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1.发明申请公开(公告)号：US20140096604A1
公开(公告)日：2014-04-10
申请号：US14109766
申请日：2013-12-17
申请人： Scott Manalis , Andrea K. Bryan , Philip Dextras , Sungmin Son , Thomas Burg , William Grover , Yao-Chung Weng
发明人： Scott Manalis , Andrea K. Bryan , Philip Dextras , Sungmin Son , Thomas Burg , William Grover , Yao-Chung Weng
IPC分类号： G01N9/00
CPC分类号： G01N9/002 , G01N15/1056 , G01N15/12 , G01N2015/1043 , G01N2015/1087
摘要： Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Suspended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.
摘要翻译： 用于改善悬浮微通道谐振器（SMR）中颗粒或细胞特性如质量的测量的方法和装置。 装置特别包括用于在SMR中捕获颗粒以延长测量周期的设计。 方法包括通过改变用于相同粒子或细胞上的重复测量的流体密度来提供差异测量的技术。
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2.发明授权Method and apparatus for extended time and varying environment measurements of single particles in microfluidic channels 有权在微流体通道中单个颗粒的延长时间和不同环境测量的方法和装置公开(公告)号：US08631685B2
公开(公告)日：2014-01-21
申请号：US12661772
申请日：2010-03-23
申请人： Scott Manalis , Andrea K. Bryan , Michel Godin , Philip Dextras , Sungmin Son , Thomas Burg , William Grover , Yao-Chung Weng
发明人： Scott Manalis , Andrea K. Bryan , Michel Godin , Philip Dextras , Sungmin Son , Thomas Burg , William Grover , Yao-Chung Weng
IPC分类号： G01N15/10
CPC分类号： G01N15/00
摘要： Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Suspended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods and for changing the fluid properties within the SMR during the extended periods. Methods include techniques to provide for cell growth over time and over time in response to changing fluid properties to aid in determining parameters such as drug resistance and drug susceptibility.
摘要翻译： 用于改善悬浮微通道谐振器（SMR）中颗粒或细胞特性如质量的测量的方法和装置。 装置特别包括用于在SMR中捕获颗粒以延长测量周期并且用于在延长的时间段内改变SMR内的流体特性的设计。 方法包括随着时间和随时间响应于改变的流体性质来提供细胞生长以帮助确定诸如耐药性和药物敏感性的参数的技术。
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3.发明申请Method and apparatus for extended time and varying environment measurements of single particles in microfluidic channels 有权在微流体通道中单个颗粒的延长时间和不同环境测量的方法和装置公开(公告)号：US20100288043A1
公开(公告)日：2010-11-18
申请号：US12661772
申请日：2010-03-23
申请人： Scott Manalis , Andrea K. Bryan , Michel Godin , Philip Dextras , Sungmin Son , Thomas Burg , William Grover , Yao-Chung Weng
发明人： Scott Manalis , Andrea K. Bryan , Michel Godin , Philip Dextras , Sungmin Son , Thomas Burg , William Grover , Yao-Chung Weng
CPC分类号： G01N15/00
摘要： Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Suspended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods and for changing the fluid properties within the SMR during the extended periods. Methods include techniques to provide for cell growth over time and over time in response to changing fluid properties to aid in determining parameters such as drug resistance and drug susceptibility.
摘要翻译： 用于改善悬浮微通道谐振器（SMR）中颗粒或细胞特性如质量的测量的方法和装置。 装置特别包括用于在SMR中捕获颗粒以延长测量周期并且用于在延长的时间段内改变SMR内的流体特性的设计。 方法包括随着时间和随时间响应于改变的流体性质来提供细胞生长以帮助确定诸如耐药性和药物敏感性的参数的技术。
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4.发明授权公开(公告)号：US08899102B2
公开(公告)日：2014-12-02
申请号：US14109766
申请日：2013-12-17
申请人： Scott Manalis , Andrea K. Bryan , Philip Dextras , Sungmin Son , Thomas Burg , William Grover , Yao-Chung Weng
发明人： Scott Manalis , Andrea K. Bryan , Philip Dextras , Sungmin Son , Thomas Burg , William Grover , Yao-Chung Weng
CPC分类号： G01N9/002 , G01N15/1056 , G01N15/12 , G01N2015/1043 , G01N2015/1087
摘要： Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Suspended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.
摘要翻译： 用于改善悬浮微通道谐振器（SMR）中颗粒或细胞特性如质量的测量的方法和装置。 装置特别包括用于在SMR中捕获颗粒以延长测量周期的设计。 方法包括通过改变用于相同粒子或细胞上的重复测量的流体密度来提供差异测量的技术。
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5.发明申请公开(公告)号：US20100154535A1
公开(公告)日：2010-06-24
申请号：US12587898
申请日：2009-10-14
申请人： Scott R. Manalis , Andrea K. Bryan , Philip Dextras , Thomas P. Burg , William H. Grover , Yao-Chung Weng , Sungmin Son
发明人： Scott R. Manalis , Andrea K. Bryan , Philip Dextras , Thomas P. Burg , William H. Grover , Yao-Chung Weng , Sungmin Son
CPC分类号： G01N9/002 , G01N15/1056 , G01N15/12 , G01N2015/1043 , G01N2015/1087
摘要： Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Susppended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.
