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    High throughput screening assay for the TRPM5 ion channel
    1.
    发明授权
    High throughput screening assay for the TRPM5 ion channel 有权
    TRPM5离子通道的高通量筛选测定

    公开(公告)号：US07749730B2

    公开(公告)日：2010-07-06

    申请号：US11592180

    申请日：2006-11-03

    申请人： Robert W. Bryant ,  S. Paul Lee ,  R. Kyle Palmer ,  Qifeng Yang ,  M. N. Tulu Buber

    发明人： Robert W. Bryant ,  S. Paul Lee ,  R. Kyle Palmer ,  Qifeng Yang ,  M. N. Tulu Buber

    IPC分类号： C12P1/00

    CPC分类号： G01N33/502 ,  G01N33/6872 ,  G01N2500/00

    摘要： There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods suffer from a lack of sensitivity, low throughput, and are labor intensive. The claimed methods provide fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5.

    摘要翻译： 本领域需要可以鉴定特异性调节快速离子通道（如TRPM5）的活性的化合物的高通量筛选测定。 目前的方法缺乏敏感性，低产量，并且是劳动密集型的。 所要求保护的方法提供具有光学读出器的荧光测定，其能够快速读出结果，具有高的信噪比背景比，易于使用，可被修改以用于自动化和小型化，并提供化合物特异性调节TRPM5的验证。

    High Throughput Screening Assay for the TRPM5 Ion Channel
    3.
    发明申请
    High Throughput Screening Assay for the TRPM5 Ion Channel 审中-公开
    TRPM5离子通道的高通量筛选测定

    公开(公告)号：US20100248988A1

    公开(公告)日：2010-09-30

    申请号：US12790013

    申请日：2010-05-28

    申请人： Robert W. BRYANT ,  S. Paul Lee ,  R. Kyle Palmer ,  Qifeng Yang ,  M.N. Tulu Buber

    发明人： Robert W. BRYANT ,  S. Paul Lee ,  R. Kyle Palmer ,  Qifeng Yang ,  M.N. Tulu Buber

    IPC分类号： C40B30/06 ,  C07H21/04

    CPC分类号： G01N33/502 ,  G01N33/6872 ,  G01N2500/00

    摘要： There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods suffer from a lack of sensitivity, low throughput, and are labor intensive. The claimed methods provide fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5.

    摘要翻译： 本领域需要可以鉴定特异性调节快速离子通道（如TRPM5）的活性的化合物的高通量筛选测定。 目前的方法缺乏敏感性，低产量，并且是劳动密集型的。 所要求保护的方法提供具有光学读出器的荧光测定，其能够快速读出结果，具有高的信噪比背景比，易于使用，可被修改以用于自动化和小型化，并提供化合物特异性调节TRPM5的验证。

    Sweetness Enhancers Including Rebaudioside A or D
    4.
    发明申请
    Sweetness Enhancers Including Rebaudioside A or D 审中-公开
    甜度增强剂包括雷鲍迪苷A或D

    公开(公告)号：US20120164083A1

    公开(公告)日：2012-06-28

    申请号：US13393942

    申请日：2010-08-31

    申请人： R. Kyle Palmer ,  F. Raymond Salemme

    发明人： R. Kyle Palmer ,  F. Raymond Salemme

    IPC分类号： A23L1/236 ,  A61K8/60 ,  A61Q11/00 ,  A61K47/26

    CPC分类号： A23L2/52 ,  A23K20/10 ,  A23K20/111 ,  A23K20/121 ,  A23K50/40 ,  A23K50/42 ,  A23L2/60 ,  A23L27/33 ,  A23L27/34 ,  A23V2002/00 ,  A23V2200/132 ,  A23V2250/258 ,  A23V2250/262

    摘要： The present invention is directed to the use of rebaudioside A or rebaudioside D in combination with one or more compounds of Formula (I), or a stereoisomer thereof, wherein R2 is rhamnose, and R and R1 are each independently selected from the group consisting of hydrogen, glucose, and beta-sophorose, for enhancing the sweet taste of carbohydrate sweeteners, such as sucrose and fructose. The present invention is also directed to consumables which include a combination of a carbohydrate sweetener, rebaudioside A or rebaudioside D, and one or more compounds of Formula (I), or a stereoisomer thereof.

    摘要翻译： 本发明涉及新蛇菊苷A或莱鲍迪苷D与一种或多种式（I）化合物或其立体异构体的组合的用途，其中R 2是鼠李糖，R 1和R 2各自独立地选自 氢，葡萄糖和β-槐糖，用于增强碳水化合物甜味剂如蔗糖和果糖的甜味。 本发明还涉及包含碳水化合物甜味剂，新蛇菊苷A或莱鲍迪甙D以及一种或多种式（I）化合物或其立体异构体的组合的消耗品。