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![[a]-FUSED INDOLE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES](/abs-image/US/2009/07/30/US20090192147A1/abs.jpg.150x150.jpg)
1.发明申请[a]-FUSED INDOLE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES 审中-公开[a] - 兴奋剂化合物，它们作为mTOR激酶和PI3激酶抑制剂使用，以及它们的合成公开(公告)号：US20090192147A1
公开(公告)日：2009-07-30
申请号：US12363013
申请日：2009-01-30
申请人： Semiramis Ayral-Kaloustian , Nan Zhang , Aranapakam Mudumbai Venkatesan , Tarek Suhayl Mansour , Thai Hiep Nguyen , James Thomas Anderson
发明人： Semiramis Ayral-Kaloustian , Nan Zhang , Aranapakam Mudumbai Venkatesan , Tarek Suhayl Mansour , Thai Hiep Nguyen , James Thomas Anderson
IPC分类号： A61K31/5383 , C07D471/00 , A61K31/437 , C07D487/00 , A61K31/4985
CPC分类号： C07D498/04 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/14 , C07D498/14 , C07D513/04 , C07D513/14
摘要： The invention relates to [a]-fused indole compounds of the Formula II, or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein. The invention also relates to compositions comprising the compounds of Formula II, and methods for making and using the compounds.
摘要翻译： 本发明涉及式[II]的[a] - 吲哚化合物或其药学上可接受的盐，其中组分变量如本文所定义。 本发明还涉及包含式II化合物的组合物，以及制备和使用该化合物的方法。
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2.发明申请3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES 审中-公开3-取代的1H-吲哚化合物，它们作为MTOR激酶和PI3激酶抑制剂使用，以及它们的合成公开(公告)号：US20090311217A1
公开(公告)日：2009-12-17
申请号：US12473605
申请日：2009-05-28
申请人： Matthew Gregory Bursavich , Nan Zhang , Semiramis Ayral-Kaloustian , James Thomas Anderson , Thai Hiep Nguyen , Sabrina Lombardi , David Malwitz , Natasja Brooijmans , Derek Cecil Cole , Adam Matthew Gilbert , Pawel Wojciech Nowak , Kaapjoo Park , Sasmita Das , Hwei-Ru Tsou , Aranapakam Mudumbai Venkatesan , Mercy Adufa Otteng , Gary Harold Birnberg , Gloria Jean MacEwan
发明人： Matthew Gregory Bursavich , Nan Zhang , Semiramis Ayral-Kaloustian , James Thomas Anderson , Thai Hiep Nguyen , Sabrina Lombardi , David Malwitz , Natasja Brooijmans , Derek Cecil Cole , Adam Matthew Gilbert , Pawel Wojciech Nowak , Kaapjoo Park , Sasmita Das , Hwei-Ru Tsou , Aranapakam Mudumbai Venkatesan , Mercy Adufa Otteng , Gary Harold Birnberg , Gloria Jean MacEwan
IPC分类号： A61K31/404 , C07D405/02 , C07D403/14 , C07D413/02 , A61K31/496 , A61K31/5377 , A61K38/21 , A61K39/395 , A61P35/00
CPC分类号： C07D405/14 , C07D405/06
摘要： The invention relates to 3-substituted-1H-indole compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
摘要翻译： 本发明涉及式I的3-取代-1H-吲哚化合物或其药学上可接受的盐，其中组分变量如本文所定义，包含该化合物的组合物，以及制备和使用该化合物的方法。
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![3-SUBSTITUTED-1H-INDOLE, 3-SUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINE AND 3-SUBSTITUTED-1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES](/abs-image/US/2010/03/11/US20100061982A1/abs.jpg.150x150.jpg)
3.发明申请3-SUBSTITUTED-1H-INDOLE, 3-SUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINE AND 3-SUBSTITUTED-1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES 审中-公开3-取代的1H-吲哚，3-取代的1H-吡咯并[2,3-b]吡啶和3-取代的1H-吡咯[3,2-B]吡啶化合物，它们作为MTOR激酶和PI3激酶抑制剂 ，和他们的合成公开(公告)号：US20100061982A1
