公开(公告)号：US06384063B1

公开(公告)日：2002-05-07

申请号：US09463354

申请日：2000-03-31

申请人： Seiichi Saito ,  Masashi Nagai ,  Tomio Morino ,  Tsugio Tomiyoshi ,  Takaaki Nishikiori ,  Atsushi Kuwahara ,  Takamichi Sato ,  Takashi Harada

发明人： Seiichi Saito ,  Masashi Nagai ,  Tomio Morino ,  Tsugio Tomiyoshi ,  Takaaki Nishikiori ,  Atsushi Kuwahara ,  Takamichi Sato ,  Takashi Harada

IPC分类号： A61K3144

CPC分类号： C07D295/185 ,  C07C229/04 ,  C07C229/34 ,  C07C323/41 ,  C07C323/60 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07D205/04 ,  C07D207/16 ,  C07D213/32 ,  C07D213/50 ,  C07D213/55 ,  C07D295/145 ,  C07D295/155 ,  C07D295/192 ,  C07D307/54

摘要： A novel cystacycline derivative which has an excellent effect of promoting the differentiation of neurons and is useful as a remedy for central nervous system disorders, a remedy for peripheral nerve disorders, etc.

摘要翻译： 一种新颖的胱天蛋白衍生物，其具有促进神经元分化的优异效果，并且可用作中枢神经系统疾病的补救剂，对于周围神经障碍的治疗等。

公开(公告)号：US5306496A

公开(公告)日：1994-04-26

申请号：US896676

申请日：1992-06-10

申请人： Tomio Morino ,  Masakazu Nishimoto ,  Mituyuki Nishide ,  Akira Masuda ,  Masatoshi Yamada ,  Eiji Kawano ,  Takaaki Nishikiori ,  Seiichi Saito

发明人： Tomio Morino ,  Masakazu Nishimoto ,  Mituyuki Nishide ,  Akira Masuda ,  Masatoshi Yamada ,  Eiji Kawano ,  Takaaki Nishikiori ,  Seiichi Saito

IPC分类号： C12P1/02 ,  A61K35/70

CPC分类号： C12P1/02

摘要： Novel antibiotics NK374186A, NK374186B, NK374186B3 and NK374186C3 having antibacterial, antineoplastic, immunomodulation, and liver regeneration promoting activities are provided.NK374186A, NK374186B, NK374186B3 and NK374186C3 are obtained by culturing NK374186 strain (FERM P-12285) (FERM-BP 3870) belonging to the genus Penicillium. NK374186A is a compound represented by a rational formula of C.sub.34 H.sub.61 N.sub.3 O.sub.12 S.sub.9 and having a molecular weight of M+ 735 (FD-MS m/z); NK374186B is a compound represented by a rational formula of C.sub.34 H.sub.61 N.sub.3 O.sub.9 and having a molecular weight of M+ 655 (FD-MS m/z); NK374186B3 is a compound represented by a rational formula of C.sub.34 H.sub.61 N.sub.3 O.sub.9 and having a molecular weight of M+ 655 (FD-MS m/z); and NK374186C3 is a compound represented by a rational formula of C.sub.32 H.sub.59 N.sub.3 O.sub.7 and having a molecular weight of M+ 597 (FD-MS m/z).

摘要翻译： 提供具有抗菌，抗肿瘤，免疫调节和肝再生促进活性的新型抗生素NK374186A，NK374186B，NK374186B3和NK374186C3​​。 通过培养属于青霉属的NK374186菌株（FERM P-12285）（FERM-BP 3870）获得NK374186A，NK374186B，NK374186B3和NK374186C3​​。 NK374186A是由C34H61N3O12S9的合理式表示的化合物，其分子量为M + 735（FD-MS m / z）; NK374186B是由合理式C34H61N3O9表示的化合物，分子量为M + 655（FD-MS m / z）; NK374186B3是由合成式C34H61N3O9表示的化合物，其分子量为M + 655（FD-MS m / z）; 并且NK374186C3​​是由合成式C32H59N3O7表示的化合物，其分子量为M + 597（FD-MS m / z）。

公开(公告)号：US5003056A

公开(公告)日：1991-03-26

申请号：US288786

申请日：1988-12-22

申请人： Takaaki Nishikiori ,  Masanori Yamazaki ,  Seiichi Saito ,  Nobuyoshi Shimada ,  Takashi Kurokawa ,  Kiyonobu Hirose ,  Takumi Yamshita ,  Takako Tsuchiya ,  Takashi Harada

