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1.发明授权Method of analyzing differential expression of proteins in proteomes by mass spectrometry 有权通过质谱分析蛋白质组蛋白差异表达的方法公开(公告)号：US08030089B2
公开(公告)日：2011-10-04
申请号：US10893415
申请日：2004-07-16
IPC分类号： G01N24/00
CPC分类号： G01N33/6848 , C12Q1/6872 , G01N33/6842 , G01N33/6851 , H01J49/0031 , Y10T436/24
摘要： A method of identifying molecules of biological origin is disclosed. The molecules are identified and the basis of the accurately determined mass to charge ratio of the molecules and at least a further physico-chemical property such as elution time or charge state. Further physico-chemical properties may be used. The experimentally determined accurate mass and physico-chemical properties can then be compared with a look-up table of information. The look-up table may generated or physico-chemical properties of data in a conventional database may be calculated. The ability to recognize and preferably identify the same molecules in two different samples may be used to determine whether a particular biological molecules has been expressed differently in an experimental sample relative to a control sample.
摘要翻译： 公开了鉴定生物来源分子的方法。 鉴定分子和准确确定分子的质荷比和至少另外的物理化学性质如洗脱时间或电荷状态的基础。 可以使用进一步的物理化学性质。 然后可以将实验确定的精确质量和物理化学性质与信息查找表进行比较。 可以生成查找表，也可以计算常规数据库中的数据的物理化学性质。 可以使用在两个不同样品中识别和优选鉴定相同分子的能力来确定特定生物分子是否在实验样品中相对于对照样品表达不同。
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公开(公告)号：US20080142696A1
公开(公告)日：2008-06-19
申请号：US10893415
申请日：2004-07-16
IPC分类号： B01D59/44
CPC分类号： G01N33/6848 , C12Q1/6872 , G01N33/6842 , G01N33/6851 , H01J49/0031 , Y10T436/24
摘要： A method of identifying molecules of biological origin is disclosed. The molecules are identified and the basis of the accurately determined mass to charge ratio of the molecules and at least a further physico-chemical property such as elution time or charge state. Further physico-chemical properties may be used. The experimentally determined accurate mass and physico-chemical properties can then be compared with a look-up table of information. The look-up table may generated or physico-chemical properties of data in a conventional database may be calculated. The ability to recognise and preferably identify the same molecules in two different samples may be used to determine whether a particular biological molecules has been expressed differently in an experimental sample relative to a control sample.
摘要翻译： 公开了鉴定生物来源分子的方法。 鉴定分子以及精确确定分子的质荷比和至少另外的物理化学性质如洗脱时间或电荷状态的基础。 可以使用进一步的物理化学性质。 然后可以将实验确定的精确质量和物理化学性质与信息查找表进行比较。 可以生成查找表，也可以计算常规数据库中的数据的物理化学性质。 可以使用在两个不同样品中识别和优选鉴定相同分子的能力来确定特定生物分子是否在实验样品中相对于对照样品表达不同。
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公开(公告)号：US20080135744A1
公开(公告)日：2008-06-12
申请号：US10893212
申请日：2004-07-16
IPC分类号： B01D59/44
CPC分类号： G01N33/6848 , C12Q1/6872 , G01N33/6842 , G01N33/6851 , H01J49/0031 , Y10T436/24
摘要： A method of identifying molecules of biological origin is disclosed. The molecules are identified and the basis of the accurately determined mass to charge ratio of the molecules and at least a further physico-chemical property such as elution time or charge state. Further physico-chemical properties may be used. The experimentally determined accurate mass and physico-chemical properties can then be compared with a look-up table of information. The look-up table may generated or physico-chemical properties of data in a conventional database may be calculated. The ability to recognise and preferably identify the same molecules in two different samples may be used to determine whether a particular biological molecules has been expressed differently in an experimental sample relative to a control sample.
摘要翻译： 公开了鉴定生物来源分子的方法。 鉴定分子和准确确定分子的质荷比和至少另外的物理化学性质如洗脱时间或电荷状态的基础。 可以使用进一步的物理化学性质。 然后可以将实验确定的精确质量和物理化学性质与信息查找表进行比较。 可以生成查找表，也可以计算常规数据库中的数据的物理化学性质。 可以使用在两个不同样品中识别和优选鉴定相同分子的能力来确定特定生物分子是否在实验样品中相对于对照样品表达不同。
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公开(公告)号：US20050092910A1
公开(公告)日：2005-05-05
申请号：US10497896
申请日：2002-12-09
申请人： Scott Geromanos , Ashok Dongre , Gregory Opiteck , Jeffrey Silva
发明人： Scott Geromanos , Ashok Dongre , Gregory Opiteck , Jeffrey Silva
IPC分类号： G01N27/62 , B01D59/44 , C12Q1/68 , G01N27/447 , G01N30/72 , G01N30/88 , G01N33/483 , G01N33/53 , G01N33/68 , H01J49/00 , H01J49/04
CPC分类号： G01N33/6848 , C12Q1/6872 , G01N33/6842 , G01N33/6851 , H01J49/0031 , Y10T436/24
摘要： A method of identifying molecules of biological origin is disclosed. The molecules are identified and the basis of the accurately determined mass to charge ratio of the molecules and at least a further physico-chemical property such as elution time or charge state. Further physico-chemical properties may be used. The experimentally determined accurate mass and physico-chemical properties can then be compared with a look-up table of information. The look-up table may generated or physico-chemical properties of data in a conventional database may be calculated. The ability to recognise and preferably identify the same molecules in two different samples may be used to determine whether a particular biological molecules has been expressed differently in an experimental sample relative to a control sample.