公开(公告)日：2010-03-11
申请号：US12556833
申请日：2009-09-10
申请人： Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Hwei-Ru Tsou , Nan Zhang , Aranapakam Mudumbai Venkatesan , Li Di , Edward Harvel Kerns
发明人： Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Hwei-Ru Tsou , Nan Zhang , Aranapakam Mudumbai Venkatesan , Li Di , Edward Harvel Kerns
IPC分类号： A61K39/395 , C07D405/06 , A61K31/40 , C07D403/06 , A61K31/497 , C07D498/02 , A61K31/5386
CPC分类号： C07D407/06 , C07D471/04
摘要： The invention relates to 3-substituted-1H-indole, 3-substituted-1H-pyrrolo[2,3-b]pyridine, and 3-substituted-1H-pyrrolo[3,2-b]pyridine compounds of the Formula 1: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
摘要翻译： 本发明涉及式1的3-取代-1H-吲哚，3-取代-1H-吡咯并[2,3-b]吡啶和3-取代-1H-吡咯并[3,2-b]吡啶化合物： 或其药学上可接受的盐，其中组成变量如本文所定义，包含该化合物的组合物，以及制备和使用该化合物的方法。
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![(2-ARYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)MORPHOLINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES](/abs-image/US/2010/01/07/US20100003250A1/abs.jpg.150x150.jpg)
4.发明申请(2-ARYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)MORPHOLINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES 审中-公开（2-ARYL-7H-吡咯并[2,3-D]嘧啶-4-基）吗啉化合物，它们作为MTOR激酶和PI3激酶抑制剂使用，以及它们的合成公开(公告)号：US20100003250A1
公开(公告)日：2010-01-07
申请号：US12496675
申请日：2009-07-02
申请人： Zecheng Chen , Aranapakam Mudumbai Venkatesan , Arie Zask , Jeroen Cunera Verheijen , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Kevin Joseph Curran
发明人： Zecheng Chen , Aranapakam Mudumbai Venkatesan , Arie Zask , Jeroen Cunera Verheijen , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Kevin Joseph Curran
IPC分类号： A61K31/5377 , C07D487/04 , A61K39/395 , A61P35/00
CPC分类号： C07D487/04
摘要： The invention relates to 2-aryl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)morpholine compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
摘要翻译： 本发明涉及式I的2-芳基-7H-吡咯并[2,3-d]嘧啶-4-基）吗啉化合物或其药学上可接受的盐，其中组分变量如本文所定义，组合物包含 化合物，以及制备和使用该化合物的方法。
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公开(公告)号：US08445486B2
公开(公告)日：2013-05-21
申请号：US13490309
申请日：2012-06-06
申请人： Aranapakam Mudumbai Venkatesan , Zecheng Chen , Christoph Martin Dehnhardt , Osvaldo Dos Santos , Efren Guillermo Delos Santos , Arie Zask , Jeroen Cunera Verheijen , Joshua Aaron Kaplan , David James Richard , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Ariamala Gopalsamy , Kevin Joseph Curran , Mengxiao Shi
发明人： Aranapakam Mudumbai Venkatesan , Zecheng Chen , Christoph Martin Dehnhardt , Osvaldo Dos Santos , Efren Guillermo Delos Santos , Arie Zask , Jeroen Cunera Verheijen , Joshua Aaron Kaplan , David James Richard , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Ariamala Gopalsamy , Kevin Joseph Curran , Mengxiao Shi
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： C07D401/12 , A61K31/5377 , A61K45/06 , C07D251/18 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/04 , C07D413/14 , C07D451/06 , C07D453/02 , C07D491/113 , C07D498/08
摘要： Compounds of formula I wherein: R1 is and R2, R4, and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.
