公开(公告)号：US08619464B1

公开(公告)日：2013-12-31

申请号：US13219537

申请日：2011-08-26

申请人： Shankar Sinha ,  Brian Wong ,  Shih-Lin S. Lee ,  Abhishek Sharma

发明人： Shankar Sinha ,  Brian Wong ,  Shih-Lin S. Lee ,  Abhishek Sharma

IPC分类号： G11C11/00

CPC分类号： G11C7/02 ,  G11C8/16 ,  G11C11/412 ,  G11C11/419 ,  H01L27/1104

摘要： Integrated circuits may have arrays of memory elements. Data may be loaded into the memory elements and read from the memory elements using data lines. Address lines may be used to apply address signals to write address transistors and read circuitry. A memory element may include a bistable storage element. Read circuitry may be coupled between the bistable storage element and a data line. The read circuitry may include a data storage node. A capacitor may be coupled between the data storage node and ground and may be used in storing preloaded data from the bistable storage element. The read circuitry may include a transistor that is coupled between the bistable storage element and the data storage node and a transistor that is coupled between the data storage node and the data line.

摘要翻译： 集成电路可以具有存储元件阵列。 数据可以被加载到存储器元件中并且使用数据线从存储器元件读取。 地址线可以用于施加地址信号以写入地址晶体管和读取电路。 存储元件可以包括双稳态存储元件。 读取电路可以耦合在双稳态存储元件和数据线之间。 所述读取电路可以包括数据存储节点。 电容器可以耦合在数据存储节点和地之间，并且可以用于存储来自双稳态存储元件的预加载的数据。 读取电路可以包括耦合在双稳态存储元件和数据存储节点之间的晶体管，以及耦合在数据存储节点和数据线之间的晶体管。

公开(公告)号：US09102963B2

公开(公告)日：2015-08-11

申请号：US14110964

申请日：2012-04-12

申请人： Anupam Gohel ,  Derek Smith ,  Brian Wong ,  Joly Sukumaran ,  Wan Lin Yeo ,  Steven J. Collier ,  Scott Novick

发明人： Anupam Gohel ,  Derek Smith ,  Brian Wong ,  Joly Sukumaran ,  Wan Lin Yeo ,  Steven J. Collier ,  Scott Novick

IPC分类号： C12P17/10 ,  C12N9/02 ,  C07D223/22 ,  C07D223/28 ,  C07D453/02 ,  C12P41/00 ,  C12N9/04

CPC分类号： C12P17/10 ,  C07D223/22 ,  C07D223/28 ,  C07D453/02 ,  C12N9/0006 ,  C12N9/004 ,  C12N11/00 ,  C12P41/002 ,  C12Y101/00 ,  Y02P20/52

摘要： The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.

摘要翻译： 本公开涉及生物催化剂及其用于有效制备西酞西泮，醋酸西拉西平及其类似物的用途。

公开(公告)号：US20110106350A1

公开(公告)日：2011-05-05

申请号：US12609545

申请日：2009-10-30

申请人： Bassam D. Jalbout ,  Brian Wong

发明人： Bassam D. Jalbout ,  Brian Wong

IPC分类号： G06F19/00

CPC分类号： B60W10/08 ,  B60K28/16 ,  B60L11/00 ,  B60L15/08 ,  B60L15/2045 ,  B60L15/2072 ,  B60L2200/26 ,  B60W2520/26 ,  B60W2550/148 ,  Y02T10/645 ,  Y02T10/646 ,  Y02T10/7283

摘要： Fixed frequency, fixed duration pulse streams are used to control power switches for one or more electrical motors of electrically powered vehicles or hybrid vehicles having one or more electric motors. The advantages of a pulse system are increased power efficiency and system simplicity over analog systems. The capability of system calibration with a single pulse allows the system to be used under any conditions, and real time adaptation to changes in conditions. Such system and methods provide much improved acceleration over other electrical systems, by making the best use of the coefficient of starting or static friction. The systems and methods provide a non slip traction control system, and the use of an off state in the pulse stream is superior to the use of braking systems for the same purpose, which waste power and cause mechanical wear. In addition, related computer program products are described.

