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11 条记录 (耗时 0.026 秒)

    Screening Assay for Inhibitors of TRPA1 Activation by a Lower Alkyl Phenol
    1.
    发明申请
    Screening Assay for Inhibitors of TRPA1 Activation by a Lower Alkyl Phenol 审中-公开
    通过低级烷基酚激活TRPA1抑制剂的筛选试验

    公开(公告)号：US20100248987A1

    公开(公告)日：2010-09-30

    申请号：US12700263

    申请日：2010-02-04

    申请人： Seunghun Paul Lee ,  Qifeng Yang ,  Robert W. Bryant ,  Tulu Buber

    发明人： Seunghun Paul Lee ,  Qifeng Yang ,  Robert W. Bryant ,  Tulu Buber

    IPC分类号： C12Q1/02 ,  C40B30/06

    CPC分类号： G01N33/6872 ,  G01N2500/04 ,  G01N2500/10

    摘要： The invention relates an assay useful for screening and identifying compounds as modulators of lower alkyl phenol activation of TRPA1. Thymol, a lower alkyl phenol anti-infective and the active ingredient in, e.g., mouthwashes, is stringent and has an objectionable burning taste sensation. Thymol activates the transient receptor potential like ion channel TRPA1. The assay described and claimed herein involves measurement of activation of TRPA1 and enables the screening of compounds that inhibit lower alkyl phenol, or thymol activation of TRPA1. Inhibitors of thymol activation of TRPA1 can be used to prevent the objectionable taste of thymol in medical uses where taste limits acceptance.

    摘要翻译： 本发明涉及用于筛选和鉴定化合物作为TRPA1的低级烷基苯酚活化调节剂的测定法。 麝香草酚，低级烷基苯酚抗感染剂和例如漱口水中的活性成分是严格的并且具有令人不快的燃烧味觉。 百里酚激活瞬时受体电位，如离子通道TRPA1。 本文描述和要求保护的测定包括测量TRPA1的活化，并且能够筛选抑制低级烷基苯酚的化合物或TRPA1的百里酚激活。 TRPA1的百里酚激活抑制剂可用于防止在味道限制接受的医疗用途中百里酚的令人反感的味道。

    Screening assay for inhibitors of TRPA1 activation by a lower alkyl phenol
    2.
    发明授权
    Screening assay for inhibitors of TRPA1 activation by a lower alkyl phenol 失效
    通过低级烷基酚对TRPA1活化抑制剂的筛选测定

    公开(公告)号：US07674594B2

    公开(公告)日：2010-03-09

    申请号：US11828955

    申请日：2007-07-26

    申请人： Seunghun Paul Lee ,  Qifeng Yang ,  Robert W. Bryant ,  Tulu Buber

    发明人： Seunghun Paul Lee ,  Qifeng Yang ,  Robert W. Bryant ,  Tulu Buber

    IPC分类号： G01N33/53 ,  C07K14/705

    CPC分类号： G01N33/6872 ,  G01N2500/04 ,  G01N2500/10

    摘要： The invention relates an assay useful for screening and identifying compounds as modulators of lower alkyl phenol activation of TRPA1. Thymol, a lower alkyl phenol anti-infective and the active ingredient in, e.g., mouthwashes, is stringent and has an objectionable burning taste sensation. Thymol activates the transient receptor potential like ion channel TRPA1. The assay described and claimed herein involves measurement of activation of TRPA1 and enables the screening of compounds that inhibit lower alkyl phenol, or thymol activation of TRPA1. Inhibitors of thymol activation of TRPA1 can be used to prevent the objectionable taste of thymol in medical uses where taste limits acceptance.

    摘要翻译： 本发明涉及用于筛选和鉴定化合物作为TRPA1的低级烷基苯酚活化调节剂的测定法。 麝香草酚，低级烷基苯酚抗感染剂和例如漱口水中的活性成分是严格的并且具有令人不快的燃烧味觉。 百里酚激活瞬时受体电位，如离子通道TRPA1。 本文描述和要求保护的测定包括测量TRPA1的活化，并且能够筛选抑制低级烷基苯酚的化合物或TRPA1的百里酚激活。 TRPA1的百里酚激活抑制剂可用于防止在味道限制接受的医疗用途中百里酚的令人反感的味道。

    High throughput screening assay for the TRPM5 ion channel
    3.
    发明授权
    High throughput screening assay for the TRPM5 ion channel 有权
    TRPM5离子通道的高通量筛选测定

    公开(公告)号：US07749730B2

    公开(公告)日：2010-07-06

    申请号：US11592180

    申请日：2006-11-03

    申请人： Robert W. Bryant ,  S. Paul Lee ,  R. Kyle Palmer ,  Qifeng Yang ,  M. N. Tulu Buber

    发明人： Robert W. Bryant ,  S. Paul Lee ,  R. Kyle Palmer ,  Qifeng Yang ,  M. N. Tulu Buber

    IPC分类号： C12P1/00

    CPC分类号： G01N33/502 ,  G01N33/6872 ,  G01N2500/00

    摘要： There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods suffer from a lack of sensitivity, low throughput, and are labor intensive. The claimed methods provide fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5.

