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公开(公告)号:US20130017548A1
公开(公告)日:2013-01-17
申请号:US13534489
申请日:2012-06-27
申请人: Sen Takeshita , Takashi Yamamoto , Ayatoshi Andou , Tomohisa Okutsu , Agung Eviryanti , Naoyuki Fukuchi , Shunsuke Kageyama
发明人: Sen Takeshita , Takashi Yamamoto , Ayatoshi Andou , Tomohisa Okutsu , Agung Eviryanti , Naoyuki Fukuchi , Shunsuke Kageyama
IPC分类号: G01N33/573 , C12Q1/68 , G01N33/566 , C12Q1/48
CPC分类号: C12Q1/485 , G01N2333/91215 , G01N2440/14 , G01N2500/02
摘要: The present invention relates to a novel method for screening for a therapeutic or prophylactic agent for an inflammatory disease.More particularly, the present invention relates to a method for screening for a therapeutic or prophylactic agent for an inflammatory disease by selecting a substance having an inhibitory activity specific to PIKfyve by using the presence or absence of the inhibitory activity as an indicator.
摘要翻译: 本发明涉及用于筛选炎性疾病的治疗或预防剂的新方法。 更具体地,本发明涉及通过使用抑制活性的存在或不存在作为指标来选择具有PIKfyve特异性抑制活性的物质来筛选炎症性疾病的治疗或预防药物的方法。
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公开(公告)号:US20100093055A1
公开(公告)日:2010-04-15
申请号:US12574947
申请日:2009-10-07
申请人: Naoyuki Fukuchi , Satoru Okamoto , Wataru Miyanaga , Sen Takeshita , Masaru Takayanagi , Yumiko Fukuda , Takao Ikenoue , Naoyuki Yamada , Naoko Arashida
发明人: Naoyuki Fukuchi , Satoru Okamoto , Wataru Miyanaga , Sen Takeshita , Masaru Takayanagi , Yumiko Fukuda , Takao Ikenoue , Naoyuki Yamada , Naoko Arashida
IPC分类号: C12N9/00 , G01N33/566 , C07D243/10 , C07D243/00
CPC分类号: C07D487/04 , A61K31/55 , A61K31/551 , C07D519/00 , C12Q1/485 , G01N33/5035 , G01N33/573 , G01N33/6845 , G01N33/6872 , G01N2333/4719 , G01N2333/91215 , G01N2500/04 , G01N2800/042
摘要: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the β subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the β subunit of a trimeric GTP-binding protein, as the active ingredient, etc.
摘要翻译: 筛选具有降血糖作用的化合物的方法(以下称为“降血糖化合物”),含有具有新的功能机制的化合物的糖尿病治疗剂等。更具体地说,可以列举一种能够将降血糖化合物 绑定到&bgr 三聚GTP结合蛋白的亚单位,包含降血糖化合物的糖尿病治疗剂,其特征在于能够结合到该组合物上。 三聚GTP结合蛋白的亚基作为活性成分等
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公开(公告)号:US08357680B2
公开(公告)日:2013-01-22
申请号:US12574947
申请日:2009-10-07
申请人: Naoyuki Fukuchi , Satoru Okamoto , Wataru Miyanaga , Sen Takeshita , Masaru Takayanagi , Yumiko Fukuda , Takao Ikenoue , Naoyuki Yamada , Naoko Arashida
发明人: Naoyuki Fukuchi , Satoru Okamoto , Wataru Miyanaga , Sen Takeshita , Masaru Takayanagi , Yumiko Fukuda , Takao Ikenoue , Naoyuki Yamada , Naoko Arashida
CPC分类号: C07D487/04 , A61K31/55 , A61K31/551 , C07D519/00 , C12Q1/485 , G01N33/5035 , G01N33/573 , G01N33/6845 , G01N33/6872 , G01N2333/4719 , G01N2333/91215 , G01N2500/04 , G01N2800/042
摘要: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the β subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the β subunit of a trimeric GTP-binding protein, as the active ingredient, etc.