摘要翻译： 固定频率固定持续时间脉冲流被用于控制具有一个或多个电动机的电动车辆或混合动力车辆的一个或多个电动机的电力开关。 脉冲系统的优点是提高了模拟系统的功率效率和系统简单性。 使用单个脉冲进行系统校准的能力允许系统在任何条件下使用，并实时适应条件变化。 这种系统和方法通过充分利用起动或静摩擦系数提供比其他电气系统更大的改进的加速度。 这些系统和方法提供了非滑动牵引力控制系统，并且在脉冲流中使用关闭状态优于使用相同目的的制动系统，其浪费功率并引起机械磨损。 此外，还描述了相关的计算机程序产品。

公开(公告)号：US20100264314A1

公开(公告)日：2010-10-21

申请号：US12426545

申请日：2009-04-20

申请人： Bassam D. Jalbout ,  Brian Wong

发明人： Bassam D. Jalbout ,  Brian Wong

IPC分类号： G01J5/02 ,  G01J5/00 ,  H05B41/36

CPC分类号： H05B37/0272

摘要： Disclosed are lighting techniques, including systems, apparatus, and methods, that employ optical transmission of two-dimensional control signals to manipulate lighting elements. The lighting apparatus can include a projector with an IR LED array to wirelessly transmit pixel information onto a target space. The pixel information controls lighting elements within the target space. The two-dimensional control signals can includes subareas corresponding to lighting elements in a control array. The lighting elements can be lights of desired wavelengths including infrared and/or visible wavelengths. LEDs can be used as light sources in exemplary embodiments.

公开(公告)号：US20100183620A1

公开(公告)日：2010-07-22

申请号：US12626534

申请日：2009-11-25

申请人： KAUMUDI BHAWE ,  Elizabeth Bosch ,  Kathleen Boyle ,  Arthur Brace ,  Anuk Das ,  Francis Farrell ,  Pitchumani Sivakumar ,  Jeffrey Finer ,  Kristen Pierce ,  Kathleen M. Sullivan ,  Brian Wong

发明人： KAUMUDI BHAWE ,  Elizabeth Bosch ,  Kathleen Boyle ,  Arthur Brace ,  Anuk Das ,  Francis Farrell ,  Pitchumani Sivakumar ,  Jeffrey Finer ,  Kristen Pierce ,  Kathleen M. Sullivan ,  Brian Wong

IPC分类号： A61K39/395 ,  A61K31/7088 ,  A61K38/02 ,  A61K38/16 ,  A61P21/00 ,  C12Q1/68

CPC分类号： C07K14/811 ,  A61K38/57 ,  C07K16/38 ,  C07K2317/76

摘要： The invention encompasses methods and compositions for increasing or decreasing collagen 1A1 expression and/or α-smooth muscle actin expression in lung fibroblasts using SERPINE2 and antagonists of SERPINE2. The invention also encompasses methods and compositions for increasing or decreasing the formation of myofibroblasts. The invention further provides methods and compositions for treatment of lung diseases, such as idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease.

摘要翻译： 本发明包括使用SERPINE2和SERPINE2拮抗剂增加或减少肺成纤维细胞中胶原1A1表达和/或α-平滑肌肌动蛋白表达的方法和组合物。 本发明还包括用于增加或减少肌成纤维细胞形成的方法和组合物。 本发明进一步提供了治疗肺部疾病如特发性肺纤维化和慢性阻塞性肺疾病的方法和组合物。

公开(公告)号：US07736846B2

公开(公告)日：2010-06-15

申请号：US10652961

申请日：2003-08-28

申请人： Esteban Masuda ,  Brian Wong

发明人： Esteban Masuda ,  Brian Wong

IPC分类号： C12Q1/10 ,  G01N33/53

CPC分类号： G01N33/5011 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5047 ,  G01N33/5091 ,  G01N33/6893 ,  G01N2333/9015 ,  G01N2510/00