摘要翻译： 公开了鉴定生物来源分子的方法。 鉴定分子和准确确定分子的质荷比和至少另外的物理化学性质如洗脱时间或电荷状态的基础。 可以使用进一步的物理化学性质。 然后可以将实验确定的精确质量和物理化学性质与信息查找表进行比较。 可以生成查找表，也可以计算常规数据库中的数据的物理化学性质。 可以使用在两个不同样品中识别和优选鉴定相同分子的能力来确定特定生物分子是否在实验样品中相对于对照样品表达不同。
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公开(公告)号：US20080286764A9
公开(公告)日：2008-11-20
申请号：US10892768
申请日：2004-07-16
申请人： Scott Geromanos , Ashok Dongre , Gregory Opiteck , Jeffrey Silva
发明人： Scott Geromanos , Ashok Dongre , Gregory Opiteck , Jeffrey Silva
CPC分类号： G01N33/6848 , C12Q1/6872 , G01N33/6842 , G01N33/6851 , H01J49/0031 , Y10T436/24
摘要： A method of identifying molecules of biological origin is disclosed. The molecules are identified and the basis of the accurately determined mass to charge ratio of the molecules and at least a further physico-chemical property such as elution time or charge state. Further physico-chemical properties may be used. The experimentally determined accurate mass and physico-chemical properties can then be compared with a look-up table of information. The look-up table may generated or physico-chemical properties of data in a conventional database may be calculated. The ability to recognise and preferably identify the same molecules in two different samples may be used to determine whether a particular biological molecules has been expressed differently in an experimental sample relative to a control sample.
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公开(公告)号：US20070009898A1
公开(公告)日：2007-01-11
申请号：US10892768
申请日：2004-07-16
申请人： Scott Geromanos , Ashok Dongre , Gregory Opiteck , Jeffrey Silva
发明人： Scott Geromanos , Ashok Dongre , Gregory Opiteck , Jeffrey Silva
CPC分类号： G01N33/6848 , C12Q1/6872 , G01N33/6842 , G01N33/6851 , H01J49/0031 , Y10T436/24
摘要： A method of identifying molecules of biological origin is disclosed. The molecules are identified and the basis of the accurately determined mass to charge ratio of the molecules and at least a further physico-chemical property such as elution time or charge state. Further physico-chemical properties may be used. The experimentally determined accurate mass and physico-chemical properties can then be compared with a look-up table of information. The look-up table may generated or physico-chemical properties of data in a conventional database may be calculated. The ability to recognise and preferably identify the same molecules in two different samples may be used to determine whether a particular biological molecules has been expressed differently in an experimental sample relative to a control sample.
摘要翻译： 公开了鉴定生物来源分子的方法。 鉴定分子和准确确定分子的质荷比和至少另外的物理化学性质如洗脱时间或电荷状态的基础。 可以使用进一步的物理化学性质。 然后可以将实验确定的精确质量和物理化学性质与信息查找表进行比较。 可以生成查找表，也可以计算常规数据库中的数据的物理化学性质。 可以使用在两个不同样品中识别和优选鉴定相同分子的能力来确定特定生物分子是否在实验样品中相对于对照样品表达不同。
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公开(公告)号：US20080070314A1
公开(公告)日：2008-03-20
申请号：US11596756
申请日：2005-05-20
申请人： Scott Geromanos , Marc Gorenstein , Jeffrey Silva , Guo-Zhong Li
发明人： Scott Geromanos , Marc Gorenstein , Jeffrey Silva , Guo-Zhong Li
CPC分类号： G06F19/16 , G01N33/6848 , G01N2030/8831 , H01J49/0036 , H01J49/0431 , H01J49/426 , G01N30/7233
摘要： A system and method for mass analysis where a sample (102) is separated in a liquid chromatograph (104), and subsequently analyzed in a mass spectrometer (112).
摘要翻译： 一种用于质量分析的系统和方法，其中样品（102）在液相色谱仪（104）中分离，随后在质谱仪（112）中分析。
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公开(公告)号：US20050095633A1
公开(公告)日：2005-05-05
申请号：US10952045
申请日：2004-09-28
申请人： Brian Cali , Douglas Holtzman , Jeffrey Silva , Joshua Trueheart , Lixin Zhang , Kevin Madden , G. Milne , Amir Sherman
发明人： Brian Cali , Douglas Holtzman , Jeffrey Silva , Joshua Trueheart , Lixin Zhang , Kevin Madden , G. Milne , Amir Sherman
IPC分类号： C12N15/09 , C07K14/37 , C07K14/38 , C07K14/385 , C12N15/31 , C12Q1/68 , C07H21/04 , C12N1/18 , C12N9/22 , C12N15/74
CPC分类号： C07K14/385 , C07K14/38
摘要： The invention relates to regulators of fungal gene expression and their use in commercial and medical applications. More particularly, the invention relates to regulators of fungal genes involved in production of enzymes, secondary metabolites and other useful products, as well as to regulators of genes involved in fungal invasion. The invention provides novel regulators of fungal gene expression, and methods for using regulator genes in commercial and medical applications.
摘要翻译： 本发明涉及真菌基因表达的调节剂及其在商业和医学应用中的应用。 更具体地，本发明涉及涉及酶，次生代谢物和其它有用产物的生产的真菌基因调节剂，以及参与真菌侵袭的基因的调节剂。 本发明提供了真菌基因表达的新型调节剂，以及在商业和医学应用中使用调节基因的方法。
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