摘要翻译: 筛选具有降血糖作用的化合物的方法(以下称为降血糖化合物),含有具有新的功能机制的化合物的糖尿病治疗剂等。更具体地说,可以列举能够结合至低血糖的化合物的方法 的&bgr 三聚GTP结合蛋白的亚单位,包含降血糖化合物的糖尿病治疗剂,其特征在于能够结合到该组合物上。 三聚GTP结合蛋白的亚基作为活性成分等
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公开(公告)号:US08173605B2
公开(公告)日:2012-05-08
申请号:US12117027
申请日:2008-05-08
申请人: Takeaki Ohsu , Sen Takeshita , Yuzuru Eto , Yusuke Amino , Naohiro Miyamura , Tomohiko Yamanaka , Hiroaki Nagasaki
发明人: Takeaki Ohsu , Sen Takeshita , Yuzuru Eto , Yusuke Amino , Naohiro Miyamura , Tomohiko Yamanaka , Hiroaki Nagasaki
IPC分类号: C07K5/06
CPC分类号: G01N33/6872 , A23L27/10 , A23L33/175 , C07K5/0215 , G01N2333/726
摘要: The present invention encompasses a method for screening for a kokumi-imparting substance by using the calcium receptor activity as an index, a composition containing a kokumi-imparting substance obtained by the screening method, a method for producing food or drink imparted with kokumi, and food or drink imparted with kokumi.
摘要翻译: 本发明包括使用钙受体活性作为指标筛选赋粉性物质的方法,含有通过筛选方法得到的赋予口味的物质的组合物,赋予口味的食品或饮料的制造方法,以及 送给kokumi的食物或饮料。
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公开(公告)号:US20080182811A1
公开(公告)日:2008-07-31
申请号:US11963550
申请日:2007-12-21
申请人: Takeaki Ohsu , Sen Takeshita , Mitsuo Takahashi , Yuzuru Eto
发明人: Takeaki Ohsu , Sen Takeshita , Mitsuo Takahashi , Yuzuru Eto
IPC分类号: A61K31/7088 , A61K31/195 , A61K31/198 , G01N33/68 , A61P9/00 , A61P17/00 , A61P25/00 , A61P27/02
CPC分类号: A61K31/708 , A61K31/185 , A61K31/198 , A61K31/401 , A61K31/403 , A61K31/405 , A61K31/4164 , A61K31/4172 , A61K31/7076 , A61K33/06 , G01N2333/70571 , A61K2300/00
摘要: Amino acids other than glutamic acid are used as a metabotropic glutamate receptor activator. More preferably, aspartic acid, valine and cysteine are used as a group I metabotropic glutamate receptor activator; alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, ornithine, taurine and hydroxyproline are used as a group II metabotropic glutamate receptor activator; and cysteine is used as a group III metabotropic glutamate receptor activator.
摘要翻译: 除谷氨酸以外的氨基酸用作代谢型谷氨酸受体激活剂。 更优选天冬氨酸,缬氨酸和半胱氨酸用作I代谢型谷氨酸受体激活剂; 丙氨酸,精氨酸,天冬酰胺,天冬氨酸,半胱氨酸,谷氨酰胺,甘氨酸,组氨酸,异亮氨酸,亮氨酸,赖氨酸,甲硫氨酸,苯丙氨酸,脯氨酸,丝氨酸,苏氨酸,色氨酸,酪氨酸,缬氨酸,鸟氨酸,牛磺酸和羟脯氨酸 代谢型谷氨酸受体激活剂; 半胱氨酸用作III族代谢型谷氨酸受体激活剂。
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公开(公告)号:US20070037886A1
公开(公告)日:2007-02-15
申请号:US11411024
申请日:2006-04-26
申请人: Sen Takeshita , Yuzuru Eto , Yoshiyuki Takahara , Kiyonobu Kamiya , Kazumi Tashiro , Maki Sugiyama , Hiroshi Yamamoto
发明人: Sen Takeshita , Yuzuru Eto , Yoshiyuki Takahara , Kiyonobu Kamiya , Kazumi Tashiro , Maki Sugiyama , Hiroshi Yamamoto
IPC分类号: A61K31/198
CPC分类号: A61K31/198 , A61K38/1816 , A61K2300/00
摘要: Bone marrow erythroid progenitor cell(s) differentiation may be induced and anemia may be treated by administering arginine. Arginine is an excellent differentiation inducer, because it has high safety, can be orally administered, and is widely used.