摘要： The present invention relates to regulation of inflammation. More particularly, the present invention is directed to nucleic acids encoding components of the ubiquitin ligation pathway, e.g., ubiquitin and ubiquitin-like molecules, E1, E2, and E3 proteins and their substrates, which are involved in modulation of the inflammatory process. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, RNAi, antisense nucleic acids, and ribozymes, that modulate the inflammatory process via modulation of the ubiquitin ligation pathway; as well as to the use of expression profiles and compositions in diagnosis and therapy related to regulation of inflammation and modulation of cytokine signaling involved in inflammation, e.g., for treatment of infection, autoimmune disease and other diseases related to the inflammatory process.

摘要翻译： 本发明涉及炎症的调节。 更具体地，本发明涉及编码泛素连接途径的组分的核酸，例如涉及炎症过程调节的泛素和泛素样分子，E1，E2和E3蛋白及其底物。 本发明还涉及用于鉴别和使用通过调节泛素连接途径调节炎症过程的试剂，包括小分子化学组合物，抗体，肽，环肽，核酸，RNAi，反义核酸和核酶的方法; 以及在与炎症调节相关的诊断和治疗相关的诊断和治疗中使用表达谱和组合物，例如用于治疗感染，自身免疫性疾病和与炎症过程相关的其它疾病。

公开(公告)号：US20100072907A1

公开(公告)日：2010-03-25

申请号：US12625118

申请日：2009-11-24

申请人： Bassam Jalbout ,  Brian Wong

发明人： Bassam Jalbout ,  Brian Wong

IPC分类号： H05B41/36 ,  H05B39/04

CPC分类号： H05B33/0815 ,  H05B33/0824

摘要： A switched preconditioner circuit is provided at the power input end of a light source to effectively drop the voltage of the light source to zero volts whenever the light source is required to be in an OFF state thereby eliminating the problem of unwanted current through the light source. The preconditioner circuit may include a terminal connected to a first power potential, a terminal connected to a power node at the power input end of the light source, and an input to receive a preconditioner control signal to place the preconditioner circuit in one of an ON state and an OFF state. The preconditioner circuit supplies the voltage to the power node in its ON state and effectively eliminates the voltage to the power node in its OFF state. The preconditioner circuit also may include a bleed path connected between the power node and a second or ground potential to shunt all power supplied to the power node when the preconditioner circuit input receives a signal to place the preconditioner circuit in the OFF state.

摘要翻译： 在光源的电源输入端设置开关预处理电路，以便在要求光源处于关断状态时有效地将光源的电压降至零伏，从而消除了通过光源的不期望的电流的问题 。 预处理器电路可以包括连接到第一电源电位的端子，连接到光源的电力输入端处的功率节点的端子和用于接收预处理器控制信号的输入端，以将预处理器电路放置在ON 状态和OFF状态。 预处理器电路将电压提供给处于其导通状态的电源节点，并且有效地消除了电源节点处于其关闭状态的电压。 预处理器电路还可以包括连接在功率节点和第二或接地电位之间的放电路径，以在预处理器电路输入接收到将预处理器电路置于OFF状态的信号时分流供应给功率节点的所有功率。

公开(公告)号：US07638950B1

公开(公告)日：2009-12-29

申请号：US11882322

申请日：2007-07-31

申请人： Bassam Jalbout ,  Brian Wong

发明人： Bassam Jalbout ,  Brian Wong

IPC分类号： H05B41/36

CPC分类号： H05B33/0815 ,  H05B33/0824

摘要： A switched preconditioner circuit is provided at the power input end of a light source to effectively drop the voltage of the light source to zero volts whenever the light source is required to be in an OFF state thereby eliminating the problem of unwanted current through the light source. The preconditioner circuit may include a terminal connected to a first power potential, a terminal connected to a power node at the power input end of the light source, and an input to receive a preconditioner control signal to place the preconditioner circuit in one of an ON state and an OFF state. The preconditioner circuit supplies the voltage to the power node in its ON state and effectively eliminates the voltage to the power node in its OFF state. The preconditioner circuit also may include a bleed path connected between the power node and a second or ground potential to shunt all power supplied to the power node when the preconditioner circuit input receives a signal to place the preconditioner circuit in the OFF state.