发明人： Takaaki Nishikiori ,  Masanori Yamazaki ,  Seiichi Saito ,  Nobuyoshi Shimada ,  Takashi Kurokawa ,  Kiyonobu Hirose ,  Takumi Yamshita ,  Takako Tsuchiya ,  Takashi Harada

IPC分类号： C07D493/20 ,  C07H19/01 ,  C12P17/18

CPC分类号： C07D493/20 ,  C07H19/01 ,  C12P17/181 ,  C12R1/465 ,  Y10S435/886

摘要： This invention relates to an antibiotic NK86-0279 of the formula: ##STR1## which exhibits antifungal, antitumor, vascularizations-inhibitory and insecticidal activities.

摘要翻译： 本发明涉及具有抗真菌，抗肿瘤，血管形成抑制和杀虫活性的下式的抗生素NK86-0279：。

公开(公告)号：US4994582A

公开(公告)日：1991-02-19

申请号：US466589

申请日：1990-01-17

申请人： Takaaki Nishikiori ,  Masanori Yamazaki ,  Seiichi Saito ,  Nobuyoshi Shimada ,  Takashi Kurokawa ,  Kiyonobu Hirose ,  Takumi Yamashita ,  Takashi Harada

发明人： Takaaki Nishikiori ,  Masanori Yamazaki ,  Seiichi Saito ,  Nobuyoshi Shimada ,  Takashi Kurokawa ,  Kiyonobu Hirose ,  Takumi Yamashita ,  Takashi Harada

IPC分类号： A01N43/90 ,  A61K31/365 ,  A61P31/04 ,  A61P31/10 ,  A61P35/00 ,  A61P43/00 ,  C07D493/18 ,  C07D493/20 ,  C12N1/20 ,  C12P17/18 ,  C12R1/465

CPC分类号： C07D493/20 ,  A01N43/90 ,  C12P17/181

摘要： This invention relates to an antibiotic NK130119 of the formula: ##STR1## which exhibits antifungal, antitumor, vascularizations-inhibitory and insecticidal activities.

公开(公告)号：US4742155A

公开(公告)日：1988-05-03

申请号：US801809

申请日：1985-11-26

申请人： Hamao Umezawa ,  Takaaki Aoyagi ,  Tomio Takeuchi ,  Masa Hamada ,  Hiroshi Naganawa ,  Yasuhiko Muraoka ,  Takaaki Nishikiori

发明人： Hamao Umezawa ,  Takaaki Aoyagi ,  Tomio Takeuchi ,  Masa Hamada ,  Hiroshi Naganawa ,  Yasuhiko Muraoka ,  Takaaki Nishikiori

IPC分类号： C12P21/04 ,  A61K35/74 ,  A61K38/00 ,  A61P37/06 ,  A61P37/08 ,  C07K7/06 ,  C07K7/64 ,  C07K14/195 ,  C07K14/41 ,  C12N1/20 ,  C12N9/99 ,  C12P21/02 ,  C12R1/085 ,  C07K5/12

CPC分类号： C07K7/06 ,  C12R1/085 ,  A61K38/00 ,  Y10S930/27

摘要： Plipastatin represented by the general formula ##STR1## wherein R.sub.1 is --C.sub.13 H.sub.27 or --C.sub.14 H.sub.29 ; and R.sub.2 is Ala or Val, or salts thereof, which is prepared by culturing a Plipastatin-producing strain belonging to the genus Bacillus to produce and accumulate Plipastatin in a cultured broth and then isolating Plipastatin from the cultured broth. Plipastatin exhibits an enzyme inhibiting activity against phospholipase A.sub.2, C and D and which will be useful as an immunosuppressive agent or as a type I anti-allergic agent.

摘要翻译： 由通式 + TR 表示的普伐他汀，其中R1为-C13H27或-C14H29; R2是Ala或Val或其盐，其通过培养属于芽孢杆菌属的Plipastatin产生菌株在培养的肉汤中产生并积累Plipastatin，然后从培养的肉汤中分离Plipastatin来制备。 Plipastatin对磷脂酶A2，C和D具有酶抑制活性，可用作免疫抑制剂或I型抗过敏剂。