摘要翻译： 式I的化合物，其中：R1是和R2，R4和R6-9在本文中定义，及其药学上可接受的盐和酯。 这些化合物抑制PI3激酶和mTOR，并可用于治疗PI3激酶和mTOR介导的疾病，如多种癌症。 公开了制备和使用本发明化合物的方法。 还公开了含有本发明化合物的各种组合物。
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公开(公告)号：US08217036B2
公开(公告)日：2012-07-10
申请号：US13218571
申请日：2011-08-26
申请人： Aranapakam Mudumbai Venkatesan , Zecheng Chen , Christoph Martin Dehnhardt , Osvaldo Dos Santos , Efren Guillermo Delos Santos , Arie Zask , Jeroen Cunera Verheijen , Joshua Aaron Kaplan , David James Richard , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Ariamala Gopalsamy , Kevin Joseph Curran , Mengxiao Shi
发明人： Aranapakam Mudumbai Venkatesan , Zecheng Chen , Christoph Martin Dehnhardt , Osvaldo Dos Santos , Efren Guillermo Delos Santos , Arie Zask , Jeroen Cunera Verheijen , Joshua Aaron Kaplan , David James Richard , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Ariamala Gopalsamy , Kevin Joseph Curran , Mengxiao Shi
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： C07D401/12 , A61K31/5377 , A61K45/06 , C07D251/18 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/04 , C07D413/14 , C07D451/06 , C07D453/02 , C07D491/113 , C07D498/08
摘要： Compounds of formula I wherein: R1 is and R2, R4, and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.
摘要翻译： 式I的化合物，其中：R1是和R2，R4和R6-9在本文中定义，及其药学上可接受的盐和酯。 这些化合物抑制PI3激酶和mTOR，并可用于治疗PI3激酶和mTOR介导的疾病，如多种癌症。 公开了制备和使用本发明化合物的方法。 还公开了含有本发明化合物的各种组合物。
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公开(公告)号：US20090304692A1
公开(公告)日：2009-12-10
申请号：US12470525
申请日：2009-05-22
申请人： Aranapakam Mudumbai Venkatesan , Zecheng Chen , Christoph Martin Dehnhardt , Osvaldo dos Santos , Efren Guillermo Delos Santos , Arie Zask , Jeroen Cunera Verheijen , Joshua Aaron Kaplan , David James Richard , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Ariamala Gopalsamy , Kevin Joseph Curran , Mengxiao Shi
发明人： Aranapakam Mudumbai Venkatesan , Zecheng Chen , Christoph Martin Dehnhardt , Osvaldo dos Santos , Efren Guillermo Delos Santos , Arie Zask , Jeroen Cunera Verheijen , Joshua Aaron Kaplan , David James Richard , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Ariamala Gopalsamy , Kevin Joseph Curran , Mengxiao Shi
IPC分类号： A61K31/5375 , C07D413/04 , C07D413/14 , C07D405/14 , C07D417/14 , C07D491/08 , C07D498/08 , A61K31/5377 , A61K31/541 , A61K31/7068 , A61K31/675 , A61K33/24 , A61K39/395 , A61P19/00 , A61P35/00
摘要： Compounds of formula I wherein: R1 is and R2, R4, and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.