摘要翻译： 在光源的电源输入端设置开关预处理电路，以便在要求光源处于关断状态时有效地将光源的电压降至零伏，从而消除了通过光源的不期望的电流的问题 。 预处理器电路可以包括连接到第一电源电位的端子，连接到光源的电力输入端处的功率节点的端子和用于接收预处理器控制信号的输入端，以将预处理器电路放置在ON 状态和OFF状态。 预处理器电路将电压提供给处于其导通状态的电源节点，并且有效地消除了电源节点处于其关闭状态的电压。 预处理器电路还可以包括连接在功率节点和第二或接地电位之间的放电路径，以在预处理器电路输入接收到将预处理器电路置于OFF状态的信号时分流供应给功率节点的所有功率。

公开(公告)号：US07622442B2

公开(公告)日：2009-11-24

申请号：US11241106

申请日：2005-09-30

申请人： Yongwon Choi ,  Brian Wong ,  Regis Josien ,  Ralph Steinman

发明人： Yongwon Choi ,  Brian Wong ,  Regis Josien ,  Ralph Steinman

IPC分类号： A61K38/17 ,  A61K38/19 ,  C07K14/00 ,  C07K14/52

CPC分类号： C07K16/2875 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/525 ,  C07K14/70575 ,  C07K2317/76 ,  C07K2319/30 ,  C12N15/1096

摘要： A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo. Preferably, the method of the present invention results in increasing immune response towards the antigen in the animal.

摘要翻译： 公开了调节动物免疫应答的方法。 这种方法将来自动物的未成熟树突状细胞与抗原离体相互作用，使得未成熟树突状细胞在其表面上存在抗原，诱导未成熟树突状细胞离体成熟，并使成熟树突状细胞离体与调节剂接触 包括TRANCE，其保守变体，其片段，其类似物或衍生物，或包含TRANCE的氨基酸序列，其保守变体或其片段的融合蛋白。 离体调节剂离体接触后，将成熟树突状细胞导入动物体内。 因此，动物中针对抗原的免疫反应相对于动物中针对抗原的免疫应答进行调节，其中树突细胞离体不与抗原相互作用，并且不离体接触调节剂。 优选地，本发明的方法导致对动物中抗原的免疫应答增加。

公开(公告)号：US20090261746A1

公开(公告)日：2009-10-22

申请号：US12466688

申请日：2009-05-15

申请人： Bassam D. Jalbout ,  Brian Wong

发明人： Bassam D. Jalbout ,  Brian Wong

IPC分类号： H05B37/02

CPC分类号： H05B33/0815 ,  H05B33/0827

摘要： A method and circuit to control the intensity of lights, illumination fixtures, and displays using pulses of a fixed duration and a fixed frequency (FD/FF) is provided. In particular, the method may be used to control one more light sources. By varying the number of pulses in a control burst, the total current flowing through the light source may be precisely controlled providing greater accuracy than other methods, such as, for example, PWM or variable pulse frequency. The FD/FF technique may be used in conjunction with any number of light sources, and finds particular application in LED displays and for any type of LED illumination fixture.

摘要翻译： 提供了使用固定持续时间和固定频率（FD / FF）的脉冲来控制光，照明器具和显示器的强度的方法和电路。 特别地，该方法可以用于控制另一个光源。 通过改变控制脉冲串中的脉冲数，可以精确地控制流过光源的总电流，提供比其它方法（例如PWM或可变脉冲频率）更高的精度。 FD / FF技术可以与任何数量的光源结合使用，并且在LED显示器和任何类型的LED照明灯具中都可以使用。