-
公开(公告)号：US20120070457A1
公开(公告)日：2012-03-22
申请号：US13199782
申请日：2011-09-08
申请人： Sean C. Daugherty , Julie C. Dunning Hotopp , David R. Riley , Samuel V. Angiuoli , Heather Huot Creasy , Todd H. Creasy , Herve Tettelin , Duccio Medini , Emilio Siena , Sonia Budroni , Maria Scarselli
发明人： Sean C. Daugherty , Julie C. Dunning Hotopp , David R. Riley , Samuel V. Angiuoli , Heather Huot Creasy , Todd H. Creasy , Herve Tettelin , Duccio Medini , Emilio Siena , Sonia Budroni , Maria Scarselli
摘要： Polypeptides comprising Neisseria meningitidis amino acid sequences. Over 36000 meningococcal polypeptide sequences are disclosed. The invention also provides related polypeptides, nucleic acids, antibodies and methods. These can all be usedin medicine for treating or preventing disease and/or infection caused by N. meningitidis, such as meningococcal meningitis.
摘要翻译： 包括脑膜炎奈瑟氏球菌氨基酸序列的多肽。 公开了36000多种脑膜炎球菌多肽序列。 本发明还提供了相关的多肽，核酸，抗体和方法。 这些都可用于治疗或预防由脑膜炎奈瑟菌引起的疾病和/或感染的药物，例如脑膜炎球菌性脑膜炎。
-
公开(公告)号：US09139621B2
公开(公告)日：2015-09-22
申请号：US13070448
申请日：2011-03-23
申请人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
IPC分类号： C07K14/22 , A61K39/095 , A61K39/00 , A61K38/00
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
-
公开(公告)号：US08524251B2
公开(公告)日：2013-09-03
申请号：US13359471
申请日：2012-01-26
申请人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
IPC分类号： A61K39/095 , A61K39/02 , A61K38/00 , C07K1/00
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
-
公开(公告)号：US07612192B2
公开(公告)日：2009-11-03
申请号：US10915740
申请日：2004-08-11
申请人： Claire Marie Fraser , Erin Kathleen Hickey , Jeremy D. Peterson , Herve Tettelin , Craig Ventor , Vega Masignani , Cesira Galeotti , Marirosa Mora , Giulio Ratti , Maria Scarselli , Vincenzo Scarlato , Rino Rappuoli , Mariagrazia Pizza , Guido Grandi
发明人： Claire Marie Fraser , Erin Kathleen Hickey , Jeremy D. Peterson , Herve Tettelin , Craig Ventor , Vega Masignani , Cesira Galeotti , Marirosa Mora , Giulio Ratti , Maria Scarselli , Vincenzo Scarlato , Rino Rappuoli , Mariagrazia Pizza , Guido Grandi
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , C12Q1/689 , C12Q2600/156
摘要： The invention provides methods of obtaining immunogenic proteins from genomic sequences including Neisseria, including the amino acid sequences and the corresponding nucleotide sequences, as well as the genomic sequence of Neisseria meningitidis B. The proteins so obtained are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
摘要翻译： 本发明提供了从包括奈瑟氏球菌在内的基因组序列获得免疫原性蛋白质的方法，包括氨基酸序列和相应的核苷酸序列，以及脑膜炎奈瑟氏球菌B的基因组序列。如此获得的蛋白质是疫苗，免疫原性组合物和 /或诊断。
-
公开(公告)号：US20070219347A1
公开(公告)日：2007-09-20
申请号：US11711740
申请日：2007-02-26
申请人： Claire Fraser , Erin Hickey , Jeremy Peterson , Herve Tettelin , J. Venter , Vega Masignani , Cesira Galeotti , Marirosa Mora , Giulio Ratti , Maria Scarselli , Vincenzo Scarlato , Rino Rappuoli , Mariagrazia Pizza , Guido Grandi
发明人： Claire Fraser , Erin Hickey , Jeremy Peterson , Herve Tettelin , J. Venter , Vega Masignani , Cesira Galeotti , Marirosa Mora , Giulio Ratti , Maria Scarselli , Vincenzo Scarlato , Rino Rappuoli , Mariagrazia Pizza , Guido Grandi
CPC分类号： C07K14/22 , A61K38/00 , A61K2039/53 , C12Q1/6886 , C12Q1/689
摘要： The invention provides methods of obtaining immunogenic proteins from genomic sequences including Neisseria, including the amino acid sequences and the corresponding nucleotide sequences, as well as the genomic sequence of Neisseria meningitidis B. The proteins so obtained are useful antigens for vaccines, immunogenic compositions, and/or diagnostics
摘要翻译： 本发明提供了从包括奈瑟氏球菌在内的基因组序列获得免疫原性蛋白质的方法，包括氨基酸序列和相应的核苷酸序列，以及脑膜炎奈瑟氏球菌B的基因组序列。如此获得的蛋白质是疫苗，免疫原性组合物和 /或诊断
-
公开(公告)号：US08431139B2
公开(公告)日：2013-04-30
申请号：US11434203
申请日：2006-05-16
申请人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
发明人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
IPC分类号： A61K39/09
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
摘要翻译： 本发明提供来自B族链球菌（无乳链球菌）和A型链球菌（化脓链球菌）的蛋白质，包括氨基酸序列和相应的核苷酸序列。 给出数据以显示蛋白质是疫苗，免疫原性组合物和/或诊断的有用抗原。 蛋白质也是抗生素的靶标。
-
公开(公告)号：US20120135024A1
公开(公告)日：2012-05-31
申请号：US13070448
申请日：2011-03-23
申请人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
-
公开(公告)号：US20090232820A1
公开(公告)日：2009-09-17
申请号：US12013047
申请日：2008-01-11
申请人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
IPC分类号： A61K39/395 , C07K7/06 , C07K7/08 , C07K14/00 , A61K38/08 , A61K38/10 , A61K38/16 , C07K16/00 , C07H21/04
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
摘要翻译： 本发明提供脑膜炎奈瑟氏球菌的蛋白质，包括氨基酸序列和相应的核苷酸序列。 蛋白质被预测为用于疫苗和/或诊断的有用的抗原。
-
公开(公告)号：US20070026021A1
公开(公告)日：2007-02-01
申请号：US11395121
申请日：2006-03-31
申请人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Peterson , Mariagrazia Pizza , Rino Rappuoli , Giulo Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , Craig Venter
发明人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Peterson , Mariagrazia Pizza , Rino Rappuoli , Giulo Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , Craig Venter
IPC分类号： A61K39/095 , C07K14/22 , C07K16/12
摘要： This invention provides, among other things, protein, polypeptides, and fragments thereof, derived from bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto (e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments and/or nucleic acids.
摘要翻译： 本发明尤其提供衍生自脑膜炎奈瑟氏球菌B的蛋白质，多肽和其片段。还提供编码这种蛋白质，多肽和/或片段的核酸，以及与其互补的核酸（例如， 反义核酸）。 另外，本发明提供了结合蛋白质，多肽和/或片段的抗体。 本发明进一步提供用于制备用作疫苗，诊断试剂，免疫原性组合物等的蛋白质，多肽，片段和/或核酸的表达载体。 还提供了用组合物制备组合物和处理方法的方法。 本发明还提供了检测蛋白质，多肽，片段和/或核酸的方法。
-
公开(公告)号：US09249196B2
公开(公告)日：2016-02-02
申请号：US13359442
申请日：2012-01-26
申请人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
IPC分类号： A61K39/095 , A61K39/00 , C07K14/22 , A61K38/00
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
-
-
-
-
-
-
-
-
-
搜索结果
72 条记录 (耗时 0.173 秒)
