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公开(公告)号：US20050101781A1
公开(公告)日：2005-05-12
申请号：US10501120
申请日：2003-01-08
申请人： Sergei Agoulnik , Kozo Akasaka , Francis Fang , Jean-Christophe Harmange , Lynn Hawkins , Yimin Jiang , Charles Johannes , Xiang-Yi Li , Pamela McGuinness , Erin Murphy , Shawn Schiller , Mary Vermeulen , Jiayi Wu
发明人： Sergei Agoulnik , Kozo Akasaka , Francis Fang , Jean-Christophe Harmange , Lynn Hawkins , Yimin Jiang , Charles Johannes , Xiang-Yi Li , Pamela McGuinness , Erin Murphy , Shawn Schiller , Mary Vermeulen , Jiayi Wu
IPC分类号： C07D303/14 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/336 , A61K31/343 , A61K31/353 , A61K31/36 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/4045 , A61K31/4427 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/498 , A61K31/662 , A61K31/69 , A61K38/00 , A61P29/00 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/00 , A61P43/00 , C07C233/76 , C07C235/82 , C07C237/06 , C07C237/08 , C07C271/22 , C07D209/48 , C07D303/36 , C07D405/12 , C07D407/12 , C07F5/02 , C07F9/655 , C07K5/078 , A61K31/382 , C07D43/02 , C07D49/02
CPC分类号： C07D209/48 , A61K38/00 , C07D303/36 , C07D405/12 , C07D407/12 , C07F5/025 , C07F9/65502 , C07K5/06139
摘要： The present invention provides compounds haviang formula (1): wherein R1-R6, A, J, D, E, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of cancer and/or inflammatory disorders, and more generally as proteasome inhibitors.
摘要翻译： 本发明提供了式（1）化合物：其中R 1 -R 6，A，J，D，E，G，Q，w，x，y， 和z如本文中所述的一般和类别和亚类所述，并且另外提供其药物组合物，以及其用于治疗癌症和/或炎症性疾病的方法，更一般地，作为蛋白酶体抑制剂。
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公开(公告)号：US20090291998A1
公开(公告)日：2009-11-26
申请号：US12396849
申请日：2009-03-03
申请人： Sergei Agoulnik , Kozo Akasaka , Francis Fang , Jean-Christophe Harmange , Lynn Hawkins , Yimin Jiang , Charles Johannes , Xiang-Yi Li , Pamela McGuinness , Erin A. Murphy , Shawn Schiller , Mary Vermeulen , Jiayi Wu
发明人： Sergei Agoulnik , Kozo Akasaka , Francis Fang , Jean-Christophe Harmange , Lynn Hawkins , Yimin Jiang , Charles Johannes , Xiang-Yi Li , Pamela McGuinness , Erin A. Murphy , Shawn Schiller , Mary Vermeulen , Jiayi Wu
IPC分类号： A61K31/4035 , C07D303/36 , C07D317/06 , C07D307/78 , C07D209/04 , C07D311/04 , A61K31/336 , A61K31/357 , A61K31/343 , A61K31/352 , A61P35/00
CPC分类号： C07D209/48 , A61K38/00 , C07D303/36 , C07D405/12 , C07D407/12 , C07F5/025 , C07F9/65502 , C07K5/06139
摘要： The present invention provides compounds having formula (1): wherein R1-R6, A, J, D, A, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of cancer and/or inflammatory disorders, and more generally as proteasome inhibitors.
摘要翻译： 本发明提供具有式（1）的化合物：其中R 1 -R 6，A，J，D，A，G，Q，w，x，y和z如本文中所述的类别和亚类所述， 其药物组合物及其用于治疗癌症和/或炎症性疾病的方法，更一般地，作为蛋白酶体抑制剂。
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公开(公告)号：US20050123566A1
公开(公告)日：2005-06-09
申请号：US11024328
申请日：2004-12-28
申请人： Lynn Hawkins , Sally Ishizaka , Michael Lewis , Pamela McGuinness , Jeffrey Rose
发明人： Lynn Hawkins , Sally Ishizaka , Michael Lewis , Pamela McGuinness , Jeffrey Rose
IPC分类号： A61K31/16 , A61K31/17 , A61K39/39 , C07F9/09 , C07F9/10 , C07F9/655 , C07F9/02 , A61K9/127 , A61K39/02
CPC分类号： C07F9/65515 , A61K31/16 , A61K31/17 , A61K39/39 , A61K2039/55511 , A61K2039/55555 , C07F9/091 , C07F9/10
摘要： The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of the invention, to novel immunostimulatory compositions which comprise an antigen and at least one of the adjuvant compounds of the invention, and to methods for the immunization of an animal by co-administration of a compound of the invention with an antigen against which the animal is to be immunized.