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公开(公告)号：US20090291079A1
公开(公告)日：2009-11-26
申请号：US12470521
申请日：2009-05-22
申请人： Aranapakam Mudumbai Venkatesan , Zecheng Chen , Christoph Martin Dehnhardt , Osvaldo dos Santos , Efren Guillermo Delos Santos , Arie Zask , Jeroen Cunera Verheijen , Joshua Aaron Kaplan , David James Richard , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Ariamala Gopalsamy , Kevin Joseph Curran , Mengxiao Shi
发明人： Aranapakam Mudumbai Venkatesan , Zecheng Chen , Christoph Martin Dehnhardt , Osvaldo dos Santos , Efren Guillermo Delos Santos , Arie Zask , Jeroen Cunera Verheijen , Joshua Aaron Kaplan , David James Richard , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Ariamala Gopalsamy , Kevin Joseph Curran , Mengxiao Shi
IPC分类号： A61K31/5377 , C07D413/14 , A61K31/7068 , A61K31/675 , A61K33/24 , A61K31/7048 , A61K31/704 , A61K39/395 , A61P19/00 , A61P29/00 , A61P37/00 , A61P35/00
CPC分类号： C07D401/12 , A61K31/5377 , A61K45/06 , C07D251/18 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/04 , C07D413/14 , C07D451/06 , C07D453/02 , C07D491/113 , C07D498/08
摘要： Compounds of formula I wherein: R1 is and R2, R4, and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.
摘要翻译： 式I的化合物，其中：R1是和R2，R4和R6-9在本文中定义，及其药学上可接受的盐和酯。 这些化合物抑制PI3激酶和mTOR，并可用于治疗PI3激酶和mTOR介导的疾病，如多种癌症。 公开了制备和使用本发明化合物的方法。 还公开了含有本发明化合物的各种组合物。
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公开(公告)号：US20130005723A1
公开(公告)日：2013-01-03
申请号：US13490309
申请日：2012-06-06
申请人： Aranapakam Mudumbai Venkatesan , Zecheng Chen , Christoph Martin Dehnhardt , Osvaldo Dos Santos , Efren Guillermo Delos Santos , Arie Zask , Jeroen Cunera Verheijen , Joshua Aaron Kaplan , David James Richard , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Ariamala Gopalsamy , Kevin Joseph Curran , Mengxiao Shi
发明人： Aranapakam Mudumbai Venkatesan , Zecheng Chen , Christoph Martin Dehnhardt , Osvaldo Dos Santos , Efren Guillermo Delos Santos , Arie Zask , Jeroen Cunera Verheijen , Joshua Aaron Kaplan , David James Richard , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Ariamala Gopalsamy , Kevin Joseph Curran , Mengxiao Shi
IPC分类号： A61K31/5377 , A61P35/00 , C07D491/08
CPC分类号： C07D401/12 , A61K31/5377 , A61K45/06 , C07D251/18 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/04 , C07D413/14 , C07D451/06 , C07D453/02 , C07D491/113 , C07D498/08
摘要： Compounds of formula I wherein: R1 is and R2, R4, and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.
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公开(公告)号：US08039469B2
公开(公告)日：2011-10-18
申请号：US12470521
申请日：2009-05-22
申请人： Aranapakam Mudumbai Venkatesan , Zecheng Chen , Christoph Martin Dehnhardt , Osvaldo dos Santos , Efren Guillermo Delos Santos , Arie Zask , Jeroen Cunera Verheijen , Joshua Aaron Kaplan , David James Richard , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Ariamala Gopalsamy , Kevin Joseph Curran , Mengxiao Shi
发明人： Aranapakam Mudumbai Venkatesan , Zecheng Chen , Christoph Martin Dehnhardt , Osvaldo dos Santos , Efren Guillermo Delos Santos , Arie Zask , Jeroen Cunera Verheijen , Joshua Aaron Kaplan , David James Richard , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Ariamala Gopalsamy , Kevin Joseph Curran , Mengxiao Shi
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： C07D401/12 , A61K31/5377 , A61K45/06 , C07D251/18 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/04 , C07D413/14 , C07D451/06 , C07D453/02 , C07D491/113 , C07D498/08
摘要： Compounds of formula I wherein: R1 is and R2, R4, and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.
摘要翻译： 式I的化合物，其中：R1是和R2，R4和R6-9在本文中定义，及其药学上可接受的盐和酯。 这些化合物抑制PI3激酶和mTOR，并可用于治疗PI3激酶和mTOR介导的疾病，如多种癌症。 公开了制备和使用本发明化合物的方法。 还公开了含有本发明化合物的各种组合物。
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