摘要翻译： 用于改善沉淀微通道谐振器（SMR）中的颗粒或细胞特性如质量的测量的方法和装置。 装置特别包括用于在SMR中捕获颗粒以延长测量周期的设计。 方法包括通过改变用于相同粒子或细胞上的重复测量的流体密度来提供差异测量的技术。
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6.发明授权公开(公告)号：US08312763B2
公开(公告)日：2012-11-20
申请号：US12587898
申请日：2009-10-14
申请人： Scott R. Manalis , Andrea K. Bryan , Philip Dextras , Thomas P. Burg , William H. Grover , Yao-Chung Weng , Sungmin Son
发明人： Scott R. Manalis , Andrea K. Bryan , Philip Dextras , Thomas P. Burg , William H. Grover , Yao-Chung Weng , Sungmin Son
IPC分类号： G01N15/06
CPC分类号： G01N9/002 , G01N15/1056 , G01N15/12 , G01N2015/1043 , G01N2015/1087
摘要： Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Susppended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.
摘要翻译： 用于改善沉淀微通道谐振器（SMR）中的颗粒或细胞特性如质量的测量的方法和装置。 装置特别包括用于在SMR中捕获颗粒以延长测量周期的设计。 方法包括通过改变用于相同粒子或细胞上的重复测量的流体密度来提供差异测量的技术。
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7.发明申请APPARATUS AND METHOD FOR MEASURING BUOYANT MASS AND DEFORMABILITY OF SINGLE CELLS 有权测量单体质量和单细胞不可逆性的装置和方法公开(公告)号：US20120118063A1
公开(公告)日：2012-05-17
申请号：US13096248
申请日：2011-04-28
申请人： Sungmin Son , Sangwon Byun , Andrea Kristine Bryan , Thomas Burg , Amneet Gulati , Jungchul Lee , Scott Manalis , Yao-Chung Weng
发明人： Sungmin Son , Sangwon Byun , Andrea Kristine Bryan , Thomas Burg , Amneet Gulati , Jungchul Lee , Scott Manalis , Yao-Chung Weng
IPC分类号： G01H13/00
CPC分类号： G01N15/1056 , G01N2015/1043 , G01N2015/105
摘要： Method for determining buoyant mass and deformability of a cell. The method includes introducing the cell into a suspended microchannel resonator that includes a constriction near a distal location in the resonator. A first frequency shift in the resonator is monitored as a cell moves to the distal location in the resonator, the first frequency shift being related to the buoyant mass of the cell. Transit time of the cell through the constriction is measured by monitoring a second frequency shift as a result of a change in cell location as it passes through the constriction, whereby deformability is determined from the measured buoyant mass and transit time.
摘要翻译： 确定电池的浮力质量和变形能力的方法。 该方法包括将细胞引入悬浮的微通道谐振器，其包括在谐振器中的远端位置附近的收缩部。 当单元移动到谐振器中的远端位置时，监测谐振器中的第一频移，第一频移与单元的浮力质量相关。 通过收缩通过监测细胞位置的变化的结果，通过监测第二频移来测量细胞通过收缩的转运时间，从而根据所测量的浮力质量和通过时间确定变形能力。
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8.发明授权Apparatus and method for measuring buoyant mass and deformability of single cells 有权用于测量单个电池的浮力质量和变形能力的装置和方法公开(公告)号：US08635911B2
公开(公告)日：2014-01-28
申请号：US13096248
申请日：2011-04-28
申请人： Sungmin Son , Sangwon Byun , Andrea Kristine Bryan , Thomas Burg , Amneet Gulati , Jungchul Lee , Scott Manalis , Yao-Chung Weng
发明人： Sungmin Son , Sangwon Byun , Andrea Kristine Bryan , Thomas Burg , Amneet Gulati , Jungchul Lee , Scott Manalis , Yao-Chung Weng
CPC分类号： G01N15/1056 , G01N2015/1043 , G01N2015/105
摘要： Method for determining buoyant mass and deformability of a cell. The method includes introducing the cell into a suspended microchannel resonator that includes a constriction near a distal location in the resonator. A first frequency shift in the resonator is monitored as a cell moves to the distal location in the resonator, the first frequency shift being related to the buoyant mass of the cell. Transit time of the cell through the constriction is measured by monitoring a second frequency shift as a result of a change in cell location as it passes through the constriction, whereby deformability is determined from the measured buoyant mass and transit time.
摘要翻译： 确定电池的浮力质量和变形能力的方法。 该方法包括将细胞引入悬浮的微通道谐振器，其包括在谐振器中的远端位置附近的收缩部。 当单元移动到谐振器中的远端位置时，监测谐振器中的第一频移，第一频移与单元的浮力质量相关。 通过收缩通过监测细胞位置的变化的结果，通过监测第二频移来测量细胞通过收缩的转运时间，从而根据所测量的浮力质量和通过时间确定变形能力。
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公开(公告)号：US20100297747A1
公开(公告)日：2010-11-25
申请号：US12739509
申请日：2008-10-24
申请人： Scott R. Manalis , Andrea K. Bryan , Yao-Chung Weng , Thomas Burg , William H. Grover , Marc W. Kirschner , Paul Jorgensen , Michel Godin
发明人： Scott R. Manalis , Andrea K. Bryan , Yao-Chung Weng , Thomas Burg , William H. Grover , Marc W. Kirschner , Paul Jorgensen , Michel Godin
IPC分类号： C12M1/34
CPC分类号： G01N15/147 , G01N15/1056 , G01N15/12 , G01N15/1484 , G01N2015/1037
摘要： Microsystem for monitoring cell growth. A microfluidic structure is designed to allow cells to circulate therethrough and the microfluidic structure includes modules to monitor mass, mass density and fluorescence of the cell.
摘要翻译： 用于监测细胞生长的微系统。 微流体结构被设计成允许细胞循环通过，微流体结构包括监测细胞的质量，质量密度和荧光的模块。
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