    摘要翻译： 本领域需要可以鉴定特异性调节快速离子通道（如TRPM5）的活性的化合物的高通量筛选测定。 目前的方法缺乏敏感性，低产量，并且是劳动密集型的。 所要求保护的方法提供具有光学读出器的荧光测定，其能够快速读出结果，具有高的信噪比背景比，易于使用，可被修改以用于自动化和小型化，并提供化合物特异性调节TRPM5的验证。

    Non-desensitizing mutant of the transient receptor potential TRPM5 ion channel
    4.
    发明授权
    Non-desensitizing mutant of the transient receptor potential TRPM5 ion channel 有权
    瞬态受体电位TRPM5离子通道的非脱敏突变体

    公开(公告)号：US07875452B2

    公开(公告)日：2011-01-25

    申请号：US12285140

    申请日：2008-09-30

    申请人： Robert W. Bryant ,  S. Paul Lee ,  Rok Cerne ,  M. N. Tulu Buber ,  Ivona Bakaj ,  Roy Kyle Palmer

    发明人： Robert W. Bryant ,  S. Paul Lee ,  Rok Cerne ,  M. N. Tulu Buber ,  Ivona Bakaj ,  Roy Kyle Palmer

    IPC分类号： C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  C12N1/21

    CPC分类号： G01N33/502 ,  C07K14/705 ,  C07K2319/21 ,  G01N33/6872 ,  G01N2500/00

    摘要： There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods, especially electrophysiological, suffer from a lack of sensitivity, rapid signal loss, low throughput, and are labor intensive. The claimed methods and compositions provide electrophysiology methods that allow prolonged sample testing and fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5.

    摘要翻译： 本领域需要可以鉴定特异性调节快速离子通道（如TRPM5）的活性的化合物的高通量筛选测定。 当前的方法，特别是电生理学，缺乏敏感性，信号丢失快，吞吐量低，是劳动密集型的。 所要求保护的方法和组合物提供电生理学方法，其允许使用光学读出器进行长时间的样品测试和荧光测定，其给出结果的快速读数，具有高的信噪比背景比，易于使用，可以被修改以用于自动化和小型化， 并提供化合物特异性调节TRPM5的验证。

    Non-desensitizing mutant of the transient receptor potential TRPM5 ion channel
    5.
    发明申请
    Non-desensitizing mutant of the transient receptor potential TRPM5 ion channel 有权
    瞬态受体电位TRPM5离子通道的非脱敏突变体

    公开(公告)号：US20090136975A1

    公开(公告)日：2009-05-28

    申请号：US12285140

    申请日：2008-09-30

    申请人： Robert W. Bryant ,  S. Paul Lee ,  Rok Cerne ,  M.N. Tulu Buber ,  Ivona Bakaj ,  Kyle Palmer

    发明人： Robert W. Bryant ,  S. Paul Lee ,  Rok Cerne ,  M.N. Tulu Buber ,  Ivona Bakaj ,  Kyle Palmer

    IPC分类号： C12Q1/56 ,  C12N15/11 ,  C12N15/00 ,  C12N5/08 ,  C07K14/00 ,  C12P21/04 ,  C12Q1/02

    CPC分类号： G01N33/502 ,  C07K14/705 ,  C07K2319/21 ,  G01N33/6872 ,  G01N2500/00

    摘要： There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods, especially electrophysiological, suffer from a lack of sensitivity, rapid signal loss, low throughput, and are labor intensive. The claimed methods and compositions provide electrophysiology methods that allow prolonged sample testing and fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5.

    摘要翻译： 本领域需要可以鉴定特异性调节快速离子通道（如TRPM5）的活性的化合物的高通量筛选测定。 当前的方法，特别是电生理学，缺乏敏感性，信号丢失快，吞吐量低，是劳动密集型的。 所要求保护的方法和组合物提供电生理学方法，其允许使用光学读出器进行长时间的样品测试和荧光测定，其给出结果的快速读数，具有高的信噪比背景比，易于使用，可以被修改以用于自动化和小型化， 并提供化合物特异性调节TRPM5的验证。

    Denture Removal Tools
    10.
    发明申请
    Denture Removal Tools 审中-公开

    公开(公告)号：US20200022780A1

    公开(公告)日：2020-01-23

    申请号：US16504047

    申请日：2019-07-05

    申请人： Robert W. Bryant

    发明人： Robert W. Bryant

    IPC分类号： A61C3/00

    摘要： A tool and set thereof providing for relatively easy removal of dentures is described. At least one embodiment comprises a set of tools: one for removal of an upper denture; and a second for removal of a lower denture. Each are characterized by a cylindrical shaft that has a flat or facet formed near its distal end that tapers towards the distal end thinning the shaft. The tip is bent to about a 90 degree angle. The thin tip can be easily maneuvered over a lip of a denture and as necessary in-between the denture lip and the underlying gum. The user holding onto the handle on the proximal end of the tool can push, pull, leverage and rotate the tip to pop the denture loose for removal.