摘要翻译: 可能诱导骨髓红细胞祖细胞分化,并可通过施用精氨酸治疗贫血。 精氨酸是一种优良的分化诱导因子,因为它具有高度的安全性,可以口服给药,被广泛使用。
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公开(公告)号:US20060257935A1
公开(公告)日:2006-11-16
申请号:US11410948
申请日:2006-04-26
申请人: Sen Takeshita , Yuzuru Eto , Yoshiyuki Takahara , Kiyonobu Kamiya , Kazumi Tashiro , Maki Sugiyama , Hiroshi Yamamoto
发明人: Sen Takeshita , Yuzuru Eto , Yoshiyuki Takahara , Kiyonobu Kamiya , Kazumi Tashiro , Maki Sugiyama , Hiroshi Yamamoto
IPC分类号: G01N33/53
CPC分类号: G01N33/5023 , G01N33/5073 , G01N2333/505 , G01N2333/65
摘要: The present invention provides methods of screening for enhancers and/or inhibitors of a hematopoietic factor production promoter comprising arginine as an active ingredient. Arginine is an excellent hematopoietic factor production promoter, because it has high safety, can be orally administered, and is widely used.
摘要翻译: 本发明提供了筛选包含精氨酸作为活性成分的造血因子产生促进剂的增强子和/或抑制剂的方法。 精氨酸是一种优良的造血因子生产促进剂,因为它具有高度的安全性,可以口服给药,并被广泛应用。
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公开(公告)号:US20110097805A1
公开(公告)日:2011-04-28
申请号:US12962051
申请日:2010-12-07
申请人: Takeaki Ohsu , Sen Takeshita , Yuzuru Eto , Yusuke Amino , Naohiro Miyamura , Tomohiko Yamanaka , Hiroaki Nagasaki
发明人: Takeaki Ohsu , Sen Takeshita , Yuzuru Eto , Yusuke Amino , Naohiro Miyamura , Tomohiko Yamanaka , Hiroaki Nagasaki
IPC分类号: G01N33/02
CPC分类号: G01N33/6872 , A23L27/10 , A23L33/175 , C07K5/0215 , G01N2333/726
摘要: The present invention encompasses a method for screening for a kokumi-imparting substance by using the calcium receptor activity as an index, a composition containing a kokumi-imparting substance obtained by the screening method, a method for producing food or drink imparted with kokumi, and food or drink imparted with kokumi.
摘要翻译: 本发明包括使用钙受体活性作为指标筛选赋粉性物质的方法,含有通过筛选方法得到的赋予口味的物质的组合物,赋予口味的食品或饮料的制造方法,以及 送给kokumi的食物或饮料。
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公开(公告)号:US20090239310A1
公开(公告)日:2009-09-24
申请号:US12117027
申请日:2008-05-08
申请人: Takeaki Ohsu , Sen Takeshita , Yuzuru Eto , Yusuke Amino , Naohiro Miyamura , Tomohiko Yamanaka , Hiroaki Nagasaki
发明人: Takeaki Ohsu , Sen Takeshita , Yuzuru Eto , Yusuke Amino , Naohiro Miyamura , Tomohiko Yamanaka , Hiroaki Nagasaki
IPC分类号: G01N33/566 , C07K5/08
CPC分类号: G01N33/6872 , A23L27/10 , A23L33/175 , C07K5/0215 , G01N2333/726
摘要: The present invention encompasses a method for screening for a kokumi-imparting substance by using the calcium receptor activity as an index, a composition containing a kokumi-imparting substance obtained by the screening method, a method for producing food or drink imparted with kokumi, and food or drink imparted with kokumi.
摘要翻译: 本发明包括使用钙受体活性作为指标筛选赋粉性物质的方法,含有通过筛选方法得到的赋予口味的物质的组合物,赋予口味的食品或饮料的制造方法,以及 送给kokumi的食物或饮料。
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公开(公告)号:US09395376B2
公开(公告)日:2016-07-19
申请号:US12962051
申请日:2010-12-07
申请人: Takeaki Ohsu , Sen Takeshita , Yuzuru Eto , Yusuke Amino , Naohiro Miyamura , Tomohiko Yamanaka , Hiroaki Nagasaki
发明人: Takeaki Ohsu , Sen Takeshita , Yuzuru Eto , Yusuke Amino , Naohiro Miyamura , Tomohiko Yamanaka , Hiroaki Nagasaki
CPC分类号: G01N33/6872 , A23L27/10 , A23L33/175 , C07K5/0215 , G01N2333/726
摘要: The present invention encompasses a method for screening for a kokumi-imparting substance by using the calcium receptor activity as an index, a composition containing a kokumi-imparting substance obtained by the screening method, a method for producing food or drink imparted with kokumi, and food or drink imparted with kokumi.
摘要翻译: 本发明包括使用钙受体活性作为指标筛选赋粉性物质的方法,含有通过筛选方法得到的赋予口味的物质的组合物,赋予口味的食品或饮料的制造方法,以及 送给kokumi的食物或饮料。
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