公开(公告)号：US20100171950A1

公开(公告)日：2010-07-08

申请号：US12575369

申请日：2009-10-07

申请人： Selena CHAN ,  Sunghoon Kwon ,  Narayan Sundararajan

发明人： Selena CHAN ,  Sunghoon Kwon ,  Narayan Sundararajan

IPC分类号： G01J3/44

CPC分类号： G01N21/658 ,  B01D67/0062 ,  B01D67/0086 ,  B01D67/0088 ,  B01D71/02 ,  B82Y15/00 ,  B82Y30/00 ,  C12Q1/6825 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/6439 ,  G01N2021/655 ,  G01N2021/656 ,  C12Q2565/632 ,  C12Q2563/155

摘要： The methods, systems 400 and apparatus disclosed herein concern metal 150 impregnated porous substrates 110, 210. Certain embodiments of the invention concern methods for producing metal-coated porous silicon substrates 110, 210 that exhibit greatly improved uniformity and depth of penetration of metal 150 deposition. The increased uniformity and depth allow improved and more reproducible Raman detection of analytes. In exemplary embodiments of the invention, the methods may comprise oxidation of porous silicon 110, immersion in a metal salt solution 130, drying and thermal decomposition of the metal salt 140 to form a metal deposit 150. In other exemplary embodiments of the invention, the methods may comprise microfluidic impregnation of porous silicon substrates 210 with one or more metal salt solutions 130. Other embodiments of the invention concern apparatus and/or systems 400 for Raman detection of analytes, comprising metal-coated porous silicon substrates 110, 210 prepared by the disclosed methods.

摘要翻译： 本文公开的方法，系统400和装置涉及金属150浸渍的多孔基材110,210。本发明的某些实施方案涉及用于制造金属涂覆的多孔硅基板110,210的方法，其显示出显着改善金属150沉积物的均匀性和深度的渗透 。 增加的均匀性和深度允许分析物的改进和更可重复的拉曼检测。 在本发明的示例性实施例中，所述方法可以包括多孔硅110的氧化，浸入金属盐溶液130中，干燥和热分解金属盐140以形成金属沉积物150.在本发明的其它示例性实施方案中， 方法可以包括多孔硅衬底210与一种或多种金属盐溶液130的微流体浸渍。本发明的其它实施方案涉及用于分析物的拉曼检测的装置和/或系统400，包括金属涂覆的多孔硅衬底110,210，由 公开的方法。

公开(公告)号：US20130243656A1

公开(公告)日：2013-09-19

申请号：US13730431

申请日：2012-12-28

申请人： Selena CHAN ,  Sunghoon Kwon ,  Narayan Sundararajan

发明人： Selena CHAN ,  Sunghoon Kwon ,  Narayan Sundararajan

IPC分类号： G01N21/65

CPC分类号： G01N21/658 ,  B01D67/0062 ,  B01D67/0086 ,  B01D67/0088 ,  B01D71/02 ,  B82Y15/00 ,  B82Y30/00 ,  C12Q1/6825 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/6439 ,  G01N2021/655 ,  G01N2021/656 ,  C12Q2565/632 ,  C12Q2563/155

摘要： The methods, systems 400 and apparatus disclosed herein concern metal 150 impregnated porous substrates 110, 210, Certain embodiments of the invention concern methods for producing metal-coated porous silicon substrates 110, 210 that exhibit greatly improved uniformity and depth of penetration of metal 150 deposition. The increased uniformity and depth allow improved and more reproducible Raman detection of analytes. In exemplary embodiments of the invention, the methods may comprise oxidation of porous silicon 110, immersion in a metal salt solution, 130, drying and thermal decomposition of the metal salt 140 to form a metal deposit 150. In other exemplary embodiments of the invention, the methods may comprise microfluidic impregnation of porous silicon substrates 210 with one or more metal salt solutions 130. Other embodiments of the invention concern apparatus and/or systems 400 for Raman detection of analytes, comprising metal-coated porous silicon substrates 110, 210 prepared by the disclosed methods.

摘要翻译： 本文公开的方法，系统400和装置涉及金属150浸渍的多孔基材110,210。本发明的某些实施方案涉及用于制造金属涂覆的多孔硅基板110,210的方法，其显示出显着改善金属150沉积物的均匀性和深度的渗透 。 增加的均匀性和深度允许分析物的改进和更可重复的拉曼检测。 在本发明的示例性实施方案中，所述方法可以包括多孔硅110的氧化，浸入金属盐溶液130，金属盐140的干燥和热分解以形成金属沉积物150.在本发明的其它示例性实施方案中， 该方法可以包括多孔硅衬底210与一种或多种金属盐溶液130的微流体浸渍。本发明的其它实施方案涉及用于分析物的拉曼检测的装置和/或系统400，包括金属涂覆的多孔硅衬底110,210，由 公开的方法。

公开(公告)号：US20120141329A1

公开(公告)日：2012-06-07

申请号：US13272858

申请日：2011-10-13

申请人： Mineo YAMAKAWA ,  John HECK ,  Selena CHAN ,  Narayan SUNDARARAJAN

发明人： Mineo YAMAKAWA ,  John HECK ,  Selena CHAN ,  Narayan SUNDARARAJAN

IPC分类号： G01N21/00

CPC分类号： B01L3/502715 ,  B01J2219/00639 ,  B01L3/50255 ,  B01L3/502753 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/0887 ,  B81B2201/0214 ,  Y10T137/2224

摘要： Microfluidic apparatus including integrated porous substrate/sensors that may be used for detecting targeted biological and chemical molecules and compounds. In one aspect, upper and lower microfluidic channels are defined in respective halves of a substrate, which are sandwiched around a porous membrane upon assembly. In other aspect, the upper and lower channels are formed such that a portion of the lower channel passes beneath a portion of the upper channel to form a cross-channel area, wherein the membrane is disposed between the two channels. In various embodiments, one or more porous membranes are disposed proximate to corresponding cross-channel areas defined by one or more upper and lower channels. The porous membrane may also have sensing characteristics, such that it produces a change in an optical and/or electronic characteristic. Accordingly, the apparatus may further include instrumentation or detection equipment to measure the changes, such as optic-based detectors and electronic instrumentation.

摘要翻译： 微流体设备包括可用于检测目标生物和化学分子和化合物的综合多孔底物/传感器。 在一个方面，上和下微流体通道限定在基底的相应的两半中，其在组装时夹在多孔膜周围。 在另一方面，上通道和下通道形成为使得下通道的一部分穿过上通道的一部分以形成交叉通道区域，其中隔膜设置在两个通道之间。 在各种实施例中，一个或多个多孔膜设置在由一个或多个上部和下部通道限定的相应交叉通道区域附近。 多孔膜也可以具有感测特性，使得其产生光学和/或电子特性的变化。 因此，该装置还可以包括用于测量变化的仪器或检测设备，例如基于光学的检测器和电子仪器。