboxamide, and (CH2)n COOR19; and (i) R19 is selected from the group consisting of hydrogen, optionally substituted C1-C4alkyl and optionally substituted arylmethyl

    摘要翻译： 本发明涉及由以下结构式表示的化合物及其药学上可接受的盐，式I：其中：（a）R 5选自（C 1 -C 3） （C 1 -C 6）烷基，（C 1 -C 6 -C 6）链烯基，取代的芳基（C 0 -C 6 - 取代的芳氧基（C 0 -C 4 -C 4烷基）烷基，取代的芳硫基（C 0 -C 4 - 烷基，未取代的芳基（C 0 -C 4 -C 4）烷基，未取代的芳氧基（C 0 -C 4 - 烷基和未取代的芳硫基（C 0 -C 4 -C 4）烷基; （b）T1为C或N; （c）Q选自O，单键，O（CH 2 CH 2）q C和C; （d）q为1或2; （e）W选自O，S，（CH 2）n N（R 20）（CH 2 CH 2） C（O）N（R 20）（CH 2）n），（CH

    Fused heterocyclic derivatives as PPAR modulators
    6.
    发明授权
    Fused heterocyclic derivatives as PPAR modulators 失效
    融合杂环衍生物作为PPAR调节剂

    公开(公告)号：US07384965B2

    公开(公告)日：2008-06-10

    申请号：US10539477

    申请日：2003-12-31

    申请人： Scott Eugene Conner ,  Nathan Bryan Mantlo ,  Guoxin Zhu

    发明人： Scott Eugene Conner ,  Nathan Bryan Mantlo ,  Guoxin Zhu

    IPC分类号： A61K31/428 ,  A61K31/426 ,  A61K31/421 ,  A61K31/423 ,  C07D277/66 ,  C07D263/57

    CPC分类号： C07D209/10 ,  C07D235/18 ,  C07D263/57 ,  C07D277/60 ,  C07D277/66 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D513/04

    摘要： The present invention is directed to compounds represented by the following structural formula, Formula I: wherein (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U ia an aliphatic linker; (c) Y is selected from the group consisting of C, O, S, NH and a single bond; (d) E is C(R3) (R4) A or A and wherein (i) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamidek, sulfonamide and acylsulfonamide; (e) B is selected from the group consisting of S, O, C, and N; (f) Z is selected from the group consisting of N and C; with the proviso that when B is C then Z is N.

    摘要翻译： 本发明涉及由以下结构式（I）表示的化合物：其中（a）X选自单键，O，S，S（O）2和 N; （b）Uia一个脂族连接体; （c）Y选自C，O，S，NH和单键; （d）E是C（R3）（R4）A或A，其中（i）A选自羧基，四唑，C 1 -C 6 烷基腈，羧酰胺，磺酰胺和酰基磺酰胺; （e）B选自S，O，C和N; （f）Z选自N和C; 条件是当B为C时，则Z为N.

    Fused heterocyclic derivatives as PPAR modulators
    7.
    发明授权
    Fused heterocyclic derivatives as PPAR modulators 失效
    融合杂环衍生物作为PPAR调节剂

    公开(公告)号：US07598266B2

    公开(公告)日：2009-10-06

    申请号：US12099929

    申请日：2008-04-09

    申请人： Scott Eugene Conner ,  Nathan Bryan Mantlo ,  Guoxin Zhu

    发明人： Scott Eugene Conner ,  Nathan Bryan Mantlo ,  Guoxin Zhu

    IPC分类号： A61K31/437 ,  A61K31/4353 ,  C07D471/04

    CPC分类号： C07D209/10 ,  C07D235/18 ,  C07D263/57 ,  C07D277/60 ,  C07D277/66 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D513/04

    摘要： The present invention is directed to compounds represented by the following structural formula, Formula I: wherein: (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U is an aliphatic linker; (c) Y is selected from the group consisting of C, O, S, NH and a single bond; (d) E is C(R3)(R4)A or A and wherein (i) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamide, sulfonamide and acylsulfonamide; (e) B is selected from the group consisting of S, O, C, and N; (f) Z is selected from the group consisting of N and C; with the proviso that when B is C then Z is N.

    摘要翻译： 本发明涉及由以下结构式（I）表示的化合物：其中：（a）X选自单键，O，S，S（O）2和N; （b）U是脂族连接体; （c）Y选自C，O，S，NH和单键; （d）E是C（R3）（R4）A或A，其中（i）A选自羧基，四唑，C 1 -C 6烷基腈，甲酰胺，磺酰胺和酰基磺酰胺; （e）B选自S，O，C和N; （f）Z选自N和C; 条件是当B为C时，则Z为N.