摘要翻译： 本发明涉及当与诸如用于细菌和病毒疾病的疫苗的抗原共同给予包括至少一种本发明的佐剂化合物的新型佐剂制剂与新的免疫刺激组合物共同施用时用作免疫佐剂的新化合物， 包括抗原和至少一种本发明的佐剂化合物，以及通过将本发明化合物与待免疫动物的抗原共同给药的动物免疫方法。
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4.发明授权公开(公告)号：US08350059B2
公开(公告)日：2013-01-08
申请号：US12746672
申请日：2008-12-08
申请人： Roch Boivin , Silvio A. Campagna , Hong Du , Francis G. Fang , Thomas Horstmann , Charles-Andre Lemelin , Jing Li , Pamela McGuinness , Xiang Niu , Matthew J. Schnaderbeck , Kevin (kuo-ming) Wu , Xiaojie (jeff) Zhu
发明人： Roch Boivin , Silvio A. Campagna , Hong Du , Francis G. Fang , Thomas Horstmann , Charles-Andre Lemelin , Jing Li , Pamela McGuinness , Xiang Niu , Matthew J. Schnaderbeck , Kevin (kuo-ming) Wu , Xiaojie (jeff) Zhu
IPC分类号： C07D493/00
CPC分类号： C07D313/00 , C07D317/22 , C07D317/24 , C07D317/30 , C07D319/08 , C07D493/04 , Y02P20/55
摘要： Disclosed herein are methods and intermediates useful in the preparation of macrolides, e.g., compounds of formula (IV) wherein R1-R12 are as defined herein.
摘要翻译： 本文公开了可用于制备大环内酯类的方法和中间体，例如其中R 1 -R 12如本文所定义的式（IV）化合物。
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公开(公告)号：US07560584B2
公开(公告)日：2009-07-14
申请号：US11024328
申请日：2004-12-28
IPC分类号： C07F9/02
CPC分类号： C07F9/65515 , A61K31/16 , A61K31/17 , A61K39/39 , A61K2039/55511 , A61K2039/55555 , C07F9/091 , C07F9/10
摘要： The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of the invention, to novel immunostimulatory compositions which comprise an antigen and at least one of the adjuvant compounds of the invention, and to methods for the immunization of an animal by co-administration of a compound of the invention with an antigen against which the animal is to be immunized.
摘要翻译： 本发明涉及当与诸如用于细菌和病毒疾病的疫苗的抗原共同给予包括至少一种本发明的佐剂化合物的新型佐剂制剂与新的免疫刺激组合物共同施用时用作免疫佐剂的新化合物， 包括抗原和至少一种本发明的佐剂化合物，以及通过将本发明化合物与待免疫动物的抗原共同给药的动物免疫方法。
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公开(公告)号：US06835721B2
公开(公告)日：2004-12-28
申请号：US10208936
申请日：2002-07-31
IPC分类号： A61K3166
CPC分类号： C07F9/65515 , A61K31/16 , A61K31/17 , A61K39/39 , A61K2039/55511 , A61K2039/55555 , C07F9/091 , C07F9/10
摘要： The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of the invention, to novel immunostimulatory compositions which comprise an antigen and at least one of the adjuvant compounds of the invention, and to methods for the immunization of an animal by co-administration of a compound of the invention with an antigen against which the animal is to be immunized.
摘要翻译： 本发明涉及当与诸如用于细菌和病毒疾病的疫苗的抗原共同给予包括至少一种本发明的佐剂化合物的新型佐剂制剂与新的免疫刺激组合物共同施用时用作免疫佐剂的新化合物， 包括抗原和至少一种本发明的佐剂化合物，以及通过将本发明化合物与待免疫动物的抗原共同给药的动物免疫方法。
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